{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:24:49Z","timestamp":1792070689589,"version":"4.4.0"},"reference-count":52,"publisher":"Japanese Society of Hypertension","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2008]]},"DOI":"10.1291\/hypres.31.363","type":"journal-article","created":{"date-parts":[[2008,3,21]],"date-time":"2008-03-21T05:52:06Z","timestamp":1206078726000},"page":"363-375","source":"Crossref","is-referenced-by-count":107,"title":["Aldosterone Nongenomically Produces NADPH Oxidase\u2212Dependent Reactive Oxygen Species and Induces Myocyte Apoptosis"],"prefix":"10.1291","volume":"31","author":[{"given":"Hironori","family":"HAYASHI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"KOBARA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"ABE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"TANAKA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"GOUDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroe","family":"TOBA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"YAMADA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"TATSUMI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"NAKATA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"MATSUBARA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"119","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Silvestre JS, Heymes C, Oubenaissa A, et al<\/i>: Activation of cardiac aldosterone production in rat myocardial infarction: effect of angiotensin II receptor blockade and role in cardiac fibrosis. Circulation<\/i> 1999; 99<\/b>: 2694-2701.","DOI":"10.1161\/01.CIR.99.20.2694"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.9.4883"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Barnett CA, Pritchett EL: Detection of corticosteroid type I binding sites in heart. Mol Cell Endocrinol<\/i> 1988; 56<\/b>: 191-198.","DOI":"10.1016\/0303-7207(88)90060-3"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Lazar G, Pagano M, Agarwal MK: Purification and characterization of the activated mineralocorticoid receptor from rat myocardium. Biochim Biophys Acta<\/i> 1990; 1033<\/b>: 41-48.","DOI":"10.1016\/0304-4165(90)90192-Y"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Lombes M, Alfaidy N, Eugene E, Lessana A, Farman N, Bonvalet JP: Prerequisite for cardiac aldosterone action. Mineralocorticoid receptor and 11 beta-hydroxysteroid dehydrogenase in the human heart. Circulation<\/i> 1995; 92<\/b>: 175-182.","DOI":"10.1161\/01.CIR.92.2.175"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Pitt B, Zannad F, Remme WJ, et al<\/i>: The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med<\/i> 1999; 341<\/b>: 709-717.","DOI":"10.1056\/NEJM199909023411001"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030207"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Mizuno Y, Yoshimura M, Yasue H, et al<\/i>: Aldosterone production is activated in failing ventricle in humans. Circulation<\/i> 2001; 103<\/b>: 72-77.","DOI":"10.1161\/01.CIR.103.1.72"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Swedberg K, Eneroth P, Kjekshus J, Wilhelmsen L: Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group. Circulation<\/i> 1990; 82<\/b>: 1730-1736.","DOI":"10.1161\/01.CIR.82.5.1730"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000030935.89559.04"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Sun Y, Zhang J, Lu L, Chen SS, Quinn MT, Weber KT: Aldosterone-induced inflammation in the rat heart: role of oxidative stress. Am J Pathol<\/i> 2002; 161<\/b>: 1773-1781.","DOI":"10.1016\/S0002-9440(10)64454-9"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.28.925"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.28.447"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Chai W, Garrelds IM, Arulmani U, Schoemaker RG, Lamers JM, Danser AH: Genomic and nongenomic effects of aldosterone in the rat heart: why is spironolactone cardioprotective? Br J Pharmacol<\/i> 2005; 145<\/b>: 664-671.","DOI":"10.1038\/sj.bjp.0706220"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Singal PK, Khaper N, Farahmand F, Bello-Klein A: Oxidative stress in congestive heart failure. Curr Cardiol Rep<\/i> 2000; 2<\/b>: 206-211.","DOI":"10.1007\/s11886-000-0070-x"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Ide T, Tsutsui H, Kinugawa S, et al<\/i>: Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium. Circ Res<\/i> 1999; 85<\/b>: 357-363.","DOI":"10.1161\/01.RES.85.4.357"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.65.5.245"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Mallat Z, Philip I, Lebret M, Chatel D, Maclouf J, Tedgui A: Elevated levels of 8-iso-prostaglandin F2alpha in pericardial fluid of patients with heart failure: a potential role for in vivo<\/i> oxidant stress in ventricular dilatation and progression to heart failure. Circulation<\/i> 1998; 97<\/b>: 1536-1539.","DOI":"10.1161\/01.CIR.97.16.1536"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. von Harsdorf R, Li PF, Dietz R: Signaling pathways in reactive oxygen species−induced cardiomyocyte apoptosis. Circulation<\/i> 1999; 99<\/b>: 2934-2941.","DOI":"10.1161\/01.CIR.99.22.2934"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200317664"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Griendling KK, Sorescu D, Ushio-Fukai M: NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res<\/i> 2000; 86<\/b>: 494-501.","DOI":"10.1161\/01.RES.86.5.494"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Heymes C, Bendall JK, Ratajczak P, et al<\/i>: Increased myocardial NADPH oxidase activity in human heart failure. J Am Coll Cardiol<\/i> 2003; 41<\/b>: 2164-2171.","DOI":"10.1016\/S0735-1097(03)00471-6"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000032031.30374.32"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005040390"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Callera GE, Montezano AC, Yogi A, et al<\/i>: c-Src−dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats. Hypertension<\/i> 2005; 46<\/b>: 1032-1038.","DOI":"10.1161\/01.HYP.0000176588.51027.35"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-4642fje"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000135599.33787.CA"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Shiraishi J, Tatsumi T, Keira N, et al<\/i>: Important role of energy-dependent mitochondrial pathways in cultured rat cardiac myocyte apoptosis. Am J Physiol Heart Circ Physiol<\/i> 2001; 281<\/b>: H1637-H1647.","DOI":"10.1152\/ajpheart.2001.281.4.H1637"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Matoba S, Tatsumi T, Keira N, et al<\/i>: Cardioprotective effect of angiotensin-converting enzyme inhibition against hypoxia\/reoxygenation injury in cultured rat cardiac myocytes. Circulation<\/i> 1999; 99<\/b>: 817-822.","DOI":"10.1161\/01.CIR.99.6.817"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Mohazzab-H KM, Kaminski PM, Wolin MS: Lactate and P<\/i>O<\/small>2<\/sub> modulate superoxide anion production in bovine cardiac myocytes: potential role of NADH oxidase. Circulation<\/i> 1997; 96<\/b>: 614-620.","DOI":"10.1161\/01.CIR.96.2.614"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Zhang M, Kho AL, Anilkumar N, et al<\/i>: Glycated proteins stimulate reactive oxygen species production in cardiac myocytes: involvement of Nox2 (gp91phox)-containing NADPH oxidase. Circulation<\/i> 2006; 113<\/b>: 1235-1243.","DOI":"10.1161\/CIRCULATIONAHA.105.581397"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000143072.36782.51"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Chai W, Garrelds IM, de Vries R, Batenburg WW, van Kats JP, Danser AH: Nongenomic effects of aldosterone in the human heart: interaction with angiotensin II. Hypertension<\/i> 2005; 46<\/b>: 701-706.","DOI":"10.1161\/01.HYP.0000182661.98259.4f"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Kuster GM, Pimentel DR, Adachi T, et al<\/i>: Alpha-adrenergic receptor−stimulated hypertrophy in adult rat ventricular myocytes is mediated via<\/i> thioredoxin-1−sensitive oxidative modification of thiols on Ras. Circulation<\/i> 2005; 111<\/b>: 1192-1198.","DOI":"10.1161\/01.CIR.0000157148.59308.F5"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Turchin A, Guo CZ, Adler GK, Ricchiuti V, Kohane IS, Williams GH: Effect of acute aldosterone administration on gene expression profile in the heart. Endocrinology<\/i> 2006; 147<\/b>: 3183-3189.","DOI":"10.1210\/en.2005-1674"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Sergeant S, McPhail LC: Opsonized zymosan stimulates the redistribution of protein kinase C isoforms in human neutrophils. J Immunol<\/i> 1997; 159<\/b>: 2877-2885.","DOI":"10.4049\/jimmunol.159.6.2877"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Serezani CH, Aronoff DM, Jancar S, Mancuso P, Peters-Golden M: Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae<\/i> through the activation of NADPH oxidase. Blood<\/i> 2005; 106<\/b>: 1067-1075.","DOI":"10.1182\/blood-2004-08-3323"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Tsubouchi H, Inoguchi T, Sonta T, et al<\/i>: Statin attenuates high glucose−induced and diabetes-induced oxidative stress in vitro<\/i> and in vivo<\/i> evaluated by electron spin resonance measurement. Free Radic Biol Med<\/i> 2005; 39<\/b>: 444-452.","DOI":"10.1016\/j.freeradbiomed.2005.03.031"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.8.3410"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5296.90"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.9.2596"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003412200"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2136717100"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.05.151"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2003.10.054"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.27.781"},{"issue":"4\/5","key":"47","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jsbmb.2003.12.014","volume":"88","author":"THOMPSON A","year":"2004","ISSN":"https:\/\/id.crossref.org\/issn\/0960-0760","issn-type":"print"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Reini SA, Wood CE, Jensen E, Keller-Wood M: Increased maternal cortisol in late-gestation ewes decreases fetal cardiac expression of 11beta-HSD2 mRNA and the ratio of AT1 to AT2 receptor mRNA. Am J Physiol Regul Integr Comp Physiol<\/i> 2006; 291<\/b>: R1708-R1716.","DOI":"10.1152\/ajpregu.00294.2006"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000080521.15238.E5"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.11.3698-3706.2002"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Frantz S, Brandes RP, Hu K, et al<\/i>: Left ventricular remodeling after myocardial infarction in mice with targeted deletion of the NADPH oxidase subunit gp91PHOX. Basic Res Cardiol<\/i> 2006; 101<\/b>: 127-132.","DOI":"10.1007\/s00395-005-0568-x"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Doerries C, Grote K, Hilfiker-Kleiner D, et al<\/i>: Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling\/dysfunction and survival after myocardial infarction. Circ Res<\/i> 2007; 100<\/b>: 894-903.","DOI":"10.1161\/01.RES.0000261657.76299.ff"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T05:44:51Z","timestamp":1684302291000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nature.com\/doifinder\/10.1291\/hypres.31.363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1291\/hypres.31.363","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}