{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:28:25Z","timestamp":1778275705672,"version":"3.51.4"},"reference-count":32,"publisher":"Japanese Society of Veterinary Science","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Vet. Med. Sci.","The Journal of Veterinary Medical Science"],"published-print":{"date-parts":[[2013]]},"DOI":"10.1292\/jvms.12-0240","type":"journal-article","created":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T23:10:50Z","timestamp":1352934650000},"page":"421-429","source":"Crossref","is-referenced-by-count":29,"title":["Evaluation of the Chondroprotective Effects of Glucosamine and Fish Collagen Peptide on a Rabbit ACLT Model Using Serum Biomarkers"],"prefix":"10.1292","volume":"75","author":[{"given":"Akihiro","family":"OHNISHI","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Medicine, Tottori University, 4\u2013101 Koyama-Minami, Tottori 680\u20138553, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"OSAKI","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine, Tottori University, 4\u2013101 Koyama-Minami, Tottori 680\u20138553, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiharu","family":"MATAHIRA","sequence":"additional","affiliation":[{"name":"R & D Division, Yaizu Suisankagaku Industry Co., Ltd., 5\u20138\u201313 Kogawa-Shinmachi, Yaizu 425\u20138570, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"TSUKA","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine, Tottori University, 4\u2013101 Koyama-Minami, Tottori 680\u20138553, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"IMAGAWA","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine, Tottori University, 4\u2013101 Koyama-Minami, Tottori 680\u20138553, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiharu","family":"OKAMOTO","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine, Tottori University, 4\u2013101 Koyama-Minami, Tottori 680\u20138553, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saburo","family":"MINAMI","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine, Tottori University, 4\u2013101 Koyama-Minami, Tottori 680\u20138553, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"122","reference":[{"key":"1","unstructured":"1. Benito-Ruiz, P., Comacho-Zambrano, M. M., Carrilo-Arcentales, J. N., Mestanza-Peralta, M. A., Vallejo-Flores, C. A., Vargas-Lopez, S. V., Villacis-Tamayo, R. A. and Zurita-Gavilanes, L. A. 2009. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. Int. J. Food Sci. Nutr. 60: 99&ndash;113."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Clark, K. L., Sebastianelli, W., Flechsenhar, K. R., Aukermann, D. F., Meza, F., Millard, R. L., Deitch, J. R., Sherbondy, P. S. and Albert, A. 2008. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr. Med. Res. Opin. 24: 1485&ndash;1496.","DOI":"10.1185\/030079908X291967"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Crolle, G. and D&rsquo;Este, E. 1980. Glucosamine sulphate for the management of arthrosis: a controlled clinical investigation. Curr. Med. Res. Opin. 7: 104&ndash;109.","DOI":"10.1185\/03007998009112035"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. De Ceuninck, F., Sabatini, M. and Pastoureau, P. 2011. Recent progress toward biomarker identification in osteoarthritis. Drug Discov. Today (in press).","DOI":"10.1016\/j.drudis.2011.01.004"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Duclos, M. E., Roualdes, O., Cararo, R., Rousseau, J. C., Roger, T. and Hartmann, D. J. 2010. Significance of the serum CTX-II level in an osteoarthritis animal model: a 5-month longitudinal study. Osteoarthritis Cartilage 18: 1467&ndash;1476.","DOI":"10.1016\/j.joca.2010.07.007"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Elliott, A. L., Kraus, V. B., Luta, G., Stabler, T., Renner, J. B., Woodard, J., Dragomir, A. D., Helmick, C. G., Hochberg, M. C. and Jordan, J. M. 2005. Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston Country Osteoarthritis Project. Arthritis Rheum. 52: 105&ndash;111.","DOI":"10.1002\/art.20724"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Eyre, D. R. 2004. Collagens and cartilage matrix homeostasis. Clin. Orthop. Relat. Res. 427: 118&ndash;122.","DOI":"10.1097\/01.blo.0000144855.48640.b9"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Garvican, E. R., Vaughan-Thomas, A., Innes, J. F. and Clegg, P. D. 2010. Biomarkers of cartilage turnover. Part 1: markers of collagen degradation and synthesis. Vet. J. 185: 36&ndash;42.","DOI":"10.1016\/j.tvjl.2010.04.011"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Goldberg, R. L., Huff, J. P., Lenz, M. E., Glickman, P., Katz, R. and Thonar, E. J. 1991. Elevated plasma levels in patients with osteoarthritis and rheumatoid arthritis. Arthritis Rheum. 34: 799&ndash;807.","DOI":"10.1002\/art.1780340704"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Henrotin, Y., Lambert, C., Couchourel, D., Ripoll, C. and Chiotelli, E. 2011. Nutraceuticals: do they represent a new era in the management of osteoarthritis?-a narrative review from the lessons taken with five products. Osteoarthritis Cartilage 19: 1&ndash;21.","DOI":"10.1016\/j.joca.2010.10.017"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Lohmander, L. S., Ionescu, M., Jugessur, H. and Poole, A. R. 1999. Changes in joint cartilage aggrecan after knee injury and in osteoarthritis. Arthritis Rheum. 42: 534&ndash;544.","DOI":"10.1002\/1529-0131(199904)42:3<534::AID-ANR19>3.0.CO;2-J"},{"key":"12","unstructured":"12. Lohmander, L. S., Ostenberg, A., Englund, M. and Roos, H. 2004. High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury. Arthritis Rheum. 50: 3145&ndash;3152."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Lopes Vaz, A. 1982. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Curr. Med. Res. Opin. 8: 145&ndash;149.","DOI":"10.1185\/03007998209112375"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Maroudas, A., Bayliiss, M. T. and Venn, M. F. 1980. Further studies on the composition of human femoral head cartilage. Ann. Rheum. Dis. 39: 514&ndash;523.","DOI":"10.1136\/ard.39.5.514"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Naito, K., Watari, T., Furuhata, A., Yomogida, S., Sakamoto, K., Kurosawa, H., Kaneko, K. and Nagaoka, I. 2010. Evaluation of the effect of glucosamine on an experimental rat osteoarthritis model. Life Sci. 86: 538&ndash;543.","DOI":"10.1016\/j.lfs.2010.02.015"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Nakatani, S., Mano, H., Sampei, C., Shimizu, J. and Wada, M. 2009. Chondroprotective effect of the bioactive peptide prolyl-hydroxyproline in mouse articular cartilage <i>in vitro<\/i> and <i>in vivo<\/i>. Osteoarthritis Cartilage 17: 1620&ndash;1627.","DOI":"10.1016\/j.joca.2009.07.001"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Oegema, T. R.Jr., Deloria, L. B., Sandy, J. D. and Hart, D. A. 2002. Effect of oral glucosamine on cartilage and meniscus in normal and chymopapain-injected knees of young rabbits. Arthritis Rheum. 46: 2495&ndash;2503.","DOI":"10.1002\/art.10499"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Oesser, S. and Seifert, J. 2003. Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. Cell Tissue Res. 311: 393&ndash;399.","DOI":"10.1007\/s00441-003-0702-8"},{"key":"19","unstructured":"19. Ohara, H., Iida, H., Ito, K., Takeuchi, Y. and Nomura, Y. 2010. Effects of Pro-Hyp, a collagen hydrolysate-derived peptide, on hyaluronic acid synthesis using <i>in vitro<\/i> cultured synovium cells and oral ingestion of collagen hydrolysates in a guinea pig model of osteoarthritis. Biosci. Biotechnol. Biochem. 74: 2096&ndash;2099."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Ohara, H., Matsumoto, H., Ito, K., Iwai, K. and Sato, K. 2007. Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources. J. Agric. Food Chem. 55: 1532&ndash;1535.","DOI":"10.1021\/jf062834s"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Okumura, M., Tagami, M. and Fujinaga, H. 1998. Measurement of serum and synovial fluid keratan sulphate and antibody to collagen type II in equine osteoarthritis. Zentralbl. Veterinarmed. A 45: 513&ndash;516.","DOI":"10.1111\/j.1439-0442.1998.tb00854.x"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Pujalte, J. M., Llavore, E. P. and Ylescupidez, F. R. 1980. Double-blind clinical evaluation of oral glucosamine sulphate in the basic treatment of osteoarthrosis. Curr. Med. Res. Opin. 7: 110&ndash;114.","DOI":"10.1185\/03007998009112036"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Rizkalla, G., Reiner, A., Roqoch, E. and Poole, A. R. 1992. Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis. Evidence for molecular heterogeneity and extensive molecular changes in disease. J. Clin. Invest. 90: 2268&ndash;2277.","DOI":"10.1172\/JCI116113"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Rousseau, J. C. and Delmas, P. D. 2007. Biological markers in osteoarthritis. Nat. Clin. Pract. Rheumatol. 3: 346&ndash;356.","DOI":"10.1038\/ncprheum0508"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Sharif, M., George, E., Shepstone, L., Knudson, W., Thonar, E. J., Crushnaghan, J. and Dieppe, P. 1995. Serum hyaluronic acid level as a predictor of disease progression in osteoarthritis of the knee. Arthritis Rheum. 38: 760&ndash;767.","DOI":"10.1002\/art.1780380608"},{"key":"26","unstructured":"26. Takahashi, K., Hashimoto, S., Kudo, T., Hirasawa, Y., Lotz, M. and Amiel, D. 2000. Effect of hyaluronan on chondrocyte apoptosis and nitric oxide production in experimentally induced osteoarthritis. J. Rheumatol. 27: 1713&ndash;1720."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Uitterlinden, E. J., Koevoet, J. L., Verkoelen, C. F., Bierma-Zeinstra, S. M., Jahr, H., Weinans, H., Verhaar, J. A. and van Osch, G. J. 2008. Glucosamine increases hyaluronic acid production in human osteoarthritic synovium explants. BMC Musculoskelet. Disord. 9: 120.","DOI":"10.1186\/1471-2474-9-120"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Vidal y Plana, R. R., Bizzarri, D. and Rovati, A. L. 1978. Articular cartilage pharmacology. I. <i>In vitro<\/i> studies on glucosamine and nonsteroidal anti-inflammatory drugs. Pharmacol. Res. Commun. 10: 557&ndash;569.","DOI":"10.1016\/S0031-6989(78)80054-X"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Wakitani, S., Nawata, M., Kawaguchi, A., Okabe, T., Takaoka, K., Tsuchiya, T., Nakaoka, R., Masuda, H. and Miyawaki, K. 2007. Serum keratin sulfate is a promising marker of early articular cartilage breakdown. Rheumatology (Oxford) 46: 1652&ndash;1656.","DOI":"10.1093\/rheumatology\/kem220"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Walrand, S., Chiotelli, E., Noirt, F., Mwewa, S. and Lassel, T. 2008. Consumption of a functional fermented milk containing collagen hydrolysate improves the concentration of collagen-specific amino acids in plasma. J. Agric. Food Chem. 56: 7790&ndash;7795.","DOI":"10.1021\/jf800691f"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Wang, S. X., Laverty, S., Dumitriu, M., Plaas, A. and Grynpas, M. D. 2007. The effects of glucosamine hydrochloride on subchondral bone changes in an animal model of osteoarthritis. Arthritis Rheum. 56: 1537&ndash;1548.","DOI":"10.1002\/art.22574"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Yoshioka, M., Coutts, R. D., Amiel, D. and Hacker, S. A. 1996. Characterization of a model of osteoarthritis in the rabbit knee. Osteoarthritis Cartilage 4: 87&ndash;98.","DOI":"10.1016\/S1063-4584(05)80318-8"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/75\/4\/75_12-0240\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T01:09:18Z","timestamp":1617066558000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/75\/4\/75_12-0240\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.12-0240","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}