{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:52:10Z","timestamp":1787021530199,"version":"build-2736575974"},"reference-count":11,"publisher":"Japanese Society of Veterinary Science","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Vet. Med. Sci.","The Journal of Veterinary Medical Science"],"published-print":{"date-parts":[[2014]]},"DOI":"10.1292\/jvms.13-0156","type":"journal-article","created":{"date-parts":[[2013,11,28]],"date-time":"2013-11-28T18:13:25Z","timestamp":1385662405000},"page":"545-548","source":"Crossref","is-referenced-by-count":17,"title":["Imatinib Responsiveness in Canine Mast Cell Tumors Carrying Novel Mutations          of &lt;i&gt;c-KIT&lt;\/i&gt; Exon 11"],"prefix":"10.1292","volume":"76","author":[{"given":"Yuko","family":"NAKANO","sequence":"first","affiliation":[{"name":"Japan Small Animal Cancer Center, 2\u201327\u20134              Nakatomi-minami, Tokorozawa, Saitama 359\u20130003, Japan"},{"name":"Division of Clinical Epidemiology, Research Center for              Medical Science, Jikei University School of Medicine, 3\u201325\u20138 Nishi-Shinbashi,              Minato-Ku, Tokyo 105\u20138461, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"KOBAYASHI","sequence":"additional","affiliation":[{"name":"Japan Small Animal Cancer Center, 2\u201327\u20134              Nakatomi-minami, Tokorozawa, Saitama 359\u20130003, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fukiko","family":"OSHIMA","sequence":"additional","affiliation":[{"name":"Japan Small Animal Cancer Center, 2\u201327\u20134              Nakatomi-minami, Tokorozawa, Saitama 359\u20130003, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"FUKAZAWA","sequence":"additional","affiliation":[{"name":"Japan Small Animal Cancer Center, 2\u201327\u20134              Nakatomi-minami, Tokorozawa, Saitama 359\u20130003, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsushi","family":"YAMAGAMI","sequence":"additional","affiliation":[{"name":"Japan Small Animal Medical Center, 2\u201327\u20134              Nakatomi-minami, Tokorozawa, Saitama 359\u20130003, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yozo","family":"SHIRAISHI","sequence":"additional","affiliation":[{"name":"Japan Small Animal Medical Center, 2\u201327\u20134              Nakatomi-minami, Tokorozawa, Saitama 359\u20130003, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamine","family":"TAKANOSU","sequence":"additional","affiliation":[{"name":"Japan Small Animal Medical Center, 2\u201327\u20134              Nakatomi-minami, Tokorozawa, Saitama 359\u20130003, Japan"},{"name":"Nasunogahara Animal Clinic, 2\u20133574\u201398 Asaka, Ohtawara,              Tochigi 324\u20130043, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"122","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Demetri, G. D., von Mehren, M., Blanke, C. D., Van den Abbeele, A. D., Eisenberg, B., Roberts, P. J., Heinrich, M. C., Tuveson, D. A., Singer, S., Janicek, M., Fletcher, J. A., Silverman, S. G., Silberman, S. L., Capdeville, R., Kiese, B., Peng, B., Dimitrijevic, S., Druker, B. J., Corless, C., Fletcher, C. D. and Joensuu, H. 2002. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. <i>N. Engl. J. Med.<\/i> 347: 472\u2013480.","DOI":"10.1056\/NEJMoa020461"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Druker, B. J., Talpaz, M., Resta, D. J., Peng, B., Buchdunger, E., Ford, J. M., Lydon, N. B., Kantarjian, H., Capdeville, R., Ohno-Jones, S. and Sawyers, C. L. 2001. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. <i>N. Engl. J. Med.<\/i> 344: 1031\u20131037.","DOI":"10.1056\/NEJM200104053441401"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Isotani, M., Ishida, N., Tominaga, M., Tamura, K., Yagihara, H., Ochi, S., Kato, R., Kobayashi, T., Fujita, M., Fujino, Y., Setoguchi, A., Ono, K., Washizu, T. and Bonkobara, M. 2008. Effect of tyrosine kinase inhibition by imatinib mesylate on mast cell tumors in dogs. <i>J. Vet. Intern. Med.<\/i> 22: 985\u2013988.","DOI":"10.1111\/j.1939-1676.2008.00132.x"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Kobayashi, M., Kuroki, S., Ito, K., Yasuda, A., Sawada, H., Ono, K., Washizu, T. and Bonkobara, M. 2013. Imatinib-associated tumour response in a dog with a non-resectable gastrointestinal stromal tumour harbouring a <i>c-kit<\/i> exon 11 deletion mutation. <i>Vet. J.<\/i> 198: 271\u2013274.","DOI":"10.1016\/j.tvjl.2013.05.035"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Kobayashi, M., Sugisaki, O., Ishii, N., Yamada, O., Ito, K., Kuroki, S., Sasaki, Y., Ono, K., Washizu, T. and Bonkobara, M. 2012. Canine intestinal mast cell tumor with c-kit exon 8 mutation responsive to imatinib therapy. <i>Vet. J.<\/i> 193: 264\u2013267.","DOI":"10.1016\/j.tvjl.2011.10.027"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Letard, S., Yang, Y., Hanssens, K., Palmerini, F., Leventhal, P. S., Guery, S., Moussy, A., Kinet, J. P., Hermine, O. and Dubreuil, P. 2008. Gain-of-function mutations in the extracellular domain of KIT are common in canine mast cell tumors. <i>Mol. Cancer Res.<\/i> 6: 1137\u20131145.","DOI":"10.1158\/1541-7786.MCR-08-0067"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Lim, K. H., Huang, M. J., Chen, L. T., Wang, T. W., Liu, C. L., Chang, C. S., Liu, M. C., Hsieh, R. K. and Tzen, C. Y. 2008. Molecular analysis of secondary kinase mutations in imatinib-resistant gastrointestinal stromal tumors. <i>Med. Oncol.<\/i> 25: 207\u2013213.","DOI":"10.1007\/s12032-007-9014-2"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Ma, Y., Longley, B. J., Wang, X., Blount, J. L., Langley, K. and Caughey, G. H. 1999. Clustering of activating mutations in c-KIT\u2019s juxtamembrane coding region in canine mast cell neoplasms. <i>J. Invest. Dermatol.<\/i> 112: 165\u2013170.","DOI":"10.1046\/j.1523-1747.1999.00488.x"},{"key":"9","unstructured":"9. Tan, C. B., Zhi, W., Shahzad, G. and Mustacchia, P. 2012. Gastrointestinal stromal tumors: a review of case reports, diagnosis, treatment, and future directions. <i>ISRN Gastroenterol.<\/i> 2012: 595968."},{"key":"10","unstructured":"10. Therasse, P., Arbuck, S. G., Eisenhauer, E. A., Wanders, J., Kaplan, R. S., Rubinstein, L., Verweij, J., Van Glabbeke, M., van Oosterom, A. T., Christian, M. C. and Gwyther, S. G. 2000. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. <i>J. Natl. Cancer Inst.<\/i> 92: 205\u2013216."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Yamada, O., Kobayashi, M., Sugisaki, O., Ishii, N., Ito, K., Kuroki, S., Sasaki, Y., Isotani, M., Ono, K., Washizu, T. and Bonkobara, M. 2011. Imatinib elicited a favorable response in a dog with a mast cell tumor carrying a c-kit c.1523A&gt;T mutation via suppression of constitutive KIT activation. <i>Vet. Immunol. Immunopathol.<\/i> 142: 101\u2013106.","DOI":"10.1016\/j.vetimm.2011.04.002"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/76\/4\/76_13-0156\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T21:12:10Z","timestamp":1617052330000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/76\/4\/76_13-0156\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.13-0156","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}