{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T03:12:02Z","timestamp":1767064322065},"reference-count":38,"publisher":"Japanese Society of Veterinary Science","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Vet. Med. Sci.","The Journal of Veterinary Medical Science"],"published-print":{"date-parts":[[2014]]},"DOI":"10.1292\/jvms.13-0419","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T06:46:31Z","timestamp":1383288391000},"page":"323-330","source":"Crossref","is-referenced-by-count":14,"title":["&lt;i&gt;Babesia bovis&lt;\/i&gt; Dihydroorotate Dehydrogenase (BboDHODH) is a          Novel Molecular Target of Drug for Bovine Babesiosis"],"prefix":"10.1292","volume":"76","author":[{"given":"Ketsarin","family":"KAMYINGKIRD","sequence":"first","affiliation":[{"name":"National Research Center for Protozoan Diseases,              Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555,              Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinuo","family":"CAO","sequence":"additional","affiliation":[{"name":"National Research Center for Protozoan Diseases,              Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555,              Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsunori","family":"MASATANI","sequence":"additional","affiliation":[{"name":"National Research Center for Protozoan Diseases,              Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555,              Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul Franck Adjou","family":"MOUMOUNI","sequence":"additional","affiliation":[{"name":"National Research Center for Protozoan Diseases,              Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555,              Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"VUDRIKO","sequence":"additional","affiliation":[{"name":"National Research Center for Protozoan Diseases,              Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555,              Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Abd El Moniem","family":"MOUSA","sequence":"additional","affiliation":[{"name":"National Research Center for Protozoan Diseases,              Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555,              Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad Alaa","family":"TERKAWI","sequence":"additional","affiliation":[{"name":"National Research Center for Protozoan Diseases,              Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555,              Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"NISHIKAWA","sequence":"additional","affiliation":[{"name":"National Research Center for Protozoan Diseases,              Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555,              Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuo","family":"IGARASHI","sequence":"additional","affiliation":[{"name":"National Research Center for Protozoan Diseases,              Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555,              Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuenan","family":"XUAN","sequence":"additional","affiliation":[{"name":"National Research Center for Protozoan Diseases,              Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555,              Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"122","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Aboulaila, M., Nakamura, K., Govind, Y., Yokoyama, N. and Igarashi, I. 2010a. Evaluation of the <i>in vitro<\/i> growth-inhibitory effect of epoxomicin on <i>Babesia<\/i> parasites. <i>Vet. Parasitol.<\/i> 167: 19\u201327.","DOI":"10.1016\/j.vetpar.2009.09.049"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182009991594"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M206854200"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1021\/bi971628y"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182004005190"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(99)01471-4"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2012.10.005"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.09.055"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(76)90143-0"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Ferreira, R. A., de Oliveira, A. B., Gualberto, S. A., Corral, J. M. M. D., Fujiwara, R. T., Guimar\u00e3es, P. H. G. and de Almeida Vitor, R. W. 2012. New naphthoquinones and an alkaloid with <i>in vitro<\/i> activity against <i>Toxoplasma gondii<\/i> RH and EGS strains. <i>Exp. Parasitol.<\/i> 132: 450\u2013457.","DOI":"10.1016\/j.exppara.2012.09.003"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Gero, A. M., O\u2019Sullivan, W. J., Wright, I. G. and Mahoney, D. F. 1983. The enzymes of pyrimidine biosynthesis in <i>Babesia bovis<\/i> and <i>Babesia bigemina<\/i>. <i>Aust. J. Exp. Biol. Med. Sci.<\/i> 61: 239\u2013243.","DOI":"10.1038\/icb.1983.22"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Gohil, S., Herrmann, S., G\u00fcnther, S. and Cooke, B. M. 2013. Bovine babesiosis in the 21st century: advances in biology and functional genomics. <i>Int. J. Parasitol.<\/i> 43: 125\u2013132.","DOI":"10.1016\/j.ijpara.2012.09.008"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Greene, S., Watanabe, K., Braatz-Trulson, J. and Lou, L. 1995. Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide. <i>Biochem. Pharmacol.<\/i> 50: 861\u2013867.","DOI":"10.1016\/0006-2952(95)00255-X"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1021\/jm200265b"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Heikkil\u00e4, T., Thirumalairajan, S., Davies, M., Parsons, M. R., McConkey, A. G., Fishwick, C. W. G. and Johnson, P. 2006. The first de novo designed inhibitors of <i>Plasmodium falciparum<\/i> dihydroorotate dehydrogenase. <i>Bioorg. Med. Chem. Lett.<\/i> 16: 88\u201392.","DOI":"10.1016\/j.bmcl.2005.09.045"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Homer, M. J., Aguilar-Delfin, I., Telford, S. R.., Krause, P. J. and Persing, D. H. 2000. Babesiosis. <i>Clin. Microbiol.<\/i> 13: 451\u2013469.","DOI":"10.1128\/CMR.13.3.451"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Hortua Triana, M. A., Huynh, M. H., Garavito, M. F., Fox, B. A., Bzik, D. J., Carruthers, V. B., L\u00f6ffler, M. and Zimmermann, B. H. 2012. Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from <i>Toxoplasma gondii<\/i>. <i>Mol. Biochem. Parasitol.<\/i> 184: 71\u201381.","DOI":"10.1016\/j.molbiopara.2012.04.009"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Igarashi, I., Njonge, F. K., Kaneko, Y. and Nakamura, Y. 1998. <i>Babesia bigemina<\/i>: <i>in vitro<\/i> and <i>in vivo<\/i> effects of curdlan sulfate on growth of parasites. <i>Exp. Parasitol.<\/i> 90: 290\u2013293.","DOI":"10.1006\/expr.1998.4331"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Knecht, W. and L\u00f6ffler, M. 1998. Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive Isoxazol and Cinchoninic acid derivatives. <i>Biochem.Pharmacol.<\/i> 56: 1259\u20131264.","DOI":"10.1016\/S0006-2952(98)00145-2"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.8.2100-2108.2000"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Lau, A. O. T., Pedroni, M. J. and Bhanot, P. 2013. Target specific-trisubstituted pyrrole inhibits <i>Babesia bovis<\/i> erythrocytic growth. <i>Exp. Parasitol.<\/i> 133: 365\u2013368.","DOI":"10.1016\/j.exppara.2012.12.013"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. L\u00f6ffler, M., Grein, K., Knecht, W., Klein, A. and Bergjohann, U. 1998. Dihydroorotate dehydrogenase: profile of a novel target for antiproliferative and immunosuppressive drugs. <i>Adv. Exp. Med. Biol.<\/i> 431: 507\u2013513.","DOI":"10.1007\/978-1-4615-5381-6_99"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Matsuu, A., Koshida, Y., Kawahara, M., Inoue, K., Ikadai, H., Hikasa, Y., Okano, S. and Higuchi, S. 2004. Efficacy of atovaquone against <i>Babesia gibsoni in vivo<\/i> and <i>in vitro<\/i>. <i>Vet. Parasitol.<\/i> 124: 9\u201318.","DOI":"10.1016\/j.vetpar.2004.07.005"},{"key":"24","unstructured":"24. Munkhjargal, T., Aboulaila, M. R. A., Sivakumar, T., Yokoyama, N. and Igarashi, I. 2009. Inhibitory effect of apicidin on <i>in vitro<\/i> and <i>in vivo<\/i> growth of <i>Babesia<\/i> parasites. <i>J. Protozool. Res.<\/i> 19: 42\u201349."},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Oz, H. S. and Tobin, T. 2012. Atovaquone ameliorate gastrointestinal Toxoplasmosis complications in a pregnancy model. <i>Med. Sci. Monit.<\/i> 18: 337\u2013345.","DOI":"10.12659\/MSM.883342"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Phillips, M. A., Gujjar, R., Malmquist, N. A., White, J., Mazouni, F. E., Baldwin, J. and Rathod, P. K. 2008. Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite <i>Plasmodium falciparum<\/i>. <i>J. Med. Chem.<\/i> 51: 3649\u20133653.","DOI":"10.1021\/jm8001026"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Phillips, M. A. and Rathod, P. K. 2010. <i>Plasmodium<\/i> dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy. <i>Infect. Disord. Drug Targets<\/i> 10: 226\u2013239.","DOI":"10.2174\/187152610791163336"},{"key":"28","unstructured":"28. Pudney, M. and Gray, J. S. 1997. Therapeutic efficacy of atovaquone against the bovine intraerythrocytic parasite, Babesia divergens. <i>J. Parasitol.<\/i> 83: 307\u2013310."},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0813167106"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01213.x"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2012.08.022"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Shambaugh, G. E. 1979. Pyrimidine biosynthesis. <i>Am. J. Clin. Nutr.<\/i> 32: 1290\u20131297.","DOI":"10.1093\/ajcn\/32.6.1290"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Sierra Pagan, M. L. and Zimmermann, B. H. 2003. Cloning and expression of the dihydroorotate dehydrogenase from <i>Toxoplasma gondii<\/i>. <i>Biochim. Biophys. Acta.<\/i> 1637: 178\u2013181.","DOI":"10.1016\/S0925-4439(02)00226-0"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Uilenberg, G. 2006. <i>Babesia<\/i>-a historical overview. <i>Vet. Parasitol<\/i>. 138: 3\u201310.","DOI":"10.1016\/j.vetpar.2006.01.035"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Vial, H. J. and Gorenflot, A. 2006. Chemotherapy against babesiosis. <i>Vet. Parasitol.<\/i> 138: 147\u2013160.","DOI":"10.1016\/j.vetpar.2006.01.048"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1021\/bi8003318"},{"key":"37","unstructured":"37. World Organization for Animal Health (OIE) Manual of diagnostic tests and vaccines (online). Paris 2008. (Bovine babesiosis: http:\/\/www.oie.int\/fr\/nomes\/mmanual\/A_00059.htm)."},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02569-06"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/76\/3\/76_13-0419\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T01:13:40Z","timestamp":1617066820000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/76\/3\/76_13-0419\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.13-0419","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}