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Aboulaila, M., Nakamura, K., Govind, Y., Yokoyama, N. and Igarashi, I. 2010. Evaluation of the <i>in vitro<\/i> growth-inhibitory effect of epoxomicin on <i>Babesia<\/i> parasites. <i>Vet. Parasitol.<\/i> 167: 19\u201327.","DOI":"10.1016\/j.vetpar.2009.09.049"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Agarwal, S., Singh, M. K., Garg, S., Chitnis, C. E. and Singh, S. 2013. Ca(2+) -mediated exocytosis of subtilisin-like protease 1: a key step in egress of <i>Plasmodium falciparum<\/i> merozoites. <i>Cell. Microbiol.<\/i> 15: 910\u2013921.","DOI":"10.1111\/cmi.12086"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Arrizabalaga, G., Ruiz, F., Moreno, S. and Boothroyd, J. C. 2004. Ionophore-resistant mutant of <i>Toxoplasma gondii<\/i> reveals involvement of a sodium\/hydrogen exchanger in calcium regulation. <i>J. Cell Biol.<\/i> 165: 653\u2013662.","DOI":"10.1083\/jcb.200309097"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Behrendt, J. H., Taubert, A., Zahner, H. and Hermosilla, C. 2008. Studies on synchronous egress of coccidian parasites (<i>Neospora caninum, Toxoplasma gondii, Eimeria bovis<\/i>) from bovine endothelial host cells mediated by calcium ionophore A23187. <i>Vet. Res. Commun.<\/i> 32: 325\u2013332.","DOI":"10.1007\/s11259-007-9033-7"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Beraldo, F. H., Mikoshiba, K. and Garcia, C. R. 2007. Human malarial parasite, <i>Plasmodium falciparum<\/i>, displays capacitative calcium entry: 2-aminoethyl diphenylborinate blocks the signal transduction pathway of melatonin action on the <i>P. falciparum<\/i> cell cycle. <i>J. Pineal Res.<\/i> 43: 360\u2013364.","DOI":"10.1111\/j.1600-079X.2007.00486.x"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Berridge, M. J., Lipp, P. and Bootman, M. D. 2000. The versatility and universality of calcium signalling. <i>Nat. Rev. Mol. Cell Biol.<\/i> 1: 11\u201321.","DOI":"10.1038\/35036035"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Bock, R., Jackson, L., de Vos, A. and Jorgensen, W. 2004. Babesiosis of cattle. <i>Parasitology<\/i> 129: S247\u2013S269.","DOI":"10.1017\/S0031182004005190"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Bork, S., Das, S., Okubo, K., Yokoyama, N. and Igarashi, I. 2006. Effects of protein kinase inhibitors on the <i>in vitro<\/i> growth of <i>Babesia bovis<\/i>. <i>Parasitology<\/i> 132: 775\u2013779.","DOI":"10.1017\/S0031182006009917"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Bork, S., Yokoyama, N., Matsuo, T., Claveria, F. G., Fujisaki, K. and Igarashi, I. 2003. Clotrimazole, ketoconazole, and clodinafop-propargyl as potent growth inhibitors of equine <i>Babesia<\/i> parasites during <i>in vitro<\/i> culture. <i>J. Parasitol.<\/i> 89: 604\u2013606.","DOI":"10.1645\/0022-3395(2003)089[0604:CKACAP]2.0.CO;2"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Bork, S., Yokoyama, N., Matsuo, T., Claveria, F. G., Fujisaki, K. and Igarashi, I. 2003. Growth inhibitory effect of triclosan on equine and bovine <i>Babesia<\/i> parasites. <i>Am. J. Trop. Med. Hyg.<\/i> 68: 334\u2013340.","DOI":"10.4269\/ajtmh.2003.68.334"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Carruthers, V. B., Giddings, O. K. and Sibley, L. D. 1999. Secretion of micronemal proteins is associated with <i>Toxoplasma<\/i> invasion of host cells. <i>Cell. Microbiol.<\/i> 1: 225\u2013235.","DOI":"10.1046\/j.1462-5822.1999.00023.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. de Waal, D. T. and Combrink, M. P. 2006. Live vaccines against bovine babesiosis. <i>Vet. Parasitol.<\/i> 138: 88\u201396.","DOI":"10.1016\/j.vetpar.2006.01.042"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Endo, T., Sethi, K. K. and Piekarski, G. 1982. <i>Toxoplasma gondii<\/i>: calcium ionophore A23187-mediated exit of trophozoites from infected murine macrophages. <i>Exp. Parasitol.<\/i> 53: 179\u2013188.","DOI":"10.1016\/0014-4894(82)90059-5"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Enomoto, M., Kawazu, S., Kawai, S., Furuyama, W., Ikegami, T., Watanabe, J. and Mikoshiba, K. 2012. Blockage of spontaneous Ca<sup>2+<\/sup> oscillation causes cell death in intraerythrocitic <i>Plasmodium falciparum<\/i>. <i>PLoS ONE<\/i> 7: e39499.","DOI":"10.1371\/journal.pone.0039499"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Garg, S., Agarwal, S., Kumar, S., Yazdani, S. S., Chitnis, C. E. and Singh, S. 2013. Calcium-dependent permeabilization of erythrocytes by a perforin-like protein during egress of malaria parasites. <i>Nat. Commun.<\/i> 4: 1736.","DOI":"10.1038\/ncomms2725"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Gerasimenko, J., Peng, S. and Gerasimenko, O. 2014. Role of acidic stores in secretory epithelia. <i>Cell Calcium<\/i> 55: 346\u2013354.","DOI":"10.1016\/j.ceca.2014.04.002"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Glushakova, S., Lizunov, V., Blank, P. S., Melikov, K., Humphrey, G. and Zimmerberg, J. 2013. Cytoplasmic free Ca<sup>2+<\/sup> is essential for multiple steps in malaria parasite egress from infected erythrocytes. <i>Malar. J.<\/i> 12: 41.","DOI":"10.1186\/1475-2875-12-41"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Hines, S. A., Palmer, G. H., Jasmer, D. P., McGuire, T. C. and McElwain, T. F. 1992. Neutralization-sensitive merozoite surface antigens of <i>Babesia bovis<\/i> encoded by members of a polymorphic gene family. <i>Mol. Biochem. Parasitol.<\/i> 55: 85\u201394.","DOI":"10.1016\/0166-6851(92)90129-8"},{"key":"19","unstructured":"19. Kuttler, K. L. 1988. Worldwide impact of babesiosis. pp. 2\u201322. <i>In<\/i>: Babesiosis of Domestic Animals and Man (Ristic, M. ed.), CRC Press Inc, Boca Raton."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Moreno, S. N., Ayong, L. and Pace, D. A. 2011. Calcium storage and function in apicomplexan parasites. <i>Essays Biochem.<\/i> 51: 97\u2013110.","DOI":"10.1042\/bse0510097"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Mosqueda, J., Olvera-Ramirez, A., Aguilar-Tipacamu, G. and Canto, G. J. 2012. Current advances in detection and treatment of babesiosis. <i>Curr. Med. Chem.<\/i> 19: 1504\u20131518.","DOI":"10.2174\/092986712799828355"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Nagamune, K., Hicks, L. M., Fux, B., Brossier, F., Chini, E. N. and Sibley, L. D. 2008. Abscisic acid controls calcium-dependent egress and development in <i>Toxoplasma gondii<\/i>. <i>Nature<\/i> 451: 207\u2013210.","DOI":"10.1038\/nature06478"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Okubo, K., Wilawan, P., Bork, S., Okamura, M., Yokoyama, N. and Igarashi, I. 2006. Calcium-ions are involved in erythrocyte invasion by equine <i>Babesia<\/i> parasites. <i>Parasitology<\/i> 133: 289\u2013294.","DOI":"10.1017\/S0031182006000436"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Passos, A. P. and Garcia, C. R. 1998. Inositol 1,4,5-trisphosphate induced Ca<sup>2+<\/sup> release from chloroquine-sensitive and -insensitive intracellular stores in the intraerythrocytic stage of the malaria parasite <i>P. chabaudi<\/i>. <i>Biochem. Biophys. Res. Commun.<\/i> 245: 155\u2013160.","DOI":"10.1006\/bbrc.1998.8338"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Sibley, L. D. 2004. Intracellular parasite invasion strategies. <i>Science<\/i> 304: 248\u2013253.","DOI":"10.1126\/science.1094717"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Sun, Y., Moreau, E., Chauvin, A. and Malandrin, L. 2011. The invasion process of bovine erythrocyte by <i>Babesia divergens<\/i>: knowledge from an <i>in vitro<\/i> assay. <i>Vet. Res.<\/i> 42: 62.","DOI":"10.1186\/1297-9716-42-62"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Thastrup, O., Cullen, P. J., Drobak, B. K., Hanley, M. R. and Dawson, A. P. 1990. Thapsigargin, a tumor promoter, discharges intracellular Ca<sup>2+<\/sup> stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase. <i>Proc. Natl. Acad. Sci. U.S.A.<\/i> 87: 2466\u20132470.","DOI":"10.1073\/pnas.87.7.2466"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Wetzel, D. M., Chen, L. A., Ruiz, F. A., Moreno, S. N. and Sibley, L. D. 2004. 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