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Aebi, S., Fink, D., Gordon, R., Kim, H. K., Zheng, H., Fink, J. L. and Howell, S. B. 1997. Resistance to cytotoxic drugs in DNA mismatch repair-deficient cells. <i>Clin. Cancer Res.<\/i> 3: 1763\u20131767."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Affolter, V. K. and Moore, P. F. 2002. Localized and disseminated histiocytic sarcoma of dendritic cell origin in dogs. <i>Vet. Pathol.<\/i> 39: 74\u201383.","DOI":"10.1354\/vp.39-1-74"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Azakami, D., Bonkobara, M., Washizu, T., Iida, A., Kondo, M., Kato, R., Niikura, Y., Iwaki, S., Tamahara, S., Matsuki, N. and Ono, K. 2006. Establishment and biological characterization of canine histiocytic sarcoma cell lines. <i>J. Vet. Med. Sci.<\/i> 68: 1343\u20131346.","DOI":"10.1292\/jvms.68.1343"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Brent, T. P., Houghton, P. J. and Houghton, J. A. 1985. O6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea. <i>Proc. Natl. Acad. Sci. U.S.A.<\/i> 82: 2985\u20132989.","DOI":"10.1073\/pnas.82.9.2985"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Buchholz, T. A., Davis, D. W., McConkey, D. J., Symmans, W. F., Valero, V., Jhingran, A., Tucker, S. L., Pusztai, L., Cristofanilli, M., Esteva, F. J., Hortobagyi, G. N. and Sahin, A. A. 2003. Chemotherapy-induced apoptosis and Bcl-2 levels correlate with breast cancer response to chemotherapy. <i>Cancer J.<\/i> 9: 33\u201341.","DOI":"10.1097\/00130404-200301000-00007"},{"key":"6","unstructured":"6. Burger, H., Foekens, J. A., Look, M. P., Meijer-van Gelder, M. E., Klijn, J. G., Wiemer, E. A., Stoter, G. and Nooter, K. 2003. RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response. <i>Clin. Cancer Res.<\/i> 9: 827\u2013836."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Chen, J., Hurford, M., Mekan, S. and Simpkins, H. 2013. Downregulation of glutathione transferase \u03c0 sensitizes lymphoma\/leukaemia cells to platinum-based chemotherapy. <i>Br. J. Haematol.<\/i> 162: 135\u2013137.","DOI":"10.1111\/bjh.12324"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Chen, S. Y., Hu, S. S., Dong, Q., Cai, J. X., Zhang, W. P., Sun, J. Y., Wang, T. T., Xie, J., He, H. R., Xing, J. F., Lu, J. and Dong, Y. L. 2013. Establishment of paclitaxel-resistant breast cancer cell line and nude mice models, and underlying multidrug resistance mechanisms <i>in vitro<\/i> and <i>in vivo<\/i>. <i>Asian Pac. J. Cancer Prev.<\/i> 14: 6135\u20136140.","DOI":"10.7314\/APJCP.2013.14.10.6135"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Chu, L. L., Rutteman, G. R., Kong, J. M., Ghahremani, M., Schmeing, M., Misdorp, W., van Garderen, E. and Pelletier, J. 1998. Genomic organization of the canine p53 gene and its mutational status in canine mammary neoplasia. <i>Breast Cancer Res. Treat.<\/i> 50: 11\u201325.","DOI":"10.1023\/A:1006010526813"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Drummond, J. T., Anthoney, A., Brown, R. and Modrich, P. 1996. Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line. <i>J. Biol. Chem.<\/i> 271: 19645\u201319648.","DOI":"10.1074\/jbc.271.33.19645"},{"key":"11","unstructured":"11. Fink, D., Aebi, S. and Howell, S. B. 1998. The role of DNA mismatch repair in drug resistance. <i>Clin. Cancer Res.<\/i> 4: 1\u20136."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Garrett, L. D., Thamm, D. H., Chun, R., Dudley, R. and Vail, D. M. 2002. Evaluation of a 6-month chemotherapy protocol with no maintenance therapy for dogs with lymphoma. <i>J. Vet. Intern. Med.<\/i> 16: 704\u2013709.","DOI":"10.1111\/j.1939-1676.2002.tb02411.x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Gerson, S. L. 2004. MGMT: its role in cancer aetiology and cancer therapeutics. <i>Nat. Rev. Cancer<\/i> 4: 296\u2013307.","DOI":"10.1038\/nrc1319"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Hafeman, S. D., Varland, D. and Dow, S. W. 2012. Bisphosphonates significantly increase the activity of doxorubicin or vincristine against canine malignant histiocytosis cells. <i>Vet. Comp. Oncol.<\/i> 10: 44\u201356.","DOI":"10.1111\/j.1476-5829.2011.00274.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Hiraoka, H., Minami, K., Kaneko, N., Shimokawa Miyama, T., Okamura, Y., Mizuno, T. and Okuda, M. 2009. Aberrations of the FHIT gene and Fhit protein in canine lymphoma cell lines. <i>J. Vet. Med. Sci.<\/i> 71: 769\u2013777.","DOI":"10.1292\/jvms.71.769"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Huang, L., Perrault, C., Coelho-Martins, J., Hu, C., Dulong, C., Varna, M., Liu, J., Jin, J., Soria, C., Cazin, L., Janin, A., Li, H., Varin, R. and Lu, H. 2013. Induction of acquired drug resistance in endothelial cells and its involvement in anticancer therapy. <i>J. Hematol. Oncol.<\/i> 6: 49.","DOI":"10.1186\/1756-8722-6-49"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Ito, K., Kuroki, S., Kobayashi, M., Ono, K., Washizu, T. and Bonkobara, M. 2013. Identification of dasatinib as an <i>in vitro<\/i> potent growth inhibitor of canine histiocytic sarcoma cells. <i>Vet. J.<\/i> 196: 536\u2013540.","DOI":"10.1016\/j.tvjl.2012.12.016"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Kalinina, E. V., Berozov, T. T., Shtil, A. A., Chernov, N. N., Glasunova, V. A., Novichkova, M. D. and Nurmuradov, N. K. 2012. Expression of genes of glutathione transferase isoforms GSTP1-1, GSTA4-4, and GSTK1-1 in tumor cells during the formation of drug resistance to cisplatin. <i>Bull. Exp. Biol. Med.<\/i> 154: 64\u201367.","DOI":"10.1007\/s10517-012-1876-4"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Kewitz, S., Stiefel, M., Kramm, C. M. and Staege, M. S. 2014. Impact of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and MGMT expression on dacarbazine resistance of Hodgkin\u2019s lymphoma cells. <i>Leuk. Res.<\/i> 38: 138\u2013143.","DOI":"10.1016\/j.leukres.2013.11.001"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Kim, E., Giese, A. and Deppert, W. 2009. 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Phase II, open-label trial of single-agent CCNU in dogs with previously untreated histiocytic sarcoma. <i>J. Vet. Intern. Med.<\/i> 24: 1528\u20131531."},{"key":"30","doi-asserted-by":"crossref","unstructured":"31. Rivera, P., Akerlund-Denneberg, N., Bergvall, K., Kessler, M., Rowe, A., Willmann, M., Persson, G., Kastengren Fr\u00f6berg, G., Westberg, S. and von Euler, H. 2013. Clinical efficacy and safety of a water-soluble micellar paclitaxel (Paccal Vet) in canine mastocytomas. <i>J. Small Anim. Pract.<\/i> 54: 20\u201327.","DOI":"10.1111\/j.1748-5827.2012.01304.x"},{"key":"31","doi-asserted-by":"crossref","unstructured":"32. R\u00fctgen, B. C., Hammer, S. E., Gerner, W., Christian, M., de Arespacochaga, A. G., Willmann, M., Kleiter, M., Schwendenwein, I. and Saalm\u00fcller, A. 2010. Establishment and characterization of a novel canine B-cell line derived from a spontaneously occurring diffuse large cell lymphoma. <i>Leuk. Res.<\/i> 34: 932\u2013938.","DOI":"10.1016\/j.leukres.2010.01.021"},{"key":"32","unstructured":"33. Sheikh, M. S., Li, X. S., Chen, J. C., Shao, Z. M., Ordonez, J. V. and Fontana, J. A. 1994. Mechanisms of regulation of WAF1\/Cip1 gene expression in human breast carcinoma: role of p53-dependent and independent signal transduction pathways. <i>Oncogene<\/i> 9: 3407\u20133415."},{"key":"33","doi-asserted-by":"crossref","unstructured":"34. Skorupski, K. A., Clifford, C. A., Paoloni, M. C., Lara-Garcia, A., Barber, L., Kent, M. S., LeBlanc, A. K., Sabhlok, A., Mauldin, E. A., Shofer, F. S., Couto, C. G. and S\u00f8renmo, K. U. 2007. CCNU for the treatment of dogs with histiocytic sarcoma. <i>J. Vet. Intern. Med.<\/i> 21: 121\u2013126.","DOI":"10.1111\/j.1939-1676.2007.tb02937.x"},{"key":"34","doi-asserted-by":"crossref","unstructured":"35. Takahashi, M., Tomiyasu, H., Hotta, E., Asada, H., Fukushima, K., Kanemoto, H., Fujino, Y., Ohno, K., Uchida, K., Nakayama, H. and Tsujimoto, H. 2014. Clinical characteristics and prognostic factors in dogs with histiocytic sarcomas in Japan. <i>J. Vet. Med. Sci.<\/i> 76: 661\u2013666.","DOI":"10.1292\/jvms.13-0414"},{"key":"35","doi-asserted-by":"crossref","unstructured":"36. Thamm, D. H., Rose, B., Kow, K., Humbert, M., Mansfield, C. D., Moussy, A., Hermine, O. and Dubreuil, P. 2012. Masitinib as a chemosensitizer of canine tumor cell lines: a proof of concept study. <i>Vet. J.<\/i> 191: 131\u2013134.","DOI":"10.1016\/j.tvjl.2011.01.001"},{"key":"36","doi-asserted-by":"crossref","unstructured":"37. Tomiyasu, H., Goto-Koshino, Y., Fujino, Y., Ohno, K. and Tsujimoto, H. 2014. Epigenetic regulation of the ABCB1 gene in drug-sensitive and drug-resistant lymphoid tumour cell lines obtained from canine patients. <i>Vet. J.<\/i> 199: 103\u2013109.","DOI":"10.1016\/j.tvjl.2013.10.022"},{"key":"37","doi-asserted-by":"crossref","unstructured":"38. Tomiyasu, H., Goto-Koshino, Y., Takahashi, M., Fujino, Y., Ohno, K. and Tsujimoto, H. 2010. 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