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Albertson, T. E., Walby, W. F. and Joy, R. M. 1992. Modification of GABA-mediated inhibition by various injectable anesthetics. <i>Anesthesiology<\/i> 77: 488\u2013499.","DOI":"10.1097\/00000542-199209000-00014"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Burkholder, W. J. 2000. Use of body condition scores in clinical assessment of the provision of optimal nutrition. <i>J. Am. Vet. Med. Assoc.<\/i> 217: 650\u2013654.","DOI":"10.2460\/javma.2000.217.650"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Diehl, K. H., Hull, R., Morton, D., Pfister, R., Rabemampianina, Y., Smith, D., Vidal, J. M., van de Vorstenbosch, C., European Federation of Pharmaceutical Industries Association and European Centre for the Validation of Alternative Methods. 2001. A good practice guide to the administration of substances and removal of blood, including routes and volumes. <i>J. Appl. 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Alfaxalone for total intravenous anaesthesia in dogs undergoing ovariohysterectomy: a comparison of premedication with acepromazine or dexmedetomidine. <i>Vet. Anaesth. Analg.<\/i> 40: 124\u2013133.","DOI":"10.1111\/j.1467-2995.2012.00752.x"},{"key":"10","unstructured":"10. Hughes, D., Rozanski, E. R., Shofer, F. S., Laster, L. L. and Drobatz, K. J. 1999. Effect of sampling site, repeated sampling, pH, and PCO2 on plasma lactate concentration in healthy dogs. <i>Am. J. Vet. Res.<\/i> 60: 521\u2013524."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Ilkiw, J. E., Rose, R. J. and Martin, I. C. 1991. A comparison of simultaneously collected arterial, mixed venous, jugular venous and cephalic venous blood samples in the assessment of blood-gas and acid-base status in the dog. <i>J. Vet. Intern. Med.<\/i> 5: 294\u2013298.","DOI":"10.1111\/j.1939-1676.1991.tb03136.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Keates, H. and Whittem, T. 2012. Effect of intravenous dose escalation with alfaxalone and propofol on occurrence of apnoea in the dog. <i>Res. Vet. Sci.<\/i> 93: 904\u2013906.","DOI":"10.1016\/j.rvsc.2011.10.003"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Kuo, W. C. and Keegan, R. D. 2004. Comparative cardiovascular, analgesic, and sedative effects of medetomidine, medetomidine-hydromorphone, and medetomidine-butorphanol in dogs. <i>Am. J. Vet. Res.<\/i> 65: 931\u2013937.","DOI":"10.2460\/ajvr.2004.65.931"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Lambert, J. J., Belelli, D., Peden, D. R., Vardy, A. W. and Peters, J. A. 2003. Neurosteroid modulation of GABAA receptors. <i>Prog. Neurobiol.<\/i> 71: 67\u201380.","DOI":"10.1016\/j.pneurobio.2003.09.001"},{"key":"15","unstructured":"15. Lamont, L. A. and Mathews, K. A. 2007. 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Pharmacokinetics of subcutaneous and intramuscular butorphanol in dogs. <i>J. Pharm. Sci.<\/i> 69: 801\u2013803.","DOI":"10.1002\/jps.2600690715"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Pypendop, B. H. and Verstegen, J. P. 1998. Hemodynamic effects of medetomidine in the dog: a dose titration study. <i>Vet. Surg.<\/i> 27: 612\u2013622.","DOI":"10.1111\/j.1532-950X.1998.tb00539.x"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Quir\u00f3s Carmona, S., Navarrete-Calvo, R., Granados, M. M., Dom\u00ednguez, J. M., Morgaz, J., Fern\u00e1ndez-Sarmiento, J. A., Mu\u00f1oz-Rasc\u00f3n, P. and G\u00f3mez-Villamandos, R. J. 2014. Cardiorespiratory and anaesthetic effects of two continuous rate infusions of dexmedetomidine in alfaxalone anaesthetized dogs. <i>Res. Vet. Sci.<\/i> 97: 132\u2013139.","DOI":"10.1016\/j.rvsc.2014.03.022"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Redondo, J. I., Rubio, M., Soler, G., Serra, I., Soler, C. and G\u00f3mez-Villamandos, R. J. 2007. Normal values and incidence of cardiorespiratory complications in dogs during general anaesthesia. A review of 1281 cases. <i>J. Vet. Med. A Physiol. Pathol. Clin. Med.<\/i> 54: 470\u2013477.","DOI":"10.1111\/j.1439-0442.2007.00987.x"},{"key":"25","unstructured":"25. Schurig, J. E., Florczyk, A. P., Rose, W. C. and Bradner, W. T. 1982. Antiemetic activity of butorphanol against cisplatin-induced emesis in ferrets and dogs. <i>Cancer Treat. Rep.<\/i> 66: 1831\u20131835."},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Shook, J. E., Watkins, W. D. and Camporesi, E. M. 1990. Differential roles of opioid receptors in respiration, respiratory disease, and opiate-induced respiratory depression. <i>Am. Rev. Respir. Dis.<\/i> 142: 895\u2013909.","DOI":"10.1164\/ajrccm\/142.4.895"},{"key":"27","unstructured":"27. Sinclair, M. D. 2003. A review of the physiological effects of alpha2-agonists related to the clinical use of medetomidine in small animal practice. <i>Can. Vet. J.<\/i> 44: 885\u2013897."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Tamura, J., Ishizuka, T., Fukui, S., Oyama, N., Kawase, K., Miyoshi, K., Sano, T., Pasloske, K. and Yamashita, K. 2015. The pharmacological effects of the anesthetic alfaxalone after intramuscular administration to dogs. <i>J. Vet. Med. Sci.<\/i> 77: 289\u2013296.","DOI":"10.1292\/jvms.14-0368"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Yoshitomi, T., Kohjitani, A., Maeda, S., Higuchi, H., Shimada, M. and Miyawaki, T. 2008. Dexmedetomidine enhances the local anesthetic action of lidocaine via an alpha-2A adrenoceptor. <i>Anesth. Analg.<\/i> 107: 96\u2013101.","DOI":"10.1213\/ane.0b013e318176be73"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Young, L. E., Brearley, J. C., Richards, D. L. S., Bartram, D. H. and Jones, R. 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