{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T05:49:20Z","timestamp":1789364960099,"version":"build-2803163510"},"reference-count":24,"publisher":"Japanese Society of Veterinary Science","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Veterinary Medical Science","J. Vet. Med. Sci."],"published-print":{"date-parts":[[2016]]},"DOI":"10.1292\/jvms.15-0433","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T22:02:54Z","timestamp":1455746574000},"page":"877-881","source":"Crossref","is-referenced-by-count":3,"title":["Detection of circulating tumor cells using GeneScan analysis for antigen receptor gene rearrangements in canine lymphoma patients"],"prefix":"10.1292","volume":"78","author":[{"given":"Saaya","family":"HIYOSHI-KANEMOTO","sequence":"first","affiliation":[{"name":"Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1\u20131\u20131 Yayoi, Bunkyo-ku, Tokyo 113\u20138657, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"GOTO-KOSHINO","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1\u20131\u20131 Yayoi, Bunkyo-ku, Tokyo 113\u20138657, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenjiro","family":"FUKUSHIMA","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1\u20131\u20131 Yayoi, Bunkyo-ku, Tokyo 113\u20138657, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"TAKAHASHI","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1\u20131\u20131 Yayoi, Bunkyo-ku, Tokyo 113\u20138657, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"KANEMOTO","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1\u20131\u20131 Yayoi, Bunkyo-ku, Tokyo 113\u20138657, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"UCHIDA","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1\u20131\u20131 Yayoi, Bunkyo-ku, Tokyo 113\u20138657, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"FUJINO","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1\u20131\u20131 Yayoi, Bunkyo-ku, Tokyo 113\u20138657, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"OHNO","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1\u20131\u20131 Yayoi, Bunkyo-ku, Tokyo 113\u20138657, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"TSUJIMOTO","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1\u20131\u20131 Yayoi, Bunkyo-ku, Tokyo 113\u20138657, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"122","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Bakakos, P., Smith, J. L., Warner, J. O., Vance, G., Moss, C. T., Hodges, E., Lanham, S. and Howell, W. M. 2001. Modification of T-cell receptor Vbeta repertoire in response to allergen stimulation in peanut allergy. <i>J. Allergy Clin. Immunol.<\/i> 107: 1089\u20131094.","DOI":"10.1067\/mai.2001.114651"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Burnett, R. C., Vernau, W., Modiano, J. F., Olver, C. S., Moore, P. F. and Avery, A. C. 2003. Diagnosis of canine lymphoid neoplasia using clonal rearrangements of antigen receptor genes. <i>Vet. Pathol.<\/i> 40: 32\u201341.","DOI":"10.1354\/vp.40-1-32"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Burton, J. H., Garrett-Mayer, E. and Thamm, D. H. 2013. Evaluation of a 15-week CHOP protocol for the treatment of canine multicentric lymphoma. <i>Vet. Comp. Oncol.<\/i> 11: 306\u2013315.","DOI":"10.1111\/j.1476-5829.2012.00324.x"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Dobson, J. M., Samuel, S., Milstein, H., Rogers, K. and Wood, J. L. 2002. Canine neoplasia in the U.K.: estimates of incidence rates from a population of insured dogs. <i>J. Small Anim. Pract.<\/i> 43: 240\u2013246.","DOI":"10.1111\/j.1748-5827.2002.tb00066.x"},{"key":"5","unstructured":"5. Dorn, C. R., Taylor, D. O., Schneider, R., Hibbard, H. H. and Klauber, M. R. 1968. Survey of animal neoplasms in Alameda and Contra Costa Counties, California. II. Cancer morbidity in dogs and cats from Alameda County. <i>J. Natl. Cancer Inst.<\/i> 40: 307\u2013318."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Fraser-Andrews, E. A., Woolford, A. J., Russell-Jones, R., Seed, P. T. and Whittaker, S. J. 2000. Detection of a peripheral blood T cell clone is an independent prognostic marker in mycosis fungoides. <i>J. Invest. Dermatol.<\/i> 114: 117\u2013121.","DOI":"10.1046\/j.1523-1747.2000.00830.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Garrett, L. D., Thamm, D. H., Chun, R., Dudley, R. and Vail, D. M. 2002. Evaluation of a 6-month chemotherapy protocol with no maintenance therapy for dogs with lymphoma. <i>J. Vet. Intern. Med.<\/i> 16: 704\u2013709.","DOI":"10.1111\/j.1939-1676.2002.tb02411.x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Gentilini, F., Calzolari, C., Turba, M. E., Bettini, G. and Famigli-Bergamini, P. 2009. GeneScanning analysis of Ig\/TCR gene rearrangements to detect clonality in canine lymphomas. <i>Vet. Immunol. Immunopathol.<\/i> 127: 47\u201356.","DOI":"10.1016\/j.vetimm.2008.09.014"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Goto-Koshino, Y., Mochizuki, H., Sato, M., Nakashima, K., Hiyoshi, S., Fujiwara-Igarashi, A., Maeda, S., Nakamura, K., Uchida, K., Fujino, Y., Ohno, K. and Tsujimoto, H. 2015. Construction of a multicolor GeneScan analytical system to detect clonal rearrangements of immunoglobulin and T cell receptor genes in canine lymphoid tumors. <i>Vet. Immunol. Immunopathol.<\/i> 165: 81\u201387.","DOI":"10.1016\/j.vetimm.2015.03.005"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Keller, E. T., MacEwen, E. G., Rosenthal, R. C., Helfand, S. C. and Fox, L. E. 1993. Evaluation of prognostic factors and sequential combination chemotherapy with doxorubicin for canine lymphoma. <i>J. Vet. Intern. Med.<\/i> 7: 289\u2013295.","DOI":"10.1111\/j.1939-1676.1993.tb01021.x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Keller, R. L., Avery, A. C., Burnett, R. C., Walton, J. A. and Olver, C. S. 2004. Detection of neoplastic lymphocytes in peripheral blood of dogs with lymphoma by polymerase chain reaction for antigen receptor gene rearrangement. <i>Vet. Clin. Pathol.<\/i> 33: 145\u2013149.","DOI":"10.1111\/j.1939-165X.2004.tb00364.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Keller, S. M. and Moore, P. F. 2012. A novel clonality assay for the assessment of canine T cell proliferations. <i>Vet. Immunol. Immunopathol.<\/i> 145: 410\u2013419.","DOI":"10.1016\/j.vetimm.2011.12.019"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Kern, W., Haferlach, C., Haferlach, T. and Schnittger, S. 2008. Monitoring of minimal residual disease in acute myeloid leukemia. <i>Cancer<\/i> 112: 4\u201316.","DOI":"10.1002\/cncr.23128"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Lana, S. E., Jackson, T. L., Burnett, R. C., Morley, P. S. and Avery, A. C. 2006. Utility of polymerase chain reaction for analysis of antigen receptor rearrangement in staging and predicting prognosis in dogs with lymphoma. <i>J. Vet. Intern. Med.<\/i> 20: 329\u2013334.","DOI":"10.1111\/j.1939-1676.2006.tb02864.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Mellanby, R. J., Herrtage, M. E. and Dobson, J. M. 2003. Owners\u2019 assessments of their dog\u2019s quality of life during palliative chemotherapy for lymphoma. <i>J. Small Anim. Pract.<\/i> 44: 100\u2013103.","DOI":"10.1111\/j.1748-5827.2003.tb00127.x"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Pott, C., Schrader, C., Gesk, S., Harder, L., Tiemann, M., Raff, T., Br\u00fcggemann, M., Ritgen, M., Gahn, B., Unterhalt, M., Dreyling, M., Hiddemann, W., Siebert, R., Dreger, P. and Kneba, M. 2006. Quantitative assessment of molecular remission after high-dose therapy with autologous stem cell transplantation predicts long-term remission in mantle cell lymphoma. <i>Blood<\/i> 107: 2271\u20132278.","DOI":"10.1182\/blood-2005-07-2845"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Sato, M., Yamzaki, J., Goto-Koshino, Y., Takahashi, M., Fujino, Y., Ohno, K. and Tsujimoto, H. 2013. The prognostic significance of minimal residual disease in the early phases of chemotherapy in dogs with high-grade B-cell lymphoma. <i>Vet. J.<\/i> 195: 319\u2013324.","DOI":"10.1016\/j.tvjl.2012.07.013"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Sato, M., Yamazaki, J., Goto-Koshino, Y., Takahashi, M., Fujino, Y., Ohno, K. and Tsujimoto, H. 2011. Increase in minimal residual disease in peripheral blood before clinical relapse in dogs with lymphoma that achieved complete remission after chemotherapy. <i>J. Vet. Intern. Med.<\/i> 25: 292\u2013296.","DOI":"10.1111\/j.1939-1676.2010.0675.x"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Sato, M., Yamazaki, J., Goto-Koshino, Y., Takahashi, M., Fujino, Y., Ohno, K. and Tsujimoto, H. 2011. Evaluation of cytoreductive efficacy of vincristine, cyclophosphamide, and Doxorubicin in dogs with lymphoma by measuring the number of neoplastic lymphoid cells with real-time polymerase chain reaction. <i>J. Vet. Intern. Med.<\/i> 25: 285\u2013291.","DOI":"10.1111\/j.1939-1676.2011.0686.x"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Scarisbrick, J. J., Whittaker, S., Evans, A. V., Fraser-Andrews, E. A., Child, F. J., Dean, A. and Russell-Jones, R. 2001. Prognostic significance of tumor burden in the blood of patients with erythrodermic primary cutaneous T-cell lymphoma. <i>Blood<\/i> 97: 624\u2013630.","DOI":"10.1182\/blood.V97.3.624"},{"key":"21","unstructured":"21. Thilakaratne, D. N., Mayer, M. N., MacDonald, V. S., Jackson, M. L., Trask, B. R. and Kidney, B. A. 2010. Clonality and phenotyping of canine lymphomas before chemotherapy and during remission using polymerase chain reaction (PCR) on lymph node cytologic smears and peripheral blood. <i>Can. Vet. J.<\/i> 51: 79\u201384."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Weng, W. K., Armstrong, R., Arai, S., Desmarais, C., Hoppe, R. and Kim, Y. H. 2013. Minimal residual disease monitoring with high-throughput sequencing of T cell receptors in cutaneous T cell lymphoma. <i>Sci. Transl. Med.<\/i> 5: 214ra171.","DOI":"10.1126\/scitranslmed.3007420"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Yamazaki, J., Takahashi, M., Setoguchi, A., Fujino, Y., Ohno, K. and Tsujimoto, H. 2010. Monitoring of minimal residual disease (MRD) after multidrug chemotherapy and its correlation to outcome in dogs with lymphoma: a proof-of-concept pilot study. <i>J. Vet. Intern. Med.<\/i> 24: 897\u2013903.","DOI":"10.1111\/j.1939-1676.2010.0536.x"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Yamazaki, J., Baba, K., Goto-Koshino, Y., Setoguchi-Mukai, A., Fujino, Y., Ohno, K. and Tsujimoto, H. 2008. Quantitative assessment of minimal residual disease (MRD) in canine lymphoma by using real-time polymerase chain reaction. <i>Vet. Immunol. Immunopathol.<\/i> 126: 321\u2013331.","DOI":"10.1016\/j.vetimm.2008.09.004"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/78\/5\/78_15-0433\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T06:09:35Z","timestamp":1498284575000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/78\/5\/78_15-0433\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.15-0433","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}