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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"FENG","sequence":"additional","affiliation":[{"name":"Division of Swine Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, No. 427 Maduan Street, Nangang District, Harbin 150001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"122","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Chen, J., Liu, X., Shi, D., Shi, H., Zhang, X. and Feng, L. 2012. Complete genome sequence of a porcine epidemic diarrhea virus variant. <i>J. Virol.<\/i> 86: 3408.","DOI":"10.1128\/JVI.07150-11"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Chen, J., Liu, X., Shi, D., Shi, H., Zhang, X., Li, C., Chi, Y. and Feng, L. 2013. Detection and molecular diversity of spike gene of porcine epidemic diarrhea virus in China. <i>Viruses<\/i> 5: 2601\u20132613.","DOI":"10.3390\/v5102601"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Chen, J., Wang, C., Shi, H., Qiu, H., Liu, S., Chen, X., Zhang, Z. and Feng, L. 2010. Molecular epidemiology of porcine epidemic diarrhea virus in China. <i>Arch. Virol.<\/i> 155: 1471\u20131476.","DOI":"10.1007\/s00705-010-0720-2"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Chen, J., Wang, C., Shi, H., Qiu, H., Liu, S., Shi, D., Zhang, X. and Feng, L. 2011. Complete genome sequence of a Chinese virulent porcine epidemic diarrhea virus strain. <i>J. Virol.<\/i> 85: 11538\u201311539.","DOI":"10.1128\/JVI.06024-11"},{"key":"5","unstructured":"5. Chen, J. F., Feng, L., Shi, H. Y. and Cui, S. J. 2010. Update on vaccines of porcine epidemic diarrhea virus. <i>Swine Ind. Sci.<\/i> 12: 51 (in Chinese)."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Chen, J. F., Sun, D. B., Wang, C. B., Shi, H. Y., Cui, X. C., Liu, S. W., Qiu, H. J. and Feng, L. 2008. Molecular characterization and phylogenetic analysis of membrane protein genes of porcine epidemic diarrhea virus isolates in China. <i>Virus Genes<\/i> 36: 355\u2013364.","DOI":"10.1007\/s11262-007-0196-7"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Chen, Q., Li, G., Stasko, J., Thomas, J. T., Stensland, W. R., Pillatzki, A. E., Gauger, P. C., Schwartz, K. J., Madson, D., Yoon, K. J., Stevenson, G. W., Burrough, E. R., Harmon, K. M., Main, R. G. and Zhang, J. 2014. Isolation and characterization of porcine epidemic diarrhea viruses associated with the 2013 disease outbreak among swine in the United States. <i>J. Clin. Microbiol.<\/i> 52: 234\u2013243.","DOI":"10.1128\/JCM.02820-13"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Chen, X., Zeng, L., Yang, J., Yu, F., Ge, J., Guo, Q., Gao, X. and Song, T. 2013. Sequence heterogeneity of the ORF3 gene of porcine epidemic diarrhea viruses field samples in Fujian, China, 2010\u20132012. <i>Viruses<\/i> 5: 2375\u20132383.","DOI":"10.3390\/v5102375"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Debouck, P. and Pensaert, M. 1980. Experimental infection of pigs with a new porcine enteric coronavirus, CV 777. <i>Am. J. Vet. Res.<\/i> 41: 219\u2013223.","DOI":"10.2460\/ajvr.1980.41.02.219"},{"key":"10","unstructured":"10. Feng, L. 2014. The updated epidemic and controls of swine enteric coronavirus in China. <i>In<\/i>: International Meeting of Swine Enteric Coronavirus Diseases (SECD), Chicago."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Gao, Y., Kou, Q., Ge, X., Zhou, L., Guo, X. and Yang, H. 2013. Phylogenetic analysis of porcine epidemic diarrhea virus field strains prevailing recently in China. <i>Arch. Virol.<\/i> 158: 711\u2013715.","DOI":"10.1007\/s00705-012-1541-2"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Ge, F. F., Yang, D. Q., Ju, H. B., Wang, J., Liu, J., Liu, P. H. and Zhou, J. P. 2013. Epidemiological survey of porcine epidemic diarrhea virus in swine farms in Shanghai, China. <i>Arch. Virol.<\/i> 158: 2227\u20132231.","DOI":"10.1007\/s00705-013-1722-7"},{"key":"13","unstructured":"13. Ge, J., Jiang, Y., Wang, M., Qiao, X., Liu, M., Tang, L. and Li, Y. 2009. Induction of immune response after oral inoculation of mice with Lactobacillus casei surface-displayed porcine epidemic diarrhea viral N protein. <i>Chin. J. Biotechnol.<\/i> 25: 813\u2013818 (in Chinese)."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Ge, J. W., Liu, D. Q. and Li, Y. J. 2012. Construction of recombinant lactobacilli expressing the core neutralizing epitope (COE) of porcine epidemic diarrhea virus and a fusion protein consisting of COE and <i>Escherichia coli<\/i> heat-labile enterotoxin B, and comparison of the immune responses by orogastric immunization. <i>Can. J. Microbiol.<\/i> 58: 1258\u20131267.","DOI":"10.1139\/w2012-098"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Hao, J., Xue, C., He, L., Wang, Y. and Cao, Y. 2014. Bioinformatics insight into the spike glycoprotein gene of field porcine epidemic diarrhea strains during 2011\u20132013 in Guangdong, China. <i>Virus Genes<\/i> 49: 58\u201367.","DOI":"10.1007\/s11262-014-1055-y"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Hou, X. L., Yu, L. Y., Liu, J. and Wang, G. H. 2007. Surface-displayed porcine epidemic diarrhea viral (PEDV) antigens on lactic acid bacteria. <i>Vaccine<\/i> 26: 24\u201331.","DOI":"10.1016\/j.vaccine.2007.10.065"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Huang, Y. W., Dickerman, A. W., Pi\u00f1eyro, P., Li, L., Fang, L., Kiehne, R., Opriessnig, T. and Meng, X. J. 2013. Investigation into the role of potentially contaminated feed as a source of the first-detected outbreaks of porcine epidemic diarrhea in Canada. <i>MBio<\/i> 4: e00737\u2013e13.","DOI":"10.1128\/mBio.00737-13"},{"key":"18","unstructured":"18. Ji, B. Y. and Zhong, X. G. 1987. Report of investigation and diagnosis of porcine epidemic diarrhea virus infection. <i>Jiangxi J. Anim. Husb. Vet. Med.<\/i> 1: 19\u201320 (in Chinese)."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Li, R., Qiao, S., Yang, Y., Su, Y., Zhao, P., Zhou, E. and Zhang, G. 2014. Phylogenetic analysis of porcine epidemic diarrhea virus (PEDV) field strains in central China based on the ORF3 gene and the main neutralization epitopes. <i>Arch. Virol.<\/i> 159: 1057\u20131065.","DOI":"10.1007\/s00705-013-1929-7"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Li, W., Li, H., Liu, Y., Pan, Y., Deng, F., Song, Y., Tang, X. and He, Q. 2012. New variants of porcine epidemic diarrhea virus, China, 2011. <i>Emerg. Infect. Dis.<\/i> 18: 1350\u20131353.","DOI":"10.3201\/eid1803.120002"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Li, Z., Chen, F., Yuan, Y., Zeng, X., Wei, Z., Zhu, L., Sun, B., Xie, Q., Cao, Y., Xue, C., Ma, J. and Bee, Y. 2013. Sequence and phylogenetic analysis of nucleocapsid genes of porcine epidemic diarrhea virus (PEDV) strains in China. <i>Arch. Virol.<\/i> 158: 1267\u20131273.","DOI":"10.1007\/s00705-012-1592-4"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Li, Z. L., Zhu, L., Ma, J. Y., Zhou, Q. F., Song, Y. H., Sun, B. L., Chen, R. A., Xie, Q. M. and Bee, Y. Z. 2012. Molecular characterization and phylogenetic analysis of porcine epidemic diarrhea virus (PEDV) field strains in south China. <i>Virus Genes<\/i> 45: 181\u2013185.","DOI":"10.1007\/s11262-012-0735-8"},{"key":"23","unstructured":"23. Liang, E. T., Liao, X. D., Huang, X. B., Wen, X. T., Cao, S. J., Yang, Y. P., Duan, S. F., Zhang, D. and Zhang, X. H. 2014. Construction and identification of attenuated Salmonella typhimurium harboring S gene of porcine epidemic diarrhea virus. <i>Chin. Vet. Sci.<\/i> 44: 264\u2013270 (in Chinese)."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Licitra, B. N., Duhamel, G. E. and Whittaker, G. R. 2014. Canine enteric coronaviruses: emerging viral pathogens with distinct recombinant spike proteins. <i>Viruses<\/i> 6: 3363\u20133376.","DOI":"10.3390\/v6083363"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Liu, D. Q., Ge, J. W., Qiao, X. Y., Jiang, Y. P., Liu, S. M. and Li, Y. J. 2012. High-level mucosal and systemic immune responses induced by oral administration with Lactobacillus-expressed porcine epidemic diarrhea virus (PEDV) S1 region combined with Lactobacillus-expressed N protein. <i>Appl. Microbiol. Biotechnol.<\/i> 93: 2437\u20132446.","DOI":"10.1007\/s00253-011-3734-0"},{"key":"26","unstructured":"26. Ma, S. Q., Wang, M. and Feng, L. 1995. Development of bi-combined inactivated vaccine against transmissible gastroenteritis virus and porcine epidemic diarrhea virus. <i>Chin. Anim. Infect. Dis.<\/i> 17: 23\u201327 (in Chinese)."},{"key":"27","unstructured":"27. Ma, S. Q., Wang, M., Zhou, J. F. and Feng, L. 1994. Adaptation of porcine epidemic diarrhea virus to Vero cells and evaluation of the inactivated vaccine against porcine epidemic diarrhea virus. <i>Chin. Anim. Infect. Dis.<\/i> 2: 15\u201318 (in Chinese)."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Meng, F., Ren, Y., Suo, S., Sun, X., Li, X., Li, P., Yang, W., Li, G. and Li, L. 2013. Evaluation on the efficacy and immunogenicity of recombinant DNA plasmids expressing spike genes from porcine transmissible gastroenteritis virus and porcine epidemic diarrhea virus. <i>PLoS ONE<\/i> 8: e57468.","DOI":"10.1371\/journal.pone.0057468"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Pasick, J., Berhane, Y., Ojkic, D., Maxie, G., Embury-Hyatt, C., Swekla, K., Handel, K., Fairles, J. and Alexandersen, S. 2014. Investigation into the role of potentially contaminated feed as a source of the first-detected outbreaks of porcine epidemic diarrhea in Canada. <i>Transbound. Emerg. Dis.<\/i> 61: 397\u2013410.","DOI":"10.1111\/tbed.12269"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Pensaert, M. B. and de Bouck, P. 1978. A new coronavirus-like particle associated with diarrhea in swine. <i>Arch. Virol.<\/i> 58: 243\u2013247.","DOI":"10.1007\/BF01317606"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Regan, A. D., Millet, J. K., Tse, L. P., Chillag, Z., Rinaldi, V. D., Licitra, B. N., Dubovi, E. J., Town, C. D. and Whittaker, G. R. 2012. Characterization of a recombinant canine coronavirus with a distinct receptor-binding (S1) domain. <i>Virology<\/i> 430: 90\u201399.","DOI":"10.1016\/j.virol.2012.04.013"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Song, D. and Park, B. 2012. Porcine epidemic diarrhoea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccines. <i>Virus Genes<\/i> 44: 167\u2013175.","DOI":"10.1007\/s11262-012-0713-1"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Sun, D., Feng, L., Shi, H., Chen, J., Cui, X., Chen, H., Liu, S., Tong, Y., Wang, Y. and Tong, G. 2008. Identification of two novel B cell epitopes on porcine epidemic diarrhea virus spike protein. <i>Vet. Microbiol.<\/i> 131: 73\u201381.","DOI":"10.1016\/j.vetmic.2008.02.022"},{"key":"34","unstructured":"34. Sun, R., Leng, Z., Zhai, S. L., Chen, D. and Song, C. 2014. Genetic variability and phylogeny of current Chinese porcine epidemic diarrhea virus strains based on spike, ORF3, and membrane genes. <i>Scientific World Journal<\/i> 2014: 208439."},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Tian, Y., Yu, Z., Cheng, K., Liu, Y., Huang, J., Xin, Y., Li, Y., Fan, S., Wang, T., Huang, G., Feng, N., Yang, Z., Yang, S., Gao, Y. and Xia, X. 2013. Molecular characterization and phylogenetic analysis of new variants of the porcine epidemic diarrhea virus in Gansu, China in 2012. <i>Viruses<\/i> 5: 1991\u20132004.","DOI":"10.3390\/v5081991"},{"key":"36","unstructured":"36. Tong, Y. E., Feng, L. and Li, W. J. 1998. Development of attenuated vaccine strain of porcine epidemic diarrhea virus. <i>Chin. Anim. Infect. Dis.<\/i> 20: 329\u2013332 (in Chinese)."},{"key":"37","unstructured":"37. Tong, Y. E., Feng, L. and Li, W. J. 1999. Development of bi-combined attenuated vaccine against transmissible gastroenteritis virus and porcine epidemic diarrhea virus. <i>Chin. J. Prev. Vet. Med.<\/i> 21: 406\u2013410 (in Chinese)."},{"key":"38","unstructured":"38. Wang, M., Ma, S. Q., Zhou, J. F., Feng, L., Tong, Y. E., Yu, W. T., Wei, F. X., Cui, X. L., Huang, S. T. and Liu, C. M. 1993. Development of the inactivated vaccine of porcine epidemic diarrhea virus. <i>Chin. Anim. Infect. Dis.<\/i> 5: 17\u201319 (in Chinese)."},{"key":"39","unstructured":"39. Wang, X. N., Li, X. M. and Li, C. L. 1989. Report of investigation and diagnosis of porcine epidemic diarrhea virus infection. <i>Zhejiang J. Anim. Sci. Vet. Med.<\/i> 4: 22\u201323 (in Chinese)."},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Wood, E. N. 1977. An apparently new syndrome of porcine epidemic diarrhoea. <i>Vet. Rec.<\/i> 100: 243\u2013244.","DOI":"10.1136\/vr.100.12.243"},{"key":"41","unstructured":"41. Xuan, H. 1984. Culture of porcine epidemic diarrhea virus by using pig intestinal monolayer cell. <i>J. People\u2019s Liberation Army Vet. Univ.<\/i> 4: 202\u2013208 (in Chinese)."},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Yang, X., Huo, J. Y., Chen, L., Zheng, F. M., Chang, H. T., Zhao, J., Wang, X. W. and Wang, C. Q. 2013. Genetic variation analysis of reemerging porcine epidemic diarrhea virus prevailing in central China from 2010 to 2011. <i>Virus Genes<\/i> 46: 337\u2013344.","DOI":"10.1007\/s11262-012-0867-x"},{"key":"43","unstructured":"43. Yu, Z. F. 1986. Porcine epidemic diarrhea diseases. <i>Contemp. Livest.<\/i> 2: 65\u201366 (in Chinese)."},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Zhang, B., Tang, C., Yue, H., Ren, Y. and Song, Z. 2014. Viral metagenomics analysis demonstrates the diversity of viral flora in piglet diarrhoeic faeces in China. <i>J. Gen. Virol.<\/i> 95: 1603\u20131611.","DOI":"10.1099\/vir.0.063743-0"},{"key":"45","unstructured":"45. Zhang, Z., Dong, Y. Q., Liu, S., Wu, F. X., Shao, W. X. and Li, X. C. 2014. Survey and surveillance of porcine epidemic diarrhea in some provinces in China. <i>Chin. Anim. Heal. 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