{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:01:12Z","timestamp":1789059672994,"version":"build-2803163510"},"reference-count":17,"publisher":"Japanese Society of Veterinary Science","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Veterinary Medical Science","J. Vet. Med. Sci."],"published-print":{"date-parts":[[2016]]},"DOI":"10.1292\/jvms.15-0520","type":"journal-article","created":{"date-parts":[[2015,11,21]],"date-time":"2015-11-21T22:02:16Z","timestamp":1448143336000},"page":"525-528","source":"Crossref","is-referenced-by-count":5,"title":["Positive correlation between patency and mRNA levels for cyclooxygenase-2 and prostaglandin E synthase in the uterine cervix of bitches with pyometra"],"prefix":"10.1292","volume":"78","author":[{"given":"Hiromichi","family":"TAMADA","sequence":"first","affiliation":[{"name":"Department of Advanced Pathobiology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 598\u20138531, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahoko","family":"ADACHI","sequence":"additional","affiliation":[{"name":"Department of Advanced Pathobiology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 598\u20138531, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noritoshi","family":"KAWATE","sequence":"additional","affiliation":[{"name":"Department of Advanced Pathobiology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 598\u20138531, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"INABA","sequence":"additional","affiliation":[{"name":"Department of Advanced Pathobiology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 598\u20138531, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"HATOYA","sequence":"additional","affiliation":[{"name":"Department of Advanced Pathobiology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 598\u20138531, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"SAWADA","sequence":"additional","affiliation":[{"name":"Department of Advanced Pathobiology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 598\u20138531, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"122","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Denison, F. C., Calder, A. A. and Kelly, R. W. 1999. The action of prostaglandin E<sub>2<\/sub> on the human cervix: stimulation of interleukin 8 and inhibition of secretory leukocyte protease inhibitor. <i>Am. J. Obstet. Gynecol.<\/i> 180: 614\u2013620.","DOI":"10.1016\/S0002-9378(99)70263-2"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Ekerhovd, E., Weijdegard, B., Brannstrom, M., Mattsby-Baltzer, I. and Norstrom, A. 2002. Nitric oxide induced cervical ripening in the human: involvement of cyclic guanosine monophosphate, prostaglandin F<sub>2\u03b1<\/sub>, and prostaglandin E<sub>2<\/sub>. <i>Am. J. Obstet. Gynecol.<\/i> 186: 745\u2013750.","DOI":"10.1067\/mob.2002.121327"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Ekman, G., Forman, A., Marsal, K. and Ulmsten, U. 1983. Intravaginal versus intracervical application of prostaglandin E<sub>2<\/sub> in viscous gel for cervical priming and induction of labor at term in patients with an unfavorable cervical state. <i>Am. J. Obstet. Gynecol.<\/i> 147: 657\u2013661.","DOI":"10.1016\/0002-9378(83)90445-3"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. El Maradny, E., Kanayama, N., Halim, A., Maehara, K., Sumimoto, K. and Terao, T. 1996. Biochemical changes in the cervical tissue of rabbit induced by interleukin-8, interleukin-1beta, dehydroepiandrosterone sulphate and prostaglandin E<sub>2<\/sub>: a comparative study. <i>Hum. Reprod.<\/i> 11: 1099\u20131104.","DOI":"10.1093\/oxfordjournals.humrep.a019304"},{"key":"5","unstructured":"5. Feldman, E.C. and Nelson, R.W. 1987. Canine and Feline Endocrinology and Reproduction, WB Saunders, Philadelphia."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Hatoya, S., Torii, R., Kumagai, D., Sugiura, K., Kawate, N., Tamada, H. and Sawada, T. 2003. Expression of estrogen receptor alpha and beta genes in the mediobasal hypothalamus, pituitary and ovary during the canine estrous cycle. <i>Neurosci. Lett.<\/i> 347: 131\u2013135.","DOI":"10.1016\/S0304-3940(03)00639-6"},{"key":"7","unstructured":"7. Jana, B., Andronowska, A. and Kucharski, J. 2001. Immunoreactivity of iNOS in porcine uterus after infusions of <i>Escherichia coli<\/i> endotoxin. <i>Folia Histochem. Cytobiol.<\/i> 39: 177\u2013178."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Lee, S. H., Soyoola, E., Chanmugam, P., Hart, S., Sun, W., Zhong, H., Liou, S., Simmons, D. and Hwang, D. 1992. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. <i>J. Biol. Chem.<\/i> 267: 25934\u201325938.","DOI":"10.1016\/S0021-9258(18)35698-9"},{"key":"9","unstructured":"9. Linharattanaruksa, P., Swangchan-Uthai, T., Srisuwatanasagul, S., Khalid, M. and Chatdarong, K. 2013. mRNA and protein expressions of prostaglandin E<sub>2<\/sub> receptors (EP<sub>2<\/sub> and EP<sub>4<\/sub>), cyclooxygenase-2 and prostaglandin E synathase in the cervix of cyclic bithches and those with pyometra. <i>Thai J. Vet. Med.<\/i> 43: 219\u2013227."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Marx, S. G., Wentz, M. J., MacKay, L. B., Schlembach, D., Maul, H., Fittkow, C., Given, R., Vedernikov, Y., Saade, G. R. and Garfield, R. E. 2006. Effects of progesterone on iNOS, COX-2, and collagen expression in the cervix. <i>J. Histochem. Cytochem.<\/i> 54: 623\u2013639.","DOI":"10.1369\/jhc.5A6759.2006"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Pretzer, S. D. 2008. Clinical presentation of canine pyometra and mucometra: a review. <i>Theriogenology<\/i> 70: 359\u2013363.","DOI":"10.1016\/j.theriogenology.2008.04.028"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Silva, E., Leitao, S., Ferreira-Dias, G., Lopes da Costa, L. and Mateus, L. 2009. Prostaglandin synthesis genes are differentially transcripted in normal and pyometra endometria of bitches. <i>Reprod. Domest. Anim.<\/i> 44 (Suppl.) 2: 200\u2013203.","DOI":"10.1111\/j.1439-0531.2009.01393.x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Smith, F. O. 2006. Canine pyometra. <i>Theriogenology<\/i> 66: 610\u2013612.","DOI":"10.1016\/j.theriogenology.2006.04.023"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Stjernholm-Vladic, Y., Stygar, D., Mansson, C., Masironi, B., Akerberg, S., Wang, H., Eckman-Ordenberg, G. and Sahlin, L. 2004. Factors involved in the inflammatory events of cervical ripening in humans. <i>Reprod. Biol. Endocrinol.<\/i> 2: 74.","DOI":"10.1186\/1477-7827-2-74"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Tamada, H., Kawata, N., Kawate, N., Inaba, T., Kida, K., Hatoya, S., Akune, A., Nakama, K., Kohsaka, T., Takahashi, M. and Sawada, T. 2012. Factors associated with patency of the uterine cervix in bitches with pyometra. <i>Res. Vet. Sci.<\/i> 93: 1203\u20131210.","DOI":"10.1016\/j.rvsc.2012.05.012"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Thomson, A. J., Lunan, C. B., Cameron, A. D., Cameron, I. T., Greer, I. A. and Norman, J. E. 1997. Nitric oxide donors induce ripening of the human uterine cervix: a randomized controlled trial. <i>Br. J. Obstet. Gynaecol.<\/i> 104: 1054\u20131057.","DOI":"10.1111\/j.1471-0528.1997.tb12066.x"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Tschugguel, W., Schneeberger, C., Lass, H., Stonek, F., Zaghlula, M. B., Czerwenka, K., Schatten, C., Kaider, A., Husslein, P. and Huber, J. C. 1999. Human cervical ripening is associated with an increase in cervical inducible nitric oxide synthase expression. <i>Biol. Reprod.<\/i> 60: 1367\u20131372.","DOI":"10.1095\/biolreprod60.6.1367"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/78\/3\/78_15-0520\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T19:57:40Z","timestamp":1653595060000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/78\/3\/78_15-0520\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.15-0520","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}