{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:47:38Z","timestamp":1792676858287,"version":"4.5.0"},"reference-count":18,"publisher":"Japanese Society of Veterinary Science","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Veterinary Medical Science","J. Vet. Med. Sci."],"published-print":{"date-parts":[[2016]]},"DOI":"10.1292\/jvms.15-0619","type":"journal-article","created":{"date-parts":[[2016,1,2]],"date-time":"2016-01-02T22:01:44Z","timestamp":1451772104000},"page":"607-612","source":"Crossref","is-referenced-by-count":3,"title":["Histological and immunohistochemical evaluation of stroma variations and their correlation with the Ki-67 index and expressions of glucose transporter 1 and monocarboxylate transporter 1 in canine thyroid C-cell carcinomas"],"prefix":"10.1292","volume":"78","author":[{"given":"Yoshio","family":"KAWAMURA","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathology, Rakuno Gakuen University, 582 Midori-machi, Bunkyo-dai, Ebetsu, Hokkaido 069\u20138501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"MIZOOKU","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Rakuno Gakuen University, 582 Midori-machi, Bunkyo-dai, Ebetsu, Hokkaido 069\u20138501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"OKAMOTO","sequence":"additional","affiliation":[{"name":"Department of Veterinary Immunology, Rakuno Gakuen University, 582 Midori-machi, Bunkyo-dai, Ebetsu, Hokkaido 069\u20138501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"MATSUDA","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Rakuno Gakuen University, 582 Midori-machi, Bunkyo-dai, Ebetsu, Hokkaido 069\u20138501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"OMACHI","sequence":"additional","affiliation":[{"name":"Patho LABO Co., Ltd., 9\u2013400, Omurokogen, Ito, Shizuoka 413\u20130235, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuko","family":"HIRAYAMA","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Rakuno Gakuen University, 582 Midori-machi, Bunkyo-dai, Ebetsu, Hokkaido 069\u20138501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"KADOSAWA","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Oncology, Rakuno Gakuen University, 582 Midori-machi, Bunkyo-dai, Ebetsu, Hokkaido 069\u20138501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"TANIYAMA","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Rakuno Gakuen University, 582 Midori-machi, Bunkyo-dai, Ebetsu, Hokkaido 069\u20138501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"122","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Abbondati, E., Del-Pozo, J., Hoather, T. M., Constantino-Casas, F. and Dobson, J. M. 2013. An immunohistochemical study of the expression of the hypoxia markers Glut-1 and Ca-IX in canine sarcomas. <i>Vet. Pathol.<\/i> 50: 1063\u20131069.","DOI":"10.1177\/0300985813486810"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Campos, M., Ducatelle, R., Kooistra, H. S., Rutteman, G., Duchateau, L., Polis, I. and Daminet, S. 2014. Immunohistochemical expression of potential therapeutic targets in canine thyroid carcinoma. <i>J. Vet. Intern. Med.<\/i> 28: 564\u2013570.","DOI":"10.1111\/jvim.12330"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Desai, S. S., Sarkar, S. and Borges, A. M. 2005. A study of histopathological features of medullary carcinoma of the thyroid: cases from a single institute in India. <i>Indian J. Cancer<\/i> 42: 25\u201329.","DOI":"10.4103\/0019-509X.15096"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Destexhe, E., Lespagnard, L., Degeyter, M., Heymann, R. and Coignoul, F. 1993. Immunohistochemical identification of myoepithelial, epithelial, and connective tissue cells in canine mammary tumors. <i>Vet. Pathol.<\/i> 30: 146\u2013154.","DOI":"10.1177\/030098589303000207"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Freeman, A., Hetzel, U., Cripps, P. and Mobasheri, A. 2010. Expression of the plasma membrane markers aquaporin 1 (AQP1), glucose transporter 1 (GLUT1) and Na, K-ATPase in canine mammary glands and mammary tumours. <i>Vet. J.<\/i> 185: 90\u201393.","DOI":"10.1016\/j.tvjl.2010.04.020"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Halestrap, A. P. and Wilson, M. C. 2012. The monocarboxylate transporter family\u2014role and regulation. <i>IUBMB Life<\/i> 64: 109\u2013119.","DOI":"10.1002\/iub.572"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Harmelin, A., Nyska, A., Aroch, I., Yakobson, B., Stern, S., Orgad, U. and Waner, T. 1993. Canine medullary thyroid carcinoma with unusual distant metastases. <i>J. Vet. Diagn. Invest.<\/i> 5: 284\u2013288.","DOI":"10.1177\/104063879300500228"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Lee, J. J., Larsson, C., Lui, W. O., H\u00f6\u00f6g, A. and Von Euler, H. 2006. A dog pedigree with familial medullary thyroid cancer. <i>Int. J. Oncol.<\/i> 29: 1173\u20131182.","DOI":"10.3892\/ijo.29.5.1173"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Majmundar, A. J., Wong, W. J. and Simon, M. C. 2010. Hypoxia-inducible factors and the response to hypoxic stress. <i>Mol. Cell<\/i> 40: 294\u2013309.","DOI":"10.1016\/j.molcel.2010.09.022"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Mbeunkui, F. and Johann, D. J. Jr. 2009. Cancer and the tumor microenvironment: a review of an essential relationship. <i>Cancer Chemother. Pharmacol.<\/i> 63: 571\u2013582.","DOI":"10.1007\/s00280-008-0881-9"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Morikawa, S., Baluk, P., Kaidoh, T., Haskell, A., Jain, R. K. and McDonald, D. M. 2002. Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. <i>Am. J. Pathol.<\/i> 160: 985\u20131000.","DOI":"10.1016\/S0002-9440(10)64920-6"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Patnaik, A. K., Lieberman, P. H., Erlandson, R. A., Acevedo, W. M. and Liu, S. K. 1978. Canine medullary carcinoma of the thyroid. <i>Vet. Pathol.<\/i> 15: 590\u2013599.","DOI":"10.1177\/030098587801500502"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Patnaik, A. K. and Lieberman, P. H. 1991. Gross, histologic, cytochemical, and immunocytochemical study of medullary thyroid carcinoma in sixteen dogs. <i>Vet. Pathol.<\/i> 28: 223\u2013233.","DOI":"10.1177\/030098589102800306"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Romero-Garcia, S., Lopez-Gonzalez, J. S., B\u00e1ez-Viveros, J. L., Aguilar-Cazares, D. and Prado-Garcia, H. 2011. Tumor cell metabolism: an integral view. <i>Cancer Biol. Ther.<\/i> 12: 939\u2013948.","DOI":"10.4161\/cbt.12.11.18140"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Shimoyama, Y., Akihara, Y., Kirat, D., Iwano, H., Hirayama, K., Kagawa, Y., Ohmachi, T., Matsuda, K., Okamoto, M., Kadosawa, T., Yokota, H. and Taniyama, H. 2007. Expression of monocarboxylate transporter 1 in oral and ocular canine melanocytic tumors. <i>Vet. Pathol.<\/i> 44: 449\u2013457.","DOI":"10.1354\/vp.44-4-449"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Watnick, R. S. 2012. The role of the tumor microenvironment in regulating angiogenesis. <i>Cold Spring Harb. Perspect. Med.<\/i> 2: a006676.","DOI":"10.1101\/cshperspect.a006676"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Weidner, N., Semple, J. P., Welch, W. R. and Folkman, J. 1991. Tumor angiogenesis and metastasis\u2014correlation in invasive breast carcinoma. <i>N. Engl. J. Med.<\/i> 324: 1\u20138.","DOI":"10.1056\/NEJM199101033240101"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Yoshimura, H., Michishita, M., Ohkusu-Tsukada, K. and Takahashi, K. 2011. Increased presence of stromal myofibroblasts and tenascin-C with malignant progression in canine mammary tumors. <i>Vet. Pathol.<\/i> 48: 313\u2013321.","DOI":"10.1177\/0300985810369901"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/78\/4\/78_15-0619\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T02:54:31Z","timestamp":1498272871000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/78\/4\/78_15-0619\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.15-0619","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}