{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:59:14Z","timestamp":1773028754195,"version":"3.50.1"},"reference-count":25,"publisher":"Japanese Society of Veterinary Science","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Veterinary Medical Science","J. Vet. Med. Sci."],"published-print":{"date-parts":[[2016]]},"DOI":"10.1292\/jvms.15-0676","type":"journal-article","created":{"date-parts":[[2016,3,13]],"date-time":"2016-03-13T22:05:21Z","timestamp":1457906721000},"page":"1079-1083","source":"Crossref","is-referenced-by-count":10,"title":["Single oral dose safety of D-allulose in dogs"],"prefix":"10.1292","volume":"78","author":[{"given":"Naohito","family":"NISHII","sequence":"first","affiliation":[{"name":"Joint Department of Veterinary Medicine, Applied Biological Sciences, Gifu University, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"NOMIZO","sequence":"additional","affiliation":[{"name":"Joint Department of Veterinary Medicine, Applied Biological Sciences, Gifu University, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"TAKASHIMA","sequence":"additional","affiliation":[{"name":"Joint Department of Veterinary Medicine, Applied Biological Sciences, Gifu University, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"MATSUBARA","sequence":"additional","affiliation":[{"name":"Joint Department of Veterinary Medicine, Applied Biological Sciences, Gifu University, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"TOKUDA","sequence":"additional","affiliation":[{"name":"Department of Cell Physiology, Faculty of Medicine, Kagawa University, Kagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"KITAGAWA","sequence":"additional","affiliation":[{"name":"Joint Department of Veterinary Medicine, Applied Biological Sciences, Gifu University, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"122","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Bates, J. A. 2008. Phosphorus: a quick reference. <i>Vet. Clin. North Am. Small Anim. Pract.<\/i> 38: 471\u2013475, viii.","DOI":"10.1016\/j.cvsm.2008.02.002"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Dunayer, E. K. and Gwaltney-Brant, S. M. 2006. Acute hepatic failure and coagulopathy associated with xylitol ingestion in eight dogs. <i>J. Am. Vet. Med. Assoc.<\/i> 229: 1113\u20131117.","DOI":"10.2460\/javma.229.7.1113"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Guptill, L., Glickman, L. and Glickman, N. 2003. Time trends and risk factors for diabetes mellitus in dogs: analysis of veterinary medical data base records (1970\u20131999). <i>Vet. J.<\/i> 165: 240\u2013247.","DOI":"10.1016\/S1090-0233(02)00242-3"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Hayashi, N., Iida, T., Yamada, T., Okuma, K., Takehara, I., Yamamoto, T., Yamada, K. and Tokuda, M. 2010. Study on the postprandial blood glucose suppression effect of D-psicose in borderline diabetes and the safety of long-term ingestion by normal human subjects. <i>Biosci. Biotechnol. Biochem.<\/i> 74: 510\u2013519.","DOI":"10.1271\/bbb.90707"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Hishiike, T., Ogawa, M., Hayakawa, S., Nakajima, D., O\u2019Charoen, S., Ooshima, H. and Sun, Y. 2013. Transepithelial transports of rare sugar D-psicose in human intestine. <i>J. Agric. Food Chem.<\/i> 61: 7381\u20137386.","DOI":"10.1021\/jf401449m"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Hossain, M. A., Kitagaki, S., Nakano, D., Nishiyama, A., Funamoto, Y., Matsunaga, T., Tsukamoto, I., Yamaguchi, F., Kamitori, K., Dong, Y., Hirata, Y., Murao, K., Toyoda, Y. and Tokuda, M. 2011. Rare sugar D-psicose improves insulin sensitivity and glucose tolerance in type 2 diabetes Otsuka Long-Evans Tokushima Fatty (OLETF) rats. <i>Biochem. Biophys. Res. Commun.<\/i> 405: 7\u201312.","DOI":"10.1016\/j.bbrc.2010.12.091"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Hossain, A., Yamaguchi, F., Matsunaga, T., Hirata, Y., Kamitori, K., Dong, Y., Sui, L., Tsukamoto, I., Ueno, M. and Tokuda, M. 2012. Rare sugar D-psicose protects pancreas \u03b2-islets and thus improves insulin resistance in OLETF rats. <i>Biochem. Biophys. Res. Commun.<\/i> 425: 717\u2013723.","DOI":"10.1016\/j.bbrc.2012.07.135"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Hossain, A., Yamaguchi, F., Hirose, K., Matsunaga, T., Sui, L., Hirata, Y., Noguchi, C., Katagi, A., Kamitori, K., Dong, Y., Tsukamoto, I. and Tokuda, M. 2015. Rare sugar D-psicose prevents progression and development of diabetes in T2DM model Otsuka Long-Evans Tokushima Fatty rats. <i>Drug Des. Devel. Ther.<\/i> 9: 525\u2013535.","DOI":"10.2147\/DDDT.S71289"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Iida, T., Kishimoto, Y., Yoshikawa, Y., Hayashi, N., Okuma, K., Tohi, M., Yagi, K., Matsuo, T. and Izumori, K. 2008. Acute D-psicose administration decreases the glycemic responses to an oral maltodextrin tolerance test in normal adults. <i>J. Nutr. Sci. Vitaminol. (Tokyo)<\/i> 54: 511\u2013514.","DOI":"10.3177\/jnsv.54.511"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Iida, T., Hayashi, N., Yamada, T., Yoshikawa, Y., Miyazato, S., Kishimoto, Y., Okuma, K., Tokuda, M. and Izumori, K. 2010. Failure of d-psicose absorbed in the small intestine to metabolize into energy and its low large intestinal fermentability in humans. <i>Metabolism<\/i> 59: 206\u2013214.","DOI":"10.1016\/j.metabol.2009.07.018"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Iida, T., Yamada, T., Hayashi, N., Okuma, K., Izumori, K., Ishii, R. and Matsuo, T. 2013. Reduction of abdominal fat accumulation in rats by 8-week ingestion of a newly developed sweetener made from high fructose corn syrup. <i>Food Chem.<\/i> 138: 781\u2013785.","DOI":"10.1016\/j.foodchem.2012.11.017"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Izumori, K. 2006. Izumoring: a strategy for bioproduction of all hexoses. <i>J. Biotechnol.<\/i> 124: 717\u2013722.","DOI":"10.1016\/j.jbiotec.2006.04.016"},{"key":"13","unstructured":"13. Kathy, K. L., Jewell, D. E., Yamka, R. M., Schoenherr, W. D., Khoo, C., Debraekeleer, J., Friesen, K. G. and Zicker, S. C. 2010. Chapter 5 Macronutrients. pp. 49\u2013105. <i>In<\/i>: Small Animal Clinical Nutrition 5th ed. (Hand, M. S., Thatcher, C. D., Remillard, R. L., Roudebush, P. and Novotny, B. J. eds.), Mark Morris Institute, Topeka."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Kuzuya, T., Kanazawa, Y. and Kosaka, K. 1969. Stimulation of insulin secretion by xylitol in dogs. <i>Endocrinology<\/i> 84: 200\u2013207.","DOI":"10.1210\/endo-84-2-200"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kuzuya, T., Kanazawa, Y., Hayashi, M., Kikuchi, M. and Ide, T. 1971. Species difference in plasma insulin responses to intravenous xylitol in man and several mammals. <i>Endocrinol. Jpn.<\/i> 18: 309\u2013320.","DOI":"10.1507\/endocrj1954.18.309"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. L\u00f3pez, I., Aguilera-Tejero, E., Estepa, J. C., Bas, S., Mayer-Valor, R., Jim\u00e9nez, A. and Rodr\u00edguez, M. 2005. Diurnal variations in the plasma concentration of parathyroid hormone in dogs. <i>Vet. Rec.<\/i> 157: 344\u2013347.","DOI":"10.1136\/vr.157.12.344"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Matsuo, T., Baba, Y., Hashiguchi, M., Takeshita, K., Izumori, K. and Suzuki, H. 2001. Dietary D-psicose, a C-3 epimer of D-fructose, suppresses the activity of hepatic lipogenic enzymes in rats. <i>Asia Pac. J. Clin. Nutr.<\/i> 10: 233\u2013237.","DOI":"10.1046\/j.1440-6047.2001.00246.x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Matsuo, T., Tanaka, T., Hashiguchi, M., Izumori, K. and Suzuki, H. 2002. Effects of oral acute administration and subchronic feeding of several levels of D-psicose in rats. <i>J. Nutr. Sci. Vitaminol. (Tokyo)<\/i> 48: 512\u2013516.","DOI":"10.3177\/jnsv.48.512"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Matsuo, T. and Izumori, K. 2006. Effects of dietary D-psicose on diurnal variation in plasma glucose and insulin concentrations of rats. <i>Biosci. Biotechnol. Biochem.<\/i> 70: 2081\u20132085.","DOI":"10.1271\/bbb.60036"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. McGreevy, P. D., Thomson, P. C., Pride, C., Fawcett, A., Grassi, T. and Jones, B. 2005. Prevalence of obesity in dogs examined by Australian veterinary practices and the risk factors involved. <i>Vet. Rec.<\/i> 156: 695\u2013702.","DOI":"10.1136\/vr.156.22.695"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Ochiai, M., Nakanishi, Y., Yamada, T., Iida, T. and Matsuo, T. 2013. Inhibition by dietary D-psicose of body fat accumulation in adult rats fed a high-sucrose diet. <i>Biosci. Biotechnol. Biochem.<\/i> 77: 1123\u20131126.","DOI":"10.1271\/bbb.130019"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Sako, T., Mori, A., Lee, P., Goto, H., Fukuta, H., Oda, H., Saeki, K., Miki, Y., Makino, Y., Ishioka, K., Mizutani, H., Kojima, Y., Koikeda, S. and Arai, T. 2010. Supplementing transglucosidase with a high-fiber diet for prevention of postprandial hyperglycemia in streptozotocin-induced diabetic dogs. <i>Vet. Res. Commun.<\/i> 34: 161\u2013172.","DOI":"10.1007\/s11259-010-9342-0"},{"key":"23","unstructured":"23. Tsukamoto, I., Hossain, A., Yamaguchi, F., Hirata, Y., Dong, Y., Kamitori, K., Sui, L., Nonaka, M., Ueno, M., Nishimoto, K., Suda, H., Morimoto, K., Shimonishi, T., Saito, M., Song, T., Konishi, R. and Tokuda, M. 2014. Intestinal absorption, organ distribution, and urinary excretion of the rare sugar D-psicose. <i>Drug Des. Devel. Ther.<\/i> 8: 1955\u20131964."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Xia, Z., He, Y. and Yu, J. 2009. Experimental acute toxicity of xylitol in dogs. <i>J. Vet. Pharmacol. Ther.<\/i> 32: 465\u2013469.","DOI":"10.1111\/j.1365-2885.2009.01065.x"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Yagi, K. and Matsuo, T. 2009. The study on long-term toxicity of d-psicose in rats. <i>J. Clin. Biochem. Nutr.<\/i> 45: 271\u2013277.","DOI":"10.3164\/jcbn.08-191"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/78\/6\/78_15-0676\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T08:14:30Z","timestamp":1498292070000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/78\/6\/78_15-0676\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.15-0676","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}