{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:27:13Z","timestamp":1761766033288,"version":"3.41.0"},"reference-count":33,"publisher":"Japanese Society of Veterinary Science","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Veterinary Medical Science","J. Vet. Med. Sci."],"published-print":{"date-parts":[[2016]]},"DOI":"10.1292\/jvms.16-0118","type":"journal-article","created":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T22:05:22Z","timestamp":1461189922000},"page":"1229-1235","source":"Crossref","is-referenced-by-count":10,"title":["Luteolin attenuates endotoxin-induced uveitis in Lewis rats"],"prefix":"10.1292","volume":"78","author":[{"given":"Kazutaka","family":"KANAI","sequence":"first","affiliation":[{"name":"Department of Small Animal Internal Medicine I, School of Veterinary Medicine, University of Kitasato, Towada, Aomori 034\u20138628, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"HATTA","sequence":"additional","affiliation":[{"name":"Department of Small Animal Internal Medicine I, School of Veterinary Medicine, University of Kitasato, Towada, Aomori 034\u20138628, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"NAGATA","sequence":"additional","affiliation":[{"name":"Department of Small Animal Internal Medicine I, School of Veterinary Medicine, University of Kitasato, Towada, Aomori 034\u20138628, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"SUGIURA","sequence":"additional","affiliation":[{"name":"Department of Small Animal Internal Medicine I, School of Veterinary Medicine, University of Kitasato, Towada, Aomori 034\u20138628, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"SATO","sequence":"additional","affiliation":[{"name":"Department of Small Animal Internal Medicine I, School of Veterinary Medicine, University of Kitasato, Towada, Aomori 034\u20138628, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"YAMASHITA","sequence":"additional","affiliation":[{"name":"Department of Small Animal Internal Medicine I, School of Veterinary Medicine, University of Kitasato, Towada, Aomori 034\u20138628, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"KIMURA","sequence":"additional","affiliation":[{"name":"Department of Small Animal Internal Medicine I, School of Veterinary Medicine, University of Kitasato, Towada, Aomori 034\u20138628, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"ITOH","sequence":"additional","affiliation":[{"name":"Department of Small Animal Internal Medicine I, School of Veterinary Medicine, University of Kitasato, Towada, Aomori 034\u20138628, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"122","reference":[{"unstructured":"1. Behar-Cohen, F. F., Savoldelli, M., Parel, J. M., Goureau, O., Thillaye-Goldenberg, B., Courtois, Y., Pouliquen, Y. and de Kozak, Y. 1998. Reduction of corneal edema in endotoxin-induced uveitis after application of L-NAME as nitric oxide synthase inhibitor in rats by iontophoresis. Invest. Ophthalmol. Vis. Sci. 39: 897\u2013904.","key":"1"},{"doi-asserted-by":"crossref","unstructured":"2. Bellot, J. L., Palmero, M., Garc\u00eda-Cabanes, C., Esp\u00ed, R., Hariton, C. and Orts, A. 1996. Additive effect of nitric oxide and prostaglandin-E2 synthesis inhibitors in endotoxin-induced uveitis in the rabbit. Inflamm. Res. 45: 203\u2013208.","key":"2","DOI":"10.1007\/BF02285162"},{"unstructured":"3. Brito, B. E., O\u2019Rourke, L. M., Pan, Y., Anglin, J., Planck, S. R. and Rosenbaum, J. T. 1999. IL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis. Invest. Ophthalmol. Vis. Sci. 40: 2583\u20132589.","key":"3"},{"doi-asserted-by":"crossref","unstructured":"4. Chan, C. C., Tuaillon, N., Li, Q. and Shen, D. F. 2000. Therapeutic applications of antiflammin peptides in experimental ocular inflammation. Ann. N. Y. Acad. Sci. 923: 141\u2013146.","key":"4","DOI":"10.1111\/j.1749-6632.2000.tb05525.x"},{"doi-asserted-by":"crossref","unstructured":"5. Chen, C. Y., Peng, W. H., Tsai, K. D. and Hsu, S. L. 2007. Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages. Life Sci. 81: 1602\u20131614.","key":"5","DOI":"10.1016\/j.lfs.2007.09.028"},{"doi-asserted-by":"crossref","unstructured":"6. de Vos, A. F., van Haren, M. A., Verhagen, C., Hoekzema, R. and Kijlstra, A. 1994. Kinetics of intraocular tumor necrosis factor and interleukin-6 in endotoxin-induced uveitis in the rat. Invest. Ophthalmol. Vis. Sci. 35: 1100\u20131106.","key":"6","DOI":"10.1016\/S0014-4835(05)80017-X"},{"unstructured":"7. de Vos, A. F., Klaren, V. N. and Kijlstra, A. 1994. Expression of multiple cytokines and IL-1RA in the uvea and retina during endotoxin-induced uveitis in the rat. Invest. Ophthalmol. Vis. Sci. 35: 3873\u20133883.","key":"7"},{"doi-asserted-by":"crossref","unstructured":"8. Helbig, H., Kittredge, K. L., Gurley, R. C., Thurau, S. R., Palestine, A. G. and Nussenblatt, R. B. 1990. Endotoxin-induced production of inflammatory mediators by cultured ciliary epithelial cells. Curr. Eye Res. 9: 501\u2013505.","key":"8","DOI":"10.3109\/02713689008999616"},{"unstructured":"9. Jacquemin, E., de Kozak, Y., Thillaye, B., Courtois, Y. and Goureau, O. 1996. Expression of inducible nitric oxide synthase in the eye from endotoxin-induced uveitis rats. Invest. Ophthalmol. Vis. Sci. 37: 1187\u20131196.","key":"9"},{"doi-asserted-by":"crossref","unstructured":"11. Jin, X. H., Ohgami, K., Shiratori, K., Suzuki, Y., Hirano, T., Koyama, Y., Yoshida, K., Ilieva, I., Iseki, K. and Ohno, S. 2006. Inhibitory effects of lutein on endotoxin-induced uveitis in Lewis rats. Invest. Ophthalmol. Vis. Sci. 47: 2562\u20132568.","key":"10","DOI":"10.1167\/iovs.05-1429"},{"doi-asserted-by":"crossref","unstructured":"12. Kanai, K., Ito, Y., Nagai, N., Itoh, N., Hori, Y., Chikazawa, S., Hoshi, F. and Higuchi, S. 2012. Effects of instillation of eyedrops containing disulfiram and hydroxypropyl-\u03b2-cyclodextrin inclusion complex on endotoxin-induced uveitis in rats. Curr. Eye Res. 37: 124\u2013131.","key":"11","DOI":"10.3109\/02713683.2011.622853"},{"doi-asserted-by":"crossref","unstructured":"13. Kanai, K., Itoh, N., Yoshioka, K., Yonezawa, T., Ikadai, H., Hori, Y., Ito, Y., Nagai, N., Chikazawa, S., Hoshi, F. and Higuchi, S. 2010. Inhibitory effects of oral disulfiram on endotoxin-induced uveitis in rats. Curr. Eye Res. 35: 892\u2013899.","key":"12","DOI":"10.3109\/02713683.2010.495442"},{"doi-asserted-by":"crossref","unstructured":"14. Karin, M. and Ben-Neriah, Y. 2000. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu. Rev. Immunol. 18: 621\u2013663.","key":"13","DOI":"10.1146\/annurev.immunol.18.1.621"},{"doi-asserted-by":"crossref","unstructured":"15. Krappmann, D., Hatada, E. N., Tegethoff, S., Li, J., Klippel, A., Giese, K., Baeuerle, P. A. and Scheidereit, C. 2000. The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component. J. Biol. Chem. 275: 29779\u201329787.","key":"14","DOI":"10.1074\/jbc.M003902200"},{"doi-asserted-by":"crossref","unstructured":"16. Kubota, S., Kurihara, T., Mochimaru, H., Satofuka, S., Noda, K., Ozawa, Y., Oike, Y., Ishida, S. and Tsubota, K. 2009. Prevention of ocular inflammation in endotoxin-induced uveitis with resveratrol by inhibiting oxidative damage and nuclear factor-kappaB activation. Invest. Ophthalmol. Vis. Sci. 50: 3512\u20133519.","key":"15","DOI":"10.1167\/iovs.08-2666"},{"doi-asserted-by":"crossref","unstructured":"17. Li, Q., Peng, B., Whitcup, S. M., Jang, S. U. and Chan, C. C. 1995. Endotoxin induced uveitis in the mouse: susceptibility and genetic control. Exp. Eye Res. 61: 629\u2013632.","key":"16","DOI":"10.1016\/S0014-4835(05)80056-9"},{"unstructured":"18. Mandai, M., Yoshimura, N., Yoshida, M., Iwaki, M. and Honda, Y. 1994. The role of nitric oxide synthase in endotoxin-induced uveitis: effects of NG-nitro L-arginine. Invest. Ophthalmol. Vis. Sci. 35: 3673\u20133680.","key":"17"},{"doi-asserted-by":"crossref","unstructured":"19. Masferrer, J. L., Zweifel, B. S., Manning, P. T., Hauser, S. D., Leahy, K. M., Smith, W. G., Isakson, P. C. and Seibert, K. 1994. Selective inhibition of inducible cyclooxygenase 2 <i>in vivo<\/i> is antiinflammatory and nonulcerogenic. Proc. Natl. Acad. Sci. U.S.A. 91: 3228\u20133232.","key":"18","DOI":"10.1073\/pnas.91.8.3228"},{"doi-asserted-by":"crossref","unstructured":"21. Nakamura, S. and Ohno, S. 2005. Anti-tumor necrosis factor alpha antibody in the treatment of Beh\u00e7et\u2019s disease. Int. Ophthalmol. Clin. 45: 179\u2013189.","key":"19","DOI":"10.1097\/01.iio.0000155901.41938.3c"},{"unstructured":"22. Ohta, K., Nakayama, K., Kurokawa, T., Kikuchi, T. and Yoshimura, N. 2002. Inhibitory effects of pyrrolidine dithiocarbamate on endotoxin-induced uveitis in Lewis rats. Invest. Ophthalmol. Vis. Sci. 43: 744\u2013750.","key":"20"},{"doi-asserted-by":"crossref","unstructured":"23. Pandurangan, A. K. and Esa, N. M. 2014. Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review. Asian Pac. J. Cancer Prev. 15: 5501\u20135508.","key":"21","DOI":"10.7314\/APJCP.2014.15.14.5501"},{"doi-asserted-by":"crossref","unstructured":"24. Park, C. M. and Song, Y. S. 2013. Luteolin and luteolin-7-O-glucoside inhibit lipopolysaccharide-induced inflammatory responses through modulation of NF-\u03baB\/AP-1\/PI3K-Akt signaling cascades in RAW 264.7 cells. Nutr. Res. Pract. 7: 423\u2013429.","key":"22","DOI":"10.4162\/nrp.2013.7.6.423"},{"unstructured":"25. Planck, S. R., Huang, X. N., Robertson, J. E. and Rosenbaum, J. T. 1994. Cytokine mRNA levels in rat ocular tissues after systemic endotoxin treatment. Invest. Ophthalmol. Vis. Sci. 35: 924\u2013930.","key":"23"},{"doi-asserted-by":"crossref","unstructured":"26. Rosenbaum, J. T. 1989. Uveitis. An internist\u2019s view. Arch. Intern. Med. 149: 1173\u20131176.","key":"24","DOI":"10.1001\/archinte.1989.00390050129026"},{"doi-asserted-by":"publisher","unstructured":"27. Rosenbaum, J. T., McDevitt, H. O., Guss, R. B. and Egbert, P. R. 1980. Endotoxin-induced uveitis in rats as a model for human disease. Nature 286: 611\u2013613.","key":"25","DOI":"10.1038\/286611a0"},{"doi-asserted-by":"crossref","unstructured":"28. Surh, Y. J. 2003. Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer 3: 768\u2013780.","key":"26","DOI":"10.1038\/nrc1189"},{"doi-asserted-by":"crossref","unstructured":"29. Surh, Y. J., Chun, K. S., Cha, H. H., Han, S. S., Keum, Y. S., Park, K. K. and Lee, S. S. 2001. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat. Res. 480\u2013481: 243\u2013268.","key":"27","DOI":"10.1016\/S0027-5107(01)00183-X"},{"doi-asserted-by":"crossref","unstructured":"30. Toguri, J. T., Lehmann, C., Laprairie, R. B., Szczesniak, A. M., Zhou, J., Denovan-Wright, E. M. and Kelly, M. E. 2014. Anti-inflammatory effects of cannabinoid CB(2) receptor activation in endotoxin-induced uveitis. Br. J. Pharmacol. 171: 1448\u20131461.","key":"28","DOI":"10.1111\/bph.12545"},{"doi-asserted-by":"crossref","unstructured":"31. Xagorari, A., Papapetropoulos, A., Mauromatis, A., Economou, M., Fotsis, T. and Roussos, C. 2001. Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages. J. Pharmacol. Exp. Ther. 296: 181\u2013187.","key":"29","DOI":"10.1016\/S0022-3565(24)29679-8"},{"doi-asserted-by":"crossref","unstructured":"32. Yadav, U. C., Srivastava, S. K. and Ramana, K. V. 2007. Aldose reductase inhibition prevents endotoxin-induced uveitis in rats. Invest. Ophthalmol. Vis. Sci. 48: 4634\u20134642.","key":"30","DOI":"10.1167\/iovs.07-0485"},{"doi-asserted-by":"crossref","unstructured":"33. Yadav, U. C., Subramanyam, S. and Ramana, K. V. 2009. Prevention of endotoxin-induced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1. Invest. Ophthalmol. Vis. Sci. 50: 2276\u20132282.","key":"31","DOI":"10.1167\/iovs.08-2816"},{"unstructured":"34. Yang, P., de Vos, A. F. and Kijlstra, A. 1996. Macrophages in the retina of normal Lewis rats and their dynamics after injection of lipopolysaccharide. Invest. Ophthalmol. Vis. Sci. 37: 77\u201385.","key":"32"},{"unstructured":"35. Yoshida, M., Yoshimura, N., Hangai, M., Tanihara, H. and Honda, Y. 1994. Interleukin-1 \u03b1, interleukin-1 \u03b2, and tumor necrosis factor gene expression in endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci. 35: 1107\u20131113.","key":"33"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/78\/8\/78_16-0118\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T20:46:25Z","timestamp":1748897185000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/78\/8\/78_16-0118\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.16-0118","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"type":"print","value":"0916-7250"},{"type":"electronic","value":"1347-7439"}],"subject":[],"published":{"date-parts":[[2016]]}}}