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Bertagnolli, M. M., Eagle, C. J., Zauber, A. G., Redston, M., Solomon, S. D., Kim, K., Tang, J., Rosenstein, R. B., Wittes, J., Corle, D., Hess, T. M., Woloj, G. M., Boisserie, F., Anderson, W. F., Viner, J. L., Bagheri, D., Burn, J., Chung, D. C., Dewar, T., Foley, T. R., Hoffman, N., Macrae, F., Pruitt, R. E., Saltzman, J. R., Salzberg, B., Sylwestrowicz, T., Gordon, G. B., Hawk, E. T. and Investigators, A. P. C. Study 2006. Celecoxib for the prevention of sporadic colorectal adenomas. <i>N. Engl. J. Med<\/i>. 355: 873\u2013884.","DOI":"10.1056\/NEJMoa061355"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Elinav, E., Nowarski, R., Thaiss, C. A., Hu, B., Jin, C. and Flavell, R. A. 2013. Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. <i>Nat. Rev. Cancer<\/i> 13: 759\u2013771.","DOI":"10.1038\/nrc3611"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Goldblatt, M. W. 1935. Properties of human seminal plasma. <i>J. Physiol.<\/i> 84: 208\u2013218.","DOI":"10.1113\/jphysiol.1935.sp003269"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Hamberg, M. and Fredholm, B. B. 1976. Isomerization of prostaglandin H2 into prostaglandin D2 in the presence of serum albumin. <i>Biochim. Biophys. Acta<\/i> 431: 189\u2013193.","DOI":"10.1016\/0005-2760(76)90273-3"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Hershko, A. Y., Charles, N., Olivera, A., Alvarez-Errico, D. and Rivera, J. 2012. Cutting edge: persistence of increased mast cell numbers in tissues links dermatitis to enhanced airway disease in a mouse model of atopy. <i>J. Immunol.<\/i> 188: 531\u2013535.","DOI":"10.4049\/jimmunol.1102703"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Hirai, H., Tanaka, K., Yoshie, O., Ogawa, K., Kenmotsu, K., Takamori, Y., Ichimasa, M., Sugamura, K., Nakamura, M., Takano, S. and Nagata, K. 2001. Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. <i>J. Exp. Med.<\/i> 193: 255\u2013261.","DOI":"10.1084\/jem.193.2.255"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Honda, K., Arima, M., Cheng, G., Taki, S., Hirata, H., Eda, F., Fukushima, F., Yamaguchi, B., Hatano, M., Tokuhisa, T. and Fukuda, T. 2003. Prostaglandin D2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine. <i>J. Exp. Med.<\/i> 198: 533\u2013543.","DOI":"10.1084\/jem.20022218"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Iwanaga, K., Nakamura, T., Maeda, S., Aritake, K., Hori, M., Urade, Y., Ozaki, H. and Murata, T. 2014. 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