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Barnard, D. L. 2009. Animal models for the study of influenza pathogenesis and therapy. <i>Antiviral Res.<\/i> 82: A110\u2013A122.","DOI":"10.1016\/j.antiviral.2008.12.014"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Chowell, G., Bertozzi, S. M., Colchero, M. A., Lopez-Gatell, H., Alpuche-Aranda, C., Hernandez, M. and Miller, M. A. 2009. Severe respiratory disease concurrent with the circulation of H1N1 influenza. <i>N. Engl. J. Med.<\/i> 361: 674\u2013679.","DOI":"10.1056\/NEJMoa0904023"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Dawood, F. S., Jain, S., Finelli, L., Shaw, M. W., Lindstrom, S., Garten, R. J., Gubareva, L. V., Xu, X., Bridges, C. B., Uyeki, T. M., Novel Swine-Origin Influenza A(H1N1) Virus Investigation Team 2009. Emergence of a novel swine-origin influenza A(H1N1) virus in humans. <i>N. Engl. J. Med.<\/i> 360: 2605\u20132615.","DOI":"10.1056\/NEJMoa0903810"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Dawood, F. S., Iuliano, A. D., Reed, C., Meltzer, M. I., Shay, D. K., Cheng, P. Y., Bandaranayake, D., Breiman, R. F., Brooks, W. A., Buchy, P., Feikin, D. R., Fowler, K. B., Gordon, A., Hien, N. T., Horby, P., Huang, Q. S., Katz, M. A., Krishnan, A., Lal, R., Montgomery, J. M., M\u00f8lbak, K., Pebody, R., Presanis, A. M., Razuri, H., Steens, A., Tinoco, Y. O., Wallinga, J., Yu, H., Vong, S., Bresee, J. and Widdowson, M. A. 2012. Estimated global mortality associated with the first 12 months of 2009 pandemic influenza A H1N1 virus circulation: a modelling study. <i>Lancet Infect. Dis.<\/i> 12: 687\u2013695.","DOI":"10.1016\/S1473-3099(12)70121-4"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Fodor, E., Crow, M., Mingay, L. J., Deng, T., Sharps, J., Fechter, P. and Brownlee, G. G. 2002. A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs. <i>J. Virol.<\/i> 76: 8989\u20139001.","DOI":"10.1128\/JVI.76.18.8989-9001.2002"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Garten, R. J., Davis, C. T., Russell, C. A., Shu, B., Lindstrom, S., Balish, A., Sessions, W. M., Xu, X., Skepner, E., Deyde, V., Okomo-Adhiambo, M., Gubareva, L., Barnes, J., Smith, C. B., Emery, S. L., Hillman, M. J., Rivailler, P., Smagala, J., de Graaf, M., Burke, D. F., Fouchier, R. A., Pappas, C., Alpuche-Aranda, C. M., L\u00f3pez-Gatell, H., Olivera, H., L\u00f3pez, I., Myers, C. A., Faix, D., Blair, P. J., Yu, C., Keene, K. M., Dotson, P. D. Jr., Boxrud, D., Sambol, A. R., Abid, S. H., St George, K., Bannerman, T., Moore, A. L., Stringer, D. J., Blevins, P., Demmler-Harrison, G. J., Ginsberg, M., Kriner, P., Waterman, S., Smole, S., Guevara, H. F., Belongia, E. A., Clark, P. A., Beatrice, S. T., Donis, R., Katz, J., Finelli, L., Bridges, C. B., Shaw, M., Jernigan, D. B., Uyeki, T. M., Smith, D. J., Klimov, A. I. and Cox, N. J. 2009. Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. <i>Science<\/i> 325: 197\u2013201.","DOI":"10.1126\/science.1176225"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Hatta, M., Gao, P., Halfmann, P. and Kawaoka, Y. 2001. Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. <i>Science<\/i> 293: 1840\u20131842.","DOI":"10.1126\/science.1062882"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Herfst, S., Chutinimitkul, S., Ye, J., de Wit, E., Munster, V. J., Schrauwen, E. J., Bestebroer, T. M., Jonges, M., Meijer, A., Koopmans, M., Rimmelzwaan, G. F., Osterhaus, A. D., Perez, D. R. and Fouchier, R. A. 2010. Introduction of virulence markers in PB2 of pandemic swine-origin influenza virus does not result in enhanced virulence or transmission. <i>J. Virol.<\/i> 84: 3752\u20133758.","DOI":"10.1128\/JVI.02634-09"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Itoh, Y., Shinya, K., Kiso, M., Watanabe, T., Sakoda, Y., Hatta, M., Muramoto, Y., Tamura, D., Sakai-Tagawa, Y., Noda, T., Sakabe, S., Imai, M., Hatta, Y., Watanabe, S., Li, C., Yamada, S., Fujii, K., Murakami, S., Imai, H., Kakugawa, S., Ito, M., Takano, R., Iwatsuki-Horimoto, K., Shimojima, M., Horimoto, T., Goto, H., Takahashi, K., Makino, A., Ishigaki, H., Nakayama, M., Okamatsu, M., Takahashi, K., Warshauer, D., Shult, P. A., Saito, R., Suzuki, H., Furuta, Y., Yamashita, M., Mitamura, K., Nakano, K., Nakamura, M., Brockman-Schneider, R., Mitamura, H., Yamazaki, M., Sugaya, N., Suresh, M., Ozawa, M., Neumann, G., Gern, J., Kida, H., Ogasawara, K. and Kawaoka, Y. 2009. In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. <i>Nature<\/i> 460: 1021\u20131025.","DOI":"10.1038\/nature08260"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Jayaraman, A., Pappas, C., Raman, R., Belser, J. A., Viswanathan, K., Shriver, Z., Tumpey, T. M. and Sasisekharan, R. 2011. A single base-pair change in 2009 H1N1 hemagglutinin increases human receptor affinity and leads to efficient airborne viral transmission in ferrets. <i>PLoS ONE<\/i> 6: e17616.","DOI":"10.1371\/journal.pone.0017616"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Kobinger, G. P., Meunier, I., Patel, A., Pillet, S., Gren, J., Stebner, S., Leung, A., Neufeld, J. L., Kobasa, D. and von Messling, V. 2010. Assessment of the efficacy of commercially available and candidate vaccines against a pandemic H1N1 2009 virus. <i>J. Infect. Dis.<\/i> 201: 1000\u20131006.","DOI":"10.1086\/651171"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Linderman, S. L., Chambers, B. S., Zost, S. J., Parkhouse, K., Li, Y., Herrmann, C., Ellebedy, A. H., Carter, D. M., Andrews, S. F., Zheng, N. Y., Huang, M., Huang, Y., Strauss, D., Shaz, B. H., Hodinka, R. L., Reyes-Ter\u00e1n, G., Ross, T. M., Wilson, P. C., Ahmed, R., Bloom, J. D. and Hensley, S. E. 2014. Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season. <i>Proc. Natl. Acad. Sci. U.S.A.<\/i> 111: 15798\u201315803.","DOI":"10.1073\/pnas.1409171111"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Maines, T. R., Jayaraman, A., Belser, J. A., Wadford, D. A., Pappas, C., Zeng, H., Gustin, K. M., Pearce, M. B., Viswanathan, K., Shriver, Z. H., Raman, R., Cox, N. J., Sasisekharan, R., Katz, J. M. and Tumpey, T. M. 2009. Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice. <i>Science<\/i> 325: 484\u2013487.","DOI":"10.1126\/science.1177238"},{"key":"14","unstructured":"14. Mart\u00ednez-Brise\u00f1o, D., Torre-Bouscoulet, L., Herrera-Zamora, J. J., D\u00edaz-Rico, J., Sandoval-Mac\u00edas, G., P\u00e9rez-Padilla, R., Hern\u00e1ndez-C\u00e1rdenas, C., Regalado-Pineda, J., Salas-Hern\u00e1ndez, J. and Santill\u00e1n-Doherty, P. 2016. Clinical Characteristics and Mortality of Influenza A H1N1 and Influenza-Like Illness in Mexico City in the 2013-2014 Winter Season. <i>Rev. Invest. Clin.<\/i> 68: 147\u2013153."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Meunier, I., Embury-Hyatt, C., Stebner, S., Gray, M., Bastien, N., Li, Y., Plummer, F., Kobinger, G. P. and von Messling, V. 2012. Virulence differences of closely related pandemic 2009 H1N1 isolates correlate with increased inflammatory responses in ferrets. <i>Virology<\/i> 422: 125\u2013131.","DOI":"10.1016\/j.virol.2011.10.018"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Munster, V. J., de Wit, E., van den Brand, J. M., Herfst, S., Schrauwen, E. J., Bestebroer, T. M., van de Vijver, D., Boucher, C. A., Koopmans, M., Rimmelzwaan, G. F., Kuiken, T., Osterhaus, A. D. and Fouchier, R. A. 2009. Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets. <i>Science<\/i> 325: 481\u2013483.","DOI":"10.1126\/science.1177127"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Muramoto, Y., Noda, T., Kawakami, E., Akkina, R. and Kawaoka, Y. 2013. Identification of novel influenza A virus proteins translated from PA mRNA. <i>J. Virol.<\/i> 87: 2455\u20132462.","DOI":"10.1128\/JVI.02656-12"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Neumann, G., Zobel, A. and Hobom, G. 1994. RNA polymerase I-mediated expression of influenza viral RNA molecules. <i>Virology<\/i> 202: 477\u2013479.","DOI":"10.1006\/viro.1994.1365"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Okada, T., Morozumi, M., Matsubara, K., Komiyama, O., Ubukata, K., Takahashi, T. and Iwata, S. 2011. Characteristic findings of pediatric inpatients with pandemic (H1N1) 2009 virus infection among severe and nonsevere illnesses. <i>J. Infect. Chemother.<\/i> 17: 238\u2013245.","DOI":"10.1007\/s10156-010-0115-z"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Otte, A., Marriott, A. C., Dreier, C., Dove, B., Mooren, K., Klingen, T. R., Sauter, M., Thompson, K. A., Bennett, A., Klingel, K., van Riel, D., McHardy, A. C., Carroll, M. W. and Gabriel, G. 2016. Evolution of 2009 H1N1 influenza viruses during the pandemic correlates with increased viral pathogenicity and transmissibility in the ferret model. <i>Sci. Rep.<\/i> 6: 28583.","DOI":"10.1038\/srep28583"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Perez-Padilla, R., de la Rosa-Zamboni, D., Ponce de Leon, S., Hernandez, M., Qui\u00f1ones-Falconi, F., Bautista, E., Ramirez-Venegas, A., Rojas-Serrano, J., Ormsby, C. E., Corrales, A., Higuera, A., Mondragon, E., Cordova-Villalobos, J. A., INER Working Group on Influenza 2009. Pneumonia and respiratory failure from swine-origin influenza A(H1N1) in Mexico. <i>N. Engl. J. Med.<\/i> 361: 680\u2013689.","DOI":"10.1056\/NEJMoa0904252"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Rodriguez, A., P\u00e9rez-Gonz\u00e1lez, A. and Nieto, A. 2007. Influenza virus infection causes specific degradation of the largest subunit of cellular RNA polymerase II. <i>J. Virol.<\/i> 81: 5315\u20135324.","DOI":"10.1128\/JVI.02129-06"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Safronetz, D., Rockx, B., Feldmann, F., Belisle, S. E., Palermo, R. E., Brining, D., Gardner, D., Proll, S. C., Marzi, A., Tsuda, Y., Lacasse, R. A., Kercher, L., York, A., Korth, M. J., Long, D., Rosenke, R., Shupert, W. L., Aranda, C. A., Mattoon, J. S., Kobasa, D., Kobinger, G., Li, Y., Taubenberger, J. K., Richt, J. A., Parnell, M., Ebihara, H., Kawaoka, Y., Katze, M. G. and Feldmann, H. 2011. Pandemic swine-origin H1N1 influenza A virus isolates show heterogeneous virulence in macaques. <i>J. Virol.<\/i> 85: 1214\u20131223.","DOI":"10.1128\/JVI.01848-10"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Sanz-Ezquerro, J. J., de la Luna, S., Ort\u00edn, J. and Nieto, A. 1995. Individual expression of influenza virus PA protein induces degradation of coexpressed proteins. <i>J. Virol.<\/i> 69: 2420\u20132426.","DOI":"10.1128\/JVI.69.4.2420-2426.1995"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Shi, M., Jagger, B. W., Wise, H. M., Digard, P., Holmes, E. C. and Taubenberger, J. K. 2012. Evolutionary conservation of the PA-X open reading frame in segment 3 of influenza A virus. <i>J. Virol.<\/i> 86: 12411\u201312413.","DOI":"10.1128\/JVI.01677-12"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Smith, H. and Sweet, C. 1988. Lessons for human influenza from pathogenicity studies with ferrets. <i>Rev. Infect. Dis.<\/i> 10: 56\u201375.","DOI":"10.1093\/clinids\/10.1.56"},{"key":"27","unstructured":"27. WHO 2010. H1N1 in post-pandemic period. http:\/\/www.who.int\/mediacentre\/news\/statements\/2010\/h1n1_vpc_20100810\/en\/ [accessed 29, 2016]."},{"key":"28","unstructured":"28. WHO 2015. Surveillance and monitoring Influenza update. http:\/\/www.who.int\/influenza\/surveillance_monitoring\/updates\/latest_update_GIP_surveillance\/en\/ [accessed December 29, 2016]."},{"key":"29","unstructured":"29. Wright, P. F., Nerumanm, G. and Kawaoka, Y. 2007. Orthomyxoviruses. pp. 1691\u20131740. <i>In<\/i>: Fields Virology, 5th ed. (Knipe, D. M. and Howley, P. M. eds.), Lippincott Williams &amp; Wilkins, Philadelphia."},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Yewdell, J. W. and Ince, W. L. 2012. Virology. Frameshifting to PA-X influenza. <i>Science<\/i> 337: 164\u2013165.","DOI":"10.1126\/science.1225539"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Zhang, Y., Zhang, Q., Gao, Y., He, X., Kong, H., Jiang, Y., Guan, Y., Xia, X., Shu, Y., Kawaoka, Y., Bu, Z. and Chen, H. 2012. Key molecular factors in hemagglutinin and PB2 contribute to efficient transmission of the 2009 H1N1 pandemic influenza virus. <i>J. Virol.<\/i> 86: 9666\u20139674.","DOI":"10.1128\/JVI.00958-12"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Zhao, Z., Yi, C., Zhao, L., Wang, S., Zhou, L., Hu, Y., Zou, W., Chen, H. and Jin, M. 2014. PB2-588I enhances 2009 H1N1 pandemic influenza virus virulence by increasing viral replication and exacerbating PB2 inhibition of beta interferon expression. <i>J. Virol.<\/i> 88: 2260\u20132267.","DOI":"10.1128\/JVI.03024-13"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Zhou, B., Li, Y., Halpin, R., Hine, E., Spiro, D. J. and Wentworth, D. E. 2011. PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza a viruses in mice. <i>J. Virol.<\/i> 85: 357\u2013365.","DOI":"10.1128\/JVI.01694-10"},{"key":"34","unstructured":"34. Zhou, B., Pearce, M. B., Li, Y., Wang, J., Mason, R. J., Tumpey, T. M. and Wentworth, D. E. 2013. 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