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Agelink, M. W., Ullrich, H. and Brockmeyer, N. H. 2001. Sildenafil does not influence autonomic neurocardiac control assessed by standard measurements of heart rate variability. <i>Circulation<\/i> 104: E145.","DOI":"10.1161\/circ.104.24.e145"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Atkins, C., Bonagura, J., Ettinger, S., Fox, P., Gordon, S., Haggstrom, J., Hamlin, R., Keene, B., Luis-Fuentes, V. and Stepien, R. 2009. Guidelines for the diagnosis and treatment of canine chronic valvular heart disease. <i>J. Vet. Intern. Med.<\/i> 23: 1142\u20131150.","DOI":"10.1111\/j.1939-1676.2009.0392.x"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Atkins, C. E. and H\u00e4ggstr\u00f6m, J. 2012. Pharmacologic management of myxomatous mitral valve disease in dogs. <i>J. Vet. Cardiol.<\/i> 14: 165\u2013184.","DOI":"10.1016\/j.jvc.2012.02.002"},{"key":"4","unstructured":"4. Atkins, C. E., Keene, B. W., Brown, W. A., Coats, J. R., Crawford, M. A., DeFrancesco, T. 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Chompoosan, C., Buranakarl, C., Chaiyabutr, N. and Chansaisakorn, W. 2014. Decreased sympathetic tone after short-term treatment with enalapril in dogs with mild chronic mitral valve disease. <i>Res. Vet. Sci.<\/i> 96: 347\u2013354.","DOI":"10.1016\/j.rvsc.2014.01.006"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Dai, W. and Kloner, R. A. 2012. Is inhibition of phosphodiesterase type 5 by sildenafil a promising therapy for volume-overload heart failure? <i>Circulation<\/i> 125: 1341\u20131343.","DOI":"10.1161\/CIRCULATIONAHA.112.094912"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. De Mello, W. C. and Frohlich, E. D. 2014. Clinical perspectives and fundamental aspects of local cardiovascular and renal Renin-Angiotensin systems. <i>Front. Endocrinol. (Lausanne)<\/i> 5: 16.","DOI":"10.3389\/fendo.2014.00016"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Desjardins, V. A., Enriquez-Sarano, M., Tajik, A. J., Bailey, K. R. and Seward, J. B. 1996. Intensity of murmurs correlates with severity of valvular regurgitation. <i>Am. J. Med.<\/i> 100: 149\u2013156.","DOI":"10.1016\/S0002-9343(97)89452-1"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Fujii, Y. and Wakao, Y. 2003. Spectral analysis of heart rate variability in dogs with mild mitral regurgitation. <i>Am. J. Vet. Res.<\/i> 64: 145\u2013148.","DOI":"10.2460\/ajvr.2003.64.145"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. H\u00e4ggstr\u00f6m, J., H\u00f6glund, K. and Borgarelli, M. 2009. An update on treatment and prognostic indicators in canine myxomatous mitral valve disease. <i>J. Small Anim. Pract.<\/i> 50 Suppl 1: 25\u201333.","DOI":"10.1111\/j.1748-5827.2009.00800.x"},{"key":"16","doi-asserted-by":"crossref","unstructured":"17. Kellum, H. B. and Stepien, R. L. 2007. Sildenafil citrate therapy in 22 dogs with pulmonary hypertension. <i>J. Vet. Intern. 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Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice. <i>Am. J. Physiol. Heart Circ. Physiol.<\/i> 294: H1398\u2013H1406.","DOI":"10.1152\/ajpheart.ajpheart.91438.2007"},{"key":"25","doi-asserted-by":"crossref","unstructured":"26. Sandercock, G. R. and Brodie, D. A. 2006. The role of heart rate variability in prognosis for different modes of death in chronic heart failure. <i>Pacing Clin. Electrophysiol.<\/i> 29: 892\u2013904.","DOI":"10.1111\/j.1540-8159.2006.00457.x"},{"key":"26","doi-asserted-by":"crossref","unstructured":"27. Schwartz, B. G., Levine, L. A., Comstock, G., Stecher, V. J. and Kloner, R. A. 2012. Cardiac uses of phosphodiesterase-5 inhibitors. <i>J. Am. Coll. Cardiol.<\/i> 59: 9\u201315.","DOI":"10.1016\/j.jacc.2011.07.051"},{"key":"27","doi-asserted-by":"crossref","unstructured":"28. Siepmann, M., Rauh, R., Dill, O., Agelink, M. W. and Mueck-Weymann, M. 2007. The effects of sildenafil on heart rate variability in healthy subjects. <i>J. Cardiovasc. Pharmacol.<\/i> 50: 598\u2013600.","DOI":"10.1097\/FJC.0b013e318148b23d"},{"key":"28","doi-asserted-by":"crossref","unstructured":"29. Takimoto, E., Champion, H. C., Li, M., Belardi, D., Ren, S., Rodriguez, E. R., Bedja, D., Gabrielson, K. L., Wang, Y. and Kass, D. A. 2005. Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. <i>Nat. Med.<\/i> 11: 214\u2013222.","DOI":"10.1038\/nm1175"},{"key":"29","unstructured":"30. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. 1996. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. <i>Eur. Heart J.<\/i> 17: 354\u2013381."},{"key":"30","doi-asserted-by":"crossref","unstructured":"31. Vanderlei, L. C., Pastre, C. M., Hoshi, R. A., Carvalho, T. D. and Godoy, M. F. 2009. Basic notions of heart rate variability and its clinical applicability. <i>Rev. Bras. Cir. Cardiovasc.<\/i> 24: 205\u2013217.","DOI":"10.1590\/S0102-76382009000200018"},{"key":"31","doi-asserted-by":"crossref","unstructured":"32. Wallis, R. M. 1999. The pharmacology of sildenafil, a novel and selective inhibitor of phosphodiesterase (PDE) type 5. <i>Nippon Yakurigaku Zasshi<\/i> 114 Suppl 1: 22P\u201326P.","DOI":"10.1254\/fpj.114.supplement_22"},{"key":"32","doi-asserted-by":"crossref","unstructured":"33. Ware, W. A., Lund, D. D., Subieta, A. R. and Schmid, P. G. 1990. Sympathetic activation in dogs with congestive heart failure caused by chronic mitral valve disease and dilated cardiomyopathy. <i>J. Am. Vet. Med. 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