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Angel, I., Bidet, S. and Langer, S. Z. 1988. Pharmacological characterization of the hyperglycemia induced by alpha-2 adrenoceptor agonists. <i>J. Pharmacol. Exp. Ther.<\/i> 246: 1098\u20131103.","DOI":"10.1016\/S0022-3565(25)22195-4"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Bhathena, J., Kulamarva, A., Martoni, C., Urbanska, A. M., Malhotra, M., Paul, A. and Prakash, S. 2011. Diet-induced metabolic hamster model of nonalcoholic fatty liver disease. <i>Diabetes Metab. Syndr. Obes.<\/i> 4: 195\u2013203.","DOI":"10.2147\/DMSO.S18435"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Dillard, A., Matthan, N. R. and Lichtenstein, A. H. 2010. Use of hamster as a model to study diet-induced atherosclerosis. <i>Nutr. Metab. (Lond.)<\/i> 7: 89.","DOI":"10.1186\/1743-7075-7-89"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Fan, Z., Li, W., Lee, S. R., Meng, Q., Shi, B., Bunch, T. D., White, K. L., Kong, I. K. and Wang, Z. 2014. Efficient gene targeting in golden Syrian hamsters by the CRISPR\/Cas9 system. <i>PLoS One<\/i> 9: e109755.","DOI":"10.1371\/journal.pone.0109755"},{"key":"5","unstructured":"5. Flecknell, P. A. 2009. Anesthesia, pp. 65\u201366. <i>In<\/i>: Laboratory Animal Anaesthesia, 3rd ed., Elsevier Science &amp; Technology, Oxford."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Flecknell, P. A. 2009. Anesthesia of common laboratory species: special consideration, pp. 194\u2013195. <i>In<\/i>: Laboratory Animal Anaesthesia, 3rd ed., Elsevier Science &amp; Technology, Oxford.","DOI":"10.1016\/B978-0-12-369376-1.00006-X"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Gao, M., Zhang, B., Liu, J., Guo, X., Li, H., Wang, T., Zhang, Z., Liao, J., Cong, N., Wang, Y., Yu, L., Zhao, D. and Liu, G. 2014. Generation of transgenic golden Syrian hamsters. <i>Cell Res.<\/i> 24: 380\u2013382.","DOI":"10.1038\/cr.2014.2"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Gimenez-Conti, I. B. and Slaga, T. J. 1993. The hamster cheek pouch carcinogenesis model. <i>J. Cell. Biochem. Suppl.<\/i> 17F: 83\u201390.","DOI":"10.1002\/jcb.240531012"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Gomes-Silva, A., Valverde, J. G., Ribeiro-Rom\u00e3o, R. P., Pl\u00e1cido-Pereira, R. M. and Da-Cruz, A. M. 2013. Golden hamster (<i>Mesocricetus auratus<\/i>) as an experimental model for Leishmania (<i>Viannia<\/i>) braziliensis infection. <i>Parasitology<\/i> 140: 771\u2013779.","DOI":"10.1017\/S0031182012002156"},{"key":"10","unstructured":"10. ISO 10993-10:2010, Biological evaluation of medical devices\u2212Part 10: Tests for irritation and skin sensitization."},{"key":"11","unstructured":"11. Ito, H. 1977. Absorption and fate. pp. 17\u201318. <i>In<\/i>: Pharmacology, 5th ed. (Japanese), Eikodo Co., Ltd., Tokyo."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Kawai, S., Takagi, Y., Kaneko, S. and Kurosawa, T. 2011. Effect of three types of mixed anesthetic agents alternate to ketamine in mice. <i>Exp. Anim.<\/i> 60: 481\u2013487.","DOI":"10.1538\/expanim.60.481"},{"key":"13","unstructured":"13. Kirihara, Y., Takechi, M., Kurosaki, K., Kobayashi, Y. and Kurosawa, T. 2013. Anesthetic effects of a mixture of medetomidine, midazolam and butorphanol in two strains of mice. <i>Exp. Anim.<\/i> 62: 173\u2013180."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Kirihara, Y., Takechi, M., Kurosaki, K., Kobayashi, Y., Saito, Y. and Takeuchi, T. 2015. Anesthetic effects of a three-drugs mixture--comparison of administrative routes and antagonistic effects of atipamezole in mice. <i>Exp. Anim.<\/i> 64: 39\u201347.","DOI":"10.1538\/expanim.14-0039"},{"key":"15","unstructured":"15. Kirihara, Y., Takechi, M., Kurosaki, K., Kobayashi, Y., Saito, Y. and Takeuchi, T. 2016. Effects of an anesthetic mixture of medetomidine, midazolam, and butorphanol in rats-strain difference and antagonism by atipamezole. <i>Exp. Anim.<\/i> 65: 27\u201336."},{"key":"16","unstructured":"16. Maxwell, K. O., Wish, C., Murphy, J. C. and Fox, J. G. 1985. Serum chemistry reference values in two strains of Syrian hamsters. <i>Lab. Anim. Sci.<\/i> 35: 67\u201370."},{"key":"17","unstructured":"17. Nakamura, T., Ichii, O., Irie, T., Hosotani, M., Dantsuka, A., Nakamura, S., Sato, S., Sotozaki, K., Kouguchi, H., Yoshiyasu, T., Nagasaki, K. and Kon, Y. 2016. Usefulness of an anesthetic mixture of medetomidine, midazolam, and butorphanol in cotton rats (<i>Sigmodon hispidus<\/i>). <i>Jpn. J. Vet. Res.<\/i> 64: 273\u2013276."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Ochiai, Y., Iwano, H., Sakamoto, T., Hirabayashi, M., Kaneko, E., Watanabe, T., Yamashita, K. and Yokota, H. 2016. Blood biochemical changes in mice after administration of a mixture of three anesthetic agents. <i>J. Vet. Med. Sci.<\/i> 78: 951\u2013956.","DOI":"10.1292\/jvms.15-0474"},{"key":"19","unstructured":"19. Pour, P. M. 2016. Why the hamster pancreatic cancer model is still the most useful tool for clinical studies? <i>J. Pancreas<\/i> 17: 565\u2013569."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Saha, J. K., Xia, J., Grondin, J. M., Engle, S. K. and Jakubowski, J. A. 2005. Acute hyperglycemia induced by ketamine\/xylazine anesthesia in rats: mechanisms and implications for preclinical models. <i>Exp. Biol. Med. (Maywood)<\/i> 230: 777\u2013784.","DOI":"10.1177\/153537020523001012"},{"key":"21","unstructured":"21. Tsubokura, Y., Kobayashi, T., Oshima, Y., Hashizume, N., Nakai, M., Ajimi, S. and Imatanaka, N. 2016. Effects of pentobarbital, isoflurane, or medetomidine-midazolam-butorphanol anesthesia on bronchoalveolar lavage fluid and blood chemistry in rats. <i>J. 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