{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:30:13Z","timestamp":1770748213658,"version":"3.49.0"},"reference-count":34,"publisher":"Japanese Society of Veterinary Science","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Veterinary Medical Science","J. Vet. Med. Sci."],"published-print":{"date-parts":[[2018]]},"DOI":"10.1292\/jvms.17-0525","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T22:10:25Z","timestamp":1517523025000},"page":"453-459","source":"Crossref","is-referenced-by-count":6,"title":["The effect of sedation with a combination of butorphanol and midazolam on quantitative contrast-enhanced ultrasonography of duodenum in healthy dogs"],"prefix":"10.1292","volume":"80","author":[{"given":"Khoirun","family":"NISA","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue Yee","family":"LIM","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan"},{"name":"Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuyuki","family":"OSUGA","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomu","family":"YOKOYAMA","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan"},{"name":"Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"TAMURA","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"NAGATA","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"SASAOKA","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angkhana","family":"DERMLIM","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rommaneeya","family":"LEELA-ARPORN","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"MORITA","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"SASAKI","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keitaro","family":"MORISHITA","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensuke","family":"NAKAMURA","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan"},{"name":"Organization for Promotion of Tenure Track, University of Miyazaki, Miyazaki 889-2192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"OHTA","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuyoshi","family":"TAKIGUCHI","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"122","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Allenspach, K., Wieland, B., Gr\u00f6ne, A. and Gaschen, F. 2007. Chronic enteropathies in dogs: evaluation of risk factors for negative outcome. <i>J. Vet. Intern. Med.<\/i> 21: 700\u2013708.","DOI":"10.1111\/j.1939-1676.2007.tb03011.x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Bland, J. M. and Altman, D. G. 1999. Measuring agreement in method comparison studies. <i>Stat. Methods Med. Res.<\/i> 8: 135\u2013160.","DOI":"10.1191\/096228099673819272"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Connolly, H. V., Maginniss, L. A. and Schumacker, P. T. 1997. Transit time heterogeneity in canine small intestine: significance for oxygen transport. <i>J. Clin. Invest.<\/i> 99: 228\u2013238.","DOI":"10.1172\/JCI119151"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Craven, M., Simpson, J. W., Ridyard, A. E. and Chandler, M. L. 2004. Canine inflammatory bowel disease: retrospective analysis of diagnosis and outcome in 80 cases (1995-2002). <i>J. Small Anim. Pract.<\/i> 45: 336\u2013342.","DOI":"10.1111\/j.1748-5827.2004.tb00245.x"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Dietrich, C. F., Averkiou, M. A., Correas, J. M., Lassau, N., Leen, E. and Piscaglia, F. 2012. An EFSUMB introduction into Dynamic Contrast-Enhanced Ultrasound (DCE-US) for quantification of tumour perfusion. <i>Ultraschall Med.<\/i> 33: 344\u2013351.","DOI":"10.1055\/s-0032-1313026"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Frank, J. D., Reimer, S. B., Kass, P. H. and Kiupel, M. 2007. Clinical outcomes of 30 cases (1997-2004) of canine gastrointestinal lymphoma. <i>J. Am. Anim. Hosp. Assoc.<\/i> 43: 313\u2013321.","DOI":"10.5326\/0430313"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Gelman, S., Reves, J. G. and Harris, D. 1983. Circulatory responses to midazolam anesthesia: emphasis on canine splanchnic circulation. <i>Anesth. Analg.<\/i> 62: 135\u2013139.","DOI":"10.1213\/00000539-198302000-00002"},{"key":"8","unstructured":"8. Girlich, C., Schacherer, D., Jung, E. M., Schreyer, A. and B\u00fcttner, R. 2012. Comparison between a clinical activity index (Harvey-Bradshaw-Index), laboratory inflammation markers and quantitative assessment of bowel wall vascularization by contrast-enhanced ultrasound in Crohn\u2019s disease. <i>Eur. J. Radiol.<\/i> 81: 1105\u20131109."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Granger, D. N., Richardson, P. D. I., Kvietys, P. R. and Mortillaro, N. A. 1980. Intestinal blood flow. <i>Gastroenterology<\/i> 78: 837\u2013863.","DOI":"10.1016\/0016-5085(80)90692-7"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Jim\u00e9nez, D. A., O\u2019Brien, R. T., Wallace, J. D. and Klocke, E. 2011. Intraoperative contrast-enhanced ultrasonography of normal canine jejunum. <i>Vet. Radiol. Ultrasound<\/i> 52: 196\u2013200.","DOI":"10.1111\/j.1740-8261.2010.01767.x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Johnson-Neitman, J. L., O\u2019Brien, R. T. and Wallace, J. D. 2012. Quantitative perfusion analysis of the pancreas and duodenum in healthy dogs by use of contrast-enhanced ultrasonography. <i>Am. J. Vet. Res.<\/i> 73: 385\u2013392.","DOI":"10.2460\/ajvr.73.3.385"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Jones, D. J., Stehling, L. C. and Zauder, H. L. 1979. Cardiovascular responses to diazepam and midazolam maleate in the dog. <i>Anesthesiology<\/i> 51: 430\u2013434.","DOI":"10.1097\/00000542-197911000-00012"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Kobayashi, Y., Muldoon, S. M., Kiyose, M., Hagiwara, T., Kumasaka, S. and Okabe, E. 1998. Inhibition by midazolam of the adrenergic function in the isolated canine mesenteric vein. <i>Acta Anaesthesiol. Scand.<\/i> 42: 1157\u20131163.","DOI":"10.1111\/j.1399-6576.1998.tb05269.x"},{"key":"14","unstructured":"14. Kojima, K., Nishimura, R., Mutoh, T., Takao, K., Matsunaga, S., Mochizuki, M. and Sasaki, N. 1999. Comparison of cardiopulmonary effects of medetomidine-midazolam, acepromazine-butorphanol and midazolam-butorphanol in dogs. <i>Zentralbl. Veterinarmed. A<\/i> 46: 353\u2013359."},{"key":"15","unstructured":"15. Kojima, K., Nishimura, R., Mutoh, T., Takao, K., Matsunaga, S., Mochizuki, M. and Sasaki, N. 1999. Comparison of sedative effects of medetomidine-midazolam, acepromazine-butorphanol and midazolam-butorphanol in dogs. <i>Zentralbl. Veterinarmed. A<\/i> 46: 141\u2013148."},{"key":"16","unstructured":"16. Lamont, L. A. and Mathews, K. A. 2007. Opioid, nonsteroidal anti-inflammatories, and analgesic adjuvants. pp. 241\u2013271. <i>In<\/i>: Lumb&amp;Jones Veterinary Anesthesia and Analgesia, 4th ed. (Tranquilli, W. J., Thurmon, J. C. and Grimm, K. A. eds.), Blackwell, Oxford."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Lawrence, C. J., Prinzen, F. W. and de Lange, S. 1996. The effect of dexmedetomidine on nutrient organ blood flow. <i>Anesth. Analg.<\/i> 83: 1160\u20131165.","DOI":"10.1097\/00000539-199612000-00005"},{"key":"18","unstructured":"18. Lemke, K. A. 2007. Anticholinergic and sedatives. pp. 203\u2013239. <i>In<\/i>: Lumb&amp;Jones Veterinary Anesthesia and Analgesia, 4th ed. (Tranquilli, W. J., Thurmon, J. C. and Grimm, K. A. eds.), Blackwell, Oxford."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Lim, S. Y., Nakamura, K., Morishita, K., Sasaki, N., Murakami, M., Osuga, T., Ohta, H., Yamasaki, M. and Takiguchi, M. 2013. Qualitative and quantitative contrast enhanced ultrasonography of the pancreas using bolus injection and continuous infusion methods in normal dogs. <i>J. Vet. Med. Sci.<\/i> 75: 1601\u20131607.","DOI":"10.1292\/jvms.13-0199"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Medellin-Kowalewski, A., Wilkens, R., Wilson, A., Ruan, J. and Wilson, S. R. 2016. Quantitative contrast-enhanced ultrasound parameters in Crohn disease: their role in disease activity determination with ultrasound. <i>AJR Am. J. Roentgenol.<\/i> 206: 64\u201373.","DOI":"10.2214\/AJR.15.14506"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Nakamura, K., Sasaki, N., Yoshikawa, M., Ohta, H., Hwang, S. J., Mimura, T., Yamasaki, M. and Takiguchi, M. 2009. Quantitative contrast-enhanced ultrasonography of canine spleen. <i>Vet. Radiol. Ultrasound<\/i> 50: 104\u2013108.","DOI":"10.1111\/j.1740-8261.2008.01499.x"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Nisa, K., Lim, S. Y., Shinohara, M., Nagata, N., Sasaoka, K., Dermlim, A., Leela-Arporn, R., Morita, T., Yokoyama, N., Osuga, T., Sasaki, N., Morishita, K., Nakamura, K., Ohta, H. and Takiguchi, M. 2017. Repeatability and reproducibility of quantitative contrast-enhanced ultrasonography for assessing duodenal perfusion in healthy dogs. <i>J. Vet. Med. Sci.<\/i> 79: 1585\u20131590.","DOI":"10.1292\/jvms.17-0174"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Novellas, R., Ruiz de Gopegui, R. and Espada, Y. 2007. Effects of sedation with midazolam and butorphanol on resistive and pulsatility indices in healthy dogs. <i>Vet. Radiol. Ultrasound<\/i> 48: 276\u2013280.","DOI":"10.1111\/j.1740-8261.2007.00242.x"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Nylund, K., Jirik, R., Mezl, M., Leh, S., Hausken, T., Pfeffer, F., \u00d8degaard, S., Taxt, T. and Gilja, O. H. 2013. Quantitative contrast-enhanced ultrasound comparison between inflammatory and fibrotic lesions in patients with Crohn\u2019s disease. <i>Ultrasound Med. Biol.<\/i> 39: 1197\u20131206.","DOI":"10.1016\/j.ultrasmedbio.2013.01.020"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Quaia, E., Sozzi, M., Angileri, R., Gennari, A. G. and Cova, M. A. 2016. Time-intensity curves obtained after microbubble injection can be used to differentiate responders from nonresponders among patients with clinically active Crohn disease after 6 weeks of pharmacologic treatment. <i>Radiology<\/i> 281: 606\u2013616.","DOI":"10.1148\/radiol.2016152461"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Quaia, E., De Paoli, L., Stocca, T., Cabibbo, B., Casagrande, F. and Cova, M. A. 2012. The value of small bowel wall contrast enhancement after sulfur hexafluoride-filled microbubble injection to differentiate inflammatory from fibrotic strictures in patients with Crohn\u2019s disease. <i>Ultrasound Med. Biol.<\/i> 38: 1324\u20131332.","DOI":"10.1016\/j.ultrasmedbio.2012.04.008"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Restitutti, F., Laitinen, M. R., Raekallio, M. R., Vainionp\u00e4\u00e4, M., O\u2019Brien, R. T., Kuusela, E. and Vainio, O. M. 2013. Effect of MK-467 on organ blood flow parameters detected by contrast-enhanced ultrasound in dogs treated with dexmedetomidine. <i>Vet. Anaesth. Analg.<\/i> 40: e48\u2013e56.","DOI":"10.1111\/vaa.12058"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Rossi, F., Fina, C., Stock, E., Vanderperren, K., Duchateau, L. and Saunders, J. H. 2016. Effect of sedation on contrast-enhanced ultrasonography of the spleen in healthy dogs. <i>Vet. Radiol. Ultrasound<\/i> 57: 276\u2013281.","DOI":"10.1111\/vru.12338"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Shepherd, A. P. and Riedel, G. L. 1988. Intramural distribution of intestinal blood flow during sympathetic stimulation. <i>Am. J. Physiol.<\/i> 255: H1091\u2013H1095.","DOI":"10.1152\/ajpheart.1988.255.5.H1091"},{"key":"30","unstructured":"30. Stick, J. A., Loeffler, B. S., Arden, W. A. and Chou, C. C. 1989. Effects of butorphanol tartrate on arterial pressure, jejunal blood flow, vascular resistance, O2 extraction, and O2 uptake in halothane-anesthetized ponies. <i>Am. J. Vet. Res.<\/i> 50: 1202\u20131206."},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Stock, E., Vanderperren, K., Van der Vekens, E., Haers, H., Duchateau, L., Polis, I., Hesta, M. and Saunders, J. H. 2014. The effect of anesthesia with propofol and sedation with butorphanol on quantitative contrast-enhanced ultrasonography of the healthy feline kidney. <i>Vet. J.<\/i> 202: 637\u2013639.","DOI":"10.1016\/j.tvjl.2014.10.008"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Tang, M. X., Mulvana, H., Gauthier, T., Lim, A. K. P., Cosgrove, D. O., Eckersley, R. J. and Stride, E. 2011. Quantitative contrast-enhanced ultrasound imaging: a review of sources of variability. <i>Interface Focus<\/i> 1: 520\u2013539.","DOI":"10.1098\/rsfs.2011.0026"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Waller, K. R., O\u2019Brien, R. T. and Zagzebski, J. A. 2007. Quantitative contrast ultrasound analysis of renal perfusion in normal dogs. <i>Vet. Radiol. Ultrasound<\/i> 48: 373\u2013377.","DOI":"10.1111\/j.1740-8261.2007.00259.x"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Ziegler, L. E., O\u2019Brien, R. T., Waller, K. R. and Zagzebski, J. A. 2003. Quantitative contrast harmonic ultrasound imaging of normal canine liver. <i>Vet. Radiol. Ultrasound<\/i> 44: 451\u2013454.","DOI":"10.1111\/j.1740-8261.2003.tb00484.x"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/80\/3\/80_17-0525\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T04:49:53Z","timestamp":1570682993000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/80\/3\/80_17-0525\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.17-0525","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}