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Anning, P. B., Grocott-Mason, R. M. and Lewis, M. J. 1997. Effects of sulphydryl- and non-sulphydryl-containing ACE inhibitors on left ventricular relaxation in the isolated guinea pig heart. <i>Endothelium<\/i> 5: 265\u2013275.","DOI":"10.3109\/10623329709052591"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Asano, K., Masuda, K., Okumura, M., Kadosawa, T. and Fujinaga, T. 1999. Plasma atrial and brain natriuretic peptide levels in dogs with congestive heart failure. <i>J. Vet. Med. Sci.<\/i> 61: 523\u2013529.","DOI":"10.1292\/jvms.61.523"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Atkins, C., Bonagura, J., Ettinger, S., Fox, P., Gordon, S., Haggstrom, J., Hamlin, R., Keene, B., Luis-Fuentes, V. and Stepien, R. 2009. Guidelines for the diagnosis and treatment of canine chronic valvular heart disease. <i>J. Vet. Intern. Med.<\/i> 23: 1142\u20131150.","DOI":"10.1111\/j.1939-1676.2009.0392.x"},{"key":"4","unstructured":"4. Atkins, C. E., Keene, B. 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A., Chiavegato, D., Poggi, M., Bellino, C., La Rosa, G., Zanatta, R., Haggstrom, J. and Tarducci, A. 2008. Survival characteristics and prognostic variables of dogs with mitral regurgitation attributable to myxomatous valve disease. <i>J. Vet. Intern. Med.<\/i> 22: 120\u2013128.","DOI":"10.1111\/j.1939-1676.2007.0008.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Boswood, A., H\u00e4ggstr\u00f6m, J., Gordon, S. G., Wess, G., Stepien, R. L., Oyama, M. A., Keene, B. W., Bonagura, J., MacDonald, K. A., Patteson, M., Smith, S., Fox, P. R., Sanderson, K., Woolley, R., Szatm\u00e1ri, V., Menaut, P., Church, W. M., O\u2019Sullivan, M. L., Jaudon, J. P., Kresken, J. G., Rush, J., Barrett, K. A., Rosenthal, S. L., Saunders, A. B., Ljungvall, I., Deinert, M., Bomassi, E., Estrada, A. H., Fernandez Del Palacio, M. J., Moise, N. S., Abbott, J. A., Fujii, Y., Spier, A., Luethy, M. W., Santilli, R. A., Uechi, M., Tidholm, A. and Watson, P. 2016. Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study-A Randomized Clinical Trial. <i>J. Vet. Intern. Med.<\/i> 30: 1765\u20131779.","DOI":"10.1111\/jvim.14586"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Buchanan, J. W. and B\u00fccheler, J. 1995. Vertebral scale system to measure canine heart size in radiographs. <i>J. Am. Vet. Med. Assoc.<\/i> 206: 194\u2013199.","DOI":"10.2460\/javma.1995.206.02.194"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Chetboul, V., Serres, F., Tissier, R., Lefebvre, H. P., Sampedrano, C. C., Gouni, V., Poujol, L., Hawa, G. and Pouchelon, J. L. 2009. Association of plasma N-terminal pro-B-type natriuretic peptide concentration with mitral regurgitation severity and outcome in dogs with asymptomatic degenerative mitral valve disease. <i>J. Vet. Intern. Med.<\/i> 23: 984\u2013994.","DOI":"10.1111\/j.1939-1676.2009.0347.x"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Ettinger, S. J., Benitz, A. M., Ericsson, G. F., Cifelli, S., Jernigan, A. D., Longhofer, S. L., Trimboli, W., Hanson, P. D., The Long-Term Investigation of Veterinary Enalapril (LIVE) Study Group. 1998. Effects of enalapril maleate on survival of dogs with naturally acquired heart failure. <i>J. Am. Vet. Med. Assoc.<\/i> 213: 1573\u20131577.","DOI":"10.2460\/javma.1998.213.11.1573"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Funabiki, K., Onishi, K., Dohi, K., Koji, T., Imanaka-Yoshida, K., Ito, M., Wada, H., Isaka, N., Nobori, T. and Nakano, T. 2004. Combined angiotensin receptor blocker and ACE inhibitor on myocardial fibrosis and left ventricular stiffness in dogs with heart failure. <i>Am. J. Physiol. Heart Circ. 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Acute and short-term hemodynamic, echocardiographic, and clinical effects of enalapril maleate in dogs with naturally acquired heart failure: results of the Invasive Multicenter PROspective Veterinary Evaluation of Enalapril study. <i>J. Vet. Intern. Med.<\/i> 9: 234\u2013242."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Guglielmini, C., Diana, A., Pietra, M., Di Tommaso, M. and Cipone, M. 2009. Use of the vertebral heart score in coughing dogs with chronic degenerative mitral valve disease. <i>J. Vet. Med. Sci.<\/i> 71: 9\u201313.","DOI":"10.1292\/jvms.71.9"},{"key":"17","unstructured":"17. Hamlin, R. L. 1968. Analysis of the cardiac silhouette in dorsoventral radiographs from dogs with heart disease. <i>J. Am. Vet. Med. Assoc.<\/i> 153: 1446\u20131460."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Hori, Y., Tsubaki, M., Katou, A., Ono, Y., Yonezawa, T., Li, X. and Higuchi, S. I. 2008. Evaluation of NT-pro BNP and CT-ANP as markers of concentric hypertrophy in dogs with a model of compensated aortic stenosis. <i>J. Vet. Intern. Med.<\/i> 22: 1118\u20131123.","DOI":"10.1111\/j.1939-1676.2008.0161.x"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Hori, Y., Sano, N., Kanai, K., Hoshi, F., Itoh, N. and Higuchi, S. 2010. Acute cardiac volume load-related changes in plasma atrial natriuretic peptide and N-terminal pro-B-type natriuretic peptide concentrations in healthy dogs. <i>Vet. J.<\/i> 185: 317\u2013321.","DOI":"10.1016\/j.tvjl.2009.06.008"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. InvestigatorsSOLVD, Yusuf, S., Pitt, B., Davis, C. E., Hood, W. B. Jr., Cohn, J. N. 1992. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. <i>N. Engl. J. Med.<\/i> 327: 685\u2013691.","DOI":"10.1056\/NEJM199209033271003"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Ishikawa, T., Tanaka, R., Suzuki, S., Miyaishi, Y., Akagi, H., Iino, Y., Fukushima, R. and Yamane, Y. 2010. The effect of angiotensin-converting enzyme inhibitors of left atrial pressure in dogs with mitral valve regurgitation. <i>J. Vet. Intern. Med.<\/i> 24: 342\u2013347.","DOI":"10.1111\/j.1939-1676.2009.0455.x"},{"key":"22","unstructured":"22. Kinugawa, T., Kato, M., Mori, M., Endo, A., Kato, T., Hamada, T., Noguchi, N., Omodani, H., Osaki, S., Ogino, K., Miyakoda, H., Hisatome, I. and Shigemasa, C. 1998. Effects of a new angiotensin-converting enzyme inhibitor, alacepril, on changes in neurohormonal factors and arterial baroreflex sensitivity in patients with congestive heart failure. <i>Eur. J. Clin. Pharmacol.<\/i> 54: 209\u2013214."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Kinugawa, T., Osaki, S., Kato, M., Ogino, K., Shimoyama, M., Tomikura, Y., Igawa, O., Hisatome, I. and Shigemasa, C. 2002. Effects of the angiotensin-converting enzyme inhibitor alacepril on exercise capacity and neurohormonal factors in patients with mild-to-moderate heart failure. <i>Clin. Exp. Pharmacol. Physiol.<\/i> 29: 1060\u20131065.","DOI":"10.1046\/j.1440-1681.2002.03779.x"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Liu, Y. H., Liu, L. Y., Wu, J. X., Chen, S. X. and Sun, Y. X. 2006. Comparison of captopril and enalapril to study the role of the sulfhydryl-group in improvement of endothelial dysfunction with ACE inhibitors in high dieted methionine mice. <i>J. Cardiovasc. Pharmacol.<\/i> 47: 82\u201388.","DOI":"10.1097\/01.fjc.0000195306.61719.64"},{"key":"25","unstructured":"25. Matsumoto, K., Nambu, K., Fujii, T., Takeyama, K., Miyazaki, H. and Hashimoto, M. 1986. Metabolism of protein conjugate of desacetyl-alacepril and its effect on angiotensin converting enzyme in renal hypertensive rats. <i>Arzneimittelforschung<\/i> 36: 52\u201354."},{"key":"26","unstructured":"26. Minato, H., Hosoki, K., Hayashi, K., Sawayama, T., Kadokawa, T. and Hashimoto, M. 1989. Antihypertensive mechanism of alacepril. Effects of its metabolites on the peripheral sympathetic nervous system. <i>Arzneimittelforschung<\/i> 39: 319\u2013324."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Mira, M. L., Silva, M. M. and Manso, C. F. 1994. The scavenging of oxygen free radicals by angiotensin converting enzyme inhibitors: the importance of the sulfhydryl group in the chemical structure of the compounds. <i>Ann. N. Y. Acad. Sci.<\/i> 723: 439\u2013441.","DOI":"10.1111\/j.1749-6632.1994.tb36771.x"},{"key":"28","unstructured":"28. Miyazaki, M. and Takai, S. 1999. Antiatherosclerotic effect of alacepril, an angiotensin-converting enzyme inhibitor, in monkeys fed a high-cholesterol diet. <i>Hypertens. Res.<\/i> 22: 49\u201354."},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Moonarmart, W., Boswood, A., Luis Fuentes, V., Brodbelt, D., Souttar, K. and Elliott, J. 2010. N-terminal pro B-type natriuretic peptide and left ventricular diameter independently predict mortality in dogs with mitral valve disease. <i>J. Small Anim. Pract.<\/i> 51: 84\u201396.","DOI":"10.1111\/j.1748-5827.2009.00889.x"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Napoli, C., Bruzzese, G., Ignarro, L. J., Crimi, E., de Nigris, F., Williams-Ignarro, S., Libardi, S., Sommese, L., Fiorito, C., Mancini, F. P., Cacciatore, F. and Liguori, A. 2008. 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Activation of the renin-angiotensin system in dogs with asymptomatic and mildly symptomatic mitral valvular insufficiency. <i>J. Vet. Intern. Med.<\/i> 9: 328\u2013331.","DOI":"10.1111\/j.1939-1676.1995.tb01092.x"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Pouchelon, J. L., Jamet, N., Gouni, V., Tissier, R., Serres, F., Carlos Sampedrano, C., Castaignet, M., Lefebvre, H. P. and Chetboul, V. 2008. Effect of benazepril on survival and cardiac events in dogs with asymptomatic mitral valve disease: a retrospective study of 141 cases. <i>J. Vet. Intern. Med.<\/i> 22: 905\u2013914.","DOI":"10.1111\/j.1939-1676.2008.0105.x"},{"key":"34","unstructured":"34. Sakatani, A., Miyagawa, Y. and Takemura, N. 2016. Evaluation of the effect of an angiotensin-converting enzyme inhibitor, alacepril, on drug-induced renin-angiotensin-aldosterone system activation in normal dogs. <i>J. Vet. Cardiol.<\/i> 18: 248\u2013254."},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Saunders, A. B., Gordon, S. G., Boggess, M. M. and Miller, M. W. 2014. Long-term outcome in dogs with patent ductus arteriosus: 520 cases (1994\u20132009). <i>J. Vet. Intern. Med.<\/i> 28: 401\u2013410.","DOI":"10.1111\/jvim.12267"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Singh, M. K., Johnson, L. R., Kittleson, M. D. and Pollard, R. E. 2012. Bronchomalacia in dogs with myxomatous mitral valve degeneration. <i>J. Vet. Intern. Med.<\/i> 26: 312\u2013319.","DOI":"10.1111\/j.1939-1676.2012.00887.x"},{"key":"37","unstructured":"37. Smith, F. W. Jr., Tilley, L. P., Oyama, M. A. and Sleeper, M. M. 2016. History and physical examination. pp. 3\u201324. <i>In<\/i>: Manual of Canine and Feline Cardiology, 5th ed. (Grompf, R. E. ed.), Elsevire, St. Louis."},{"key":"38","unstructured":"38. Takeyama, K., Minato, H., Fukuya, F., Kawahara, S., Hosoki, K. and Kadokawa, T. 1985. Antihypertensive activity of alacepril in spontaneously hypertensive rats and deoxycorticosterone acetate-salt hypertensive rats and dogs. <i>Arzneimittelforschung<\/i> 35: 1507\u20131512."},{"key":"39","unstructured":"39. Takeyama, K., Minato, H., Fukuya, F., Kawahara, S., Hosoki, K. and Kadokawa, T. 1985. Antihypertensive activity of alacepril, an orally active angiotensin converting enzyme inhibitor, in renal hypertensive rats and dogs. <i>Arzneimittelforschung<\/i> 35: 1502\u20131507."},{"key":"40","unstructured":"40. Takeyama, K., Minato, H., Ikeno, A., Hosoki, K. and Kadokawa, T. 1986. Antihypertensive mechanism of alacepril: effect on norepinephrine-induced vasoconstrictive response in vitro and in vivo. <i>Arzneimittelforschung<\/i> 36: 74\u201377."},{"key":"41","unstructured":"41. Takeyama, K., Minato, H., Nakatsuji, K., Suzuki, H., Nose, I., Oka, M., Hosoki, K., Hatano, N. and Kadokawa, T. 1986. Effect of the novel orally active angiotensin converting enzyme inhibitor alacepril on cardiovascular system in experimental animals. <i>Arzneimittelforschung<\/i> 36: 69\u201373."},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Tyralla, K., Adamczak, M., Benz, K., Campean, V., Gross, M. L., Hilgers, K. F., Ritz, E. and Amann, K. 2011. High-dose enalapril treatment reverses myocardial fibrosis in experimental uremic cardiomyopathy. <i>PLoS One<\/i> 6: e15287.","DOI":"10.1371\/journal.pone.0015287"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Yoshikawa, T., Handa, S., Nagami, K., Suzuki, M., Wainai, Y., Minami, T., Suzuki, K. and Kitazawa, S. 1995. Effect of the angiotensin-converting enzyme inhibitor alacepril on ventricular function and beta-adrenoceptor number in rabbits with aortic regurgitation. <i>Jpn. 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