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Sci."],"published-print":{"date-parts":[[2018]]},"DOI":"10.1292\/jvms.18-0136","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T22:35:16Z","timestamp":1532990116000},"page":"1373-1379","source":"Crossref","is-referenced-by-count":1,"title":["Protective efficacy of a canine brucellosis vaccine candidate based on live attenuated &lt;i&gt;Salmonella&lt;\/i&gt; expressing recombinant &lt;i&gt;Brucella&lt;\/i&gt; BCSP31, Omp3b and SOD proteins in Beagles"],"prefix":"10.1292","volume":"80","author":[{"given":"Won Kyong","family":"KIM","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Chonbuk National University Special Campus, Iksan 54596, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ja Young","family":"MOON","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Chonbuk National University Special Campus, Iksan 54596, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Sang","family":"CHO","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Chonbuk National University Special Campus, Iksan 54596, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Yong","family":"PARK","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Chonbuk National University Special Campus, Iksan 54596, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"HUR","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Chonbuk National University Special Campus, Iksan 54596, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"122","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Adone, R., Francia, M., Pistoia, C., Petrucci, P., Pesciaroli, M. and Pasquali, P. 2012. Protective role of antibodies induced by <i>Brucella melitensis<\/i> B115 against <i>B. melitensis<\/i> and <i>Brucella abortus<\/i> infections in mice. <i>Vaccine<\/i> 30: 3992\u20133995.","DOI":"10.1016\/j.vaccine.2012.04.009"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Avila-Calder\u00f3n, E. D., Lopez-Merino, A., Sriranganathan, N., Boyle, S. M. and Contreras-Rodr\u00edguez, A. 2013. A history of the development of <i>Brucella<\/i> vaccines. <i>BioMed Res. Int.<\/i> 2013: 743509.","DOI":"10.1155\/2013\/743509"},{"key":"3","unstructured":"3. Baek, B. K., Lim, C. W., Rahman, M. S., Kim, C. H., Oluoch, A. and Kakoma, I. 2003. <i>Brucella abortus<\/i> infection in indigenous Korean dogs. <i>Can. J. Vet. Res.<\/i> 67: 312\u2013314."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Baldwin, C. L. and Goenka, R. 2006. Host immune responses to the intracellular bacteria <i>Brucella<\/i>: does the bacteria instruct the host to facilitate chronic infection? <i>Crit. Rev. Immunol.<\/i> 26: 407\u2013442.","DOI":"10.1615\/CritRevImmunol.v26.i5.30"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Barr, S. C., Eilts, B. E., Roy, A. F. and Miller, R. 1986. <i>Brucella suis<\/i> biotype 1 infection in a dog. <i>J. Am. Vet. Med. Assoc.<\/i> 189: 686\u2013687.","DOI":"10.2460\/javma.1986.189.06.686"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Bicknell, S. R., Bell, R. A. and Richards, P. A. 1976. <i>Brucella abortus<\/i> in the bitch. <i>Vet. Rec.<\/i> 99: 85\u201386.","DOI":"10.1136\/vr.99.5.85"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Bicknell, S. R. and Bell, R. A. 1979. <i>Brucella abortus<\/i> in the bitch: subclinical infection associated with urinary excretion. <i>J. Hyg. (Lond.)<\/i> 82: 249\u2013254.","DOI":"10.1017\/S0022172400025663"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Boeri, E. J., Wanke, M. M., Madariaga, M. J., Teijeiro, M. L., Elena, S. A. and Trangoni, M. D. 2018. Comparison of four polymerase chain reaction assays for the detection of <i>Brucella<\/i> spp. in clinical samples from dogs. <i>Vet. World<\/i> 11: 201\u2013208.","DOI":"10.14202\/vetworld.2018.201-208"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Bowden, R. A., Cloeckaert, A., Zygmunt, M. S., Bernard, S. and Dubray, G. 1995. Surface exposure of outer membrane protein and lipopolysaccharide epitopes in <i>Brucella<\/i> species studied by enzyme-linked immunosorbent assay and flow cytometry. <i>Infect. Immun.<\/i> 63: 3945\u20133952.","DOI":"10.1128\/IAI.63.10.3945-3952.1995"},{"key":"10","unstructured":"10. Bricker, B. J. and Halling, S. M. 1994. Differentiation of <i>Brucella abortus<\/i> bv. 1, 2, and 4, <i>Brucella melitensis, Brucella ovis<\/i>, and <i>Brucella suis<\/i> bv. 1 by PCR. <i>J. Clin. Microbiol.<\/i> 32: 2660\u20132666."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Bricker, B. J. and Halling, S. M. 1995. Enhancement of the Brucella AMOS PCR assay for differentiation of Brucella abortus vaccine strains S19 and RB51. <i>J. Clin. Microbiol.<\/i> 33: 1640\u20131642.","DOI":"10.1128\/JCM.33.6.1640-1642.1995"},{"key":"12","unstructured":"12. Brumme, S., Arnold, T., Sigmarsson, H., Lehmann, J., Scholz, H. C., Hardt, W. D., Hensel, A., Truyen, U. and Roesler, U. 2007. Impact of <i>Salmonella<\/i> Typhimurium DT104 virulence factors invC and sseD on the onset, clinical course, colonization patterns and immune response of porcine salmonellosis. <i>Vet. Microbiol.<\/i> 124: 274\u2013285."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Clegg, F. G. and Rorrison, J. M. 1968. Brucella abortus infection in the dog: a case of polyarthritis. <i>Res. Vet. Sci.<\/i> 9: 183\u2013185.","DOI":"10.1016\/S0034-5288(18)34581-8"},{"key":"14","unstructured":"14. Cloeckaert, A., Vizca\u00edno, N., Paquet, J. Y., Bowden, R. A. and Elzer, P. H. 2002. Major outer membrane proteins of <i>Brucella<\/i> spp.: past, present and future. <i>Vet. Microbiol.<\/i> 90: 229\u2013247."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Forbes, L. B. 1990. <i>Brucella abortus<\/i> infection in 14 farm dogs. <i>J. Am. Vet. Med. Assoc.<\/i> 196: 911\u2013916.","DOI":"10.2460\/javma.1990.196.06.911"},{"key":"16","unstructured":"16. Hur, J., Byeon, H. and Lee, J. H. 2014. Immunologic study and optimization of Salmonella delivery strains expressing adhesin and toxin antigens for protection against progressive atrophic rhinitis in a murine model. <i>Can. J. Vet. Res.<\/i> 78: 297\u2013303."},{"key":"17","unstructured":"17. Hur, J. and Lee, J. H. 2011. Immune responses to new vaccine candidates constructed by a live attenuated <i>Salmonella<\/i> Typhimurium delivery system expressing <i>Escherichia coli<\/i> F4, F5, F6, F41 and intimin adhesin antigens in a murine model. <i>J. Vet. Med. Sci.<\/i> 73: 1265\u20131273."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Hur, J. and Lee, J. H. 2010. Immunization of pregnant sows with a novel virulence gene deleted live Salmonella vaccine and protection of their suckling piglets against salmonellosis. <i>Vet. Microbiol.<\/i> 143: 270\u2013276.","DOI":"10.1016\/j.vetmic.2009.11.034"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Jiang, X. and Baldwin, C. L. 1993. Effects of cytokines on intracellular growth of <i>Brucella abortus<\/i>. <i>Infect. Immun.<\/i> 61: 124\u2013134.","DOI":"10.1128\/IAI.61.1.124-134.1993"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Kim, W. K., Moon, J. Y., Cho, J. S. and Hur, J. 2017. Protective efficacy by various doses of a new brucellosis vaccine candidate based on <i>Salmonella<\/i> strains expressing <i>Brucella abortus<\/i> BSCP31, Omp3b and superoxide dismutase against brucellosis in murine model. <i>Pathog. Dis.<\/i> 75: ftx094.","DOI":"10.1093\/femspd\/ftx094"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Kim, W. K., Moon, J. Y., Kim, S. and Hur, J. 2016. Comparison between immunization routes of live attenuated <i>Salmonella<\/i> Typhimurium strain expressing BCSP31, Omp3b, and SOD of <i>Brucella abortus<\/i> in murine model. <i>Front. Microbiol.<\/i> 7: 550.","DOI":"10.3389\/fmicb.2016.00550"},{"key":"22","unstructured":"22. Kimberling, C. V., Luchsinger, D. W. and Anderson, R. K. 1966. Three cases of canine brucellosis. <i>J. Am. Vet. Med. Assoc.<\/i> 148: 900\u2013901."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Lee, J. J., Lim, J. J., Kim, D. G., Simborio, H. L., Kim, D. H., Reyes, A. W., Min, W., Lee, H. J., Kim, D. H., Chang, H. H. and Kim, S. 2014. Characterization of culture supernatant proteins from <i>Brucella abortus<\/i> and its protection effects against murine brucellosis. <i>Comp. Immunol. Microbiol. Infect. Dis.<\/i> 37: 221\u2013228.","DOI":"10.1016\/j.cimid.2014.06.001"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Manterola, L., Guzm\u00e1n-Verri, C., Chaves-Olarte, E., Barquero-Calvo, E., de Miguel, M. J., Moriy\u00f3n, I., Grill\u00f3, M. J., L\u00f3pez-Go\u00f1i, I. and Moreno, E. 2007. BvrR\/BvrS-controlled outer membrane proteins Omp3a and Omp3b are not essential for <i>Brucella abortus<\/i> virulence. <i>Infect. Immun.<\/i> 75: 4867\u20134874.","DOI":"10.1128\/IAI.00439-07"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Mastroeni, P., Chabalgoity, J. A., Dunstan, S. J., Maskell, D. J. and Dougan, G. 2001. <i>Salmonella<\/i>: immune responses and vaccines. <i>Vet. J.<\/i> 161: 132\u2013164.","DOI":"10.1053\/tvjl.2000.0502"},{"key":"26","unstructured":"26. Morse, E. V., Ristic, M., Witt, L. E. and Wipf, L. 1953. Canine abortion apparently due to <i>brucella abortus<\/i>. <i>J. Am. Vet. Med. Assoc.<\/i> 122: 18\u201320."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Oliveira, S. C. and Splitter, G. A. 1995. CD8<sup>+<\/sup> type 1 CD44<sup>hi<\/sup> CD45 RB<sup>lo<\/sup> T lymphocytes control intracellular <i>Brucella abortus<\/i> infection as demonstrated in major histocompatibility complex class I- and class II-deficient mice. <i>Eur. J. Immunol.<\/i> 25: 2551\u20132557.","DOI":"10.1002\/eji.1830250922"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Olsen, S. C. 2013. Recent developments in livestock and wildlife brucellosis vaccination. <i>Rev. - Off. Int. Epizoot.<\/i> 32: 207\u2013217.","DOI":"10.20506\/rst.32.1.2201"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Palmer, M. V. and Cheville, N. F. 1997. Effects of oral or intravenous inoculation with <i>Brucella abortus<\/i> strain RB51 vaccine in beagles. <i>Am. J. Vet. Res.<\/i> 58: 851\u2013856.","DOI":"10.2460\/ajvr.1997.58.08.851"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Pedersen, K., Quance, C. R., Robbe-Austerman, S., Piaggio, A. J., Bevins, S. N., Goldstein, S. M., Gaston, W. D. and DeLiberto, T. J. 2014. Identification of Brucella suis from feral swine in selected states in the USA. <i>J. Wildl. Dis.<\/i> 50: 171\u2013179.","DOI":"10.7589\/2013-09-235"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Roesler, U., Heller, P., Waldmann, K. H., Truyen, U. and Hensel, A. 2006. Immunization of sows in an integrated pig-breeding herd using a homologous inactivated Salmonella vaccine decreases the prevalence of Salmonella typhimurium infection in the offspring. <i>J. Vet. Med. B Infect. Dis. Vet. 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DNA polymorphism in the omp25\/omp31 family of <i>Brucella<\/i> spp.: identification of a 1.7-kb inversion in <i>Brucella cetaceae<\/i> and of a 15.1-kb genomic island, absent from <i>Brucella ovis<\/i>, related to the synthesis of smooth lipopolysaccharide. <i>Microbes Infect.<\/i> 6: 821\u2013834."},{"key":"39","unstructured":"39. Zhan, Y., Kelso, A. and Cheers, C. 1993. Cytokine production in the murine response to <i>brucella<\/i> infection or immunization with antigenic extracts. <i>Immunology<\/i> 80: 458\u2013464."},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Zhan, Y., Liu, Z. and Cheers, C. 1996. Tumor necrosis factor alpha and interleukin-12 contribute to resistance to the intracellular bacterium <i>Brucella abortus<\/i> by different mechanisms. <i>Infect. 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