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Asanoi, H., Ishizaka, S., Kameyama, T., Ishise, H. and Sasayama, S. 1994. Disparate inotropic and lusitropic responses to pimobendan in conscious dogs with tachycardia-induced heart failure. <i>J. Cardiovasc. Pharmacol.<\/i> 23: 268\u2013274.","DOI":"10.1097\/00005344-199402000-00014"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Boswood, A., H\u00e4ggstr\u00f6m, J., Gordon, S. G., Wess, G., Stepien, R. L., Oyama, M. A., Keene, B. W., Bonagura, J., MacDonald, K. A., Patteson, M., Smith, S., Fox, P. R., Sanderson, K., Woolley, R., Szatm\u00e1ri, V., Menaut, P., Church, W. M., O\u2019Sullivan, M. L., Jaudon, J. P., Kresken, J. G., Rush, J., Barrett, K. A., Rosenthal, S. L., Saunders, A. B., Ljungvall, I., Deinert, M., Bomassi, E., Estrada, A. H., Fernandez Del Palacio, M. J., Moise, N. S., Abbott, J. A., Fujii, Y., Spier, A., Luethy, M. W., Santilli, R. A., Uechi, M., Tidholm, A. and Watson, P. 2016. Effect of pimobendan in dogs with preclinical myxomatous mitral valve disease and cardiomegaly: The EPIC study-a randomized clinical trial. <i>J. Vet. Intern. Med.<\/i> 30: 1765\u20131779.","DOI":"10.1111\/jvim.14586"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Fujino, K., Sperelakis, N. and Solaro, R. J. 1988. Sensitization of dog and guinea pig heart myofilaments to Ca2+ activation and the inotropic effect of pimobendan: comparison with milrinone. <i>Circ. Res.<\/i> 63: 911\u2013922.","DOI":"10.1161\/01.RES.63.5.911"},{"key":"4","unstructured":"4. Hagemeijer, F., Roth, W. and Brand, H. J. 1989. Correlations between the cardiovascular effects of pimobendan and plasma concentrations of the parent compound and of its major active metabolite, UD-CG 212 CL, in patients with congestive heart failure. <i>J. Cardiovasc. Pharmacol.<\/i> 14 Suppl 2: S57\u2013S64."},{"key":"5","doi-asserted-by":"crossref","unstructured":"6. H\u00e4ggstr\u00f6m, J., Lord, P. F., H\u00f6glund, K., Ljungvall, I., J\u00f6ns, O., Kvart, C. and Hansson, K. 2013. Short-term hemodynamic and neuroendocrine effects of pimobendan and benazapril in dogs with myxomatous mitral valve disease and congestive heart failure. <i>J. Vet. Intern. Med.<\/i> 27: 1452\u20131462.","DOI":"10.1111\/jvim.12217"},{"key":"6","doi-asserted-by":"crossref","unstructured":"7. Honerj\u00e4ger, P. 1991. Pharmacology of bipyridine phosphodiesterase III inhibitors. <i>Am. Heart J.<\/i> 121: 1939\u20131944.","DOI":"10.1016\/0002-8703(91)90828-6"},{"key":"7","doi-asserted-by":"crossref","unstructured":"8. Johnson, W. B., Katugampola, S., Able, S., Napier, C. and Harding, S. E. 2012. Profiling of cAMP and cGMP phosphodiesterases in isolated ventricular cardiomyocytes from human hearts: comparison with rat and guinea pig. <i>Life Sci.<\/i> 90: 328\u2013336.","DOI":"10.1016\/j.lfs.2011.11.016"},{"key":"8","doi-asserted-by":"crossref","unstructured":"9. Kawano, H., Arakawa, S., Satoh, O., Matsumoto, Y., Hayano, M., Nakatomi, D., Yamasa, T. and Maemura, K. 2014. Effect of pimobendan in addition to standard therapy for heart failure on prevention of readmission in elderly patients with severe chronic heart failure. <i>Geriatr. Gerontol. Int.<\/i> 14: 109\u2013114.","DOI":"10.1111\/ggi.12067"},{"key":"9","unstructured":"10. Lee, J. A., Ruegg, J. C. and Allen, D. G. 1989. Effects of pimobendan, a novel inotropic agent, on intracellular calcium and tension in isolated ferret ventricular muscle. <i>Clin. Sci.<\/i> 76: 609\u2013618."},{"key":"10","doi-asserted-by":"crossref","unstructured":"11. Lombard, C. W., J\u00f6ns, O. and Bussadori, C. M. 2006. Clinical efficacy of pimobendan versus benazepril for the treatment of acquired atrioventricular valvular disease in dogs. <i>J. Am. Anim. Hosp. Assoc.<\/i> 42: 249\u2013261.","DOI":"10.5326\/0420249"},{"key":"11","doi-asserted-by":"crossref","unstructured":"12. Movsesian, M., Stehlik, J., Vandeput, F. and Bristow, M. R. 2009. Phosphodiesterase inhibition in heart failure. <i>Heart Fail. Rev.<\/i> 14: 255\u2013263.","DOI":"10.1007\/s10741-008-9130-x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"13. O\u2019Grady, M. R., Minors, S. L., O\u2019Sullivan, M. L. and Horne, R. 2008. Effect of pimobendan on case fatality rate in Doberman Pinschers with congestive heart failure caused by dilated cardiomyopathy. <i>J. Vet. Intern. Med.<\/i> 22: 897\u2013904.","DOI":"10.1111\/j.1939-1676.2008.0116.x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"14. Ohte, N., Cheng, C. P., Suzuki, M. and Little, W. C. 1997. The cardiac effects of pimobendan (but not amrinone) are preserved at rest and during exercise in conscious dogs with pacing-induced heart failure. <i>J. Pharmacol. Exp. Ther.<\/i> 282: 23\u201331.","DOI":"10.1016\/S0022-3565(24)36774-6"},{"key":"14","unstructured":"15. Pagel, P. S., Hettrick, D. A. and Warltier, D. C. 1996. Influence of levosimendan, pimobendan, and milrinone on the regional distribution of cardiac output in anaesthetized dogs. <i>Br. J. Pharmacol.<\/i> 119: 609\u2013615."},{"key":"15","doi-asserted-by":"crossref","unstructured":"16. Pouleur, H., Hanet, C., Schr\u00f6der, E., Col, J., Van Mechelen, H., Etienne, J. and Rousseau, M. F. 1989. Effects of pimobendan (UD-CG 115 BS) on left ventricular inotropic state in conscious dogs and in patients with heart failure. <i>J. Cardiovasc. Pharmacol.<\/i> 14 Suppl 2: S18\u2013S22.","DOI":"10.1097\/00005344-198906142-00005"},{"key":"16","doi-asserted-by":"crossref","unstructured":"17. Shakur, Y., Holst, L. S., Landstrom, T. R., Movsesian, M., Degerman, E. and Manganiello, V. 2001. Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family. <i>Prog. Nucleic Acid Res. Mol. Biol.<\/i> 66: 241\u2013277.","DOI":"10.1016\/S0079-6603(00)66031-2"},{"key":"17","doi-asserted-by":"crossref","unstructured":"18. Solaro, R. J., Fujino, K. and Sperelakis, N. 1989. The positive inotropic effect of pimobendan involves stereospecific increases in the calcium sensitivity of cardiac myofilaments. <i>J. Cardiovasc. Pharmacol.<\/i> 14 Suppl 2: S7\u2013S12.","DOI":"10.1097\/00005344-198900142-00003"},{"key":"18","doi-asserted-by":"crossref","unstructured":"19. Suzuki, S., Fukushima, R., Ishikawa, T., Hamabe, L., Aytemiz, D., Huai-Che, H., Nakao, S., Machida, N. and Tanaka, R. 2011. The effect of pimobendan on left atrial pressure in dogs with mitral valve regurgitation. <i>J. Vet. Intern. Med.<\/i> 25: 1328\u20131333.","DOI":"10.1111\/j.1939-1676.2011.00800.x"},{"key":"19","unstructured":"20. Takahashi, R. and Endoh, M. 2001. Increase in myofibrillar Ca2+ sensitivity induced by UD-CG 212 Cl, an active metabolite of pimobendan, in canine ventricular myocardium. <i>J. Cardiovasc. Pharmacol.<\/i> 37: 209\u2013218."},{"key":"20","doi-asserted-by":"crossref","unstructured":"21. The EPOCH Study Group. 2002. Effects of pimobendan on adverse cardiac events and physical activities in patients with mild to moderate chronic heart failure: the effects of pimobendan on chronic heart failure study (EPOCH study). <i>Circ. J.<\/i> 66: 149\u2013157.","DOI":"10.1253\/circj.66.149"},{"key":"21","doi-asserted-by":"crossref","unstructured":"22. van Meel, J. C. and Diederen, W. 1989. Hemodynamic profile of the cardiotonic agent pimobendan. <i>J. Cardiovasc. Pharmacol.<\/i> 14 Suppl 2: S1\u2013S6.","DOI":"10.1097\/00005344-198906142-00002"},{"key":"22","unstructured":"23. Verdouw, P. D., Hartog, J. M., Duncker, D. J., Roth, W. and Saxena, P. R. 1986. Cardiovascular profile of pimobendan, a benzimidazole-pyridazinone derivative with vasodilating and inotropic properties. <i>Eur. J. Pharmacol.<\/i> 126: 21\u201330."},{"key":"23","doi-asserted-by":"crossref","unstructured":"24. Yata, M., McLachlan, A. J., Foster, D. J., Page, S. W. and Beijerink, N. J. 2016. 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