{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:21:36Z","timestamp":1788520896824,"version":"build-2803163510"},"reference-count":46,"publisher":"Japanese Society of Veterinary Science","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Vet. Med. Sci.","The Journal of Veterinary Medical Science"],"published-print":{"date-parts":[[2019]]},"DOI":"10.1292\/jvms.18-0617","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T17:36:27Z","timestamp":1549301787000},"page":"491-498","source":"Crossref","is-referenced-by-count":15,"title":["The impact of ecbolic therapy in the early postpartum period on uterine involution and reproductive health in dairy cows"],"prefix":"10.1292","volume":"81","author":[{"given":"Cyril P.","family":"STEPHEN","sequence":"first","affiliation":[{"name":"Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada"},{"name":"School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia"},{"name":"Graham Centre for Agricultural Innovation, Charles Sturt University, Wagga Wagga, NSW 2678, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter H.","family":"JOHNSON","sequence":"additional","affiliation":[{"name":"Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"LEBLANC","sequence":"additional","affiliation":[{"name":"Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"FOSTER","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey S.","family":"CHENIER","sequence":"additional","affiliation":[{"name":"Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"122","reference":[{"key":"1","unstructured":"1. Abramson, J. H. 2011. WINPEPI updated: computer programs for epidemiologists, and their teaching potential. <i>Epidemiol. Perspect. Innov.<\/i> 8: 1\u20139."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Bajcsy, A. C., Szenci, O., van der Weijden, G. C., Doornenbal, A., Maassen, F., Bartyik, J. and Taverne, M. A. 2006. The effect of a single oxytocin or carbetocin treatment on uterine contractility in early postpartum dairy cows. <i>Theriogenology<\/i> 65: 400\u2013414.","DOI":"10.1016\/j.theriogenology.2005.05.040"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Bajcsy, A. C., Szenci, O., Doornenbal, A., van der Weijden, G. C., Csorba, C., Kocsis, L., Szucs, I., Ostgard, S. and Taverne, M. A. 2005. Characteristics of bovine early puerperal uterine contractility recorded under farm conditions. <i>Theriogenology<\/i> 64: 99\u2013111.","DOI":"10.1016\/j.theriogenology.2004.11.005"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Barlund, C. S., Carruthers, T. D., Waldner, C. L. and Palmer, C. W. 2008. A comparison of diagnostic techniques for postpartum endometritis in dairy cattle. <i>Theriogenology<\/i> 69: 714\u2013723.","DOI":"10.1016\/j.theriogenology.2007.12.005"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Barrett, A. J., Murray, R. D., Christley, R. M., Dobson, H. and Smith, R. F. 2009. Effects of the administration of oxytocin or carbetocin to dairy cows at parturition on their subsequent fertility. <i>Vet. Rec.<\/i> 165: 623\u2013626.","DOI":"10.1136\/vr.165.21.623"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Bruckmaier, R. M. and Blum, J. W. 1998. Oxytocin release and milk removal in ruminants. <i>J. Dairy Sci.<\/i> 81: 939\u2013949.","DOI":"10.3168\/jds.S0022-0302(98)75654-1"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Bruckmaier, R. M. 2003. Chronic oxytocin treatment causes reduced milk ejection in dairy cows. <i>J. Dairy Res.<\/i> 70: 123\u2013126.","DOI":"10.1017\/S0022029902005940"},{"key":"8","unstructured":"8. Cooper, M. D. and Foote, R. H. 1986. Effect of oxytocin, prostaglandin F2 alpha and reproductive tract manipulations on uterine contractility in Holstein cows on days 0 and 7 of the estrous cycle. <i>J. Anim. Sci.<\/i> 63: 151\u2013161."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. de Boer, M. W., LeBlanc, S. J., Dubuc, J., Meier, S., Heuwieser, W., Arlt, S., Gilbert, R. O. and McDougall, S. 2014. Invited review: Systematic review of diagnostic tests for reproductive-tract infection and inflammation in dairy cows. <i>J. Dairy Sci.<\/i> 97: 3983\u20133999.","DOI":"10.3168\/jds.2013-7450"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Dubuc, J., Duffield, T. F., Leslie, K. E., Walton, J. S. and LeBlanc, S. J. 2012. Risk factors and effects of postpartum anovulation in dairy cows. <i>J. Dairy Sci.<\/i> 95: 1845\u20131854.","DOI":"10.3168\/jds.2011-4781"},{"key":"11","unstructured":"11. Eiler, H., Hopkins, F. M., Armstrong-Backus, C. S. and Lyke, W. A. 1984. Uterotonic effect of prostaglandin F2 alpha and oxytocin on the postpartum cow. <i>Am. J. Vet. Res.<\/i> 45: 1011\u20131014."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Ferguson, S. S., Barak, L. S., Zhang, J. and Caron, M. G. 1996. G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins. <i>Can. J. Physiol. Pharmacol.<\/i> 74: 1095\u20131110.","DOI":"10.1139\/cjpp-74-10-1095"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Fuchs, A. R., Rollyson, M. K., Meyer, M., Fields, M. J., Minix, J. M. and Randel, R. D. 1996. Oxytocin induces prostaglandin F2 alpha release in pregnant cows: influence of gestational age and oxytocin receptor concentrations. <i>Biol. Reprod.<\/i> 54: 647\u2013653.","DOI":"10.1095\/biolreprod54.3.647"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Gilbert, R. O., Shin, S. T., Guard, C. L., Erb, H. N. and Frajblat, M. 2005. Prevalence of endometritis and its effects on reproductive performance of dairy cows. <i>Theriogenology<\/i> 64: 1879\u20131888.","DOI":"10.1016\/j.theriogenology.2005.04.022"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Goto, A., Nakada, K. and Katamoto, H. 2016. The association of culling and death rate within 30 days after calving with productivity or reproductive performance in dairy herds in Fukuoka, Southern Japan. <i>J. Vet. Med. Sci.<\/i> 78: 587\u2013592.","DOI":"10.1292\/jvms.15-0554"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Haimerl, P., Arlt, S. and Heuwieser, W. 2012. Evidence-based medicine: quality and comparability of clinical trials investigating the efficacy of prostaglandin F<sub>2\u03b1<\/sub> for the treatment of bovine endometritis. <i>J. Dairy Res.<\/i> 79: 287\u2013296.","DOI":"10.1017\/S002202991200012X"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Hickey, G. J., White, M. E., Wickenden, R. P. and Armstrong, D. A. 1984. Effects of oxytocin on placental retention following dystocia. <i>Vet. Rec.<\/i> 114: 189\u2013190.","DOI":"10.1136\/vr.114.8.189"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Hirsbrunner, G., Burkhardt, H. W. and Steiner, A. 2006. Effects of a single administration of prostaglandin F2alpha, or a combination of prostaglandin F2alpha and prostaglandin E2, or placebo on fertility variables in dairy cows 3\u22125 weeks post partum, a randomized, double-blind clinical trial. <i>Reprod. Biol. Endocrinol.<\/i> 4: 65.","DOI":"10.1186\/1477-7827-4-65"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Hirsbrunner, G., K\u00fcpfer, U., Burkhardt, H. and Steiner, A. 1998. Effect of different prostaglandins on intrauterine pressure and uterine motility during diestrus in experimental cows. <i>Theriogenology<\/i> 50: 445\u2013455.","DOI":"10.1016\/S0093-691X(98)00151-4"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Kamimura, S., Ohgi, T., Takahashi, M. and Tsukamoto, T. 1993. Postpartum resumption of ovarian activity and uterine involution monitored by ultrasonography in Holstein cows. <i>J. Vet. Med. Sci.<\/i> 55: 643\u2013647.","DOI":"10.1292\/jvms.55.643"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Kasimanickam, R., Duffield, T. F., Foster, R. A., Gartley, C. J., Leslie, K. E., Walton, J. S. and Johnson, W. H. 2004. Endometrial cytology and ultrasonography for the detection of subclinical endometritis in postpartum dairy cows. <i>Theriogenology<\/i> 62: 9\u201323.","DOI":"10.1016\/j.theriogenology.2003.03.001"},{"key":"22","unstructured":"22. Kasimanickam, R., Duffield, T. F., Foster, R. A., Gartley, C. J., Leslie, K. E., Walton, J. S. and Johnson, W. H. 2005. A comparison of the cytobrush and uterine lavage techniques to evaluate endometrial cytology in clinically normal postpartum dairy cows. <i>Can. Vet. J.<\/i> 46: 255\u2013259."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. LeBlanc, S. J. 2008. Postpartum uterine disease and dairy herd reproductive performance: a review. <i>Vet. J.<\/i> 176: 102\u2013114.","DOI":"10.1016\/j.tvjl.2007.12.019"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. LeBlanc, S. J., Duffield, T. F., Leslie, K. E., Bateman, K. G., Keefe, G. P., Walton, J. S. and Johnson, W. H. 2002. Defining and diagnosing postpartum clinical endometritis and its impact on reproductive performance in dairy cows. <i>J. Dairy Sci.<\/i> 85: 2223\u20132236.","DOI":"10.3168\/jds.S0022-0302(02)74302-6"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Lindell, J. O. and Kindahl, H. 1983. Exogenous prostaglandin F2 alpha promotes uterine involution in the cow. <i>Acta Vet. Scand.<\/i> 24: 269\u2013274.","DOI":"10.1186\/BF03546730"},{"key":"26","unstructured":"26. Madej, A., Kindahl, H., Woyno, W., Edqvist, L. E. and Stupnicki, R. 1984. Blood levels of 15-keto-13, 14-dihydroprostaglandin F<sub>2\u03b1<\/sub> during the postpartum period in primiparous cows. <i>Theriogenology<\/i> 21: 279\u2013287."},{"key":"27","unstructured":"27. Marion, G. B., Norwood, J. S. and Gier, H. T. 1968. Uterus of the cow after parturition: factors affecting regression. <i>Am. J. Vet. Res.<\/i> 29: 71\u201375."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Martin, L. R., Williams, W. F., Russek, E. and Gross, T. S. 1981. Postpartum uterine motility measurements in dairy cows retaining their fetal membranes. <i>Theriogenology<\/i> 15: 513\u2013524.","DOI":"10.1016\/0093-691X(81)90095-9"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. McDougall, S., Macaulay, R. and Compton, C. 2007. Association between endometritis diagnosis using a novel intravaginal device and reproductive performance in dairy cattle. <i>Anim. Reprod. Sci.<\/i> 99: 9\u201323.","DOI":"10.1016\/j.anireprosci.2006.03.017"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Miller, B. J. and Lodge, J. R. 1984. Postpartum oxytocin treatment for prevention of retained placentas. <i>Theriogenology<\/i> 22: 385\u2013388.","DOI":"10.1016\/0093-691X(84)90458-8"},{"key":"31","unstructured":"31. Morrow, D. A., Roberts, S. J. and McEntee, K. 1969. Postpartum ovarian activity and involution of the uterus and cervix in dairy cattle. 1. Ovarian activity. <i>Cornell Vet.<\/i> 59: 173\u2013190."},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Okano, A. and Tomizuka, T. 1987. Ultrasonic observation of postpartum uterine involution in the cow. <i>Theriogenology<\/i> 27: 369\u2013376.","DOI":"10.1016\/0093-691X(87)90225-1"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Opsomer, G., Gr\u00f6hn, Y. T., Hertl, J., Coryn, M., Deluyker, H. and de Kruif, A. 2000. Risk factors for post partum ovarian dysfunction in high producing dairy cows in Belgium: a field study. <i>Theriogenology<\/i> 53: 841\u2013857.","DOI":"10.1016\/S0093-691X(00)00234-X"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Palomares, R. A., Guti\u00e9rrez, J. C., Portillo, G., Boscan, J. C., Montero, M., L\u00f3pez, Y., Maxwell, H. S., Carson, R. L. and Soto, E. 2010. Oxytocin treatment immediately after calving does not reduce the incidence of retained fetal membranes or improve reproductive performance in crossbred Zebu cows. <i>Theriogenology<\/i> 74: 1414\u20131419.","DOI":"10.1016\/j.theriogenology.2010.06.013"},{"key":"35","unstructured":"35. Patil, R. K., Sinha, S. N., Einarsson, S. and Settergren, I. 1980. The effect of prostaglandin F2 alpha and oxytocin on bovine myometrium in vitro. <i>Nord. Vet. Med.<\/i> 32: 474\u2013479."},{"key":"36","unstructured":"36. Perumamthadathil, C. S., Johnson, W. H., Leblanc, S. J., Foster, R. A. and Chenier, T. S. 2014. Persistence of oxytocin receptors in the bovine uterus during the first 7 d after calving: an immunohistochemical study. <i>Can. J. Vet. Res.<\/i> 78: 72\u201377."},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Phaneuf, S., Asb\u00f3th, G., MacKenzie, I. Z., Melin, P. and L\u00f3pez Bernal, A. 1994. Effect of oxytocin antagonists on the activation of human myometrium in vitro: atosiban prevents oxytocin-induced desensitization. <i>Am. J. Obstet. Gynecol.<\/i> 171: 1627\u20131634.","DOI":"10.1016\/0002-9378(94)90414-6"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Plested, C. P. and Bernal, A. L. 2001. Desensitisation of the oxytocin receptor and other G-protein coupled receptors in the human myometrium. <i>Exp. Physiol.<\/i> 86: 303\u2013312.","DOI":"10.1113\/eph8602187"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Salasel, B. and Mokhtari, A. 2011. Effect of early postpartum PGF2\u03b1 treatment on reproductive performance in dairy cows with calving and puerperal traits. <i>Theriogenology<\/i> 76: 1723\u20131729.","DOI":"10.1016\/j.theriogenology.2011.07.004"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Schams, D., Schmidt-Polex, B. and Kruse, V. 1979. Oxytocin determination by radioimmunoassay in cattle. I. Method and preliminary physiological data. <i>Acta Endocrinol.<\/i> 92: 258\u2013270.","DOI":"10.1530\/acta.0.0920258"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Sheldon, I. M., Noakes, D. E., Rycroft, A. N. and Dobson, H. 2003. The effect of intrauterine administration of estradiol on postpartum uterine involution in cattle. <i>Theriogenology<\/i> 59: 1357\u20131371.","DOI":"10.1016\/S0093-691X(02)01169-X"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Sheldon, I. M., Williams, E. J., Miller, A. N., Nash, D. M. and Herath, S. 2008. Uterine diseases in cattle after parturition. <i>Vet. J.<\/i> 176: 115\u2013121.","DOI":"10.1016\/j.tvjl.2007.12.031"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Silvestre, F. T., Bartolome, J. A., Kamimura, S., Arteche, A. C., Pancarci, S. M., Trigg, T. and Thatcher, W. W. 2009. Postpartum suppression of ovarian activity with a Deslorelin implant enhanced uterine involution in lactating dairy cows. <i>Anim. Reprod. Sci.<\/i> 110: 79\u201395.","DOI":"10.1016\/j.anireprosci.2007.12.015"},{"key":"44","unstructured":"44. Stolla, R. and Schmid, G. 1990. [Effects of natural and synthetic PGF2 alpha preparations on the uterine contractility of cattle]. <i>Berl. Munch. Tierarztl. Wochenschr.<\/i> 103: 198\u2013202."},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Thatcher, W. W., Bilby, T. R., Bartolome, J. A., Silvestre, F., Staples, C. R. and Santos, J. E. 2006. Strategies for improving fertility in the modern dairy cow. <i>Theriogenology<\/i> 65: 30\u201344.","DOI":"10.1016\/j.theriogenology.2005.10.004"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Toni, F., Vincenti, L., Ricci, A. and Schukken, Y. H. 2015. Postpartum uterine diseases and their impacts on conception and days open in dairy herds in Italy. <i>Theriogenology<\/i> 84: 1206\u20131214.","DOI":"10.1016\/j.theriogenology.2015.06.022"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/81\/3\/81_18-0617\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T07:16:35Z","timestamp":1662880595000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/81\/3\/81_18-0617\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.18-0617","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}