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Sci.","The Journal of Veterinary Medical Science"],"published-print":{"date-parts":[[2019]]},"DOI":"10.1292\/jvms.18-0712","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T18:07:35Z","timestamp":1557425255000},"page":"937-945","source":"Crossref","is-referenced-by-count":10,"title":["Anesthetic effect of a mixture of alfaxalone, medetomidine, and butorphanol          for inducing surgical anesthesia in ICR, BALB\/c, and C57BL\/6 mouse strains"],"prefix":"10.1292","volume":"81","author":[{"given":"Yoriko","family":"TSUKAMOTO","sequence":"first","affiliation":[{"name":"Department of Laboratory Animal Science, School of              Veterinary Medicine, Rakuno-Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu,              Hokkaido 069-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihide","family":"YAMADA","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Science, School of              Veterinary Medicine, Rakuno-Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu,              Hokkaido 069-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenjiro","family":"MIYOSHI","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, School of              Veterinary Medicine, Rakuno-Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu,              Hokkaido 069-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuto","family":"YAMASHITA","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, School of              Veterinary Medicine, Rakuno-Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu,              Hokkaido 069-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"OHSUGI","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Science, School of              Veterinary Medicine, Rakuno-Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu,              Hokkaido 069-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"122","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Ferr\u00e9, P.                J., Pasloske,                K.,              Whittem, T.,                Ranasinghe, M.              G., Li,                Q. and                Lefebvre, H.              P.          2006. Plasma pharmacokinetics of alfaxalone in dogs after an            intravenous bolus of Alfaxan-CD RTU. <i>Vet. Anaesth.              Analg.<\/i>          33: 229\u2013236.","DOI":"10.1111\/j.1467-2995.2005.00264.x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Fink,              G., Sarkar,                D. K., Dow,                R. C.,              Dick, H.,                Borthwick,              N., Malnick,                S. and                Twine,            M.          1982. Sex difference in response to alphaxalone anaesthesia            may be oestrogen dependent. <i>Nature<\/i>          298: 270\u2013272.","DOI":"10.1038\/298270a0"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Fujita,              T.,              Yamashita,            D., Katsunuma,                S.,                Hasegawa,              S., Tanimoto,                H. and              Nibu,            K.          2012. Increased inner ear susceptibility to noise injury in            mice with streptozotocin-induced diabetes.              <i>Diabetes<\/i>          61: 2980\u20132986.","DOI":"10.2337\/db11-1845"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Goodwin,                W., Keates,                H.,                Pasloske,              K., Pearson,                M., Sauer,                B. and                Ranasinghe, M.              G.          2012. Plasma pharmacokinetics and pharmacodynamics of            alfaxalone in neonatal foals after an intravenous bolus of alfaxalone following            premedication with butorphanol tartrate. <i>Vet. Anaesth.              Analg.<\/i>          39: 503\u2013510.","DOI":"10.1111\/j.1467-2995.2012.00734.x"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Goodwin, W.                A., Keates,                H. L.,                Pasloske,              K., Pearson,                M., Sauer,                B. and                Ranasinghe, M.              G.          2011. The pharmacokinetics and pharmacodynamics of the            injectable anaesthetic alfaxalone in the horse. <i>Vet.              Anaesth. Analg.<\/i>          38: 431\u2013438.","DOI":"10.1111\/j.1467-2995.2011.00634.x"},{"key":"6","unstructured":"6. Higuchi,                S., Yamada,                R.,                Hashimoto,              A., Miyoshi,                K.,                Yamashita,              K. and              Ohsugi,            T.          2016. Evaluation of a combination of alfaxalone with            medetomidine and butorphanol for inducing surgical anesthesia in laboratory            mice. <i>Jpn. J. Vet. Res.<\/i>          64: 131\u2013139."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Kawai,              S., Takagi,                Y., Kaneko,                S. and                Kurosawa,              T.          2011. Effect of three types of mixed anesthetic agents            alternate to ketamine in mice. <i>Exp.            Anim.<\/i>          60: 481\u2013487.","DOI":"10.1538\/expanim.60.481"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Keates,              H.          2003. Induction of anaesthesia in pigs using a new alphaxalone            formulation. <i>Vet. Rec.<\/i>          153: 627\u2013628.","DOI":"10.1136\/vr.153.20.627"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Keates,              H. and                Whittem,            T.          2012. Effect of intravenous dose escalation with alfaxalone            and propofol on occurrence of apnoea in the dog. <i>Res.              Vet. Sci.<\/i>          93: 904\u2013906.","DOI":"10.1016\/j.rvsc.2011.10.003"},{"key":"10","unstructured":"10. Kirihara,                Y.,              Takechi, M.,                Kurosaki,              K.,              Kobayashi, Y.            and Kurosawa,              T.          2013. Anesthetic effects of a mixture of medetomidine,            midazolam and butorphanol in two strains of mice. <i>Exp.              Anim.<\/i>          62: 173\u2013180."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Kirihara,                Y.,              Takechi, M.,                Kurosaki,              K.,              Kobayashi,            Y., Saito,                Y. and                Takeuchi,              T.          2015. Anesthetic effects of a three-drugs mixture--comparison            of administrative routes and antagonistic effects of atipamezole in          mice. <i>Exp. Anim.<\/i>          64: 39\u201347.","DOI":"10.1538\/expanim.14-0039"},{"key":"12","unstructured":"12. Kirihara,                Y.,              Takechi, M.,                Kurosaki,              K.,              Kobayashi,            Y., Saito,                Y. and                Takeuchi,              T.          2016. Effects of an anesthetic mixture of medetomidine,            midazolam, and butorphanol in rats-strain difference and antagonism by            atipamezole. <i>Exp. Anim.<\/i>          65: 27\u201336."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Kuroda,              N., Inoue,                K., Ikeda,                T., Hara,                Y., Wake,                K. and              Sato,            T.          2014. Apoptotic response through a high mobility box 1            protein-dependent mechanism in LPS\/GalN-induced mouse liver failure and            glycyrrhizin-mediated inhibition. <i>PLoS            One<\/i>          9: e92884.","DOI":"10.1371\/journal.pone.0092884"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Lau,              C.,                Ranasinghe, M.              G., Shiels,                I., Keates,                H.,                Pasloske,              K. and                Bellingham, M.              C.          2013. Plasma pharmacokinetics of alfaxalone after a single            intraperitoneal or intravenous injection of Alfaxan(<sup>\u00ae<\/sup>) in            rats. <i>J. Vet. Pharmacol. Ther.<\/i>          36: 516\u2013520.","DOI":"10.1111\/jvp.12055"},{"key":"15","unstructured":"15. Lee,              J., Suh,                S., Choi,                R. and              Hyun,            C.          2016. Cardiorespiratory and anesthetic effects produced by the            combination of butorphanol, medetomidine and alfaxalone administered intramuscularly in            Beagle dogs. <i>J. Vet. Med. Sci.<\/i>          77: 1677\u20131680."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Muir,              W., Lerche,                P., Wiese,                A., Nelson,                L.,                Pasloske,              K. and                Whittem,            T.          2008. Cardiorespiratory and anesthetic effects of clinical and            supraclinical doses of alfaxalone in dogs. <i>Vet. Anaesth.              Analg.<\/i>          35: 451\u2013462.","DOI":"10.1111\/j.1467-2995.2008.00406.x"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. O\u2019Hagan,                B.,                Pasloske,              K., McKinnon,                C.,              Perkins, N.            and Whittem,            T.          2012. Clinical evaluation of alfaxalone as an anaesthetic            induction agent in dogs less than 12 weeks of age. <i>Aust.              Vet. J.<\/i>          90: 346\u2013350.","DOI":"10.1111\/j.1751-0813.2012.00974.x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. O\u2019Hagan, B.                J., Pasloske,                K.,                McKinnon,              C., Perkins,                N. R. and                Whittem,            T.          2012. Clinical evaluation of alfaxalone as an anaesthetic            induction agent in cats less than 12 weeks of age. <i>Aust.              Vet. J.<\/i>          90: 395\u2013401.","DOI":"10.1111\/j.1751-0813.2012.00983.x"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Ochiai,              Y., Iwano,                H.,                Sakamoto,              T.,                Hirabayashi,              M., Kaneko,                E.,                Watanabe,              T.,              Yamashita, K.            and Yokota,            H.          2016. Blood biochemical changes in mice after administration            of a mixture of three anesthetic agents. <i>J. Vet. Med.              Sci.<\/i>          78: 951\u2013956.","DOI":"10.1292\/jvms.15-0474"},{"key":"20","unstructured":"20. Psatha,              E., Alibhai,                H. I.,                Jimenez-Lozano,              A.,                Armitage-Chan,              E. and                Brodbelt, D.              C.          2011. Clinical efficacy and cardiorespiratory effects of            alfaxalone, or diazepam\/fentanyl for induction of anaesthesia in dogs that are a poor            anaesthetic risk. <i>Vet. Anaesth. Analg.<\/i>          38: 24\u201336."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Ramoo,              S., Bradbury,                L. A.,                Anderson, G.              A. and Abraham,                L. A.          2013. Sedation of hyperthyroid cats with subcutaneous            administration of a combination of alfaxalone and butorphanol.              <i>Aust. Vet. J.<\/i>          91: 131\u2013136.","DOI":"10.1111\/avj.12034"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Saegusa,                Y. and                Tabata,            H.          2003. Usefulness of infrared thermometry in determining body            temperature in mice. <i>J. Vet. Med. Sci.<\/i>          65: 1365\u20131367.","DOI":"10.1292\/jvms.65.1365"},{"key":"23","unstructured":"23. Seo, J.              I., Han, S.                H., Choi,                R., Han,                J., Lee,                L. and              Hyun,            C.          2015. Cardiopulmonary and anesthetic effects of the            combination of butorphanol, midazolam and alfaxalone in Beagle dogs.              <i>Vet. Anaesth. Analg.<\/i>          42: 304\u2013308."},{"key":"24","unstructured":"24. Siriarchavatana,                P., Ayers,                J. D. and                Kendall, L.              V.          2016. Anesthetic activity of alfaxalone compared with ketamine            in mice. <i>J. Am. Assoc. Lab. Anim. Sci.<\/i>          55: 426\u2013430."},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Tamura,              J., Ishizuka,                T., Fukui,                S., Oyama,                N., Kawase,                K.,              Miyoshi, K.,                Sano, T.,                Pasloske,              K. and                Yamashita,              K.          2015. The pharmacological effects of the anesthetic alfaxalone            after intramuscular administration to dogs. <i>J. Vet. Med.              Sci.<\/i>          77: 289\u2013296.","DOI":"10.1292\/jvms.14-0368"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Tsukamoto,                A.,                Serizawa,              K., Sato,                R.,                Yamazaki,              J. and                Inomata,            T.          2015. Vital signs monitoring during injectable and inhalant            anesthesia in mice. <i>Exp. Anim.<\/i>          64: 57\u201364.","DOI":"10.1538\/expanim.14-0050"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Visser, S.                A., Smulders,                C. J.,                Gladdines, W.              W., Irth,                H., van der                Graaf, P. H. and                Danhof,            M.          2000. High-performance liquid chromatography of the            neuroactive steroids alphaxalone and pregnanolone in plasma using dansyl hydrazine as            fluorescent label: application to a pharmacokinetic-pharmacodynamic study in            rats. <i>J. Chromatogr. B Biomed. Sci.            Appl.<\/i>          745: 357\u2013363.","DOI":"10.1016\/S0378-4347(00)00296-6"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. White, K.                L., Paine,                S. and                Harris,            J.          2017. A clinical evaluation of the pharmacokinetics and            pharmacodynamics of intravenous alfaxalone in cyclodextrin in male and female rats            following a loading dose and constant rate infusion.              <i>Vet. Anaesth. Analg.<\/i>          44: 865\u2013875.","DOI":"10.1016\/j.vaa.2017.01.001"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Zaki,              S.,              Ticehurst, K.            and Miyaki,            Y.          2009. Clinical evaluation of Alfaxan-CD(R) as an intravenous            anaesthetic in young cats. <i>Aust. Vet.            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