{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:06:32Z","timestamp":1788307592297,"version":"build-2803163510"},"reference-count":27,"publisher":"Japanese Society of Veterinary Science","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Vet. Med. Sci.","The Journal of Veterinary Medical Science"],"published-print":{"date-parts":[[2019]]},"DOI":"10.1292\/jvms.19-0289","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T22:04:03Z","timestamp":1571090643000},"page":"1730-1734","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of monitoring methods in asymptomatic dogs with high serum cystatin C concentrations"],"prefix":"10.1292","volume":"81","author":[{"given":"Naoki","family":"IWASA","sequence":"first","affiliation":[{"name":"Hashima Animal Hospital, 2-17 Asahira, Hashima, Gifu 501-6255, Japan"},{"name":"Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"TAKASHIMA","sequence":"additional","affiliation":[{"name":"Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"IWASA","sequence":"additional","affiliation":[{"name":"Hashima Animal Hospital, 2-17 Asahira, Hashima, Gifu 501-6255, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuko","family":"IWASA","sequence":"additional","affiliation":[{"name":"Hashima Animal Hospital, 2-17 Asahira, Hashima, Gifu 501-6255, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"SUZUKI","sequence":"additional","affiliation":[{"name":"Hashima Animal Hospital, 2-17 Asahira, Hashima, Gifu 501-6255, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"KUMAZAWA","sequence":"additional","affiliation":[{"name":"Hashima Animal Hospital, 2-17 Asahira, Hashima, Gifu 501-6255, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"NOMURA","sequence":"additional","affiliation":[{"name":"Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"KOBATAKE","sequence":"additional","affiliation":[{"name":"Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"KITAGAWA","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Faculty of Veterinary Medicine, Okayama University of Science, 1-3 Ikoi-no-oka, Imabari, Ehime 794-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohito","family":"NISHII","sequence":"additional","affiliation":[{"name":"Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"122","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Abrahamson, M., Olafsson, I., Palsdottir, A., Ulvsb\u00e4ck, M., Lundwall, A., Jensson, O. and Grubb, A. 1990. Structure and expression of the human cystatin C gene. <i>Biochem. J.<\/i> 268: 287\u2013294.","DOI":"10.1042\/bj2680287"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Almy, F. S., Christopher, M. M., King, D. P. and Brown, S. A. 2002. Evaluation of cystatin C as an endogenous marker of glomerular filtration rate in dogs. <i>J. Vet. Intern. Med.<\/i> 16: 45\u201351.","DOI":"10.1111\/j.1939-1676.2002.tb01605.x"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Braun, J. P., Lefebvre, H. P. and Watson, A. D. 2003. Creatinine in the dog: a review. <i>Vet. Clin. Pathol.<\/i> 32: 162\u2013179.","DOI":"10.1111\/j.1939-165X.2003.tb00332.x"},{"key":"4","unstructured":"4. Brown, S. A., Finco, D. R., Boudinot, F. D., Wright, J., Taver, S. L. and Cooper, T. 1996. Evaluation of a single injection method, using iohexol, for estimating glomerular filtration rate in cats and dogs. <i>Am. J. Vet. Res.<\/i> 57: 105\u2013110."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Feeman, W. E. 3rd., Couto, C. G. and Gray, T. L. 2003. Serum creatinine concentrations in retired racing Greyhounds. <i>Vet. Clin. Pathol.<\/i> 32: 40\u201342.","DOI":"10.1111\/j.1939-165X.2003.tb00312.x"},{"key":"6","unstructured":"6. Filler, G., B\u00f6kenkamp, A., Hofmann, W., Le Bricon, T., Mart\u00ednez-Br\u00fa, C. and Grubb, A. 2005. Cystatin C as a marker of GFR--history, indications, and future research. <i>Clin. Biochem.<\/i> 38: 1\u20138."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Finco, D. R., Brown, S. A., Crowell, W. A. and Barsanti, J. A. 1991. Exogenous creatinine clearance as a measure of glomerular filtration rate in dogs with reduced renal mass. <i>Am. J. Vet. Res.<\/i> 52: 1029\u20131032.","DOI":"10.2460\/ajvr.1991.52.07.1029"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Finco, D. R., Brown, S. A., Vaden, S. L. and Ferguson, D. C. 1995. Relationship between plasma creatinine concentration and glomerular filtration rate in dogs. <i>J. Vet. Pharmacol. Ther.<\/i> 18: 418\u2013421.","DOI":"10.1111\/j.1365-2885.1995.tb00619.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Ghys, L., Paepe, D., Smets, P., Lefebvre, H., Delanghe, J. and Daminet, S. 2014. Cystatin C: a new renal marker and its potential use in small animal medicine. <i>J. Vet. Intern. Med.<\/i> 28: 1152\u20131164.","DOI":"10.1111\/jvim.12366"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Hall, J. A., Yerramilli, M., Obare, E., Yerramilli, M., Melendez, L. D. and Jewell, D. E. 2015. Relationship between lean body mass and serum renal biomarkers in healthy dogs. <i>J. Vet. Intern. Med.<\/i> 29: 808\u2013814.","DOI":"10.1111\/jvim.12607"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Hari, P., Ramakrishnan, L., Gupta, R., Kumar, R. and Bagga, A. 2014. Cystatin C-based glomerular filtration rate estimating equations in early chronic kidney disease. <i>Indian Pediatr.<\/i> 51: 273\u2013277.","DOI":"10.1007\/s13312-014-0400-5"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Inker, L. A., Schmid, C. H., Tighiouart, H., Eckfeldt, J. H., Feldman, H. I., Greene, T., Kusek, J. W., Manzi, J., Van Lente, F., Zhang, Y. L., Coresh, J., Levey, A. S., CKD-EPI Investigators. 2012. Estimating glomerular filtration rate from serum creatinine and cystatin C. <i>N. Engl. J. Med.<\/i> 367: 20\u201329.","DOI":"10.1056\/NEJMoa1114248"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Iwasa, N., Takashima, S., Iwasa, T., Iwasa, K., Suzuki, T., Kobatake, Y., Kitagawa, H. and Nishii, N. 2018. Serum cystatin C concentration measured routinely is a prognostic marker for renal disease in dogs. <i>Res. Vet. Sci.<\/i> 119: 122\u2013126.","DOI":"10.1016\/j.rvsc.2018.06.014"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Jensen, A. L., Bomholt, M. and Moe, L. 2001. Preliminary evaluation of a particle-enhanced turbidimetric immunoassay (PETIA) for the determination of serum cystatin C-like immunoreactivity in dogs. <i>Vet. Clin. Pathol.<\/i> 30: 86\u201390.","DOI":"10.1111\/j.1939-165X.2001.tb00263.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kaseda, R., Iino, N., Hosojima, M., Takeda, T., Hosaka, K., Kobayashi, A., Yamamoto, K., Suzuki, A., Kasai, A., Suzuki, Y., Gejyo, F. and Saito, A. 2007. Megalin-mediated endocytosis of cystatin C in proximal tubule cells. <i>Biochem. Biophys. Res. Commun.<\/i> 357: 1130\u20131134.","DOI":"10.1016\/j.bbrc.2007.04.072"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Laterza, O. F., Price, C. P. and Scott, M. G. 2002. Cystatin C: an improved estimator of glomerular filtration rate? <i>Clin. Chem.<\/i> 48: 699\u2013707.","DOI":"10.1093\/clinchem\/48.5.699"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. M\u00e9daille, C., Trumel, C., Concordet, D., Vergez, F. and Braun, J. P. 2004. Comparison of plasma\/serum urea and creatinine concentrations in the dog: a 5-year retrospective study in a commercial veterinary clinical pathology laboratory. <i>J. Vet. Med. A Physiol. Pathol. Clin. Med.<\/i> 51: 119\u2013123.","DOI":"10.1111\/j.1439-0442.2004.00616.x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Miyagawa, Y., Takemura, N. and Hirose, H. 2009. Evaluation of the measurement of serum cystatin C by an enzyme-linked immunosorbent assay for humans as a marker of the glomerular filtration rate in dogs. <i>J. Vet. Med. Sci.<\/i> 71: 1169\u20131176.","DOI":"10.1292\/jvms.71.1169"},{"key":"19","unstructured":"19. O\u2019Neill, D. G., Elliott, J., Church, D. B., McGreevy, P. D., Thomson, P. C. and Brodbelt, D. C. 2013. Chronic kidney disease in dogs in U.K. veterinary practices: prevalence, risk factors, and survival. <i>J. Vet. Intern. Med.<\/i> 27: 814\u2013821."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Parker, V. J. and Freeman, L. M. 2011. Association between body condition and survival in dogs with acquired chronic kidney disease. <i>J. Vet. Intern. Med.<\/i> 25: 1306\u20131311.","DOI":"10.1111\/j.1939-1676.2011.00805.x"},{"key":"21","unstructured":"21. Peralta, C. A., Shlipak, M. G., Judd, S., Cushman, M., McClellan, W., Zakai, N. A., Safford, M. M., Zhang, X., Muntner, P. and Warnock, D. 2011. Detection of chronic kidney disease with creatinine, cystatin C, and urine albumin-to-creatinine ratio and association with progression to end-stage renal disease and mortality. <i>JAMA<\/i> 305: 1545\u20131552."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Prause, L. C. and Grauer, G. F. 1998. Association of gastrointestinal hemorrhage with increased blood urea nitrogen and BUN\/creatinine ratio in dogs: a literature review and retrospective study. <i>Vet. Clin. Pathol.<\/i> 27: 107\u2013111.","DOI":"10.1111\/j.1939-165X.1998.tb01028.x"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Shlipak, M. G., Matsushita, K., \u00c4rnl\u00f6v, J., Inker, L. A., Katz, R., Polkinghorne, K. R., Rothenbacher, D., Sarnak, M. J., Astor, B. C., Coresh, J., Levey, A. S., Gansevoort, R. T., CKD Prognosis Consortium. 2013. Cystatin C versus creatinine in determining risk based on kidney function. <i>N. Engl. J. Med.<\/i> 369: 932\u2013943.","DOI":"10.1056\/NEJMoa1214234"},{"key":"24","unstructured":"24. Stevens, L. A., Coresh, J., Schmid, C. H., Feldman, H. I., Froissart, M., Kusek, J., Rossert, J., Van Lente, F., Bruce, R. D. 3rd., Zhang, Y. L., Greene, T. and Levey, A. S. 2008. Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD. <i>Am. J. Kidney Dis.<\/i> 51: 395\u2013406."},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Tenstad, O., Roald, A. B., Grubb, A. and Aukland, K. 1996. Renal handling of radiolabelled human cystatin C in the rat. <i>Scand. J. Clin. Lab. Invest.<\/i> 56: 409\u2013414.","DOI":"10.3109\/00365519609088795"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Wehner, A., Hartmann, K. and Hirschberger, J. 2008. Utility of serum cystatin C as a clinical measure of renal function in dogs. <i>J. Am. Anim. Hosp. Assoc.<\/i> 44: 131\u2013138.","DOI":"10.5326\/0440131"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Wu, C. K., Lin, J. W., Caffrey, J. L., Chang, M. H., Hwang, J. J. and Lin, Y. S. 2010. Cystatin C and long-term mortality among subjects with normal creatinine-based estimated glomerular filtration rates: NHANES III (Third National Health and Nutrition Examination Survey). <i>J. Am. Coll. Cardiol.<\/i> 56: 1930\u20131936.","DOI":"10.1016\/j.jacc.2010.04.069"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/81\/12\/81_19-0289\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:39:47Z","timestamp":1721867987000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/81\/12\/81_19-0289\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.19-0289","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}