{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:36:40Z","timestamp":1780504600356,"version":"3.54.1"},"reference-count":16,"publisher":"Japanese Society of Veterinary Science","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Vet. Med. Sci.","The Journal of Veterinary Medical Science"],"published-print":{"date-parts":[[2019]]},"DOI":"10.1292\/jvms.19-0401","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T18:05:21Z","timestamp":1571681121000},"page":"1810-1816","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of Juzen-taiho-to against vincristine-induced toxicity in          dogs"],"prefix":"10.1292","volume":"81","author":[{"given":"Yuta","family":"SHINOHARA","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Pharmacology, Department of              Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and              Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan"},{"name":"Pet Health & Food Division, Iskara Industry Co.,              Ltd., 1-14-2, Nihonbashi, Chuo-ku, Tokyo 103-0027, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"NISHINO","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pharmacology, Department of              Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and              Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"YAMANAKA","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pharmacology, Department of              Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and              Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keitaro","family":"OHMORI","sequence":"additional","affiliation":[{"name":"Cooperative Department of Veterinary Medicine, Tokyo              University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509,              Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"ELBADAWY","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pharmacology, Department of              Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and              Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan"},{"name":"Department of Pharmacology, Faculty of Veterinary              Medicine, Benha University, 13736, Moshtohor, Toukh, Elqaliobiya,            Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"USUI","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pharmacology, Department of              Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and              Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"SASAKI","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pharmacology, Department of              Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and              Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"122","reference":[{"key":"1","unstructured":"1. Alexander, J.                G., Jill,                E. M. and                Grant,            G.          2008. Gastrointestinal drugs. pp. 472\u2013473. <i>In<\/i>: Small Animal          Clinical Pharmacology, 2nd ed. (Maddison, J. E., Page, S. W. and Church, D. B. eds.),          Elsevier, Amsterdam."},{"key":"2","unstructured":"2. Heather,                W. and                Claudia,            B.          2012. Chemotherapy. p. 1223. <i>In<\/i>: Small Animal Clinical          Pharmacology &amp; Therapeutics, 2nd ed. (Dawn, M. B.). Elsevier,          Amsterdam."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Ito,              M., Maruyama,                Y.,                Kitamura,              K.,              Kobayashi,            T., Takahashi,                H.,                Yamanaka,              N.,              Harabuchi,            Y., Origasa,                H. and                Yoshizaki,              T.          2017. Randomized controlled trial of juzen-taiho-to in            children with recurrent acute otitis media. <i>Auris Nasus              Larynx<\/i>          44: 390\u2013397.","DOI":"10.1016\/j.anl.2016.10.002"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Kimura,              Y. and                Sumiyoshi,              M.          2012. Effects of an Atractylodes lancea rhizome extract and a            volatile component \u03b2-eudesmol on gastrointestinal motility in mice.              <i>J. Ethnopharmacol.<\/i>          141: 530\u2013536.","DOI":"10.1016\/j.jep.2012.02.031"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Liu, S.              Y., Huang, C.                H., Shieh,                J. C. and                Lee, T. L.              N.          2017. Cinnamomum osmophloeum Kanehira ethanol extracts            prevents human liver-derived HepG2 cell death from oxidation stress by induction of            ghrelin gene expression. <i>J. Biosci.<\/i>          42: 439\u2013448.","DOI":"10.1007\/s12038-017-9697-2"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Ogawa,              K., Omatsu,                T.,                Matsumoto,              C., Tsuchiya,                N.,                Yamamoto,              M., Naito,                Y. and                Yoshikawa,              T.          2012. Protective effect of the Japanese traditional medicine            juzentaihoto on myelosuppression induced by the anticancer drug TS-1 and identification            of a potential biomarker of this effect. <i>BMC Complement.              Altern. Med.<\/i>          12: 118.","DOI":"10.1186\/1472-6882-12-118"},{"key":"7","unstructured":"7. Runthanne,                C., Laura,                D. G. and                David, M.              V.          2007. Cancer chemotherapy. p. 184. <i>In<\/i>: Withrow &amp;          MacEwen\u2019s Small Animal Clinical Oncology, 4 th ed. (Withrow, S. J. and Vail, D. M. eds.),          Elsevier, Amsterdam."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Shinohara,                Y., Oyama,                A., Usui,                T. and                Sasaki,            K.          2019. Possible Anti-oxidative Effects of long-term            administration of Juzen-taiho-to in Dogs. <i>J. Vet. Med.              Sci.<\/i> (in press).","DOI":"10.1292\/jvms.19-0380"},{"key":"9","unstructured":"9. Shono,              S., Todaka,                M.,              Onozawa, E.,                Ishii, S.,                Goto, A.,                Miyajima,              F., Oda,                H., Mori,                A. and              Sako,            T.          2018. The measurement of acetaminophen for future            determination of gastric emptying time in healthy dogs: a preliminary            study. <i>J. Pet. Anim. Nutr.<\/i>          21: 7\u201312."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Sugiyama,                K., Ueda,                H. and                Ichio,            Y.          1995. Protective effect of juzen-taiho-to against            carboplatin-induced toxic side effects in mice. <i>Biol.              Pharm. Bull.<\/i>          18: 544\u2013548.","DOI":"10.1248\/bpb.18.544"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Takemi,              S., Sakata,                I., Kuroda,                K., Miyano,                Y., Mondal,                A. and                Sakai,            T.          2017. The important role of ghrelin on gastric contraction in            Suncus murinus. <i>Endocr. J.<\/i>          64 Suppl.: S11\u2013S14.","DOI":"10.1507\/endocrj.64.S11"},{"key":"12","unstructured":"12. Tomiyasu,                H.,                Takahashi,              M., Fujino,                Y., Ohno,                K. and                Tsujimoto,              H.          2010. Gastrointestinal and hematologic adverse events after            administration of vincristine, cyclophosphamide, and doxorubicin in dogs with lymphoma            that underwent a combination multidrug chemotherapy protocol.              <i>J. Vet. Med. Sci.<\/i>          72: 1391\u20131397."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Tsukamoto,                A., Ohno,                K.,                Tsukagoshi,              T., Maeda,                S.,                Nakashima,              K.,              Fukushima,            K., Fujino,                Y. and                Tsujimoto,              H.          2011. Real-time ultrasonographic evaluation of canine gastric            motility in the postprandial state. <i>J. Vet. Med.              Sci.<\/i>          73: 1133\u20131138.","DOI":"10.1292\/jvms.11-0044"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Tsukamoto,                A., Ohno,                K.,                Tsukagoshi,              T., Maeda,                S.,                Nakashima,              K.,              Fukushima,            K., Fujino,                Y.,                Takeuchi,              A. and                Tsujimoto,              H.          2011. Ultrasonographic evaluation of vincristine-induced            gastric hypomotility and the prokinetic effect of mosapride in dogs.              <i>J. Vet. Intern. Med.<\/i>          25: 1461\u20131464.","DOI":"10.1111\/j.1939-1676.2011.00795.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Xu,                Z., Lan,                T., Wu,                W. and Wu,                Y.          2011. The effects of ginsenoside Rb1 on endothelial damage and            ghrelin expression induced by hyperhomocysteine. <i>J.              Vasc. Surg.<\/i>          53: 156\u2013164.","DOI":"10.1016\/j.jvs.2010.06.170"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Yanai,              M., Mochiki,                E., Ogawa,                A., Morita,                H.,                Toyomasu,              Y., Ogata,                K., Tabe,                Y., Ando,                H., Ohno,                T., Asao,                T., Aomori,                T., Fujita,                Y. and                Kuwano,            H.          2013. Intragastric administration of rikkunshito stimulates            upper gastrointestinal motility and gastric emptying in conscious dogs.              <i>J. Gastroenterol.<\/i>          48: 611\u2013619.","DOI":"10.1007\/s00535-012-0687-8"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/81\/12\/81_19-0401\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T22:34:31Z","timestamp":1579905271000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/81\/12\/81_19-0401\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.19-0401","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}