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Birkenheuer, A. J., Levy, M. G. and Breitschwerdt, E. B. 2004. Efficacy of combined atovaquone and azithromycin for therapy of chronic Babesia gibsoni (Asian genotype) infections in dogs. <i>J. Vet. Intern. Med.<\/i> 18: 494\u2013498.","DOI":"10.1111\/j.1939-1676.2004.tb02573.x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"3. Birkenheuer, A. J., Correa, M. T., Levy, M. G. and Breitschwerdt, E. B. 2005. Geographic distribution of babesiosis among dogs in the United States and association with dog bites: 150 cases (2000\u20132003). <i>J. Am. Vet. Med. Assoc.<\/i> 227: 942\u2013947.","DOI":"10.2460\/javma.2005.227.942"},{"key":"3","doi-asserted-by":"crossref","unstructured":"4. Birkenheuer, A. J., Levy, M. G., Savary, K. C., Gager, R. B. and Breitschwerdt, E. B. 1999. Babesia gibsoni infections in dogs from North Carolina. <i>J. Am. Anim. Hosp. Assoc.<\/i> 35: 125\u2013128.","DOI":"10.5326\/15473317-35-2-125"},{"key":"4","doi-asserted-by":"crossref","unstructured":"5. Birkenheuer, A. J., Marr, H. S., Wilson, J. M., Breitschwerdt, E. B. and Qurollo, B. A. 2018. Babesia gibsoni cytochrome b mutations in canine blood samples submitted to a US veterinary diagnostic laboratory. <i>J. Vet. Intern. Med.<\/i> 32: 1965\u20131969.","DOI":"10.1111\/jvim.15300"},{"key":"5","unstructured":"6. Chang, G. and Tu, C. 1992. A serological survey of canine babesiosis in Taiwan. <i>J. Chin. Soc. Vet. Sci.<\/i> 18: 125\u2013131."},{"key":"6","unstructured":"7. Chou, S. J., Wu, J. T., Liao, P. J., Huang, H. C., Wang, K. T., Chang, H. Y., Hsieh, Y. C., Lee, C. C., Wang, J. H. and Chan, K. W. 2012. Epidemiological survey of tick-borne disease of stray dogs in Yun Chia Nan areas in Taiwan. <i>Taiwan Shouyixue Zazhi<\/i> 38: 276\u2013282."},{"key":"7","doi-asserted-by":"crossref","unstructured":"8. Collett, M. G. 2000. Survey of canine babesiosis in South Africa. <i>J. S. Afr. Vet. Assoc.<\/i> 71: 180\u2013186.","DOI":"10.4102\/jsava.v71i3.710"},{"key":"8","unstructured":"9. Farwell, G. E., LeGrand, E. K. and Cobb, C. C. 1982. Clinical observations on Babesia gibsoni and Babesia canis infections in dogs. <i>J. Am. Vet. Med. Assoc.<\/i> 180: 507\u2013511."},{"key":"9","unstructured":"10. Fowler, J. L., Ruff, M. D., Fernau, R. C. and Furusho, Y. 1972. Babesia gibsoni: chemotherapy in dogs. <i>Am. J. Vet. Res.<\/i> 33: 1109\u20131114."},{"key":"10","doi-asserted-by":"crossref","unstructured":"11. Groves, M. G. and Vanniasingham, J. A. 1970. Treatment of Babesia gibsoni infections with phenamidine isethionate. <i>Vet. Rec.<\/i> 86: 8\u201310.","DOI":"10.1136\/vr.86.1.8"},{"key":"11","doi-asserted-by":"crossref","unstructured":"12. Hartelt, K., Rieker, T., Oehme, R. M., Brockmann, S. O., M\u00fcller, W. and Dorn, N. 2007. First evidence of Babesia gibsoni (Asian genotype) in dogs in Western Europe. <i>Vector Borne Zoonotic Dis.<\/i> 7: 163\u2013166.","DOI":"10.1089\/vbz.2006.0580"},{"key":"12","doi-asserted-by":"crossref","unstructured":"13. Iguchi, A., Soma, T., Suzuki, H. and Xuan, X. 2016. The epidemiological survey for atovaquone resistant related gene of Babesia gibsoni in Japan. <i>J. Vet. Med. Sci.<\/i> 78: 489\u2013491.","DOI":"10.1292\/jvms.15-0480"},{"key":"13","doi-asserted-by":"crossref","unstructured":"14. Inokuma, H., Yoshizaki, Y., Matsumoto, K., Okuda, M., Onishi, T., Nakagome, K., Kosugi, R. and Hirakawa, M. 2004. Molecular survey of Babesia infection in dogs in Okinawa, Japan. <i>Vet. Parasitol.<\/i> 121: 341\u2013346.","DOI":"10.1016\/j.vetpar.2004.03.012"},{"key":"14","doi-asserted-by":"crossref","unstructured":"15. Jefferies, R., Ryan, U. M., Muhlnickel, C. J. and Irwin, P. J. 2003. Two species of canine Babesia in Australia: detection and characterization by PCR. <i>J. Parasitol.<\/i> 89: 409\u2013412.","DOI":"10.1645\/0022-3395(2003)089[0409:TSOCBI]2.0.CO;2"},{"key":"15","doi-asserted-by":"crossref","unstructured":"16. Jefferies, R., Ryan, U. M., Jardine, J., Robertson, I. D. and Irwin, P. J. 2007. 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Parasitol.<\/i> 186: 159\u2013164.","DOI":"10.1016\/j.vetpar.2011.11.073"},{"key":"19","doi-asserted-by":"crossref","unstructured":"20. Lin, M. Y. and Huang, H. P. 2010. Use of a doxycycline-enrofloxacin-metronidazole combination with\/without diminazene diaceturate to treat naturally occurring canine babesiosis caused by Babesia gibsoni. <i>Acta Vet. Scand.<\/i> 52: 27.","DOI":"10.1186\/1751-0147-52-27"},{"key":"20","doi-asserted-by":"crossref","unstructured":"21. Macintire, D. K., Boudreaux, M. K., West, G. D., Bourne, C., Wright, J. C. and Conrad, P. A. 2002. Babesia gibsoni infection among dogs in the southeastern United States. <i>J. Am. Vet. Med. Assoc.<\/i> 220: 325\u2013329.","DOI":"10.2460\/javma.2002.220.325"},{"key":"21","doi-asserted-by":"crossref","unstructured":"22. Matsuu, A., Kawabe, A., Koshida, Y., Ikadai, H., Okano, S. and Higuchi, S. 2004. Incidence of canine Babesia gibsoni infection and subclinical infection among Tosa dogs in Aomori Prefecture, Japan. <i>J. Vet. Med. Sci.<\/i> 66: 893\u2013897.","DOI":"10.1292\/jvms.66.893"},{"key":"22","doi-asserted-by":"crossref","unstructured":"23. Matsuu, A., Koshida, Y., Kawahara, M., Inoue, K., Ikadai, H., Hikasa, Y., Okano, S. and Higuchi, S. 2004. Efficacy of atovaquone against Babesia gibsoni in vivo and in vitro. <i>Vet. Parasitol.<\/i> 124: 9\u201318.","DOI":"10.1016\/j.vetpar.2004.07.005"},{"key":"23","doi-asserted-by":"crossref","unstructured":"24. Onishi, T., Nakai, M., Goto, A., Horie, M., Nakata, E. and Kajikawa, T. 1994. Prevalence of canine babesiosis due to Babesia gibsoni in Japan. <i>Nippon Juishikai Zasshi<\/i> 47: 23\u201328.","DOI":"10.12935\/jvma1951.47.23"},{"key":"24","unstructured":"25. Otsuka, H. 1974. Studies on transmission of Babesia gibsoni Patton (1910) by Haemaphysalis longicornis Neumann (1901). <i>Bull. Fac. Agric. Miyazaki Univ.<\/i> 21: 359\u2013367."},{"key":"25","unstructured":"26. Patton, W. 1910. Preliminary report on a new piroplasm (Piroplasma gibsoni sp. nov.) found in the blood of the hounds of the Madras Hunt and subsequently discovered in the blood of the jackal Canis aureus. <i>Bull. Soc. Pathol. Exot.<\/i> 3: 274\u2013280."},{"key":"26","doi-asserted-by":"crossref","unstructured":"27. Rajamanickam, C., Wiesenhutter, E., Zin, F. M. and Hamid, J. 1985. The incidence of canine haematozoa in Peninsular Malaysia. <i>Vet. Parasitol.<\/i> 17: 151\u2013157.","DOI":"10.1016\/0304-4017(85)90101-3"},{"key":"27","doi-asserted-by":"crossref","unstructured":"28. Sakuma, M., Setoguchi, A. and Endo, Y. 2009. Possible emergence of drug-resistant variants of Babesia gibsoni in clinical cases treated with atovaquone and azithromycin. <i>J. Vet. Intern. Med.<\/i> 23: 493\u2013498.","DOI":"10.1111\/j.1939-1676.2009.0300.x"},{"key":"28","unstructured":"29. Shiranaga, N. and Inokuma, H. 2018. Effects of low-dose diminazene aceturate injection followed by clindamycin administration for treating canine Babesia gibsoni infection. <i>Jpn. J. Vet. Res.<\/i> 66: 221\u2013225."},{"key":"29","unstructured":"30. Suh, M., Shin, Y., Suh, M. and Shin, Y. 1997. Intraerythrocytic culture and development of serological diagnostic tests of Babesia gibsoni. <i>Korean J. Vet. Res.<\/i> 37: 583\u2013593."},{"key":"30","doi-asserted-by":"crossref","unstructured":"31. Suzuki, K., Wakabayashi, H., Takahashi, M., Fukushima, K., Yabuki, A. and Endo, Y. 2007. A Possible treatment strategy and clinical factors to estimate the treatment response in Bebesia gibsoni infection. <i>J. Vet. Med. Sci.<\/i> 69: 563\u2013568.","DOI":"10.1292\/jvms.69.563"},{"key":"31","doi-asserted-by":"crossref","unstructured":"32. Wong, S. S. Y., Teng, J. L. L., Poon, R. W. S., Choi, G. K. Y., Chan, K. H., Yeung, M. L., Hui, J. J. Y. and Yuen, K. Y. 2011. Comparative evaluation of a point-of-care immunochromatographic test SNAP 4Dx with molecular detection tests for vector-borne canine pathogens in Hong Kong. <i>Vector Borne Zoonotic Dis.<\/i> 11: 1269\u20131277.","DOI":"10.1089\/vbz.2010.0265"},{"key":"32","doi-asserted-by":"crossref","unstructured":"33. Wulansari, R., Wijaya, A., Ano, H., Horii, Y., Nasu, T., Yamane, S. and Makimura, S. 2003. Clindamycin in the treatment of Babesia gibsoni infections in dogs. <i>J. Am. Anim. Hosp. 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