{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:03:23Z","timestamp":1782831803393,"version":"3.54.5"},"reference-count":32,"publisher":"Japanese Society of Veterinary Science","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Vet. Med. Sci.","The Journal of Veterinary Medical Science"],"published-print":{"date-parts":[[2020]]},"DOI":"10.1292\/jvms.20-0426","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T22:05:45Z","timestamp":1599170745000},"page":"1529-1536","source":"Crossref","is-referenced-by-count":11,"title":["Changes in peripheral blood oxidative stress markers and hepatic gene          expression related to oxidative stress in Holstein cows with and without subacute ruminal          acidosis during the periparturient period"],"prefix":"10.1292","volume":"82","author":[{"given":"Yoshiyuki","family":"TSUCHIYA","sequence":"first","affiliation":[{"name":"Graduate School of Veterinary Sciences, Iwate              University, Morioka, Iwate 020-8550, Japan"},{"name":"Yamagata Prefectural Agricultural Mutual Aid              Association, Tendo, Yamagata 994-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"OZAI","sequence":"additional","affiliation":[{"name":"Cooperative Department of Veterinary Medicine, Faculty              of Agriculture, Iwate University, Morioka, Iwate 020-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"SUGINO","sequence":"additional","affiliation":[{"name":"The Research Center for Animal Science, Graduate School              of Integrated Science for Life, Hiroshima University, Higashi-Hiroshima 739-8528,              Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"KAWASHIMA","sequence":"additional","affiliation":[{"name":"Chiba Prefectural Livestock Research Center, Yachimata,              Chiba 289-1113, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"KUSHIBIKI","sequence":"additional","affiliation":[{"name":"Institute of Livestock and Grassland Science, NARO,              Tsukuba, Ibaraki 305-0901, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yo-Han","family":"KIM","sequence":"additional","affiliation":[{"name":"Cooperative Department of Veterinary Medicine, Faculty              of Agriculture, Iwate University, Morioka, Iwate 020-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"SATO","sequence":"additional","affiliation":[{"name":"Graduate School of Veterinary Sciences, Iwate              University, Morioka, Iwate 020-8550, Japan"},{"name":"Cooperative Department of Veterinary Medicine, Faculty              of Agriculture, Iwate University, Morioka, Iwate 020-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"122","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Abaker, J.                A., Xu, T.                L., Jin,                D., Chang,                G. J.,                Zhang, K.            and Shen, X.            Z.          2017. Lipopolysaccharide derived from the digestive tract            provokes oxidative stress in the liver of dairy cows fed a high-grain            diet. <i>J. Dairy Sci.<\/i>          100: 666\u2013678.","DOI":"10.3168\/jds.2016-10871"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Abuelo,              \u00c1.,              Hern\u00e1ndez,            J., Benedito,                J. L. and                Castillo,              C.          2015. The connexion between serum redox balance and            concentration of lactic acid enantiomers in dairy cows around the time of            calving. <i>Comp. Clin. Pathol.<\/i>          24: 465\u2013468.","DOI":"10.1007\/s00580-014-1975-x"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Abuelo,              A.,              Hern\u00e1ndez,            J., Benedito,                J. L. and                Castillo,              C.          2019. Redox biology in transition periods of dairy cattle:            role in the health of periparturient and neonatal animals.              <i>Antioxidants<\/i>          8: 20.","DOI":"10.3390\/antiox8010020"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Bell, A.                W. and Bauman,                D. E.          1997. Adaptations of glucose metabolism during pregnancy and            lactation. <i>J. Mammary Gland Biol.            Neoplasia<\/i>          2: 265\u2013278.","DOI":"10.1023\/A:1026336505343"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Bernabucci,                U., Ronchi,                B.,                Lacetera,              N. and                Nardone,            A.          2005. Influence of body condition score on relationships            between metabolic status and oxidative stress in periparturient dairy            cows. <i>J. Dairy Sci.<\/i>          88: 2017\u20132026.","DOI":"10.3168\/jds.S0022-0302(05)72878-2"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Botsoglou, N.                A., Fletouris,                D. J.,                Papageorgiou, G.              E., Vassilopoulos,                V. N.,                Mantis, A.              J. and Trakatellis,                A. G.          1994. Rapid, sensitive, and specific thiobarbituric acid            method for measuring lipid peroxidation in animal tissue, food, and feedstuff            samples. <i>J. Agric. Food Chem.<\/i>          42: 1931\u20131937.","DOI":"10.1021\/jf00045a019"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Cani, P.                D., Amar,                J.,                Iglesias, M.              A., Poggi,                M., Knauf,                C.,                Bastelica,              D., Neyrinck,                A. M.,              Fava, F.,                Tuohy, K.              M., Chabo,                C., Waget,                A., Delm\u00e9e,                E., Cousin,                B.,              Sulpice, T.,                Chamontin,              B.,              Ferri\u00e8res,            J., Tanti,                J. F.,                Gibson, G.              R., Casteilla,                L.,                Delzenne, N.              M., Alessi,                M. C. and                Burcelin,              R.          2007. Metabolic endotoxemia initiates obesity and insulin            resistance. <i>Diabetes<\/i>          56: 1761\u20131772.","DOI":"10.2337\/db06-1491"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Coyne, G.                S., Kenny,                D. A. and                Waters, S.              M.          2011. Effect of dietary n-3 polyunsaturated fatty acid            supplementation on bovine uterine endometrial and hepatic gene expression of the            insulin-like growth factor system.              <i>Theriogenology<\/i>          75: 500\u2013512.","DOI":"10.1016\/j.theriogenology.2010.09.018"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Domouzoglou, E.                M. and Maratos-Flier,                E.          2011. Fibroblast growth factor 21 is a metabolic regulator            that plays a role in the adaptation to ketosis. <i>Am. J.              Clin. Nutr.<\/i>          93: 901S\u20135.","DOI":"10.3945\/ajcn.110.001941"},{"key":"10","unstructured":"10. Duehlmeier,                R., Sammet,                K., Widdel,                A., von                Engelhardt, W.,                Wernery,            U., Kinne,                J. and                Sallmann, H.              P.          2007. Distribution patterns of the glucose transporters GLUT4            and GLUT1 in skeletal muscles of rats (<i>Rattus norvegicus<\/i>), pigs              (<i>Sus scrofa<\/i>), cows (<i>Bos taurus<\/i>), adult goats, goat            kids (<i>Capra hircus<\/i>), and camels (<i>Camelus            dromedarius<\/i>). <i>Comp. Biochem. Physiol. A Mol.              Integr. Physiol.<\/i>          146: 274\u2013282."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Gessner, D.                K., Schlegel,                G., Keller,                J.,              Schwarz, F.              J., Ringseis,                R. and              Eder,            K.          2013. Expression of target genes of nuclear factor E2-related            factor 2 in the liver of dairy cows in the transition period and at different stages of            lactation. <i>J. Dairy Sci.<\/i>          96: 1038\u20131043.","DOI":"10.3168\/jds.2012-5967"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Gozho, G.                N., Plaizier,                J. C.,                Krause, D.              O., Kennedy,                A. D. and                Wittenberg, K.              M.          2005. Subacute ruminal acidosis induces ruminal            lipopolysaccharide endotoxin release and triggers an inflammatory            response. <i>J. Dairy Sci.<\/i>          88: 1399\u20131403.","DOI":"10.3168\/jds.S0022-0302(05)72807-1"},{"key":"13","unstructured":"13. Guo,              Y., Xu,                X., Zou,                Y., Yang,                Z., Li,                S. and Cao,                Z.          2013. Changes in feed intake, nutrient digestion, plasma            metabolites, and oxidative stress parameters in dairy cows with subacute ruminal            acidosis and its regulation with pelleted beet pulp. <i>J.              Anim. Sci. Biotechnol.<\/i>          4: 31."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Khan, M.                J., Jacometo,                C. B.,                Graugnard, D.              E., Corr\u00eaa,                M. N.,                Schmitt,            E., Cardoso,                F. and              Loor, J.            J.          2014. Overfeeding dairy cattle during late-pregnancy alters            hepatic PPAR\u03b1-regulated pathways including hepatokines: impact on metabolism and            peripheral insulin sensitivity. <i>Gene Regul. Syst.              Bio.<\/i>          8: 97\u2013111.","DOI":"10.4137\/GRSB.S14116"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kim, Y.              H., Toji,                N., Kizaki,                K.,                Kushibiki,              S., Ichijo,                T. and              Sato,            S.          2016. Effects of dietary forage and calf starter on ruminal pH            and transcriptomic adaptation of the rumen epithelium in Holstein calves during the            weaning transition. <i>Physiol. Genomics<\/i>          48: 803\u2013809.","DOI":"10.1152\/physiolgenomics.00086.2016"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Kleen, J.                L., Hooijer,                G. A.,                Rehage, J.            and Noordhuizen, J. P. T.              M.          2003. Subacute ruminal acidosis (SARA): a            review. <i>J. Vet. Med. A Physiol. Pathol. Clin.              Med.<\/i>          50: 406\u2013414.","DOI":"10.1046\/j.1439-0442.2003.00569.x"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Lappas,              M.          2018. Expression and regulation of metallothioneins in            myometrium and fetal membranes. <i>Am. J. Reprod.              Immunol.<\/i>          80: e13040.","DOI":"10.1111\/aji.13040"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Livak, K.                J. and Schmittgen,                T. D.          2001. Analysis of relative gene expression data using            real-time quantitative PCR and the 2<sup>(-\u0394 \u0394 C(T)<\/sup>) Method.              <i>Methods<\/i>          25: 402\u2013408.","DOI":"10.1006\/meth.2001.1262"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Lopes-Marques,                M., Cunha,                I.,                Reis-Henriques, M.              A., Santos,                M. M. and                Castro, L.              F.          2013. Diversity and history of the long-chain acyl-CoA            synthetase (Acsl) gene family in vertebrates. <i>BMC Evol.              Biol.<\/i>          13: 271.","DOI":"10.1186\/1471-2148-13-271"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Maeda,              M., Kawasumi,                K., Sato,                S. and              Arai,            T.          2019. Evaluation of blood adiponectin levels as an index for            subacute ruminal acidosis in cows: a preliminary study.              <i>Vet. Res. Commun.<\/i>          43: 215\u2013224.","DOI":"10.1007\/s11259-019-09760-0"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Mavangira,                V. and                Sordillo, L.              M.          2018. Role of lipid mediators in the regulation of oxidative            stress and inflammatory responses in dairy cattle. <i>Res.              Vet. Sci.<\/i>          116: 4\u201314.","DOI":"10.1016\/j.rvsc.2017.08.002"},{"key":"22","unstructured":"22. Plaizier, J.                C., Krause,                D. O.,                Gozho, G.              N. and McBride,                B. W.          2008. Subacute ruminal acidosis in dairy cows: the            physiological causes, incidence and consequences. <i>Vet.              J.<\/i>          176: 21\u201331."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Pregel,              P., Bollo,                E.,                Cannizzo, F.              T., Biolatti,                B.,              Contato, E.            and Biolatti, P.              G.          2005. Antioxidant capacity as a reliable marker of stress in            dairy calves transported by road. <i>Vet.            Rec.<\/i>          156: 53\u201354.","DOI":"10.1136\/vr.156.2.53"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Radcliff, R.                P., McCormack,                B. L.,                Crooker, B.              A. and Lucy,                M. C.          2003. Plasma hormones and expression of growth hormone            receptor and insulin-like growth factor-I mRNA in hepatic tissue of periparturient dairy            cows. <i>J. Dairy Sci.<\/i>          86: 3920\u20133926.","DOI":"10.3168\/jds.S0022-0302(03)74000-4"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Saini-Chohan, H.                K., Mitchell,                R. W., Vaz,                F. M.,                Zelinski,              T. and Hatch,                G. M.          2012. Delineating the role of alterations in lipid metabolism            to the pathogenesis of inherited skeletal and cardiac muscle disorders: Thematic Review            Series: Genetics of Human Lipid Diseases. <i>J. Lipid              Res.<\/i>          53: 4\u201327.","DOI":"10.1194\/jlr.R012120"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Selim,              S., Salin,                S.,              Taponen, J.,                Vanhatalo,              A., Kokkonen,                T. and Elo,                K. T.          2014. Prepartal dietary energy alters transcriptional            adaptations of the liver and subcutaneous adipose tissue of dairy cows during the            transition period. <i>Physiol. Genomics<\/i>          46: 328\u2013337.","DOI":"10.1152\/physiolgenomics.00115.2013"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Shi,              X., Li,                D., Deng,                Q., Li,                Y., Sun,                G., Yuan,                X., Song,                Y., Wang,                Z., Li,                X., Li,                X. and Liu,                G.          2015. NEFAs activate the oxidative stress-mediated NF-\u03baB            signaling pathway to induce inflammatory response in calf hepatocytes.              <i>J. Steroid Biochem. Mol. Biol.<\/i>          145: 103\u2013112.","DOI":"10.1016\/j.jsbmb.2014.10.014"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Song,              Y., Li,                N., Gu,                J., Fu,                S., Peng,                Z., Zhao,                C., Zhang,                Y., Li,                X., Wang,                Z., Li,                X. and Liu,                G.          2016. \u03b2-Hydroxybutyrate induces bovine hepatocyte apoptosis            via an ROS-p38 signaling pathway. <i>J. Dairy            Sci.<\/i>          99: 9184\u20139198.","DOI":"10.3168\/jds.2016-11219"},{"key":"29","unstructured":"29. Sordillo, L.                M. and Raphael,                W.          2013. Significance of metabolic stress, lipid mobilization,            and inflammation on transition cow disorders. <i>Vet. Clin.              North Am. Food Anim. Pract.<\/i>          29: 267\u2013278."},{"key":"30","unstructured":"30. Tsuchiya,                Y., Chiba,                E., Sugino,                T.,                Kawashima,              K., Hasunuma,                T.,                Kushibiki,              S., Kim,                Y. H. and                Sato,            S.          2020. Changes in rumen fermentation, bacterial community, and            predicted functional pathway in Holstein cows with and without subacute ruminal acidosis            during the periparturient period. <i>J. Dairy            Sci.<\/i>          103: 4702\u20134716."},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Tucci,              S., Herebian,                D., Sturm,                M., Seibt,                A. and                Spiekerkoetter,              U.          2012. Tissue-specific strategies of the very-long chain            acyl-CoA dehydrogenase-deficient (VLCAD<sup>-\/-<\/sup>) mouse to compensate a defective            fatty acid \u03b2-oxidation. <i>PLoS One<\/i>          7: e45429.","DOI":"10.1371\/journal.pone.0045429"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Valko,              M.,              Leibfritz,            D., Moncol,                J., Cronin,                M. T.,                Mazur, M.            and Telser,            J.          2007. Free radicals and antioxidants in normal physiological            functions and human disease. <i>Int. J. Biochem. Cell              Biol.<\/i>          39: 44\u201384.","DOI":"10.1016\/j.biocel.2006.07.001"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/82\/10\/82_20-0426\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T03:11:24Z","timestamp":1604113884000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/82\/10\/82_20-0426\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.20-0426","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}