{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:31:31Z","timestamp":1788622291360,"version":"build-2803163510"},"reference-count":20,"publisher":"Japanese Society of Veterinary Science","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Vet. Med. Sci.","The Journal of Veterinary Medical Science"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1292\/jvms.21-0061","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T22:19:00Z","timestamp":1617920340000},"page":"911-915","source":"Crossref","is-referenced-by-count":6,"title":["Copper-associated hepatitis in a young Dalmatian dog in Japan"],"prefix":"10.1292","volume":"83","author":[{"given":"Munekazu","family":"NAKAICHI","sequence":"first","affiliation":[{"name":"Department of Veterinary Radiology, Joint Faculty of Veterinary Science, Yamaguchi University, Yamaguchi, Yamaguchi 753-8515, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshie","family":"ISERI","sequence":"additional","affiliation":[{"name":"Department of Veterinary Radiology, Joint Faculty of Veterinary Science, Yamaguchi University, Yamaguchi, Yamaguchi 753-8515, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiro","family":"HORIKIRIZONO","sequence":"additional","affiliation":[{"name":"Department of Veterinary Radiology, Joint Faculty of Veterinary Science, Yamaguchi University, Yamaguchi, Yamaguchi 753-8515, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misa","family":"KOMINE","sequence":"additional","affiliation":[{"name":"IDEXX Laboratories K.K., Koganei, Tokyo 184-8515, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harumichi","family":"ITOH","sequence":"additional","affiliation":[{"name":"Department of Veterinary Small Animal Clinical Science, Joint Faculty of Veterinary Science, Yamaguchi University, Yamaguchi, Yamaguchi 753-8515, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"SUNAHARA","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery, Joint Faculty of Veterinary Science, Yamaguchi University, Yamaguchi, Yamaguchi 753-8515, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"NEMOTO","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery, Joint Faculty of Veterinary Science, Yamaguchi University, Yamaguchi, Yamaguchi 753-8515, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhito","family":"ITAMOTO","sequence":"additional","affiliation":[{"name":"Department of Veterinary Small Animal Clinical Science, Joint Faculty of Veterinary Science, Yamaguchi University, Yamaguchi, Yamaguchi 753-8515, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"TANI","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery, Joint Faculty of Veterinary Science, Yamaguchi University, Yamaguchi, Yamaguchi 753-8515, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"122","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Bexfield, N. H., Buxton, R. J., Vicek, T. J., Day, M. J., Bailey, S. M., Haugland, S. P., Morrison, L. R., Else, R. W., Constantino-Casas, F. and Watson, P. J. 2012. Breed, age and gender distribution of dogs with chronic hepatitis in the United Kingdom. Vet. J.<\/i> 193: 124\u2013128.","DOI":"10.1016\/j.tvjl.2011.11.024"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Cooper, V. L., Carlson, M. P., Jacobson, J. and Schneider, N. R. 1997. Hepatitis and increased copper levels in a dalmatian. J. Vet. Diagn. Invest.<\/i> 9: 201\u2013203.","DOI":"10.1177\/104063879700900217"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Dirksen, K., Spee, B., Penning, L. C., van den Ingh, T. S. G. A. M., Burgener, I. A., Watson, A. L., Groot Koerkamp, M., Rothuizen, J., van Steenbeek, F. G. and Fieten, H. 2017. Gene expression patterns in the progression of canine copper-associated chronic hepatitis. PLoS One<\/i> 12: e0176826.","DOI":"10.1371\/journal.pone.0176826"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Fieten, H., Leegwater, P. A. J., Watson, A. L. and Rothuizen, J. 2012. Canine models of copper toxicosis for understanding mammalian copper metabolism. Mamm. Genome<\/i> 23: 62\u201375.","DOI":"10.1007\/s00335-011-9378-7"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Forman, O. P., Boursnell, M. E., Dunmore, B. J., Stendall, N., van den Sluis, B., Fretwell, N., Jones, C., Wijmenga, C., Rothuizen, J., van Oost, B. A., Holmes, N. G., Binns, M. M. and Jones, P. 2005. Characterization of the COMMD1 (MURR1)<\/i> mutation causing copper toxicosis in Bedlington terriers. Anim. Genet.<\/i> 36: 497\u2013501.","DOI":"10.1111\/j.1365-2052.2005.01360.x"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Haywood, S., Rutgers, H. C. and Christian, M. K. 1988. Hepatitis and copper accumulation in Skye terriers. Vet. Pathol.<\/i> 25: 408\u2013414.","DOI":"10.1177\/030098588802500602"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Hoffmann, G. 2009. Copper-associated liver diseases. Vet. Clin. North Am. Small Anim. Pract.<\/i> 39: 489\u2013511.","DOI":"10.1016\/j.cvsm.2009.02.001"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Hoffmann, G., van den Ingh, T. S., Bode, P. and Rothuizen, J. 2006. Copper-associated chronic hepatitis in Labrador Retrievers. J. Vet. Intern. Med.<\/i> 20: 856\u2013861.","DOI":"10.1111\/j.1939-1676.2006.tb01798.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Kim, Y. G., Kim, S. Y., Kim, J. H., Lee, K. K. and Yun, Y. M. 2016. Prevalence and clinical relevance of exon 2 deletion of COMMD1<\/i> in Bedlington terriers in Korea. J. Vet. Intern. Med.<\/i> 30: 1846\u20131850.","DOI":"10.1111\/jvim.14590"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Lee, S. A., Fillipich, L. J. and Hyun, C. 2007. Prevalence of the exon 2 deletion of the COMMD1 gene in Australian Bedlington terriers. J. Genet.<\/i> 86: 289\u2013291.","DOI":"10.1007\/s12041-007-0039-2"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Mandigers, P. J., van den Ingh, T. S., Bode, P., Teske, E. and Rothuizen, J. 2004. Association between liver copper concentration and subclinical hepatitis in Doberman Pinschers. J. Vet. Intern. Med.<\/i> 18: 647\u2013650.","DOI":"10.1111\/j.1939-1676.2004.tb02600.x"},{"key":"12","unstructured":"12. Napier, P. 1996. Hepatic necrosis with toxic copper levels in a two-year-old Dalmation. Can. Vet. J.<\/i> 37: 45."},{"key":"13","unstructured":"13. Noaker, L. J., Washabau, R. J., Detrisac, C. J., Heldmann, E. and Hendrick, M. J. 1999. Copper associated acute hepatic failure in a dog. J. Am. Vet. Med. Assoc.<\/i> 214: 1502\u20131506, 1495."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Pindar, S. and Ramirez, C. 2019. Predicting copper toxicosis: relationship between the ATP7A and ATP7B gene mutations and hepatic copper quantification in dogs. Hum. Genet.<\/i> 138: 541\u2013546.","DOI":"10.1007\/s00439-019-02010-y"},{"key":"15","unstructured":"15. Rifkin, J. and Miller, M. D. 2014. Copper-associated hepatitis in a Pembroke Welsh corgi. Can. Vet. J.<\/i> 55: 573\u2013576."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Smedley, R., Mullaney, T. and Rumbeiha, W. 2009. Copper-associated hepatitis in Labrador retrievers. Vet. Pathol.<\/i> 46: 484\u2013490.","DOI":"10.1354\/vp.08-VP-0197-S-FL"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Thornburg, L. P., Shaw, D., Dolan, M., Raisbeck, M., Crawford, S., Dennis, G. L. and Olwin, D. B. 1986. Hereditary copper toxicosis in West Highland white terriers. Vet. Pathol.<\/i> 23: 148\u2013154.","DOI":"10.1177\/030098588602300207"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. van De Sluis, B., Rothuizen, J., Pearson, P. L., van Oost, B. A. and Wijmenga, C. 2002. Identification of a new copper metabolism gene by positional cloning in a purebred dog population. Hum. Mol. Genet.<\/i> 11: 165\u2013173.","DOI":"10.1093\/hmg\/11.2.165"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Webb, C. B., Twedt, D. C. and Meyer, D. J. 2002. Copper-associated liver disease in Dalmatians: a review of 10 dogs (1998\u20132001). J. Vet. Intern. Med.<\/i> 16: 665\u2013668.","DOI":"10.1111\/j.1939-1676.2002.tb02405.x"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Wu, X., den Boer, E. R., Vos-Loohuis, M., Steenbeek, F. G. V., Monroe, G. R., Nijman, I. J., Leegwater, P. A. J. and Fieten, H. 2020. Investigation of genetic modifiers of copper toxicosis in Labrador retrievers. Life (Basel)<\/i> 10: 266.","DOI":"10.3390\/life10110266"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/83\/6\/83_21-0061\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:44:50Z","timestamp":1623199490000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/83\/6\/83_21-0061\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.21-0061","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}