{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T09:35:20Z","timestamp":1774344920624,"version":"3.50.1"},"reference-count":46,"publisher":"Japanese Society of Veterinary Science","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Vet. Med. Sci.","The Journal of Veterinary Medical Science"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1292\/jvms.22-0102","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T22:09:49Z","timestamp":1652911789000},"page":"914-923","source":"Crossref","is-referenced-by-count":2,"title":["The immunohistochemical detection of peroxiredoxin 1 and 2 in canine spontaneous vascular endothelial tumors"],"prefix":"10.1292","volume":"84","author":[{"given":"Narumi","family":"OTSUKA","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Pathology, Joint Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kairi","family":"ISHIMARU","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mami","family":"MURAKAMI","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Clinical Oncology, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minami","family":"GOTO","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"HIRATA","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Joint Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan"},{"name":"Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"SAKAI","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Joint Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan"},{"name":"Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"122","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Anwar, S., Yanai, T. and Sakai, H. 2016. Overexpression of Peroxiredoxin 6 protects neoplastic cells against apoptosis in canine haemangiosarcoma. <i>J. Comp. Pathol.<\/i> 155: 29\u201339.","DOI":"10.1016\/j.jcpa.2016.05.002"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Arevalo, J. A. and V\u00e1zquez-Medina, J. P. 2018. The role of peroxiredoxin 6 in cell signaling. <i>Antioxidants<\/i> 7: 172.","DOI":"10.3390\/antiox7120172"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Barata, A. G. and Dick, T. P. 2020. A role for peroxiredoxins in H<sub>2<\/sub>O<sub>2<\/sub>- and MEKK-dependent activation of the p38 signaling pathway. <i>Redox Biol.<\/i> 28: 101340.","DOI":"10.1016\/j.redox.2019.101340"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Chen, Y., Yang, S., Zhou, H. and Su, D. 2020. PRDX2 promotes the proliferation and metastasis of non-small cell lung cancer <i>in vitro<\/i> and <i>in vivo<\/i>. <i>BioMed Res. Int.<\/i> 2020: 8359860.","DOI":"10.1155\/2020\/8359860"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Dammeyer, P. and Arn\u00e9r, E. S. J. 2011. Human Protein Atlas of redox systems-what can be learnt?  <i>Biochim. Biophys. Acta<\/i> 1810: 111\u2013138.","DOI":"10.1016\/j.bbagen.2010.07.004"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Demasi, A. P. D., Ceratti, D., Furuse, C., Cury, P., Junqueira, J. L. C. and Ara\u00fajo, V. C. 2007. Expression of peroxiredoxin I in plasma cells of oral inflammatory diseases. <i>Eur. J. Oral Sci.<\/i> 115: 334\u2013337.","DOI":"10.1111\/j.1600-0722.2007.00462.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Feng, A. L., Han, X., Meng, X., Chen, Z., Li, Q., Shu, W., Dai, H., Zhu, J. and Yang, Z. 2020. PRDX2 plays an oncogenic role in esophageal squamous cell carcinoma via Wnt\/\u03b2-catenin and AKT pathways. <i>Clin. Transl. Oncol.<\/i> 22: 1838\u20131848.","DOI":"10.1007\/s12094-020-02323-9"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Goto, M., Owaki, K., Hirata, A., Yanai, T. and Sakai, H. 2019. Tumour necrosis factor-related apoptosis-inducing ligand induces apoptosis in canine hemangiosarcoma cells <i>in vitro<\/i>. <i>Vet. Comp. Oncol.<\/i> 17: 285\u2013297.","DOI":"10.1111\/vco.12471"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. He, T., Hatem, E., Vernis, L., Lei, M. and Huang, M. E. 2015. PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug. <i>J. Exp. Clin. Cancer Res.<\/i> 34: 152\u2013164.","DOI":"10.1186\/s13046-015-0270-2"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Hu, X., Lu, E., Pan, C., Xu, Y. and Zhu, X. 2020. Overexpression and biological function of PRDX6 in human cervical cancer. <i>J. Cancer<\/i> 11: 2390\u20132400.","DOI":"10.7150\/jca.39892"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Huang, S. C., Zhang, L., Sung, Y. S., Chen, C. L., Kao, Y. C., Agaram, N. P., Singer, S., Tap, W. D., D\u2019Angelo, S. and Antonescu, C. R. 2016. Recurrent CIC gene abnormalities in angiosarcomas: A molecular study of 120 cases with concurrent investigation of PLCG1, KDR, MYC, and FLT4 gene alterations. <i>Am. J. Surg. Pathol.<\/i> 40: 645\u2013655.","DOI":"10.1097\/PAS.0000000000000582"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Immenschuh, S., Baumgart-Vogt, E., Tan, M., Iwahara, S., Ramadori, G. and Fahimi, H. D. 2003. Differential cellular and subcellular localization of heme-binding protein 23\/peroxiredoxin I and heme oxygenase-1 in rat liver. <i>J. Histochem. Cytochem.<\/i> 51: 1621\u20131631.","DOI":"10.1177\/002215540305101206"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Ishii, T., Itoh, K., Akasaka, J., Yanagawa, T., Takahashi, S., Yoshida, H., Bannai, S. and Yamamoto, M. 2000. Induction of murine intestinal and hepatic peroxiredoxin MSP23 by dietary butylated hydroxyanisole. <i>Carcinogenesis<\/i> 21: 1013\u20131016.","DOI":"10.1093\/carcin\/21.5.1013"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Kinnula, V. L., Lehtonen, S., Sormunen, R., Kaarteenaho-Wiik, R., Kang, S. W., Rhee, S. G. and Soini, Y. 2002. Overexpression of peroxiredoxins I, II, III, V, and VI in malignant mesothelioma. <i>J. Pathol.<\/i> 196: 316\u2013323.","DOI":"10.1002\/path.1042"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kang, D. H., Lee, D. J., Lee, K. W., Park, Y. S., Lee, J. Y., Lee, S. H., Koh, Y. J., Koh, G. Y., Choi, C., Yu, D. Y., Kim, J. and Kang, S. W. 2011. Peroxiredoxin II is an essential antioxidant enzyme that prevents the oxidative inactivation of VEGF receptor-2 in vascular endothelial cells. <i>Mol. Cell<\/i> 44: 545\u2013558.","DOI":"10.1016\/j.molcel.2011.08.040"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Kim, J. H., Graef, A. J., Dickerson, E. B. and Modiano, J. F. 2015. Pathobiology of hemangiosarcoma in dogs: Research advances and future perspectives. <i>Vet. Sci.<\/i> 2: 388\u2013405.","DOI":"10.3390\/vetsci2040388"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Kang, S. W., Chang, T. S., Lee, T. H., Kim, E. S., Yu, D. Y. and Rhee, S. G. 2004. Cytosolic peroxiredoxin attenuates the activation of Jnk and p38 but potentiates that of Erk in Hela cells stimulated with tumor necrosis factor-\u03b1. <i>J. Biol. Chem.<\/i> 279: 2535\u20132543.","DOI":"10.1074\/jbc.M307698200"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Kim, J. H., Bogner, P. N., Baek, S. H., Ramnath, N., Liang, P., Kim, H. R., Andrews, C. and Park, Y. M. 2008. Up-regulation of peroxiredoxin 1 in lung cancer and its implication as a prognostic and therapeutic target. <i>Clin. Cancer Res.<\/i> 14: 2326\u20132333.","DOI":"10.1158\/1078-0432.CCR-07-4457"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Kim, Y. and Jang, H. H. 2019. Role of cytosolic 2-cys prx1 and prx2 in redox signaling. <i>Antioxidants<\/i> 8: 169\u2013183.","DOI":"10.3390\/antiox8060169"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Kinnula, V. L., Lehtonen, S., Kaarteenaho-Wiik, R., Lakari, E., P\u00e4\u00e4kk\u00f6, P., Kang, S. W., Rhee, S. G. and Soini, Y. 2002. Cell specific expression of peroxiredoxins in human lung and pulmonary sarcoidosis. <i>Thorax<\/i> 57: 157\u2013164.","DOI":"10.1136\/thorax.57.2.157"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Lee, S. C., Chae, H. Z., Lee, J. E., Kwon, B. D., Lee, J. B., Won, Y. H., Ahn, K. Y. and Kim, Y. P. 2000. Peroxiredoxin is ubiquitously expressed in rat skin: isotype-specific expression in the epidermis and hair follicle. <i>J. Invest. Dermatol.<\/i> 115: 1108\u20131114.","DOI":"10.1046\/j.1523-1747.2000.00177.x"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Lee, S. C., Na, Y. P. and Lee, J. B. 2003. Expression of peroxiredoxin II in vascular tumors of the skin: a novel vascular marker of endothelial cells. <i>J. Am. Acad. Dermatol.<\/i> 49: 487\u2013491.","DOI":"10.1067\/S0190-9622(03)01485-3"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Li, H. X., Sun, X. Y., Yang, S. M., Wang, Q. and Wang, Z. Y. 2018. Peroxiredoxin 1 promoted tumor metastasis and angiogenesis in colorectal cancer. <i>Pathol. Res. Pract.<\/i> 214: 655\u2013660.","DOI":"10.1016\/j.prp.2018.03.026"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Lu, E., Hu, X., Pan, C., Chen, J., Xu, Y. and Zhu, X. 2020. Up-regulation of peroxiredoxin-1 promotes cell proliferation and metastasis and inhibits apoptosis in cervical cancer. <i>J. Cancer<\/i> 11: 1170\u20131181.","DOI":"10.7150\/jca.37147"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Mei, W., Peng, Z., Lu, M., Liu, C., Deng, Z., Xiao, Y., Liu, J., He, Y., Yuan, Q., Yuan, X., Tang, D., Yang, H. and Tao, L. 2015. Peroxiredoxin 1 inhibits the oxidative stress induced apoptosis in renal tubulointerstitial fibrosis. <i>Nephrology (Carlton)<\/i> 20: 832\u2013842.","DOI":"10.1111\/nep.12515"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Mizusawa, H., Ishii, T. and Bannai, S. 2000. Peroxiredoxin I (macrophage 23 kDa stress protein) is highly and widely expressed in the rat nervous system. <i>Neurosci. Lett.<\/i> 283: 57\u201360.","DOI":"10.1016\/S0304-3940(00)00910-1"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Murai, A., Asa, S. A., Kodama, A., Hirata, A., Yanai, T. and Sakai, H. 2012. Constitutive phosphorylation of the mTORC2\/Akt\/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines. <i>BMC Vet. Res.<\/i> 8: 128\u2013141.","DOI":"10.1186\/1746-6148-8-128"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Naka, N., Tomita, Y., Nakanishi, H., Araki, N., Hongyo, T., Ochi, T. and Aozasa, K. 1997. Mutations of p53 tumor-suppressor gene in angiosarcoma. <i>Int. J. Cancer<\/i> 71: 952\u2013955.","DOI":"10.1002\/(SICI)1097-0215(19970611)71:6<952::AID-IJC7>3.0.CO;2-X"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Nicolussi, A., D\u2019Inzeo, S., Capalbo, C., Giannini, G. and Coppa, A. 2017. The role of peroxiredoxins in cancer. <i>Mol. Clin. Oncol.<\/i> 6: 139\u2013153.","DOI":"10.3892\/mco.2017.1129"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. N\u00f3brega, D. F., Sehaber, V. F., Madureira, R. and Bracarense, A. P. F. R. L. 2019. Canine cutaneous haemangiosarcoma: biomarkers and survival. <i>J. Comp. Pathol.<\/i> 166: 87\u201396.","DOI":"10.1016\/j.jcpa.2018.10.181"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Oberley, T. D., Verwiebe, E., Zhong, W., Kang, S. W. and Rhee, S. G. 2001. Localization of the thioredoxin system in normal rat kidney. <i>Free Radic. Biol. Med.<\/i> 30: 412\u2013424.","DOI":"10.1016\/S0891-5849(00)00486-X"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Riddell, J. R., Maier, P., Sass, S. N., Moser, M. T., Foster, B. A. and Gollnick, S. O. 2012. Peroxiredoxin 1 stimulates endothelial cell expression of VEGF via TLR4 dependent activation of HIF-1\u03b1. <i>PLoS One<\/i> 7: e50394.","DOI":"10.1371\/journal.pone.0050394"},{"key":"33","unstructured":"33. Roccabianca, P., Schulman, Y., Avallone, G., Foster, R., Scruggs, J., Dittmer, K. and Kiupel, M. 2021. Surgical Pathology of Tumors of Domestic Animals, Volume 3, the Armed Forces Institute of Pathology, Washington, DC."},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Schiffman, J. D. and Breen, M. 2015. Comparative oncology: what dogs and other species can teach us about humans with cancer. <i>Philos. Trans. R. Soc. Lond. B Biol. Sci.<\/i> 370: 20140231.","DOI":"10.1098\/rstb.2014.0231"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Stacey, M. M., Vissers, M. C. and Winterbourn, C. C. 2012. Oxidation of 2-cys peroxiredoxins in human endothelial cells by hydrogen peroxide, hypochlorous acid, and chloramines. <i>Antioxid. Redox Signal.<\/i> 17: 411\u2013421.","DOI":"10.1089\/ars.2011.4348"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Sun, Y. L., Cai, J. Q., Liu, F., Bi, X. Y., Zhou, L. P. and Zhao, X. H. 2015. Aberrant expression of peroxiredoxin 1 and its clinical implications in liver cancer. <i>World J. Gastroenterol.<\/i> 21: 10840\u201310852.","DOI":"10.3748\/wjg.v21.i38.10840"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Taniuchi, K., Furihata, M., Hanazaki, K., Iwasaki, S., Tanaka, K., Shimizu, T., Saito, M. and Saibara, T. 2015. Peroxiredoxin 1 promotes pancreatic cancer cell invasion by modulating p38 MAPK activity. <i>Pancreas<\/i> 44: 331\u2013340.","DOI":"10.1097\/MPA.0000000000000270"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Wang, G., Wu, M., Durham, A. C., Radaelli, E., Mason, N. J., Xu, X. and Roth, D. B. 2020. Molecular subtypes in canine hemangiosarcoma reveal similarities with human angiosarcoma. <i>PLoS One<\/i> 15: e0229728.","DOI":"10.1371\/journal.pone.0229728"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Wang, Y., Liu, M., Yang, P. and Peng, H. 2018. Peroxiredoxin 1 (PRDX1) suppresses progressions and metastasis of osteosarcoma and fibrosarcoma of bone. <i>Med. Sci. Monit.<\/i> 24: 4113\u20134120.","DOI":"10.12659\/MSM.908736"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Wong, K., Ludwig, L., Krijgsman, O., Adams, D. J., Wood, G. A. and van der Weyden, L. 2021. Comparison of the oncogenomic landscape of canine and feline hemangiosarcoma shows novel parallels with human angiosarcoma. <i>Dis. Model. Mech.<\/i> 14: dmm049044.","DOI":"10.1242\/dmm.049044"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Wood, Z. A., Schr\u00f6der, E., Robin Harris, J. and Poole, L. B. 2003. Structure, mechanism and regulation of peroxiredoxins. <i>Trends Biochem. Sci.<\/i> 28: 32\u201340.","DOI":"10.1016\/S0968-0004(02)00003-8"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Yonemaru, K., Sakai, H., Murakami, M., Yanai, T. and Masegi, T. 2006. Expression of vascular endothelial growth factor, basic fibroblast growth factor, and their receptors (flt-1, flk-1, and flg-1) in canine vascular tumors. <i>Vet. Pathol.<\/i> 43: 971\u2013980.","DOI":"10.1354\/vp.43-6-971"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Yonglitthipagon, P., Pairojkul, C., Chamgramol, Y., Loukas, A., Mulvenna, J., Bethony, J., Bhudhisawasdi, V. and Sripa, B. 2012. Prognostic significance of peroxiredoxin 1 and ezrin-radixin-moesin-binding phosphoprotein 50 in cholangiocarcinoma. <i>Hum. Pathol.<\/i> 43: 1719\u20131730.","DOI":"10.1016\/j.humpath.2011.11.021"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Zhang, S., He, J., Tang, M. and Sun, H. 2020. Prdx2 upregulation promotes the growth and survival of gastric cancer cells. <i>Pathol. Oncol. Res.<\/i> 26: 1869\u20131877.","DOI":"10.1007\/s12253-019-00783-1"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Zhao, S., Su, G., Yang, W., Yue, P., Bai, B., Lin, Y., Zhang, J., Ba, Y., Luo, Z., Liu, X., Zhao, L., Xie, Y., Xu, Y., Li, S., Meng, W., Xie, X. and Li, X. 2017. Identification and comparison of differentiation-related proteins in hepatocellular carcinoma tissues by proteomics. <i>Technol. Cancer Res. Treat.<\/i> 16: 1092\u20131101.","DOI":"10.1177\/1533034617732426"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Zhu, H., Tao, X., Zhou, L., Sheng, B., Zhu, X. and Zhu, X. 2019. Expression of thioredoxin 1 and peroxiredoxins in squamous cervical carcinoma and its predictive role in NACT. <i>BMC Cancer<\/i> 19: 865\u2013873.","DOI":"10.1186\/s12885-019-6046-x"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/84\/7\/84_22-0102\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T04:59:07Z","timestamp":1715230747000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/84\/7\/84_22-0102\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.22-0102","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"22-0102"}}