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Sci.","The Journal of Veterinary Medical Science"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1292\/jvms.22-0136","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T22:10:02Z","timestamp":1659564602000},"page":"1345-1351","source":"Crossref","is-referenced-by-count":7,"title":["Toltrazuril and diclazuril: comparative evaluation of anti-coccidial drugs          using a murine model"],"prefix":"10.1292","volume":"84","author":[{"given":"Parnian","family":"AHMADI","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Parasitic Diseases, Department              of Veterinary Sciences, Faculty of Agriculture, University of Miyazaki, Miyazaki,              Japan"},{"name":"Faculty of Veterinary Science, Balkh University, Balkh,              Afghanistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"BAAKHTARI","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science, Balkh University, Balkh,              Afghanistan"},{"name":"Laboratory of Veterinary Anatomy, Department of              Veterinary Sciences, Faculty of Agriculture, University of Miyazaki, Miyazaki,              Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"YASUDA","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Anatomy, Department of              Veterinary Sciences, Faculty of Agriculture, University of Miyazaki, Miyazaki,              Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nariaki","family":"NONAKA","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology, Faculty of Veterinary              Medicine, Hokkaido University, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"YOSHIDA","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Parasitic Diseases, Department              of Veterinary Sciences, Faculty of Agriculture, University of Miyazaki, Miyazaki,              Japan"},{"name":"Center for Animal Diseases Control, University of              Miyazaki, Miyazaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"122","reference":[{"key":"1","unstructured":"1. Bohrmann              R. 1991.            Treatment with toltrazuril in a natural outbreak of coccidiosis in            calves. <i>Dtsch Tierarztl Wochenschr<\/i>          98: 343\u2013345."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Catchpole              J, Norton              CC, Gregory              MW. 1993.            Immunisation of lambs against coccidiosis.              <i>Vet Rec<\/i>          132: 56\u201359.","DOI":"10.1136\/vr.132.3.56"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Cornelissen              AWCA,                Verstegen              R, van den                Brand              H, Perie              NM, Eysker              M, Lam              TJGM, Pijpers              A. 1995.            An observational study of <i>Eimeria<\/i> species in housed            cattle on Dutch dairy farms. <i>Vet            Parasitol<\/i>          56: 7\u201316.","DOI":"10.1016\/0304-4017(94)00671-X"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Dalloul              RA, Lillehoj              HS. 2006.            Poultry coccidiosis: recent advancements in control measures and vaccine            development. <i>Expert Rev Vaccines<\/i>          5: 143\u2013163.","DOI":"10.1586\/14760584.5.1.143"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Daugschies              A, Agneessens              J, Goossens              L, Mengel              H, Veys              P. 2007.            The effect of a metaphylactic treatment with diclazuril (Vecoxan) on the            oocyst excretion and growth performance of calves exposed to a natural Eimeria            infection. <i>Vet Parasitol<\/i>          149: 199\u2013206.","DOI":"10.1016\/j.vetpar.2007.08.003"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Daugschies              A, Najdrowski              M. 2005.            Eimeriosis in cattle: current understanding.              <i>J Vet Med B Infect Dis Vet Public Health<\/i>          52: 417\u2013427.","DOI":"10.1111\/j.1439-0450.2005.00894.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Girardi              M. 2007.            Cutaneous perspectives on adaptive immunity.              <i>Clin Rev Allergy Immunol<\/i>          33: 4\u201314.","DOI":"10.1007\/s12016-007-0040-9"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Inoue              K, Tsujio              M,                Matsubayashi              M, Inoue              R, Hatai              H, Andoh              M, Abe              K, Matsui              T, Matsuo              T. 2019.            Susceptibility to Various Coccidiostats in the Murine Coccidian Parasite              <i>Eimeria krijgsmanni<\/i>. <i>Acta              Parasitol<\/i>          64: 418\u2013422.","DOI":"10.2478\/s11686-019-00052-w"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Iqbal              A, Tariq              KA, Wazir              VS, Singh              R. 2013.            Antiparasitic efficacy of Artemisia absinthium, toltrazuril and amprolium            against intestinal coccidiosis in goats. <i>J Parasit              Dis<\/i>          37: 88\u201393.","DOI":"10.1007\/s12639-012-0137-9"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Jonsson              NN, Piper              EK, Gray              CP, Deniz              A,                Constantinoiu              CC. 2011.            Efficacy of toltrazuril 5 % suspension against <i>Eimeria              bovis<\/i> and <i>Eimeria zuernii<\/i> in calves and observations on the            associated immunopathology. <i>Parasitol            Res<\/i>          109Suppl 1:            S113\u2013S128.","DOI":"10.1007\/s00436-011-2408-2"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Kirino              Y, Tanida              M, Hasunuma              H, Kato              T, Irie              T, Horii              Y, Nonaka              N. 2015.            Increase of <i>Clostridium perfringens<\/i> in association with              <i>Eimeria<\/i> in haemorrhagic enteritis in Japanese beef            cattle. <i>Vet Rec<\/i>          177: 202.","DOI":"10.1136\/vr.103237"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Koutny              H, Joachim              A, Tichy              A,                Baumgartner              W. 2012.            Bovine <i>Eimeria<\/i> species in Austria.              <i>Parasitol Res<\/i>          110: 1893\u20131901.","DOI":"10.1007\/s00436-011-2715-7"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Lan              LH, Sun              BB, Zuo              BXZ, Chen              XQ, Du              AF. 2017.            Prevalence and drug resistance of avian <i>Eimeria<\/i> species            in broiler chicken farms of Zhejiang province, China.              <i>Poult Sci<\/i>          96: 2104\u20132109.","DOI":"10.3382\/ps\/pew499"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. \u0141ebkowska-Wieruszewska              BI, Kowalski              CJ. 2010.            Sulfachlorpyrazine residues depletion in turkey edible            tissues. <i>J Vet Pharmacol Ther<\/i>          33: 389\u2013395.","DOI":"10.1111\/j.1365-2885.2009.01147.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Le                Sueur              C, Mage              C, Mundt              HC. 2009.            Efficacy of toltrazuril (Baycox 5% suspension) in natural infections with            pathogenic Eimeria spp. in housed lambs. <i>Parasitol              Res<\/i>          104: 1157\u20131162.","DOI":"10.1007\/s00436-008-1305-9"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Li              L, Crabtree              J, Fischer              S, Pinney              D, Stoeckert              CJ              Jr, Sibley              LD, Roos              DS. 2004.            ApiEST-DB: analyzing clustered EST data of the apicomplexan            parasites. <i>Nucleic Acids Res<\/i>          32: D326\u2013D328.","DOI":"10.1093\/nar\/gkh112"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Maes              L, Coussement              W, Vanparijs              O, Marsboom              R. 1988.            In vivo action of the anticoccidial diclazuril (Clinacox) on the            developmental stages of Eimeria tenella: a histological study.              <i>J Parasitol<\/i>          74: 931\u2013938.","DOI":"10.2307\/3282212"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Metwaly              MS, Dkhil              MA,                Al-Quraishy              S. 2012.            The potential role of Phoenix dactylifera on <i>Eimeria              papillata<\/i>-induced infection in mice.              <i>Parasitol Res<\/i>          111: 681\u2013687.","DOI":"10.1007\/s00436-012-2887-9"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Mundt              HC, Bangoura              B, Mengel              H, Keidel              J, Daugschies              A. 2005.            Control of clinical coccidiosis of calves due to <i>Eimeria              bovis<\/i> and <i>Eimeria zuernii<\/i> with toltrazuril under field            conditions. <i>Parasitol Res<\/i>          97 Suppl 1:            S134\u2013S142.","DOI":"10.1007\/s00436-005-1457-9"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Mundt              HC, Bangoura              B, Rinke              M, Rosenbruch              M, Daugschies              A. 2005.            Pathology and treatment of <i>Eimeria zuernii<\/i> coccidiosis            in calves: investigations in an infection model.              <i>Parasitol Int<\/i>          54: 223\u2013230.","DOI":"10.1016\/j.parint.2005.06.003"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Mundt              HC,                Daugschies              A, Uebe              F, Rinke              M. 2003.            Efficacy of toltrazuril against artificial infections with              <i>Eimeria bovis<\/i> in calves. <i>Parasitol              Res<\/i>          90 Suppl 3:            S166\u2013S167.","DOI":"10.1007\/s00436-003-0929-z"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Mundt              HC, R\u00f6dder              F, Mengel              H, Bangoura              B, Ocak              M, Daugschies              A. 2007.            Control of coccidiosis due to <i>Eimeria bovis<\/i> and              <i>Eimeria zuernii<\/i> in calves with toltrazuril under field conditions in            comparison with diclazuril and untreated controls.              <i>Parasitol Res<\/i>          101: 93\u2013104.","DOI":"10.1007\/s00436-007-0616-6"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Philippe              P, Alzieu              JP, Taylor              MA, Dorchies              P. 2014.            Comparative efficacy of diclazuril (Vecoxan<sup>\u00ae<\/sup>) and toltrazuril            (Baycox bovis\u00ae) against natural infections of <i>Eimeria bovis<\/i> and              <i>Eimeria zuernii<\/i> in French calves. <i>Vet              Parasitol<\/i>          206: 129\u2013137.","DOI":"10.1016\/j.vetpar.2014.10.003"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Ramadan              A, Abo                el-Sooud              K, el-Bahy              MM. 1997.            Anticoccidial efficacy of toltrazuril and halofuginone against              <i>Eimeria tenella<\/i> infection in broiler chickens in            Egypt. <i>Res Vet Sci<\/i>          62: 175\u2013178.","DOI":"10.1016\/S0034-5288(97)90142-9"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Roberts              SJ, Smith              AL, West              AB, Wen              L, Findly              RC, Owen              MJ, Hayday              AC. 1996.            T-cell \u03b1 \u03b2 <sup>+<\/sup> and \u03b3 \u03b4 <sup>+<\/sup> deficient mice display            abnormal but distinct phenotypes toward a natural, widespread infection of the            intestinal epithelium. <i>Proc Natl Acad Sci            USA<\/i>          93: 11774\u201311779.","DOI":"10.1073\/pnas.93.21.11774"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Romero              J, Sanabria              R, Traver\u00eda              G, Di Paolo              L, Peralta              L. 2013.            Metaphylactic effect of Diclazuril 0.25% in suckling beef calves, during            a coccidiosis outbreak in extensive farming. <i>Vet              Parasitol<\/i>          193: 277\u2013280.","DOI":"10.1016\/j.vetpar.2012.11.022"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Rose              ME, Hesketh              P, Wakelin              D. 1992.            Immune control of murine coccidiosis: CD4<sup>+<\/sup> and CD8<sup>+<\/sup>            T lymphocytes contribute differentially in resistance to primary and secondary            infections. <i>Parasitology<\/i>          105: 349\u2013354.","DOI":"10.1017\/S0031182000074515"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Rose              ME, Hesketh              P. 1984.            Infection with <i>Eimeria tenella<\/i>: modulation of lymphocyte            blastogenesis by specific antigen, and evidence for immunodepression.              <i>J Protozool<\/i>          31: 549\u2013553.","DOI":"10.1111\/j.1550-7408.1984.tb05500.x"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Rose              ME, Owen              DG, Hesketh              P. 1984.            Susceptibility to coccidiosis: effect of strain of mouse on reproduction            of <i>Eimeria vermiformis<\/i>.              <i>Parasitology<\/i>          88: 45\u201354.","DOI":"10.1017\/S0031182000054330"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Schito              ML, Barta              JR. 1997.            Nonspecific immune responses and mechanisms of resistance to              <i>Eimeria papillata<\/i> infections in mice.              <i>Infect Immun<\/i>          65: 3165\u20133170.","DOI":"10.1128\/iai.65.8.3165-3170.1997"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Shivaramaiah              C, Barta              JR,                Hernandez-Velasco              X, T\u00e9llez              G, Hargis              BM. 2014.            Coccidiosis: recent advancements in the immunobiology of              <i>Eimeria<\/i> species, preventive measures, and the importance of            vaccination as a control tool against these Apicomplexan parasites.              <i>Vet Med (Auckl)<\/i>          5: 23\u201334.","DOI":"10.2147\/VMRR.S57839"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Smith              AL, Hayday              AC. 2000.            Genetic dissection of primary and secondary responses to a widespread            natural pathogen of the gut, <i>Eimeria vermiformis<\/i>.              <i>Infect Immun<\/i>          68: 6273\u20136280.","DOI":"10.1128\/IAI.68.11.6273-6280.2000"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Steinfelder              S, Lucius              R, Greif              G, Pogonka              T. 2005.            Treatment of mice with the anticoccidial drug Toltrazuril does not            interfere with the development of a specific cellular intestinal immune response to              <i>Eimeria falciformis<\/i>. <i>Parasitol              Res<\/i>          97: 458\u2013465.","DOI":"10.1007\/s00436-005-1464-x"},{"key":"34","unstructured":"34. Takeo              T, Tanaka              T,                Matsubayashi              M, Tsujio              M,                Umemiya-Shirafuji              R, Tsuji              N, Fujisaki              K, Matsui              T, Matsuo              T. 2015.            Evaluation of <i>Eimeria krijgsmanni<\/i> as a murine model for            testing the efficacy of anti-parasitic agents. <i>Acta              Parasitol<\/i>          60: 190\u2013195."},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Takeuchi              O, Akira              S. 2010.            Pattern recognition receptors and inflammation.              <i>Cell<\/i>          140: 805\u2013820.","DOI":"10.1016\/j.cell.2010.01.022"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Taylor              MA, Catchpole              J, Marshall              J, Marshall              RN, Hoeben              D. 2003.            Histopathological observations on the activity of diclazuril (Vecoxan)            against the endogenous stages of Eimeria crandallis in sheep.              <i>Vet Parasitol<\/i>          116: 305\u2013314.","DOI":"10.1016\/S0304-4017(03)00256-5"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Taylor              MA, Marshall              RN, Marshall              JA, Catchpole              J, Bartram              D. 2011.            Dose-response effects of diclazuril against pathogenic species of ovine            coccidia and the development of protective immunity. <i>Vet              Parasitol<\/i>          178: 48\u201357.","DOI":"10.1016\/j.vetpar.2010.12.024"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Verheyen              A, Maes              L, Coussement              W, Vanparijs              O, Lauwers              F, Vlaminckx              E, Borgers              M, Marsboom              R. 1988.              <i>In vivo<\/i> action of the anticoccidial diclazuril            (Clinacox) on the developmental stages of <i>Eimeria tenella<\/i>: an            ultrastructural evaluation. <i>J            Parasitol<\/i>          74: 939\u2013949.","DOI":"10.2307\/3282213"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Veronesi              F, Diaferia              M, Viola              O, Fioretti              DP. 2011.            Long-term effect of toltrazuril on growth performances of dairy heifers            and beef calves exposed to natural <i>Eimeria zuernii<\/i> and <i>Eimeria              bovis<\/i> infections. <i>Vet J<\/i>          190: 296\u2013299.","DOI":"10.1016\/j.tvjl.2010.10.009"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/84\/10\/84_22-0136\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T05:00:18Z","timestamp":1715230818000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/84\/10\/84_22-0136\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.22-0136","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"22-0136"}}