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Aksglaede L, S\u00f8rensen K, Boas M, Mouritsen A, Hagen CP, Jensen RB, Petersen JH, Linneberg A, Andersson AM, Main KM, Skakkeb\u00e6k NE, Juul A.  2010. Changes in anti-M\u00fcllerian hormone (AMH) throughout the life span: a population-based study of 1027 healthy males from birth (cord blood) to the age of 69 years. <i>J Clin Endocrinol Metab<\/i> 95: 5357\u20135364.","DOI":"10.1210\/jc.2010-1207"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Al-Attar L, No\u00ebl K, Dutertre M, Belville C, Forest MG, Burgoyne PS, Josso N, Rey R.  1997. Hormonal and cellular regulation of Sertoli cell anti-M\u00fcllerian hormone production in the postnatal mouse. <i>J Clin Invest<\/i> 100: 1335\u20131343.","DOI":"10.1172\/JCI119653"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Almeida J, Conley AJ, Ball BA.  2013. Expression of anti-M\u00fcllerian hormone, CDKN1B, connexin 43, androgen receptor and steroidogenic enzymes in the equine cryptorchid testis. <i>Equine Vet J<\/i> 45: 538\u2013545.","DOI":"10.1111\/evj.12013"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Amann RP, Veeramachaneni DNR.  2007. Cryptorchidism in common eutherian mammals. <i>Reproduction<\/i> 133: 541\u2013561.","DOI":"10.1530\/REP-06-0272"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Barnes MA, Boockfor FR, Bierley ST, Kazmer GW, Halman RD, Dickey JF.  1981. Effect of unilateral castration and unilateral cryptorchidism on gonadotropin and testosterone response to gonadotropin releasing hormone in the bull. <i>J Anim Sci<\/i> 53: 1341\u20131350.","DOI":"10.2527\/jas1981.5351341x"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Chemes HE, Rey RA, Nistal M, Regadera J, Musse M, Gonz\u00e1lez-Peramato P, Serrano A.  2008. Physiological androgen insensitivity of the fetal, neonatal, and early infantile testis is explained by the ontogeny of the androgen receptor expression in Sertoli cells. <i>J Clin Endocrinol Metab<\/i> 93: 4408\u20134412.","DOI":"10.1210\/jc.2008-0915"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Cimino I, Casoni F, Liu X, Messina A, Parkash J, Jamin SP, Catteau-Jonard S, Collier F, Baroncini M, Dewailly D, Pigny P, Prescott M, Campbell R, Herbison AE, Prevot V, Giacobini P.  2016. Novel role for anti-M\u00fcllerian hormone in the regulation of GnRH neuron excitability and hormone secretion. <i>Nat Commun<\/i> 7: 10055.","DOI":"10.1038\/ncomms10055"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Davenport M, Brain C, Vandenberg C, Zappala S, Duffy P, Ransley PG, Grant D.  1995. The use of the hCG stimulation test in the endocrine evaluation of cryptorchidism. <i>Br J Urol<\/i> 76: 790\u2013794.","DOI":"10.1111\/j.1464-410X.1995.tb00776.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. De Briyne N, Berg C, Blaha T, Temple D.  2016. Pig castration: will the EU manage to ban pig castration by 2018? <i>Porcine Health Manag<\/i> 2: 29.","DOI":"10.1186\/s40813-016-0046-x"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Devillers MM, Petit F, Cluzet V, Fran\u00e7ois CM, Giton F, Garrel G, Cohen-Tannoudji J, Guigon CJ.  2019. FSH inhibits AMH to support ovarian estradiol synthesis in infantile mice. <i>J Endocrinol<\/i> 240: 215\u2013228.","DOI":"10.1530\/JOE-18-0313"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Ewoldt JM.  2008. Surgery of the scrotum. <i>Vet Clin North Am Food Anim Pract<\/i> 24: 253\u2013266, vi.","DOI":"10.1016\/j.cvfa.2008.02.001"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Gutzwiller A, Ampuero Kragten S.  2013. Suppression of boar taint in cryptorchid pigs using a vaccine against the gonadotropin-releasing hormone. <i>Schweiz Arch Tierheilkd<\/i> 155: 677\u2013680.","DOI":"10.1024\/0036-7281\/a000533"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Janett F, Gerig T, Tschuor AC, Amatayakul-Chantler S, Walker J, Howard R, Bollwein H, Thun R.  2012. Vaccination against gonadotropin-releasing factor (GnRF) with Bopriva significantly decreases testicular development, serum testosterone levels and physical activity in pubertal bulls. <i>Theriogenology<\/i> 78: 182\u2013188.","DOI":"10.1016\/j.theriogenology.2012.01.035"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Janett F, Gerig T, Tschuor AC, Amatayakul-Chantler S, Walker J, Howard R, Piechotta M, Bollwein H, Hartnack S, Thun R.  2012. Effect of vaccination against gonadotropin-releasing factor (GnRF) with Bopriva<sup>\u00ae<\/sup> in the prepubertal bull calf. <i>Anim Reprod Sci<\/i> 131: 72\u201380.","DOI":"10.1016\/j.anireprosci.2012.02.012"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kaneko Y, Torisu S, Kitahara G, Hidaka Y, Satoh H, Asanuma T, Mizutani S, Osawa T, Naganobu K.  2015. Laparoscopic cryptorchidectomy in standing bulls. <i>J Vet Med Sci<\/i> 77: 631\u2013635.","DOI":"10.1292\/jvms.14-0587"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Karolewski L da SL, Fernandes V, Souza LAF de, Baise G de F, Piau J\u00fanior R, Ribeiro R de CL.  2020. Testicular features of semi\u2013confined Nellore bulls subjected to immunocastration. <i>Braz J Vet Res Anim Sci<\/i> 57: e171210.","DOI":"10.11606\/issn.1678-4456.bjvras.2020.171210"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Kellaway RC, Seamark RF, Farrant RK.  1971. Sterilisation of cattle by induced cryptorchidism. <i>Aust Vet J<\/i> 47: 547\u2013550.","DOI":"10.1111\/j.1751-0813.1971.tb02052.x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Kitahara G, El-Sheikh Ali H, Sato T, Kobayashi I, Hemmi K, Shirao Y, Kamimura S.  2012. Anti-M\u00fcllerian hormone (AMH) profiles as a novel biomarker to evaluate the existence of a functional cryptorchid testis in Japanese Black calves. <i>J Reprod Dev<\/i> 58: 310\u2013315.","DOI":"10.1262\/jrd.11-072T"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Kitahara G, Kamata R, Sasaki Y, El-Sheikh Ali H, Mido S, Kobayashi I, Hemmi K, Osawa T.  2016. Changes in peripheral anti-M\u00fcllerian hormone concentration and their relationship with testicular structure in beef bull calves. <i>Domest Anim Endocrinol<\/i> 57: 127\u2013132.","DOI":"10.1016\/j.domaniend.2016.06.005"},{"key":"20","unstructured":"20. Leslie SW, Sajjad H, Villanueva CA.  2022, Cryptorchidism. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470270\/ [accessed on October 27, 2022]."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. McCue PM.  2014. Diagnostic endocrinology: hCG stimulation test. <i>Equine Reproductive Procedures<\/i> 153: 496\u2013497.","DOI":"10.1002\/9781118904398.ch153"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Monle\u00f3n E, Noya A, Carmen Garza M, Ripoll G, Sanz A.  2020. Effects of an anti-gonadotrophin releasing hormone vaccine on the morphology, structure and function of bull testes. <i>Theriogenology<\/i> 141: 211\u2013218.","DOI":"10.1016\/j.theriogenology.2019.07.019"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Nguyen DV, Nguyen OC, Malau-Aduli AEO.  2021. Main regulatory factors of marbling level in beef cattle. <i>Vet Anim Sci<\/i> 14: 100219.","DOI":"10.1016\/j.vas.2021.100219"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Pasqualini T, Chemes H, Rivarla MA.  1981. Testicular testosterone levels during puberty in cryptorchidism. <i>Clin Endocrinol (Oxf)<\/i> 15: 545\u2013554.","DOI":"10.1111\/j.1365-2265.1981.tb00700.x"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Rota A, Ballarin C, Vigier B, Cozzi B, Rey R.  2002. Age dependent changes in plasma anti-M\u00fcllerian hormone concentrations in the bovine male, female, and freemartin from birth to puberty: relationship between testosterone production and influence on sex differentiation. <i>Gen Comp Endocrinol<\/i> 129: 39\u201344.","DOI":"10.1016\/S0016-6480(02)00514-2"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Rouiller-Fabre V, Carmona S, Merhi RA, Cate R, Habert R, Vigier B.  1998. Effect of anti-M\u00fcllerian hormone on Sertoli and Leydig cell functions in fetal and immature rats. <i>Endocrinology<\/i> 139: 1213\u20131220.","DOI":"10.1210\/endo.139.3.5785"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Schanbacher BD.  1979. Testosterone secretion in cryptorchid and intact bulls injected with gonadotropin-releasing hormone and luteinizing hormone. <i>Endocrinology<\/i> 104: 360\u2013364.","DOI":"10.1210\/endo-104-2-360"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Schanbacher BD.  1980. Androgen response of cryptorchid and intact rams to ovine LH. <i>J Reprod Fertil<\/i> 59: 151\u2013154.","DOI":"10.1530\/jrf.0.0590151"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Schanbacher BD, Pratt BR.  1985. Response of a cryptorchid stallion to vaccination against luteinising hormone releasing hormone. <i>Vet Rec<\/i> 116: 74\u201375.","DOI":"10.1136\/vr.116.3.74"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Srisuwatanasagul K, Srisuwatanasagul S, Roongsitthichai A.  2021. Expressions of cytochrome P450 aromatase and anti-M\u00fcllerian hormone in testes of fattening pigs by the timing of the first vaccination for immunocastration. <i>Reprod Domest Anim<\/i> 56: 400\u2013407.","DOI":"10.1111\/rda.13875"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. St Jean G, Gaughan EM, Constable PD.  1992. Cryptorchidism in North American cattle: breed predisposition and clinical findings. <i>Theriogenology<\/i> 38: 951\u2013958.","DOI":"10.1016\/0093-691X(92)90169-R"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Stupka R, \u010c\u00edtek J, Vehovsk\u00fd K, Zadinov\u00e1 K, Okrouhl\u00e1 M, Urbanov\u00e1 D, St\u00e1dn\u00edk L.  2017. Effects of immunocastration on growth performance, body composition, meat quality, and boar taint. <i>Czech J Anim Sci<\/i> 62: 249\u2013258.","DOI":"10.17221\/99\/2016-CJAS"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Teh A, Izzati UZ, Mori K, Fuke N, Hirai T, Kitahara G, Yamaguchi R.  2018. Histological and immunohistochemical evaluation of granulosa cells during different stages of folliculogenesis in bovine ovaries. <i>Reprod Domest Anim<\/i> 53: 569\u2013581.","DOI":"10.1111\/rda.13132"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Theubet G, Thun R, Hilbe M, Janett F.  2010. Wirkung einer Impfung gegen GnRH (Bopriva\u00ae) beim m\u00e4nnlichen pubert\u00e4ren Kalb. <i>Schweiz Arch Tierheilkd<\/i> 152: 459\u2013469 (in German).","DOI":"10.1024\/0036-7281\/a000106"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Umer S, Sammad A, Zou H, Khan A, Weldegebriall Sahlu B, Hao H, Zhao X, Wang Y, Zhao S, Zhu H.  2019. Regulation of AMH, AMHR\u2013II, and BMPs (2,6) genes of bovine granulosa cells treated with exogenous FSH and their association with protein hormones. <i>Genes (Basel)<\/i> 10: 1038.","DOI":"10.3390\/genes10121038"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. van Helden J, Evliyaoglu O, Weiskirchen R.  2019. Has GnRH a direct role in AMH regulation? <i>Clin Endocrinol (Oxf)<\/i> 90: 827\u2013833.","DOI":"10.1111\/cen.13967"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Young J, Chanson P, Salenave S, No\u00ebl M, Brailly S, O\u2019Flaherty M, Schaison G, Rey R.  2005. 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