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Catania S, Bilato D, Gobbo F, Granato A, Terregino C, Iob L, Nicholas RA.  2010. Treatment of eggshell abnormalities and reduced egg production caused by <i>Mycoplasma synoviae<\/i> infection. <i>Avian Dis<\/i> 54: 961\u2013964.","DOI":"10.1637\/9121-110309-Case.1"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Catania S, Gobbo F, Bilato D, Gagliazzo L, Moronato ML, Terregino C, Bradbury JM, Ram\u00edrez AS.  2016. Two strains of <i>Mycoplasma synoviae<\/i> from chicken flocks on the same layer farm differ in their ability to produce eggshell apex abnormality. <i>Vet Microbiol<\/i> 193: 60\u201366.","DOI":"10.1016\/j.vetmic.2016.08.007"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Chen X, Miflin JK, Zhang P, Blackall PJ.  1996. Development and application of DNA probes and PCR tests for <i>Haemophilus paragallinarum<\/i>. <i>Avian Dis<\/i> 40: 398\u2013407.","DOI":"10.2307\/1592238"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Cisneros-Tamayo M, Kempf I, Coton J, Michel V, Bougeard S, de Boiss\u00e9son C, Lucas P, B\u00e4yon-Auboyer MH, Chiron G, Mindus C, Gautier-Bouchardon AV.  2020. Investigation on eggshell apex abnormality (EAA) syndrome in France: isolation of <i>Mycoplasma synoviae<\/i> is frequently associated with <i>Mycoplasma pullorum<\/i>. <i>BMC Vet Res<\/i> 16: 271.","DOI":"10.1186\/s12917-020-02487-0"},{"key":"5","unstructured":"5. European Medicines Agency (EMA). 2022. Product information: Nobilis MS Live, lyophilisate for oculonasal suspension for chickens. https:\/\/medicines.health.europa.eu\/veterinary\/en\/documents\/download\/ef1fa36e-3129-4ba9-b685-cfbe3929c446 [accessed on March 4, 2025]."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Feberwee A, de Wit JJ, Landman WJM.  2009. Induction of eggshell apex abnormalities by <i>Mycoplasma synoviae<\/i>: field and experimental studies. <i>Avian Pathol<\/i> 38: 77\u201385.","DOI":"10.1080\/03079450802662772"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Feberwee A, Morrow CJ, Ghorashi SA, Noormohammadi AH, Landman WJM.  2009. Effect of a live <i>Mycoplasma synoviae<\/i> vaccine on the production of eggshell apex abnormalities induced by a <i>M. synoviae<\/i> infection preceded by an infection with infectious bronchitis virus D1466. <i>Avian Pathol<\/i> 38: 333\u2013340.","DOI":"10.1080\/03079450903183652"},{"key":"8","unstructured":"8. Ferguson-Noel N, Noormohammadi AH.  2020. <i>Mycoplasma synoviae<\/i> Infection. pp. 924\u2013929. In: Diseases of Poultry, 14th ed. (Swayne DE, Boulianne M, Logue CM eds.), Wiley-Blackwell, Hoboken."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Jeon EO, Kim JN, Lee HR, Koo BS, Min KC, Han MS, Lee SB, Bae YJ, Mo JS, Cho SH, Lee CH, Mo IP.  2014. Eggshell apex abnormalities associated with <i>Mycoplasma synoviae<\/i> infection in layers. <i>J Vet Sci<\/i> 15: 579\u2013582.","DOI":"10.4142\/jvs.2014.15.4.579"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Kleven SH.  2008. Control of avian mycoplasma infections in commercial poultry. <i>Avian Dis<\/i> 52: 367\u2013374.","DOI":"10.1637\/8323-041808-Review.1"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Kleven SH, Fletcher OJ, Davis RB.  1975. Influence of strain of <i>Mycoplasma synoviae<\/i> and route of infection on development of synovitis or airsacculitis in broilers. <i>Avian Dis<\/i> 19: 126\u2013135.","DOI":"10.2307\/1588963"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Kleven SH, King DD, Anderson DP.  1972. Airsacculitis in broilers from <i>Mycoplasma synoviae<\/i>: effect on air-sac lesions of vaccinating with infectious bronchitis and Newcastle virus. <i>Avian Dis<\/i> 16: 915\u2013924.","DOI":"10.2307\/1588772"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Kursa O, Paku\u0142a A, Tomczyk G, Pa\u015bko S, Sawicka A.  2019. Eggshell apex abnormalities caused by two different <i>Mycoplasma synoviae<\/i> genotypes and evaluation of eggshell anomalies by full-field optical coherence tomography. <i>BMC Vet Res<\/i> 15: 1.","DOI":"10.1186\/s12917-018-1758-8"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Landman WJ, Feberwee A.  2004. Aerosol-induced <i>Mycoplasma synoviae<\/i> arthritis: the synergistic effect of infectious bronchitis virus infection. <i>Avian Pathol<\/i> 33: 591\u2013598.","DOI":"10.1080\/03079450400013170"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Lockaby SB, Hoerr FJ, Lauerman LH, Kleven SH.  1998. Pathogenicity of <i>Mycoplasma synoviae<\/i> in broiler chickens. <i>Vet Pathol<\/i> 35: 178\u2013190.","DOI":"10.1177\/030098589803500303"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Mase M, Tsukamoto K, Imai K, Yamaguchi S.  2004. Phylogenetic analysis of avian infectious bronchitis virus strains isolated in Japan. <i>Arch Virol<\/i> 149: 2069\u20132078.","DOI":"10.1007\/s00705-004-0369-9"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Morrow CJ, Markham JF, Whithear KG.  1998. Production of temperature-sensitive clones of <i>Mycoplasma synoviae<\/i> for evaluation as live vaccines. <i>Avian Dis<\/i> 42: 667\u2013670.","DOI":"10.2307\/1592700"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Nanthakumar T, Kataria RS, Tiwari AK, Butchaiah G, Kataria JM.  2000. Pathotyping of Newcastle disease viruses by RT-PCR and restriction enzyme analysis. <i>Vet Res Commun<\/i> 24: 275\u2013286.","DOI":"10.1023\/A:1006403017578"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Raviv Z, Ferguson-Noel N, Laibinis V, Wooten R, Kleven SH.  2007. Role of <i>Mycoplasma synoviae<\/i> in commercial layer <i>Escherichia coli<\/i> peritonitis syndrome. <i>Avian Dis<\/i> 51: 685\u2013690.","DOI":"10.1637\/0005-2086(2007)51[685:ROMSIC]2.0.CO;2"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Wetzel AN, Lefevre KM, Raviv Z.  2010. Revised <i>Mycoplasma synoviae vlhA<\/i> PCRs. <i>Avian Dis<\/i> 54: 1292\u20131297.","DOI":"10.1637\/9349-033010-ResNote.1"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Whithear KG.  1996. Control of avian mycoplasmoses by vaccination. <i>Rev Sci Tech<\/i> 15: 1527\u20131553.","DOI":"10.20506\/rst.15.4.985"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. 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