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In: Canine Internal Medicine Secrets (Rubin SI, Carr AP edrs.), Mosby St. Louis.","DOI":"10.1016\/B978-1-56053-629-1.50020-0"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Fukuda K, Date H, Doi S, Fukumoto Y, Fukushima N, Hatano M, Ito H, Kuwana M, Matsubara H, Momomura SI, Nishimura M, Ogino H, Satoh T, Shimokawa H, Yamauchi-Takihara K, Tatsumi K, Ishibashi-Ueda H, Yamada N, Yoshida S, Abe K, Ogawa A, Ogo T, Kasai T, Kataoka M, Kawakami T, Kogaki S, Nakamura M, Nakayama T, Nishizaki M, Sugimura K, Tanabe N, Tsujino I, Yao A, Akasaka T, Ando M, Kimura T, Kuriyama T, Nakanishi N, Nakanishi T, Tsutsui H. Japanese Circulation Society and the Japanese Pulmonary Circulation and Pulmonary Hypertension Society Joint Working Group. 2019. Guidelines for the treatment of pulmonary hypertension (JCS 2017\/JPCPHS 2017). <i>Circ J<\/i> 83: 842\u2013945.","DOI":"10.1253\/circj.CJ-66-0158"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Greet V, Bode EF, Dukes-McEwan J, Oliveira P, Connolly DJ, Sargent J.  2021. Clinical features and outcome of dogs and cats with bidirectional and continuous right-to-left shunting patent ductus arteriosus. <i>J Vet Intern Med<\/i> 35: 780\u2013788.","DOI":"10.1111\/jvim.16072"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Heath D, Edwards JE.  1958. The pathology of hypertensive pulmonary vascular disease; a description of six grades of structural changes in the pulmonary arteries with special reference to congenital cardiac septal defects. <i>Circulation<\/i> 18: 533\u2013547.","DOI":"10.1161\/01.CIR.18.4.533"},{"key":"8","unstructured":"8. Iizuka T, Hoshi K, Ohmaki M, Sakata I.  2010. Surgical ligation of patent ductus arterisus suspected severe pulmonary hypertension in a dog.<i>Abv Anim Cardiol<\/i> 42: 43\u201348."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Kurihara J, Sahara T, Kato H.  1990. Protective effect of beraprost sodium, a new chemically stable prostacyclin analogue, against the deterioration of baroreceptor reflex following transient global cerebral ischaemia in dogs. <i>Br J Pharmacol<\/i> 99: 91\u201396.","DOI":"10.1111\/j.1476-5381.1990.tb14659.x"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Michelakis ED.  2003. The role of the NO axis and its therapeutic implications in pulmonary arterial hypertension. <i>Heart Fail Rev<\/i> 8: 5\u201321.","DOI":"10.1023\/A:1022150819223"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Miller MW, Gordon SG, Saunders AB, Arsenault WG, Meurs KM, Lehmkuhl LB, Bonagura JD, Fox PR.  2006. Angiographic classification of patent ductus arteriosus morphology in the dog. <i>J Vet Cardiol<\/i> 8: 109\u2013114.","DOI":"10.1016\/j.jvc.2006.07.001"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Nakamura K, Yamasaki M, Ohta H, Sasaki N, Murakami M, Bandula Kumara WR, Takiguchi M.  2011. Effects of sildenafil citrate on five dogs with Eisenmenger\u2019s syndrome. <i>J Small Anim Pract<\/i> 52: 595\u2013598.","DOI":"10.1111\/j.1748-5827.2011.01127.x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Oswald GP, Orton EC.  1993. Patent ductus arteriosus and pulmonary hypertension in related Pembroke Welsh corgis. <i>J Am Vet Med Assoc<\/i> 202: 761\u2013764.","DOI":"10.2460\/javma.1993.202.05.761"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Oyamada J, Toyono M, Shimada S, Aoki-Okazaki M, Tamura M, Takahashi T.  2009. Long-term administration of beraprost sodium for pulmonary arterial hypertension associated with congenital heart disease. <i>Intern Med<\/i> 48: 1531\u20131534.","DOI":"10.2169\/internalmedicine.48.2251"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Philip R, Nathaniel Johnson J, Naik R, Kimura D, Boston U, Chilakala S, Hendrickson B, Rush Waller B, Sathanandam S.  2019. Effect of patent ductus arteriosus on pulmonary vascular disease. <i>Congenit Heart Dis<\/i> 14: 37\u201341.","DOI":"10.1111\/chd.12702"},{"key":"16","unstructured":"16. Plumb DC.  2018. Plumb\u2019s Veterinary Drug Handbook. Ninth ed., Pharma Vet Inc., Stockholm."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Pyle RL, Park RD, Alexander AF, Hill BL.  1981. Patent ductus arteriosus with pulmonary hypertension in the dog. <i>J Am Vet Med Assoc<\/i> 178: 565\u2013571.","DOI":"10.2460\/javma.1981.178.06.565"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Schrope DP.  2015. Prevalence of congenital heart disease in 76,301 mixed-breed dogs and 57,025 mixed-breed cats. <i>J Vet Cardiol<\/i> 17: 192\u2013202.","DOI":"10.1016\/j.jvc.2015.06.001"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Seibert RL, Maisenbacher HW 3rd, Prosek R, Adin DB, Arsenault WG, Estrada AH.  2010. Successful closure of left-to-right patent ductus arteriosus in three dogs with concurrent pulmonary hypertension. <i>J Vet Cardiol<\/i> 12: 67\u201373.","DOI":"10.1016\/j.jvc.2009.12.002"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Seiji K, Tsuda M, Matsuhashi T, Takase K, Miyachi H, Yamada T, Ishibashi T, Higano S, Takahashi S.  2009. Treatment of in-stent restenosis with beraprost sodium: an experimental study of short- and intermediate-term effects in dogs. <i>Clin Exp Pharmacol Physiol<\/i> 36: 1164\u20131169.","DOI":"10.1111\/j.1440-1681.2009.05209.x"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Suzuki R, Yuchi Y, Saito T, Teshima T, Matsumoto H, Koyama H.  2022. Investigation of beraprost sodium on cardiac function and hemodynamics in canine models of chronic pulmonary hypertension. <i>Front Vet Sci<\/i> 9: 876178.","DOI":"10.3389\/fvets.2022.876178"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Suzuki R, Yuchi Y, Saito T, Yasumura Y, Teshima T, Matsumoto H, Koyama H.  2022. Beraprost Sodium for Pulmonary Hypertension in Dogs: Effect on Hemodynamics and Cardiac Function. <i>Animals (Basel)<\/i> 12: 2078.","DOI":"10.3390\/ani12162078"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Velayati A, Valerio MG, Shen M, Tariq S, Lanier GM, Aronow WS.  2016. Update on pulmonary arterial hypertension pharmacotherapy. <i>Postgrad Med<\/i> 128: 460\u2013473.","DOI":"10.1080\/00325481.2016.1188664"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Winter RL, Remaks JD, Newhard DK.  2020. Development of spontaneous echocardiographic contrast after transarterial occlusion of a patent ductus arteriosus in an adult dog with concurrent pulmonary hypertension. <i>Front Vet Sci<\/i> 7: 103.","DOI":"10.3389\/fvets.2020.00103"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Yamashita M, Shibazaki A.  2008. 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