{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:01:38Z","timestamp":1757617298361,"version":"3.44.0"},"reference-count":13,"publisher":"Japanese Society of Veterinary Science","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Vet. Med. Sci.","The Journal of Veterinary Medical Science"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1292\/jvms.25-0301","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T22:06:22Z","timestamp":1753740382000},"page":"1092-1094","source":"Crossref","is-referenced-by-count":0,"title":["Comparative evaluation of anesthetic effects of medetomidine\u2013midazolam\u2013butorphanol and medetomidine\u2013remimazolam\u2013butorphanol administered subcutaneously and intraperitoneally in C57BL\/6J mice"],"prefix":"10.1292","volume":"87","author":[{"given":"Takeru","family":"SASAKI","sequence":"first","affiliation":[{"name":"Laboratory of Laboratory Animal Science and Medicine, School of Veterinary Medicine, Kitasato University, Aomori, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"WATANABE","sequence":"additional","affiliation":[{"name":"Laboratory of Laboratory Animal Science and Medicine, School of Veterinary Medicine, Kitasato University, Aomori, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"OMORI","sequence":"additional","affiliation":[{"name":"Laboratory of Laboratory Animal Science and Medicine, School of Veterinary Medicine, Kitasato University, Aomori, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"NAKANISHI","sequence":"additional","affiliation":[{"name":"Laboratory of Laboratory Animal Science and Medicine, School of Veterinary Medicine, Kitasato University, Aomori, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuya","family":"SASAKI","sequence":"additional","affiliation":[{"name":"Laboratory of Laboratory Animal Science and Medicine, School of Veterinary Medicine, Kitasato University, Aomori, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"122","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Al Shoyaib A, Archie SR, Karamyan VT.  2019. Intraperitoneal route of drug administration: should it be used in experimental animal studies? <i>Pharm Res<\/i> 37: 12.","DOI":"10.1007\/s11095-019-2745-x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Doi M, Morita K, Takeda J, Sakamoto A, Yamakage M, Suzuki T.  2020. Efficacy and safety of remimazolam versus propofol for general anesthesia: a multicenter, single-blind, randomized, parallel-group, phase IIb\/III trial. <i>J Anesth<\/i> 34: 543\u2013553.","DOI":"10.1007\/s00540-020-02788-6"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Kanto JH.  1985. Midazolam: the first water-soluble benzodiazepine. Pharmacology, pharmacokinetics and efficacy in insomnia and anesthesia. <i>Pharmacotherapy<\/i> 5: 138\u2013155.","DOI":"10.1002\/j.1875-9114.1985.tb03411.x"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Kawai S, Takagi Y, Kaneko S, Kurosawa T.  2011. Effect of three types of mixed anesthetic agents alternate to ketamine in mice. <i>Exp Anim<\/i> 60: 481\u2013487.","DOI":"10.1538\/expanim.60.481"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Keam SJ.  2020. Remimazolam: first approval. <i>Drugs<\/i> 80: 625\u2013633.","DOI":"10.1007\/s40265-020-01299-8"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Kirihara Y, Takechi M, Kurosaki K, Kobayashi Y, Kurosawa T.  2013. Anesthetic effects of a mixture of medetomidine, midazolam and butorphanol in two strains of mice. <i>Exp Anim<\/i> 62: 173\u2013180.","DOI":"10.1538\/expanim.62.173"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Kirihara Y, Takechi M, Kurosaki K, Kobayashi Y, Saito Y, Takeuchi T.  2015. Anesthetic effects of a three-drugs mixture\u2014comparison of administrative routes and antagonistic effects of atipamezole in mice. <i>Exp Anim<\/i> 64: 39\u201347.","DOI":"10.1538\/expanim.14-0039"},{"key":"8","unstructured":"8. Miwa Y, Tsubota K, Kurihara T.  2019. Effect of midazolam, medetomidine, and butorphanol tartrate combination anesthetic on electroretinograms of mice. <i>Mol Vis<\/i> 25: 645\u2013653."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Navarro KL, Huss M, Smith JC, Sharp P, Marx JO, Pacharinsak C.  2021. Mouse anesthesia: the art and science. <i>ILAR J<\/i> 62: 238\u2013273.","DOI":"10.1093\/ilar\/ilab016"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Savola JM, Ruskoaho H, Puurunen J, Salonen JS, K\u00e4rki NT.  1986. Evidence for medetomidine as a selective and potent agonist at alpha 2-adrenoreceptors. <i>J Auton Pharmacol<\/i> 6: 275\u2013284.","DOI":"10.1111\/j.1474-8673.1986.tb00654.x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Shibuta H, Yamana R, Kashimoto J, Kamio K, Suda A.  2020. Comparison of the anesthetic effect by the injection route of mixed anesthesia (medetomidine, midazolam and butorphanol) and the effect of this anesthetic agent on the respiratory function. <i>J Vet Med Sci<\/i> 82: 35\u201342.","DOI":"10.1292\/jvms.19-0438"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Watanabe M, Nikaido Y, Sasaki N.  2024. Validation of the anesthetic effect of a mixture of remimazolam, medetomidine, and butorphanol in three mouse strains. <i>Exp Anim<\/i> 73: 223\u2013232.","DOI":"10.1538\/expanim.23-0158"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Wiltshire HR, Kilpatrick GJ, Tilbrook GS, Borkett KM.  2012. A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): Part II. Population pharmacokinetic and pharmacodynamic modeling and simulation. <i>Anesth Analg<\/i> 115: 284\u2013296.","DOI":"10.1213\/ANE.0b013e318241f68a"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/87\/9\/87_25-0301\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T03:18:04Z","timestamp":1757128684000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/87\/9\/87_25-0301\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.25-0301","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"type":"print","value":"0916-7250"},{"type":"electronic","value":"1347-7439"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"25-0301"}}