{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T22:47:37Z","timestamp":1776120457815,"version":"3.50.1"},"reference-count":104,"publisher":"Japanese Society of Veterinary Science","issue":"12","funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Vet. Med. Sci.","The Journal of Veterinary Medical Science"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1292\/jvms.25-0304","type":"journal-article","created":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T22:08:02Z","timestamp":1760306882000},"page":"1441-1450","source":"Crossref","is-referenced-by-count":2,"title":["Pathogenicity analysis and control strategies to combat avian diseases: mechanisms of increased virulence of Marek\u2019s disease virus and the development of vaccines against poultry red mites"],"prefix":"10.1292","volume":"87","author":[{"given":"Shiro","family":"MURATA","sequence":"first","affiliation":[{"name":"Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan"},{"name":"Veterinary Research Unit, International Institute for Zoonosis Control, Hokkaido University, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"122","reference":[{"key":"1","unstructured":"1. Abdigoudarzi M, Mirafzali MS, Belgheiszadeh H. 2013. Human infestation with Dermanyssus gallinae<\/i> (Acari: Dermanyssidae) in a family referred with pruritus and skin lesions. J Arthropod Borne Dis<\/i> 8: 119\u2013123."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Ariizumi T, Murata S, Fujisawa S, Isezaki M, Maekawa N, Okagawa T, Sato T, Oishi E, Taneno A, Konnai S, Ohashi K. 2021. Selection of reference genes for quantitative PCR analysis in poultry red mite (Dermanyssus gallinae<\/i>). J Vet Med Sci<\/i> 83: 558\u2013565.","DOI":"10.1292\/jvms.20-0677"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Ariizumi T, Murata S, Fujisawa S, Isezaki M, Sato T, Oishi E, Taneno A, Ichii O, Maekawa N, Okagawa T, Konnai S, Ohashi K. 2022. In vitro<\/i> evaluation of a cysteine protease from poultry red mites, Demanyssus gallinae<\/i>, as a vaccine antigen for chickens. Poult Sci<\/i> 101: 101638.","DOI":"10.1016\/j.psj.2021.101638"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Bartley K, Chen W, Lloyd Mills RI, Nunn F, Price DRG, Rombauts S, Van de Peer Y, Roy L, Nisbet AJ, Burgess STG. 2021. Transcriptomic analysis of the poultry red mite, Dermanyssus gallinae<\/i>, across all stages of the lifecycle. BMC Genomics<\/i> 22: 248.","DOI":"10.1186\/s12864-021-07547-9"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Bartley K, Huntley JF, Wright HW, Nath M, Nisbet AJ. 2012. Assessment of cathepsin D and L-like proteinases of poultry red mite, Dermanyssus gallinae<\/i> (De Geer), as potential vaccine antigens. Parasitology<\/i> 139: 755\u2013765.","DOI":"10.1017\/S0031182011002356"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Bartley K, Nisbet AJ, Offer JE, Sparks NH, Wright HW, Huntley JF. 2009. Histamine release factor from Dermanyssus gallinae<\/i> (De Geer): characterization and in vitro<\/i> assessment as a protective antigen. Int J Parasitol<\/i> 39: 447\u2013456.","DOI":"10.1016\/j.ijpara.2008.09.006"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Bartley K, Turnbull F, Wright HW, Huntley JF, Palarea-Albaladejo J, Nath M, Nisbet AJ. 2017. Field evaluation of poultry red mite (Dermanyssus gallinae<\/i>) native and recombinant prototype vaccines. Vet Parasitol<\/i> 244: 25\u201334.","DOI":"10.1016\/j.vetpar.2017.06.020"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Bartley K, Wright HW, Huntley JF, Manson ED, Inglis NF, McLean K, Nath M, Bartley Y, Nisbet AJ. 2015. Identification and evaluation of vaccine candidate antigens from the poultry red mite (Dermanyssus gallinae<\/i>). Int J Parasitol<\/i> 45: 819\u2013830.","DOI":"10.1016\/j.ijpara.2015.07.004"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Bellido-Mart\u00edn B, Rijnink WF, Iervolino M, Kuiken T, Richard M, Fouchier RAM. 2025. Evolution, spread and impact of highly pathogenic H5 avian influenza A viruses. Nat Rev Microbiol<\/i>; Online ahead of print.","DOI":"10.1038\/s41579-025-01189-4"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Boodhoo N, Gurung A, Sharif S, Behboudi S. 2016. Marek\u2019s disease in chickens: a review with focus on immunology. Vet Res<\/i> 47: 119.","DOI":"10.1186\/s13567-016-0404-3"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Brown AC, Baigent SJ, Smith LP, Chattoo JP, Petherbridge LJ, Hawes P, Allday MJ, Nair V. 2006. Interaction of MEQ protein and C-terminal-binding protein is critical for induction of lymphomas by Marek\u2019s disease virus. Proc Natl Acad Sci USA<\/i> 103: 1687\u20131692.","DOI":"10.1073\/pnas.0507595103"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Burgess STG, Bartley K, Nunn F, Wright HW, Hughes M, Gemmell M, Haldenby S, Paterson S, Rombauts S, Tomley FM, Blake DP, Pritchard J, Schicht S, Strube C, \u00d8ines \u00d8, Van Leeuwen T, Van de Peer Y, Nisbet AJ. 2018. Draft genome assembly of the poultry red mite, Dermanyssus gallinae<\/i>. Microbiol Resour Announc<\/i> 7: e01221\u2013e18.","DOI":"10.1128\/mra.01221-18"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Calnek BW. 2001. Pathogenesis of Marek\u2019s disease virus infection. Curr Top Microbiol Immunol<\/i> 255: 25\u201355.","DOI":"10.1007\/978-3-642-56863-3_2"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Camarda A, Pugliese N, Bevilacqua A, Circella E, Gradoni L, George D, Sparagano O, Giangaspero A. 2018. Efficacy of a novel neem oil formulation (RP03\u2122) to control the poultry red mite Dermanyssus gallinae<\/i>. Med Vet Entomol<\/i> 32: 290\u2013297.","DOI":"10.1111\/mve.12296"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Chu TT, Murano T, Uno Y, Usui T, Yamaguchi T. 2015. Molecular epidemiological characterization of poultry red mite, Dermanyssus gallinae<\/i>, in Japan. J Vet Med Sci<\/i> 77: 1397\u20131403.","DOI":"10.1292\/jvms.15-0203"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Ciloglu A, Yildirim A, Onder Z, Yetismis G, Duzlu O, Simsek E, Inci A. 2020. Molecular characterization of poultry red mite, Dermanyssus gallinae<\/i> lineages in Turkey and first report of Plasmodium<\/i> species in the mite populations. Int J Acarol<\/i> 46: 241\u2013246.","DOI":"10.1080\/01647954.2020.1758775"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Cinotti E, Labeille B, Bernigaud C, Fang F, Chol C, Chermette R, Guillot J, Cambazard F, Perrot JL. 2015. Dermoscopy and confocal microscopy for in vivo<\/i> detection and characterization of Dermanyssus gallinae<\/i> mite. J Am Acad Dermatol<\/i> 73: e15\u2013e16.","DOI":"10.1016\/j.jaad.2015.03.022"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Conradie AM, Bertzbach LD, Bhandari N, Parcells M, Kaufer BB. 2019. A common live-attenuated avian herpesvirus vaccine expresses a very potent oncogene. MSphere<\/i> 4: e00658\u2013e19.","DOI":"10.1128\/mSphere.00658-19"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Conradie AM, Bertzbach LD, Trimpert J, Patria JN, Murata S, Parcells MS, Kaufer BB. 2020. Distinct polymorphisms in a single herpesvirus gene are capable of enhancing virulence and mediating vaccinal resistance. PLoS Pathog<\/i> 16: e1009104.","DOI":"10.1371\/journal.ppat.1009104"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Decru E, Mul M, Nisbet AJ, Vargas Navarro AH, Chiron G, Walton J, Norton T, Roy L, Sleeckx N. 2020. Possibilities for IPM strategies in European laying hen farms for improved control of the poultry red mite (Dermanyssus gallinae<\/i>): details and state of affairs. Front Vet Sci<\/i> 7: 565866.","DOI":"10.3389\/fvets.2020.565866"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. de la Fuente J, Ghosh S. 2024. Evolution of tick vaccinology. Parasitology<\/i> 151: 1045\u20131052.","DOI":"10.1017\/S003118202400043X"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Deng X, Li X, Shen Y, Qiu Y, Shi Z, Shao D, Jin Y, Chen H, Ding C, Li L, Chen P, Ma Z. 2010. The Meq oncoprotein of Marek\u2019s disease virus interacts with p53 and inhibits its transcriptional and apoptotic activities. Virol J<\/i> 7: 348.","DOI":"10.1186\/1743-422X-7-348"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Di Palma A, Giangaspero A, Cafiero MA, Germinara GS. 2012. A gallery of the key characters to ease identification of Dermanyssus gallinae<\/i> (Acari: Gamasida: Dermanyssidae) and allow differentiation from Ornithonyssus sylviarum<\/i> (Acari: Gamasida: Macronyssidae). Parasit Vectors<\/i> 5: 104.","DOI":"10.1186\/1756-3305-5-104"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Dolatyabi S, Renu S, Schrock J, Renukaradhya GJ. 2024. Chitosan-nanoparticle-based oral Salmonella enteritidis subunit vaccine elicits cross-protection against Salmonella typhimurium in broilers. Poult Sci<\/i> 103: 103569.","DOI":"10.1016\/j.psj.2024.103569"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Dunn JR, Black Pyrkosz A, Steep A, Cheng HH. 2019. Identification of Marek\u2019s disease virus genes associated with virulence of US strains. J Gen Virol<\/i> 100: 1132\u20131139.","DOI":"10.1099\/jgv.0.001288"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Dunn JR, Silva RF. 2012. Ability of MEQ-deleted MDV vaccine candidates to adversely affect lymphoid organs and chicken weight gain. Avian Dis<\/i> 56: 494\u2013500.","DOI":"10.1637\/10062-011812-Reg.1"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Fujisawa S, Murata S, Isezaki M, Ariizumi T, Sato T, Oishi E, Taneno A, Maekawa N, Okagawa T, Ichii O, Konnai S, Ohashi K. 2021. Characterization of a novel cysteine protease inhibitor from poultry red mites: potential vaccine for chickens. Vaccines (Basel)<\/i> 9: 1472.","DOI":"10.3390\/vaccines9121472"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Fujisawa S, Murata S, Isezaki M, Ariizumi T, Sato T, Oishi E, Taneno A, Maekawa N, Okagawa T, Ichii O, Konnai S, Ohashi K. 2022. Characterization of a copper transporter 1 from Dermanyssus gallinae<\/i> as a vaccine antigen. Parasitology<\/i> 149: 105\u2013115.","DOI":"10.1017\/S0031182021001608"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Fujisawa S, Murata S, Isezaki M, Oishi E, Taneno A, Maekawa N, Okagawa T, Konnai S, Ohashi K. 2020. Transcriptome dynamics of blood-fed and starved poultry red mites, Dermanyssus gallinae<\/i>. Parasitol Int<\/i> 78: 102156.","DOI":"10.1016\/j.parint.2020.102156"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Fujisawa S, Murata S, Takehara M, Aoyama J, Morita A, Isezaki M, Win SY, Ariizumi T, Sato T, Oishi E, Taneno A, Maekawa N, Okagawa T, Ichii O, Konnai S, Ohashi K. 2021. In vitro<\/i> characterization of adipocyte plasma membrane-associated protein from poultry red mites, Dermanyssus gallinae<\/i>, as a vaccine antigen for chickens. Vaccine<\/i> 39: 6057\u20136066.","DOI":"10.1016\/j.vaccine.2021.08.104"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Fulton JE, Arango J, Wolc A. 2025. Effect of MHC haplotype on mortality due to Marek\u2019s disease in commercial laying hens. Animals (Basel)<\/i> 15: 1647.","DOI":"10.3390\/ani15111647"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Horio F, Seo H, Win SY, Sato J, Motai Y, Yamagami S, Sato T, Ohishi E, Maekawa N, Okagawa T, Konnai S, Ohashi K, Murata S. 2025. Characterization of a lipocalin-like molecule from Dermanyssus gallinae<\/i> as a potential vaccine antigen. Vet Immunol Immunopathol<\/i> 283: 110921.","DOI":"10.1016\/j.vetimm.2025.110921"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Hwang ET. 2023. Management of the poultry red mite Dermanyssus gallinae<\/i> with physical control methods by inorganic material and future perspectives. Poult Sci<\/i> 102: 102772.","DOI":"10.1016\/j.psj.2023.102772"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Jansson DS, Otman F, Lundqvist L, H\u00f6glund J, Engstr\u00f6m A, Chirico J. 2014. Northern fowl mite (Ornithonyssus sylviarum<\/i>) in Sweden. Med Vet Entomol<\/i> 28: 443\u2013446.","DOI":"10.1111\/mve.12053"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Jones D, Lee L, Liu JL, Kung HJ, Tillotson JK. 1992. Marek disease virus encodes a basic-leucine zipper gene resembling the fos\/jun oncogenes that is highly expressed in lymphoblastoid tumors. Proc Natl Acad Sci USA<\/i> 89: 4042\u20134046.","DOI":"10.1073\/pnas.89.9.4042"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Kavallari A, K\u00fcster T, Papadopoulos E, Hondema LS, \u00d8ines \u00d8, Skov J, Sparagano O, Tiligada E. 2018. Avian mite dermatitis: Diagnostic challenges and unmet needs. Parasite Immunol<\/i> 40: e12539.","DOI":"10.1111\/pim.12539"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Koenraadt CJ, Dicke M. 2010. The role of volatiles in aggregation and host-seeking of the haematophagous poultry red mite Dermanyssus gallinae<\/i> (Acari: Dermanyssidae). Exp Appl Acarol<\/i> 50: 191\u2013199.","DOI":"10.1007\/s10493-009-9305-8"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Kumar P, Dong H, Lenihan D, Gaddamanugu S, Katneni U, Shaikh S, Tavlarides-Hontz P, Reddy SM, Peters W, Parcells MS. 2012. Selection of a recombinant Marek\u2019s disease virus in vivo<\/i> through expression of the Marek\u2019s EcoRI-Q (Meq)-encoded oncoprotein: characterization of an rMd5-based mutant expressing the Meq of strain RB-1B. Avian Dis<\/i> 56: 328\u2013340.","DOI":"10.1637\/9955-100611-Reg.1"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Lee LF, Kreager K, Heidari M, Zhang H, Lupiani B, Reddy SM, Fadly A. 2013. Properties of a meq<\/i>-deleted rmd5 Marek\u2019s disease vaccine: protection against virulent MDV challenge and induction of lymphoid organ atrophy are simultaneously attenuated by serial passage in vitro<\/i>. Avian Dis<\/i> 57Suppl: 491\u2013497.","DOI":"10.1637\/10388-092612-Reg.1"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Lee SI, Takagi M, Ohashi K, Sugimoto C, Onuma M. 2000. Difference in the meq<\/i> gene between oncogenic and attenuated strains of Marek\u2019s disease virus serotype 1. J Vet Med Sci<\/i> 62: 287\u2013292.","DOI":"10.1292\/jvms.62.287"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Lesna I, Sabelis MW, van Niekerk TG, Komdeur J. 2012. Laboratory tests for controlling poultry red mites (Dermanyssus gallinae<\/i>) with predatory mites in small \u2018laying hen\u2019 cages. Exp Appl Acarol<\/i> 58: 371\u2013383.","DOI":"10.1007\/s10493-012-9596-z"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Li K, Liu Y, Xu Z, Zhang Y, Luo D, Gao Y, Qian Y, Bao C, Liu C, Zhang Y, Qi X, Cui H, Wang Y, Gao L, Wang X. 2019. Avian oncogenic herpesvirus antagonizes the cGAS-STING DNA-sensing pathway to mediate immune evasion. PLoS Pathog<\/i> 15: e1007999.","DOI":"10.1371\/journal.ppat.1007999"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Liao Y, Lupiani B, Izumiya Y, Reddy SM. 2021. Marek\u2019s disease virus Meq oncoprotein interacts with chicken HDAC 1 and 2 and mediates their degradation via proteasome dependent pathway. Sci Rep<\/i> 11: 637.","DOI":"10.1038\/s41598-020-80792-2"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Liao Y, Reddy SM, Khan OA, Sun A, Lupiani B. 2021. A novel effective and safe vaccine for prevention of Marek\u2019s disease caused by infection with a very virulent plus (vv+) Marek\u2019s disease virus. Vaccines (Basel)<\/i> 9: 159.","DOI":"10.3390\/vaccines9020159"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Lima-Barbero JF, Contreras M, Bartley K, Price DRG, Nunn F, Sanchez-Sanchez M, Prado E, H\u00f6fle U, Villar M, Nisbet AJ, de la Fuente J. 2019. Reduction in oviposition of poultry red mite (Dermanyssus gallinae<\/i>) in hens vaccinated with recombinant Akirin. Vaccines (Basel)<\/i> 7: 121.","DOI":"10.3390\/vaccines7030121"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Lima-Barbero JF, Contreras M, Mateos-Hern\u00e1ndez L, Mata-Lorenzo FM, Triguero-Oca\u00f1a R, Sparagano O, Finn RD, Strube C, Price DRG, Nunn F, Bartley K, H\u00f6fle U, Boadella M, Nisbet AJ, Fuente J, Villar M. 2019. A vaccinology approach to the identification and characterization of Dermanyssus gallinae<\/i> candidate protective antigens for the control of poultry red mite infestations. Vaccines (Basel)<\/i> 7: 190.","DOI":"10.3390\/vaccines7040190"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Liu JL, Kung HJ. 2000. Marek\u2019s disease herpesvirus transforming protein MEQ: a c-Jun analogue with an alternative life style. Virus Genes<\/i> 21: 51\u201364.","DOI":"10.1007\/978-1-4615-1707-8_5"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Liu JL, Teng M, Zheng LP, Zhu FX, Ma SX, Li LY, Zhang ZH, Chai SJ, Yao Y, Luo J. 2023. Emerging hypervirulent Marek\u2019s disease virus variants significantly overcome protection conferred by commercial vaccines. Viruses<\/i> 15: 1434.","DOI":"10.3390\/v15071434"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Lupiani B, Lee LF, Cui X, Gimeno I, Anderson A, Morgan RW, Silva RF, Witter RL, Kung HJ, Reddy SM. 2004. Marek\u2019s disease virus-encoded Meq<\/i> gene is involved in transformation of lymphocytes but is dispensable for replication. Proc Natl Acad Sci USA<\/i> 101: 11815\u201311820.","DOI":"10.1073\/pnas.0404508101"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Machida Y, Murata S, Matsuyama-Kato A, Isezaki M, Taneno A, Sakai E, Konnai S, Ohashi K. 2017. Isolation and purification of Gallid herpesvirus 2<\/i> strains currently distributed in Japan. J Vet Med Sci<\/i> 79: 115\u2013122.","DOI":"10.1292\/jvms.16-0329"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Masier S, Taudi\u00e8re A, Roy LJM, Carrasco D, Barnagaud JY, Planchon C, Souli\u00e9 AS, Sleeckx N, Roy L. 2023. High-throughput behavioral phenotyping of tiny arthropods: Chemosensory traits in a mesostigmatic hematophagous mite. J Exp Zool A Ecol Integr Physiol<\/i> 339: 46\u201362.","DOI":"10.1002\/jez.2651"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Matsuyama-Kato A, Iseki H, Boodhoo N, Bavananthasivam J, Alqazlan N, Abdul-Careem MF, Plattner BL, Behboudi S, Sharif S. 2022. Phenotypic characterization of gamma delta (\u03b3\u03b4) T cells in chickens infected with or vaccinated against Marek\u2019s disease virus. Virology<\/i> 568: 115\u2013125.","DOI":"10.1016\/j.virol.2022.01.012"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Matsuyama-Kato A, Shojadoost B, Boodhoo N, Raj S, Alizadeh M, Fazel F, Fletcher C, Zheng J, Gupta B, Abdul-Careem MF, Plattner BL, Behboudi S, Sharif S. 2023. Activated chicken gamma delta T cells are involved in protective immunity against Marek\u2019s disease. Viruses<\/i> 15: 285.","DOI":"10.3390\/v15020285"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Mescolini G, Lupini C, Felice V, Guerrini A, Silveira F, Cecchinato M, Catelli E. 2019. Molecular characterization of the meq<\/i> gene of Marek\u2019s disease viruses detected in unvaccinated backyard chickens reveals the circulation of low- and high-virulence strains. Poult Sci<\/i> 98: 3130\u20133137.","DOI":"10.3382\/ps\/pez095"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Motai Y, Murata S, Sato J, Nishi A, Maekawa N, Okagawa T, Konnai S, Ohashi K. 2024. Characterization of a very short Meq protein isoform in a Marek\u2019s disease virus strain in Japan. Vet Sci<\/i> 11: 43.","DOI":"10.3390\/vetsci11010043"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Murata S, Hashiguchi T, Hayashi Y, Yamamoto Y, Matsuyama-Kato A, Takasaki S, Isezaki M, Onuma M, Konnai S, Ohashi K. 2013. Characterization of Meq proteins from field isolates of Marek\u2019s disease virus in Japan. Infect Genet Evol<\/i> 16: 137\u2013143.","DOI":"10.1016\/j.meegid.2012.12.032"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Murata S, Machida Y, Isezaki M, Maekawa N, Okagawa T, Konnai S, Ohashi K. 2020. Genetic characterization of a Marek\u2019s disease virus strain isolated in Japan. Virol J<\/i> 17: 186.","DOI":"10.1186\/s12985-020-01456-1"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58. Murata S, Okada T, Kano R, Hayashi Y, Hashiguchi T, Onuma M, Konnai S, Ohashi K. 2011. Analysis of transcriptional activities of the Meq proteins present in highly virulent Marek\u2019s disease virus strains, RB1B and Md5. Virus Genes<\/i> 43: 66\u201371.","DOI":"10.1007\/s11262-011-0612-x"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Murata S, Taniguchi A, Isezaki M, Fujisawa S, Sakai E, Taneno A, Ichii O, Ito T, Maekawa N, Okagawa T, Konnai S, Ohashi K. 2021. Characterisation of a cysteine protease from poultry red mites and its potential use as a vaccine for chickens. Parasite<\/i> 28: 9.","DOI":"10.1051\/parasite\/2021005"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60. Murata S, Yamamoto E, Sakashita N, Maekawa N, Okagawa T, Konnai S, Ohashi K. 2021. Research Note: Characterization of S-Meq containing the deletion in Meq protein\u2019s transactivation domain in a Marek\u2019s disease virus strain in Japan. Poult Sci<\/i> 100: 101461.","DOI":"10.1016\/j.psj.2021.101461"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61. Murillo AC, Mullens BA. 2020. Collecting and monitoring for northern fowl mite (Acari: Macronyssidae) and poultry red mite (Acari: Dermanyssidae) in poultry systems. J Insect Sci<\/i> 20: 12.","DOI":"10.1093\/jisesa\/ieaa032"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62. Navarrete-Dechent C, Uribe P. 2018. A case of gamasoidosis caused by Dermanyssus gallinae<\/i>, misdiagnosed as delusional parasitosis. Clin Exp Dermatol<\/i> 43: 950\u2013952.","DOI":"10.1111\/ced.13687"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63. Padhi A, Parcells MS. 2016. Positive selection drives rapid evolution of the meq<\/i> oncogene of Marek\u2019s disease virus. PLoS One<\/i> 11: e0162180.","DOI":"10.1371\/journal.pone.0162180"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64. Price DRG, K\u00fcster T, \u00d8ines \u00d8, Oliver EM, Bartley K, Nunn F, Lima Barbero JF, Pritchard J, Karp-Tatham E, Hauge H, Blake DP, Tomley FM, Nisbet AJ. 2019. Evaluation of vaccine delivery systems for inducing long-lived antibody responses to Dermanyssus gallinae<\/i> antigen in laying hens. Avian Pathol<\/i> 48supl: S60\u2013S74.","DOI":"10.1080\/03079457.2019.1612514"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65. Raele DA, Galante D, Pugliese N, La Salandra G, Lomuto M, Cafiero MA. 2018. First report of Coxiella burnetii<\/i> and Borrelia burgdorferi<\/i> sensu lato in poultry red mites, Dermanyssus gallinae<\/i> (Mesostigmata, Acari<\/i>), related to urban outbreaks of dermatitis in Italy. New Microbes New Infect<\/i> 23: 103\u2013109.","DOI":"10.1016\/j.nmni.2018.01.004"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66. Renz KG, Cooke J, Clarke N, Cheetham BF, Hussain Z, Fakhrul Islam AFM, Tannock GA, Walkden-Brown SW. 2012. Pathotyping of Australian isolates of Marek\u2019s disease virus and association of pathogenicity with meq<\/i> gene polymorphism. Avian Pathol<\/i> 41: 161\u2013176.","DOI":"10.1080\/03079457.2012.656077"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67. R\u00fcster V, L\u00fcckemann AK, Wittmann M, Strube C, Bartels T. 2023. Successful long-term control of poultry red mite (Dermanyssus gallinae<\/i>) infestations in floor-kept laying hens via integrated pest management-a case report. Parasitol Res<\/i> 122: 2549\u20132555.","DOI":"10.1007\/s00436-023-07954-9"},{"key":"68","doi-asserted-by":"crossref","unstructured":"68. Sabsabi MA, Kheimar A, You Y, von La Roche D, H\u00e4rtle S, G\u00f6bel TW, von Heyl T, Schusser B, Kaufer BB. 2024. Unraveling the role of \u03b3\u03b4 T cells in the pathogenesis of an oncogenic avian herpesvirus. MBio<\/i> 15: e0031524.","DOI":"10.1128\/mbio.00315-24"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69. Sato J, Murata S, Yang Z, Kaufer BB, Fujisawa S, Seo H, Maekawa N, Okagawa T, Konnai S, Osterrieder N, Parcells MS, Ohashi K. 2022. Effect of insertion and deletion in the Meq protein encoded by highly oncogenic Marek\u2019s disease virus on transactivation activity and virulence. Viruses<\/i> 14: 249.","DOI":"10.3390\/v14020382"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70. Schat KA. 2016. History of the first-generation Marek\u2019s disease vaccines: the science and little-known facts. Avian Dis<\/i> 60: 715\u2013724.","DOI":"10.1637\/11429-050216-Hist"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71. Schiavone A, Pugliese N, Circella E, Camarda A. 2020. Association between the poultry red mite Dermanyssus gallinae<\/i> and potential avian pathogenic Escherichia coli<\/i> (APEC). Vet Parasitol<\/i> 284: 109198.","DOI":"10.1016\/j.vetpar.2020.109198"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72. Schiavone A, Price DRG, Pugliese N, Burgess STG, Siddique I, Circella E, Nisbet AJ, Camarda A. 2023. Profiling of Dermanyssus gallinae<\/i> genes involved in acaricide resistance. Vet Parasitol<\/i> 319: 109957.","DOI":"10.1016\/j.vetpar.2023.109957"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73. Schicht S, Qi W, Poveda L, Strube C. 2014. Whole transcriptome analysis of the poultry red mite Dermanyssus gallinae<\/i> (De Geer, 1778). Parasitology<\/i> 141: 336\u2013346.","DOI":"10.1017\/S0031182013001467"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74. Seo H, Murata S, Ichii O, Namba T, Win SY, Sato T, Oishi E, Taneno A, Maekawa N, Okagawa T, Konnai S, Ohashi K. 2023. Analysis of gene expression in poultry red mite, Dermanyssus gallinae<\/i>, by RNAscope in situ<\/i> hybridization. J Vet Med Sci<\/i> 85: 532\u2013535.","DOI":"10.1292\/jvms.22-0544"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75. Shamblin CE, Greene N, Arumugaswami V, Dienglewicz RL, Parcells MS. 2004. Comparative analysis of Marek\u2019s disease virus (MDV) glycoprotein-, lytic antigen pp38- and transformation antigen Meq-encoding genes: association of meq<\/i> mutations with MDVs of high virulence. Vet Microbiol<\/i> 102: 147\u2013167.","DOI":"10.1016\/j.vetmic.2004.06.007"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76. Sigognault Flochlay A, Thomas E, Sparagano O. 2017. Poultry red mite (Dermanyssus gallinae<\/i>) infestation: a broad impact parasitological disease that still remains a significant challenge for the egg-laying industry in Europe. Parasit Vectors<\/i> 10: 357.","DOI":"10.1186\/s13071-017-2292-4"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77. Sioutas G, Petridou E, Minoudi S, Papageorgiou KV, Symeonidou I, Giantsis IA, Triantafyllidis A, Papadopoulos E. 2023. Isolation of Listeria monocytogenes<\/i> from poultry red mite (Dermanyssus gallinae<\/i>) infesting a backyard chicken farm in Greece. Sci Rep<\/i> 13: 685.","DOI":"10.1038\/s41598-023-27862-3"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78. Sparagano OAE, George DR, Harrington DWJ, Giangaspero A. 2014. Significance and control of the poultry red mite, Dermanyssus gallinae<\/i>. Annu Rev Entomol<\/i> 59: 447\u2013466.","DOI":"10.1146\/annurev-ento-011613-162101"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79. Sparagano OAE, Ho J. 2020. Parasitic mite fauna in Asian poultry farming systems. Front Vet Sci<\/i> 7: 400.","DOI":"10.3389\/fvets.2020.00400"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80. Sparagano O, Khallaayoune K, Duvallet G, Nayak S, George D. 2013. Comparing terpenes from plant essential oils as pesticides for the poultry red mite (Dermanyssus gallinae<\/i>). Transbound Emerg Dis<\/i> 60Suppl 2: 150\u2013153.","DOI":"10.1111\/tbed.12138"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81. Sun T, Wu H, Liu J, Jiang L, Wang X, Xu F, Li X. 2025. Safety study of fluralaner solution on poultry red mite: A clinical study screening of the optimal dose and focusing on hepatic and renal parameters. Poult Sci<\/i> 104: 104685.","DOI":"10.1016\/j.psj.2024.104685"},{"key":"82","doi-asserted-by":"crossref","unstructured":"82. Suresh R, Olaitan Comfort S, Dolatyabi S, Schrock J, Singh M, Renukaradhya GJ. 2025. Evaluation of mucosal adjuvants to chitosan-nanoparticle-based oral subunit vaccine for controlling salmonellosis in broilers. Front Immunol<\/i> 16: 1509990.","DOI":"10.3389\/fimmu.2025.1509990"},{"key":"83","doi-asserted-by":"crossref","unstructured":"83. Tabari MA, Youssefi MR, Benelli G. 2017. Eco-friendly control of the poultry red mite, Dermanyssus gallinae<\/i> (Dermanyssidae), using the \u03b1-thujone-rich essential oil of Artemisia sieberi<\/i> (Asteraceae): toxic and repellent potential. Parasitol Res<\/i> 116: 1545\u20131551.","DOI":"10.1007\/s00436-017-5431-0"},{"key":"84","doi-asserted-by":"crossref","unstructured":"84. Takehara M, Murata S, Katakura K, Fujisawa S, Hmoon MM, Win SY, Bawm S, Htun LL, Aung YH, Win MM, Isezaki M, Maekawa N, Okagawa T, Konnai S, Ohashi K. 2019. Haematophagous mites on poultry farms in the Republic of the Union of Myanmar. Heliyon<\/i> 5: e01544.","DOI":"10.1016\/j.heliyon.2019.e01544"},{"key":"85","doi-asserted-by":"crossref","unstructured":"85. Teng M, Zheng LP, Li HZ, Ma SM, Zhu ZJ, Chai SJ, Yao Y, Nair V, Zhang GP, Luo J. 2022. Pathogenicity and pathotype analysis of Henan isolates of Marek\u2019s disease virus reveal long-term circulation of highly virulent MDV variant in China. Viruses<\/i> 14: 1651.","DOI":"10.3390\/v14081651"},{"key":"86","doi-asserted-by":"crossref","unstructured":"86. Thomas E, Chiquet M, Sander B, Zschiesche E, Flochlay AS. 2017. Field efficacy and safety of fluralaner solution for administration in drinking water for the treatment of poultry red mite (Dermanyssus gallinae<\/i>) infestations in commercial flocks in Europe. Parasit Vectors<\/i> 10: 457.","DOI":"10.1186\/s13071-017-2390-3"},{"key":"87","doi-asserted-by":"crossref","unstructured":"87. Tischer BK, von Einem J, Kaufer B, Osterrieder N. 2006. Two-step red-mediated recombination for versatile high-efficiency markerless DNA manipulation in Escherichia coli<\/i>. Biotechniques<\/i> 40: 191\u2013197.","DOI":"10.2144\/000112096"},{"key":"88","doi-asserted-by":"crossref","unstructured":"88. Tomer H, Blum T, Arye I, Faigenboim A, Gottlieb Y, Ment D. 2018. Activity of native and commercial strains of Metarhizium<\/i> spp. against the poultry red mite Dermanyssus gallinae<\/i> under different environmental conditions. Vet Parasitol<\/i> 262: 20\u201325.","DOI":"10.1016\/j.vetpar.2018.09.010"},{"key":"89","doi-asserted-by":"crossref","unstructured":"89. Tomley FM, Sparagano O. 2018. Spotlight on avian pathology: red mite, a serious emergent problem in layer hens. Avian Pathol<\/i> 47: 533\u2013535.","DOI":"10.1080\/03079457.2018.1490493"},{"key":"90","doi-asserted-by":"crossref","unstructured":"90. Trimpert J, Groenke N, Jenckel M, He S, Kunec D, Szpara ML, Spatz SJ, Osterrieder N, McMahon DP. 2017. A phylogenomic analysis of Marek\u2019s disease virus reveals independent paths to virulence in Eurasia and North America. Evol Appl<\/i> 10: 1091\u20131101.","DOI":"10.1111\/eva.12515"},{"key":"91","doi-asserted-by":"crossref","unstructured":"91. Wajid SJ, Katz ME, Renz KG, Walkden-Brown SW. 2013. Prevalence of Marek\u2019s disease virus in different chicken populations in Iraq and indicative virulence based on sequence variation in the ecoRI-q (meq<\/i>) gene. Avian Dis<\/i> 57Suppl: 562\u2013568.","DOI":"10.1637\/10342-083112-Reg.1"},{"key":"92","doi-asserted-by":"crossref","unstructured":"92. Willadsen P. 2004. Anti-tick vaccines. Parasitology<\/i> 129Suppl: S367\u2013S387.","DOI":"10.1017\/S0031182003004657"},{"key":"93","doi-asserted-by":"crossref","unstructured":"93. Win SY, Horio F, Sato J, Motai Y, Seo H, Fujisawa S, Sato T, Oishi E, Htun LL, Bawm S, Okagawa T, Maekawa N, Konnai S, Ohashi K, Murata S. 2025. Potential of histamine release factor for the utilization as a universal vaccine antigen against poultry red mites, tropical fowl mites, and northern fowl mites. J Vet Med Sci<\/i> 87: 1\u201312.","DOI":"10.1292\/jvms.24-0186"},{"key":"94","doi-asserted-by":"crossref","unstructured":"94. Win SY, Murata S, Fujisawa S, Seo H, Sato J, Motai Y, Sato T, Oishi E, Taneno A, Htun LL, Bawm S, Okagawa T, Maekawa N, Konnai S, Ohashi K. 2023. Characterization of cysteine proteases from poultry red mite, tropical fowl mite, and northern fowl mite to assess the feasibility of developing a broadly efficacious vaccine against multiple mite species. PLoS One<\/i> 18: e0288565.","DOI":"10.1371\/journal.pone.0288565"},{"key":"95","doi-asserted-by":"crossref","unstructured":"95. Win SY, Murata S, Fujisawa S, Seo H, Sato J, Motai Y, Sato T, Oishi E, Taneno A, Htun LL, Bawm S, Okagawa T, Maekawa N, Konnai S, Ohashi K. 2023. Potential of ferritin 2 as an antigen for the development of a universal vaccine for avian mites, poultry red mites, tropical fowl mites, and northern fowl mites. Front Vet Sci<\/i> 10: 1182930.","DOI":"10.3389\/fvets.2023.1182930"},{"key":"96","doi-asserted-by":"crossref","unstructured":"96. Win SY, Seo H, Horio F, Fujisawa S, Sato J, Motai Y, Sato T, Oishi E, Taneno A, Htun LL, Bawm S, Okagawa T, Maekawa N, Konnai S, Ohashi K, Murata S. 2024. In vivo<\/i> characterization of the anti-glutathione S-transferase antibody using an in vitro<\/i> mite feeding model. Vaccines (Basel)<\/i> 12: 148.","DOI":"10.3390\/vaccines12020148"},{"key":"97","doi-asserted-by":"crossref","unstructured":"97. Witter RL. 1997. Increased virulence of Marek\u2019s disease virus field isolates. Avian Dis<\/i> 41: 149\u2013163.","DOI":"10.2307\/1592455"},{"key":"98","doi-asserted-by":"crossref","unstructured":"98. Witter RL, Calnek BW, Buscaglia C, Gimeno IM, Schat KA. 2005. Classification of Marek\u2019s disease viruses according to pathotype: philosophy and methodology. Avian Pathol<\/i> 34: 75\u201390.","DOI":"10.1080\/03079450500059255"},{"key":"99","doi-asserted-by":"crossref","unstructured":"99. Wright HW, Bartley K, Huntley JF, Nisbet AJ. 2016. Characterisation of tropomyosin and paramyosin as vaccine candidate molecules for the poultry red mite, Dermanyssus gallinae<\/i>. Parasit Vectors<\/i> 9: 544.","DOI":"10.1186\/s13071-016-1831-8"},{"key":"100","doi-asserted-by":"crossref","unstructured":"100. Xu X, Wang C, Huang Y, Zhang S, Yu H, Meng J, Pan B. 2020. Evaluation of the vaccine efficacy of three digestive protease antigens from Dermanyssus gallinae<\/i> using an in vivo<\/i> rearing system. Vaccine<\/i> 38: 7842\u20137849.","DOI":"10.1016\/j.vaccine.2020.10.010"},{"key":"101","doi-asserted-by":"crossref","unstructured":"101. Xu X, Wang C, Liu Q, Huang Y, Sun W, Pan B. 2022. Two ferritins from Dermanyssus gallinae<\/i>: characterization and in vivo<\/i> assessment as protective antigens. Pest Manag Sci<\/i> 78: 561\u2013571.","DOI":"10.1002\/ps.6664"},{"key":"102","doi-asserted-by":"crossref","unstructured":"102. Yamagami S, Sato J, Motai Y, Maekawa N, Okagawa T, Konnai S, Ohashi K, Murata S. 2025. Genomic characteristics and distinctive genetic polymorphisms of Marek\u2019s disease virus strains circulating in Japan. J Vet Med Sci<\/i> 87: 517\u2013531.","DOI":"10.1292\/jvms.25-0011"},{"key":"103","doi-asserted-by":"crossref","unstructured":"103. Zhao Y, Kurian D, Xu H, Petherbridge L, Smith LP, Hunt L, Nair V. 2009. Interaction of Marek\u2019s disease virus oncoprotein Meq with heat-shock protein 70 in lymphoid tumour cells. J Gen Virol<\/i> 90: 2201\u20132208.","DOI":"10.1099\/vir.0.012062-0"},{"key":"104","doi-asserted-by":"crossref","unstructured":"104. Zhou T, Guo P, Gao L, Liu R, Liu C, Zhang Y, Cui H, Qi X, Liu Y, Wang S, Chen Y, Duan Y, Wang X, Gao Y, Li K. 2024. Marek\u2019s disease virus inhibits the JAK-STAT signaling pathway to evade the innate immune response. J Integr Agric<\/i> (in press).","DOI":"10.1016\/j.jia.2024.11.019"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/87\/12\/87_25-0304\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T03:41:47Z","timestamp":1764992507000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/87\/12\/87_25-0304\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":104,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.25-0304","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"25-0304"}}