{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T22:17:11Z","timestamp":1772921831243,"version":"3.50.1"},"reference-count":32,"publisher":"Japanese Society of Veterinary Science","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Vet. Med. Sci.","The Journal of Veterinary Medical Science"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1292\/jvms.25-0381","type":"journal-article","created":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T22:09:16Z","timestamp":1768169356000},"page":"424-431","source":"Crossref","is-referenced-by-count":0,"title":["Hematological, biochemical and hormonal profiles in dogs with obesity-related          metabolic disorder"],"prefix":"10.1292","volume":"88","author":[{"given":"Adri\u00e1n","family":"CARZOLI","sequence":"first","affiliation":[{"name":"Unidad de Imagenolog\u00eda, Laboratorio de An\u00e1lisis Cl\u00ednicos y LEMA, Facultad              de Veterinaria-UdelaR, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"PESSINA","sequence":"additional","affiliation":[{"name":"Unidad de Imagenolog\u00eda, Laboratorio de An\u00e1lisis Cl\u00ednicos y LEMA, Facultad              de Veterinaria-UdelaR, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"CASTILLO","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Cl\u00ednica M\u00e9dica de Peque\u00f1os Animales, Facultad de Ciencias              Veterinarias, Universidad de Buenos Aires, Buenos Aires, Rep\u00fablica              Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"MEIKLE","sequence":"additional","affiliation":[{"name":"Unidad de Imagenolog\u00eda, Laboratorio de An\u00e1lisis Cl\u00ednicos y LEMA, Facultad              de Veterinaria-UdelaR, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"122","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Abha              P, Keshari              JR, Sinha              SR, Nishant              K, Kumari              R, Prakash              P. 2023.            Association of thyroid function with lipid profile in patients with            metabolic syndrome: a prospective cross-sectional study in the Indian            population. <i>Cureus<\/i>          15: e44745.","DOI":"10.7759\/cureus.44745"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Acierno              MJ, Brown              S, Coleman              AE, Jepson              RE, Papich              M, Stepien              RL, Syme              HM. 2018.            ACVIM consensus statement: Guidelines for the identification, evaluation,            and management of systemic hypertension in dogs and cats.              <i>J Vet Intern Med<\/i>          32: 1803\u20131822.","DOI":"10.1111\/jvim.15331"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Aguirre              GA, De Ita              JR, de la                Garza              RG,                Castilla-Cortazar              I. 2016.            Insulin-like growth factor-1 deficiency and metabolic            syndrome. <i>J Transl Med<\/i>          14: 3.","DOI":"10.1186\/s12967-015-0762-z"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Arjunan              A, Sah              DK, Woo              M, Song              J. 2023.            Identification of the molecular mechanism of insulin-like growth factor-1            (IGF-1): a promising therapeutic target for neurodegenerative diseases associated with            metabolic syndrome. <i>Cell Biosci<\/i>          13: 16.","DOI":"10.1186\/s13578-023-00966-z"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Carzoli              A, Meikle              A, Pessina              P. 2025.            Canine obesity, overweight, and adipokine serum concentration are            associated with hematological, biochemical, hormonal, and cardiovascular            markers. <i>Open Vet J<\/i>          15: 619\u2013629.","DOI":"10.5455\/OVJ.2025.v15.i2.10"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Chandler              ML. 2016.            Impact of obesity on cardiopulmonary disease.              <i>Vet Clin North Am Small Anim Pract<\/i>          46: 817\u2013830.","DOI":"10.1016\/j.cvsm.2016.04.005"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Cortese              L, Terrazzano              G, Pelagalli              A. 2019.            Leptin and immunological profile in obesity and its associated diseases            in dogs. <i>Int J Mol Sci<\/i>          20: 1\u201319.","DOI":"10.3390\/ijms20102392"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Gouda              W, Mageed              L, Ashour              E, Afify              M, Awad              M, Shalby              S, Ezzat              WM, Shaker              Y. 2017.            Relationship between sex hormone-binding globulin (SHBG) and insulin-like            growth factor-I (IGF-I) with metabolic syndrome. <i>Egypt J              Chem<\/i>          60: 957\u2013964.","DOI":"10.21608\/ejchem.2017.1510.1111"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Gromnatska              N, Pasichnyuk              I,                Tomashevska              O. 2023.            Role of cortisol in the formation of metabolic syndrome in children:            literature review and own observations. <i>Miznarodnij              Endokrinologicnij Zurnal<\/i>          19: 279\u2013283.","DOI":"10.22141\/2224-0721.19.4.2023.1286"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Han              Y, Sun              Q, Chen              W, Gao              Y, Ye              J, Chen              Y, Wang              T, Gao              L, Liu              Y, Yang              Y. 2024.            New advances of adiponectin in regulating obesity and related metabolic            syndromes. <i>J Pharm Anal<\/i>          14: 100913.","DOI":"10.1016\/j.jpha.2023.12.003"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Hashemi              SM,                Kheirandish              M, Rafati              S, Ghazalgoo              A,                Amini-Salehi              E, Keivanlou              MH,                Abbaszadeh              S, Saberian              P, Rahimi              A. 2024.            The association between neutrophil and lymphocyte to high-density            lipoprotein cholesterol ratio and metabolic syndrome among Iranian population, finding            from Bandare Kong cohort study. <i>Lipids Health              Dis<\/i>          23: 393.","DOI":"10.1186\/s12944-024-02378-5"},{"key":"12","unstructured":"12. Jeric\u00f3              MM, Neto              JP, Kogika              de AMM. 2015.          Tratado de Medicina Interna de C\u00e3es e Gatos, 1st ed., Editora ROCA Rio de          Janeiro."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Khatiwada              S, Sah              SK, Kc              R, Baral              N, Lamsal              M. 2016.            Thyroid dysfunction in metabolic syndrome patients and its relationship            with components of metabolic syndrome. <i>Clin Diabetes              Endocrinol<\/i>          2: 3.","DOI":"10.1186\/s40842-016-0021-0"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Martocchia              A, Gallucci              M, Noale              M, Maggi              S, Cassol              M, Stefanelli              M,                Postacchini              D, Proietti              A, Barbagallo              M, Dominguez              LJ, Ferri              C, Desideri              G, Toussan              L, Pastore              F, Falaschi              GM, Paolisso              G, Falaschi              P. AGICO            Investigators.          2020. The cortisol burden in elderly subjects with metabolic            syndrome and its association with low-grade inflammation.              <i>Aging Clin Exp Res<\/i>          32: 1309\u20131315.","DOI":"10.1007\/s40520-019-01322-3"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Marzullo              P, Minocci              A, Giarda              P, Marconi              C,                Tagliaferri              A, Walker              GE, Scacchi              M, Aimaretti              G, Liuzzi              A. 2014.            Lymphocytes and immunoglobulin patterns across the threshold of severe            obesity. <i>Endocrine<\/i>          45: 392\u2013400.","DOI":"10.1007\/s12020-013-0006-z"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Maury              E, Brichard              SM. 2010.            Adipokine dysregulation, adipose tissue inflammation and metabolic            syndrome. <i>Mol Cell Endocrinol<\/i>          314: 1\u201316.","DOI":"10.1016\/j.mce.2009.07.031"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Meng              W, Zhang              C, Zhang              Q, Song              X, Lin              H, Zhang              D, Zhang              Y, Zhu              Z, Wu              S, Liu              Y, Tang              F, Yang              X, Xue              F. 2012.            Association between leukocyte and metabolic syndrome in urban Han            Chinese: a longitudinal cohort study. <i>PLoS            One<\/i>          7: e49875.","DOI":"10.1371\/journal.pone.0049875"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Montoya-Alonso              JA,                Bautista-Casta\u00f1o              I, Pe\u00f1a              C, Su\u00e1rez              L, Juste              MC,                Tvarijonaviciute              A. 2017.            Prevalence of canine obesity, obesity-related metabolic dysfunction, and            relationship with owner obesity in an obesogenic region of Spain.              <i>Front Vet Sci<\/i>          4: 59.","DOI":"10.3389\/fvets.2017.00059"},{"key":"19","unstructured":"19. Nassar de                Marchi              P, Chalfun                Guimar\u00e3es-Okamoto              PT, Melchert              A, Antunes                Ribeiro              JF, Yamauti dos                Santos              TH, de Ara\u00fajo                Machado              LH. 2016.            S\u00edndrome metab\u00f3lica: Rela\u00e7\u00e3o entre obesidade, resist\u00eancia insul\u00ednica e            hipertens\u00e3o arterial sist\u00eamica nos pequenos animais. <i>Vet              Zootec<\/i>          23: 184\u2013191 (in          Portuguese)."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Padmalayam              I, Suto              M. 2013.            Role of adiponectin in the metabolic syndrome: current perspectives on            its modulation as a treatment strategy. <i>Curr Pharm              Des<\/i>          19: 5755\u20135763.","DOI":"10.2174\/13816128113199990360"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Raya-Cano              E,                Vaquero-Abell\u00e1n              M,                Molina-Luque              R,                Molina-Recio              G,                Guzm\u00e1n-Garc\u00eda              JM,                Jim\u00e9nez-M\u00e9rida              R,                Romero-Salda\u00f1a              M. 2023.            Association between metabolic syndrome and leukocytes: systematic review            and meta-analysis. <i>J Clin Med<\/i>          12: 1\u201316.","DOI":"10.1038\/s41598-022-22025-2"},{"key":"22","unstructured":"22. Shastri              N, Paunikar              VM, Nisar              M, Baig              H. 2012.            Association of obesity with total leucocyte count in patients of            Metabolic syndrome. <i>International Journal of Biological              &amp; Medical Research Int J Biol Med Res<\/i>          3: 1399\u20131401."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Tvarijonaviciute              A,                Bari\u0107-Rafaj              R, Horvatic              A,                Mu\u00f1oz-Prieto              A, Guillemin              N, Lamy              E, Tumpa              A, Ceron              JJ,                Martinez-Subiela              S, Mrljak              V. 2019.            Identification of changes in serum analytes and possible metabolic            pathways associated with canine obesity-related metabolic dysfunction.              <i>Vet J<\/i>          244: 51\u201359.","DOI":"10.1016\/j.tvjl.2018.12.006"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Tvarijonaviciute              A, Ceron              JJ, Holden              SL,                Cuthbertson              DJ, Biourge              V, Morris              PJ, German              AJ. 2012.            Obesity-related metabolic dysfunction in dogs: a comparison with human            metabolic syndrome. <i>BMC Vet Res<\/i>          8: 147.","DOI":"10.1186\/1746-6148-8-147"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Tvarijonaviciute              A, Ceron              JJ, de Torre              C, Ljubi\u0107              BB, Holden              SL, Queau              Y, Morris              PJ, Pastor              J, German              AJ. 2016.            Obese dogs with and without obesity-related metabolic dysfunction - a            proteomic approach. <i>BMC Vet Res<\/i>          12: 211.","DOI":"10.1186\/s12917-016-0839-9"},{"key":"26","unstructured":"26. Tvarijonaviciute              A,                Mart\u00ednez-Subiela              S, Cer\u00f3n              JJ. 2010.            Validation of 2 commercially available enzyme-linked immunosorbent assays            for adiponectin determination in canine serum samples.              <i>Can J Vet Res<\/i>          74: 279\u2013285."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Verkest              KR, Fleeman              LM, Rand              JS, Morton              JM. 2010.            Basal measures of insulin sensitivity and insulin secretion and            simplified glucose tolerance tests in dogs. <i>Domest Anim              Endocrinol<\/i>          39: 194\u2013204.","DOI":"10.1016\/j.domaniend.2010.06.001"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Verkest              KR, Rand              JS, Fleeman              LM, Morton              JM. 2012.            Spontaneously obese dogs exhibit greater postprandial glucose,            triglyceride, and insulin concentrations than lean dogs.              <i>Domest Anim Endocrinol<\/i>          42: 103\u2013112.","DOI":"10.1016\/j.domaniend.2011.10.002"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Verkest              KR. 2014.            Is the metabolic syndrome a useful clinical concept in dogs? A review of            the evidence. <i>Vet J<\/i>          199: 24\u201330.","DOI":"10.1016\/j.tvjl.2013.09.057"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Wang              M, Ma              G, Tao              Z. 2024.            The association of neutrophil-to-lymphocyte ratio with cardiovascular and            all-cause mortality among the metabolic syndrome population.              <i>BMC Cardiovasc Disord<\/i>          24: 594.","DOI":"10.1186\/s12872-024-04284-1"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Wang              X, Fu              J, Gu              Y, Chi              VTQ, Zhang              Q, Liu              L, Meng              G, Yao              Z, Wu              H, Bao              X, Zhang              S, Liu              M, Wang              Y, Lu              Z, Wang              L, Zheng              L, Wang              X, Tian              C, Sun              S, Zhou              M, Jia              Q, Song              K, Niu              K. 2019.            Relationship between serum levels of immunoglobulins and metabolic            syndrome in an adult population: A population study from the TCLSIH cohort            study. <i>Nutr Metab Cardiovasc Dis<\/i>          29: 916\u2013922.","DOI":"10.1016\/j.numecd.2019.05.053"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Winer              DA, Winer              S, Shen              L, Wadia              PP, Yantha              J, Paltser              G, Tsui              H, Wu              P, Davidson              MG, Alonso              MN, Leong              HX, Glassford              A, Caimol              M, Kenkel              JA, Tedder              TF,                McLaughlin              T, Miklos              DB, Dosch              HM, Engleman              EG. 2011.            B cells promote insulin resistance through modulation of T cells and            production of pathogenic IgG antibodies. <i>Nat              Med<\/i>          17: 610\u2013617.","DOI":"10.1038\/nm.2353"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/88\/3\/88_25-0381\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T03:47:18Z","timestamp":1772855238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/88\/3\/88_25-0381\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.25-0381","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"25-0381"}}