{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:01:25Z","timestamp":1780718485651,"version":"3.54.1"},"reference-count":20,"publisher":"Japanese Society of Veterinary Science","issue":"6","funder":[{"name":"Center for Diversity, Equity and Inclusion, Azabu University"},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K02183"],"award-info":[{"award-number":["25K02183"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K27081"],"award-info":[{"award-number":["23K27081"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K06014"],"award-info":[{"award-number":["22K06014"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Vet. Med. Sci.","The Journal of Veterinary Medical Science"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1292\/jvms.25-0516","type":"journal-article","created":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T22:10:06Z","timestamp":1773612606000},"page":"859-864","source":"Crossref","is-referenced-by-count":0,"title":["Re-maturation of canine chemically-induced hepatic progenitor cells toward biliary epithelial cells"],"prefix":"10.1292","volume":"88","author":[{"given":"Kaoruko","family":"KIKUCHI","sequence":"first","affiliation":[{"name":"Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, Azabu University, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"NISHI","sequence":"additional","affiliation":[{"name":"Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, Azabu University, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"YAMADA","sequence":"additional","affiliation":[{"name":"Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, Azabu University, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"YAMAZAKI","sequence":"additional","affiliation":[{"name":"Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, Azabu University, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakurako","family":"NEO","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Diagnostics, School of Veterinary Medicine, Azabu University, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"TSUKUI","sequence":"additional","affiliation":[{"name":"Nihon Zenyaku Co., Ltd., Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"TATEISHI","sequence":"additional","affiliation":[{"name":"Nihon Zenyaku Co., Ltd., Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"IGARASHI","sequence":"additional","affiliation":[{"name":"Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, Azabu University, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihide","family":"KAMIYA","sequence":"additional","affiliation":[{"name":"Department of Molecular Life Sciences, Tokai University School of Medicine, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"HISASUE","sequence":"additional","affiliation":[{"name":"Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, Azabu University, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"122","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Babicki S, Arndt D, Marcu A, Liang Y, Grant JR, Maciejewski A, Wishart DS.  2016. Heatmapper: web-enabled heat mapping for all. <i>Nucleic Acids Res<\/i> 44W1: W147\u201353.","DOI":"10.1093\/nar\/gkw419"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Banales JM, Huebert RC, Karlsen T, Strazzabosco M, LaRusso NF, Gores GJ.  2019. Cholangiocyte pathobiology. <i>Nat Rev Gastroenterol Hepatol<\/i> 16: 269\u2013281.","DOI":"10.1038\/s41575-019-0125-y"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Cogliati B, Aloia TP, Bosch RV, Alves VA, Hernandez-Blazquez FJ, Dagli ML.  2010. Identification of hepatic stem\/progenitor cells in canine hepatocellular and cholangiocellular carcinoma. <i>Vet Comp Oncol<\/i> 8: 112\u2013121.","DOI":"10.1111\/j.1476-5829.2010.00210.x"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Eulenberg VM, Lidbury JA.  2018. Hepatic fibrosis in dogs. <i>J Vet Intern Med<\/i> 32: 26\u201341.","DOI":"10.1111\/jvim.14891"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Fukumoto M, Miyamoto D, Soyama A, Hara T, Maruya Y, Li P, Matsushima H, Migita K, Enjoji T, Tetsuo H, Fujita T, Yamashita M, Imamura H, Adachi T, Kanetaka K, Ochiya T, Eguchi S.  2024. Characteristics of chemically induced liver progenitors derived from a pig model of metabolic dysfunction-associated steatotic liver disease. <i>PLoS One<\/i> 19: e0313312.","DOI":"10.1371\/journal.pone.0313312"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Higuchi Y, Kawai K, Kanaki T, Yamazaki H, Chesn\u00e9 C, Guguen-Guillouzo C, Suemizu H.  2016. Functional polymer-dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes. <i>Hepatol Res<\/i> 46: 1045\u20131057.","DOI":"10.1111\/hepr.12644"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Hu H, Gehart H, Artegiani B, L\u00d6pez-Iglesias C, Dekkers F, Basak O, van Es J, Chuva de Sousa Lopes SM, Begthel H, Korving J, van den Born M, Zou C, Quirk C, Chiriboga L, Rice CM, Ma S, Rios A, Peters PJ, de Jong YP, Clevers H, Clevers H.  2018. Long-term expansion of functional mouse and human hepatocytes as 3D organoids. <i>Cell<\/i> 175: 1591\u20131606.e19.","DOI":"10.1016\/j.cell.2018.11.013"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Huang K, He Y, Liang T, Mo S, Liao Y, Gao Q, Liao X, Han C, Zhu G, Peng T.  2024. Analysis of clinicopathologic and imaging features of dual-phenotype hepatocellular carcinoma. <i>Sci Rep<\/i> 14: 3314.","DOI":"10.1038\/s41598-024-53831-5"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Huang Y, Sakai Y, Hara T, Katsuda T, Ochiya T, Gu WL, Miyamoto D, Hamada T, Kanetaka K, Adachi T, Eguchi S.  2020. Differentiation of chemically induced liver progenitor cells to cholangiocytes: Investigation of the optimal conditions. <i>J Biosci Bioeng<\/i> 130: 545\u2013552.","DOI":"10.1016\/j.jbiosc.2020.07.009"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Kaplowitz N.  2005. Idiosyncratic drug hepatotoxicity. <i>Nat Rev Drug Discov<\/i> 4: 489\u2013499.","DOI":"10.1038\/nrd1750"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Katsuda T, Ochiya T.  2019. Chemically induced liver progenitors (CLiPs): a novel cell source for hepatocytes and biliary epithelial cells. <i>Methods Mol Biol<\/i> 1905: 117\u2013130.","DOI":"10.1007\/978-1-4939-8961-4_11"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Kikuchi K, Yamada Y, Neo S, Nitta S, Igarashi H, Kamiya A, Hisasue M.  2025. Development of rematuration of canine chemically induced hepatic progenitor cells using 3D rocking culture. <i>Regen Ther<\/i> 30: 430\u2013438.","DOI":"10.1016\/j.reth.2025.06.002"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Li AP, Lu C, Brent JA, Pham C, Fackett A, Ruegg CE, Silber PM.  1999. Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. <i>Chem Biol Interact<\/i> 121: 17\u201335.","DOI":"10.1016\/S0009-2797(99)00088-5"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Nantasanti S, Spee B, Kruitwagen HS, Chen C, Geijsen N, Oosterhoff LA, van Wolferen ME, Pelaez N, Fieten H, Wubbolts RW, Grinwis GC, Chan J, Huch M, Vries RRG, Clevers H, de Bruin A, Rothuizen J, Penning LC, Schotanus BA.  2015. Disease modeling and gene therapy of copper storage disease in canine hepatic organoids. <i>Stem Cell Reports<\/i> 5: 895\u2013907.","DOI":"10.1016\/j.stemcr.2015.09.002"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Pillai S, Center SA, McDonough SP, Demarco J, Pintar J, Henderson AK, Cooper J, Bolton T, Sharpe K, Hill S, Benedict AG, Haviland R.  2016. Ductal plate malformation in the liver of boxer dogs: clinical and histological features. <i>Vet Pathol<\/i> 53: 602\u2013613.","DOI":"10.1177\/0300985815610567"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Pu W, Zhu H, Zhang M, Pikiolek M, Ercan C, Li J, Huang X, Han X, Zhang Z, Lv Z, Li Y, Liu K, He L, Liu X, Heim MH, Terracciano LM, Tchorz JS, Zhou B.  2023. Bipotent transitional liver progenitor cells contribute to liver regeneration. <i>Nat Genet<\/i> 55: 651\u2013664.","DOI":"10.1038\/s41588-023-01335-9"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Scheers I, Maerckx C, Khuu DN, Marcelle S, Decottignies A, Najimi M, Sokal E.  2012. Adult-derived human liver progenitor cells in long-term culture maintain appropriate gatekeeper mechanisms against transformation. <i>Cell Transplant<\/i> 21: 2241\u20132255.","DOI":"10.3727\/096368912X639026"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Stresser DM, Turner SD, Blanchard AP, Miller VP, Crespi CL.  2002. Cytochrome P450 fluorometric substrates: identification of isoform-selective probes for rat CYP2D2 and human CYP3A4. <i>Drug Metab Dispos<\/i> 30: 845\u2013852.","DOI":"10.1124\/dmd.30.7.845"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Vestentoft PS, Jelnes P, Hopkinson BM, Vainer B, M\u00f8llg\u00e5rd K, Quistorff B, Bisgaard HC.  2011. Three-dimensional reconstructions of intrahepatic bile duct tubulogenesis in human liver. <i>BMC Dev Biol<\/i> 11: 56.","DOI":"10.1186\/1471-213X-11-56"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Yamazaki Y, Kikuchi K, Yamada Y, Neo S, Nitta S, Igarashi H, Kamiya A, Hisasue M.  2024. Reprogramming canine cryopreserved hepatocytes to hepatic progenitor cells using small molecule compounds. <i>Regen Ther<\/i> 26: 1078\u20131086.","DOI":"10.1016\/j.reth.2024.09.003"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/88\/6\/88_25-0516\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T03:21:44Z","timestamp":1780716104000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/88\/6\/88_25-0516\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.25-0516","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"25-0516"}}