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Sci.","The Journal of Veterinary Medical Science"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1292\/jvms.25-0517","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T22:10:39Z","timestamp":1774303839000},"page":"710-718","source":"Crossref","is-referenced-by-count":0,"title":["Malignant epithelial tumors associated with &lt;i&gt;Felis catus&lt;\/i&gt;          papilloma virus type 3 and type 4 infections at distinct anatomical sites in a domestic          cat"],"prefix":"10.1292","volume":"88","author":[{"given":"Hinata","family":"ABE","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Pathology, Department of Veterinary Science,              Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanami X","family":"KATO","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Microbiology, Department of Veterinary Science,              Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"TANABE","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Diagnostic Center, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taichi","family":"SHIMABUKURO","sequence":"additional","affiliation":[{"name":"Ryukyu Animal Medical Center, Okinawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saki","family":"HASHIMOTO","sequence":"additional","affiliation":[{"name":"Saki Animal Hospital, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"HIRAI","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Department of Veterinary Science,              Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan"},{"name":"Graduate School of Medicine and Veterinary Medicine, University of              Miyazaki, Miyazaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"FUKE","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Department of Veterinary Science,              Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akatsuki","family":"SAITO","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Microbiology, Department of Veterinary Science,              Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan"},{"name":"Graduate School of Medicine and Veterinary Medicine, University of              Miyazaki, Miyazaki, Japan"},{"name":"Center for Animal Disease Control, University of Miyazaki, Miyazaki,              Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"122","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Altamura              G, Cuccaro              B, Eleni              C, Strohmayer              C, Brandt              S,                Borzacchiello              G. 2022.            Investigation of multiple Felis catus papillomavirus types            (-1\/-2\/-3\/-4\/-5\/-6) DNAs in feline oral squamous cell carcinoma: a multicentric            study. <i>J Vet Med Sci<\/i>          84: 881\u2013884.","DOI":"10.1292\/jvms.22-0060"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Bernard              HU, Chan              SY, Delius              H. 1994.            Evolution of papillomaviruses. <i>Curr Top              Microbiol Immunol<\/i>          186: 33\u201354.","DOI":"10.1007\/978-3-642-78487-3_3"},{"key":"3","unstructured":"3. Boyer              SN, Wazer              DE, Band              V. 1996.            E7 protein of human papilloma virus-16 induces degradation of            retinoblastoma protein through the ubiquitin-proteasome pathway.              <i>Cancer Res<\/i>          56: 4620\u20134624."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Carvalho              CCR, Batista              MVA, Silva              MAR, Balbino              VQ, Freitas              AC. 2012.            Detection of bovine papillomavirus types, co-infection and a putative new            BPV11 subtype in cattle. <i>Transbound Emerg            Dis<\/i>          59: 441\u2013447.","DOI":"10.1111\/j.1865-1682.2011.01296.x"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Cunningham              LL               Jr, Pagano              GM, Li              M, Tandon              R, Holm              SW, White              DK, Lele              SM. 2006.            Overexpression of p16INK4 is a reliable marker of human            papillomavirus-induced oral high-grade squamous dysplasia.              <i>Oral Surg Oral Med Oral Pathol Oral Radiol Endod<\/i>          102: 77\u201381.","DOI":"10.1016\/j.tripleo.2005.11.028"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Doorbar              J. 2005.            The papillomavirus life cycle. <i>J Clin              Virol<\/i>          32 Suppl 1: S7\u2013S15.","DOI":"10.1016\/j.jcv.2004.12.006"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Doorbar              J, Quint              W, Banks              L, Bravo              IG, Stoler              M, Broker              TR, Stanley              MA. 2012.            The biology and life-cycle of human papillomaviruses.              <i>Vaccine<\/i>          30 Suppl 5:          F55\u2013F70.","DOI":"10.1016\/j.vaccine.2012.06.083"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Dunowska              M, Munday              JS, Laurie              RE, Hills              SFK. 2014.            Genomic characterisation of Felis catus papillomavirus 4, a novel            papillomavirus detected in the oral cavity of a domestic cat.              <i>Virus Genes<\/i>          48: 111\u2013119.","DOI":"10.1007\/s11262-013-1002-3"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. F\u00e5hraeus              R, Paramio              JM, Ball              KL, La\u00edn              S, Lane              DP. 1996.            Inhibition of pRb phosphorylation and cell-cycle progression by a            20-residue peptide derived from p16CDKN2\/INK4A. <i>Curr              Biol<\/i>          6: 84\u201391.","DOI":"10.1016\/S0960-9822(02)00425-6"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Graham              SV. 2017.            The human papillomavirus replication cycle, and its links to cancer            progression: a comprehensive review. <i>Clin Sci              (Lond)<\/i>          131: 2201\u20132221.","DOI":"10.1042\/CS20160786"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Houghton              O, McCluggage              WG. 2009.            The expression and diagnostic utility of p63 in the female genital            tract. <i>Adv Anat Pathol<\/i>          16: 316\u2013321.","DOI":"10.1097\/PAP.0b013e3181b507c6"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Ito              S, Chambers              JK, Sumi              A,                Yamashita-Kawanishi              N, Omachi              T, Haga              T, Nakayama              H, Uchida              K. 2022.            Involvement of <i>Felis catus<\/i> papillomavirus type 2 in the            tumorigenesis of feline Merkel cell carcinoma. <i>Vet              Pathol<\/i>          59: 63\u201374.","DOI":"10.1177\/03009858211045440"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Klaes              R, Friedrich              T, Spitkovsky              D, Ridder              R, Rudy              W, Petry              U,                Dallenbach-Hellweg              G, Schmidt              D, von Knebel                Doeberitz              M. 2001.            Overexpression of p16(INK4A) as a specific marker for dysplastic and            neoplastic epithelial cells of the cervix uteri. <i>Int J              Cancer<\/i>          92: 276\u2013284.","DOI":"10.1002\/ijc.1174"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Lange              CE, Jennings              SH, Diallo              A, Lyons              J. 2019.            Canine papillomavirus types 1 and 2 in classical papillomas: High            abundance, different morphological associations and frequent            co-infections. <i>Vet J<\/i>          250: 1\u20135.","DOI":"10.1016\/j.tvjl.2019.05.016"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Mack              ZE, Caserta              LC, Renshaw              RW, Nakagun              S, Gerdes              RS, Diel              DG,                Childs-Sanford              SE,                Peters-Kennedy              J. 2023.            Histopathologic and molecular characterization of <i>Erethizon              dorsatum<\/i> papillomavirus 1 and <i>Erethizon dorsatum<\/i>            papillomavirus 2 infection in North American porcupines (<i>Erethizon              dorsatum<\/i>). <i>Vet Pathol<\/i>          60: 898\u2013904.","DOI":"10.1177\/03009858231176564"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Mazzei              M, Forzan              M, Carlucci              V, Anfossi              AG, Alberti              A, Albanese              F, Binanti              D, Millanta              F, Baroncini              L, Pirone              A, Abramo              F. 2018.            A study of multiple Felis catus papillomavirus types (1, 2, 3, 4) in cat            skin lesions in Italy by quantitative PCR. <i>J Feline Med              Surg<\/i>          20: 772\u2013779.","DOI":"10.1177\/1098612X17732255"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. McBride              AA. 2013.            The papillomavirus E2 proteins.              <i>Virology<\/i>          445: 57\u201379.","DOI":"10.1016\/j.virol.2013.06.006"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Medeiros-Fonseca              B,                Faustino-Rocha              AI, Medeiros              R, Oliveira              PA, Gil da                Costa              RM. 2023.            Canine and feline papillomaviruses: an update.              <i>Front Vet Sci<\/i>          10: 1174673.","DOI":"10.3389\/fvets.2023.1174673"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Munday              JS. 2014.            Bovine and human papillomaviruses: a comparative review.              <i>Vet Pathol<\/i>          51: 1063\u20131075.","DOI":"10.1177\/0300985814537837"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Munday              JS. 2014.            Papillomaviruses in felids. <i>Vet              J<\/i>          199: 340\u2013347.","DOI":"10.1016\/j.tvjl.2013.11.025"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Munday              JS, French              A, Thomson              N. 2017.            Detection of DNA sequences from a novel papillomavirus in a feline basal            cell carcinoma. <i>Vet Dermatol<\/i>          28: 236\u2013e60.","DOI":"10.1111\/vde.12402"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Munday              JS, Knight              CG. 2024.            Papillomaviruses and papillomaviral disease in dogs and cats: a            comprehensive review. <i>Pathogens<\/i>          13: 1057.","DOI":"10.3390\/pathogens13121057"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Munday              JS, Thomson              NA. 2021.            Papillomaviruses in domestic cats.              <i>Viruses<\/i>          13: 1664.","DOI":"10.3390\/v13081664"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Munday              JS, Thomson              NA, Luff              JA. 2017.            Papillomaviruses in dogs and cats. <i>Vet              J<\/i>          225: 23\u201331.","DOI":"10.1016\/j.tvjl.2017.04.018"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Oyervides-Mu\u00f1oz              MA,                P\u00e9rez-Maya              AA,                S\u00e1nchez-Dom\u00ednguez              CN,                Berlanga-Garza              A,                Antonio-Macedo              M,                Vald\u00e9z-Chapa              LD,                Cerda-Flores              RM, Trevino              V,                Barrera-Salda\u00f1a              HA,                Garza-Rodr\u00edguez              ML. 2020.            Multiple HPV infections and viral load association in persistent cervical            lesions in mexican women. <i>Viruses<\/i>          12: 380.","DOI":"10.3390\/v12040380"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Ozbun              MA. 2002.            Human papillomavirus type 31b infection of human keratinocytes and the            onset of early transcription. <i>J Virol<\/i>          76: 11291\u201311300.","DOI":"10.1128\/JVI.76.22.11291-11300.2002"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Parry              D, Bates              S, Mann              DJ, Peters              G. 1995.            Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high            levels of p16INK4\/MTS1 tumour suppressor gene product.              <i>EMBO J<\/i>          14: 503\u2013511.","DOI":"10.1002\/j.1460-2075.1995.tb07026.x"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Pitolli              C, Wang              Y, Candi              E, Shi              Y, Melino              G, Amelio              I. 2019.            p53-mediated tumor suppression: dna-damage response and alternative            mechanisms. <i>Cancers (Basel)<\/i>          11: 1983.","DOI":"10.3390\/cancers11121983"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Rector              A, Lemey              P, Tachezy              R, Mostmans              S, Ghim              SJ, Van                Doorslaer              K, Roelke              M, Bush              M, Montali              RJ, Joslin              J, Burk              RD, Jenson              AB, Sundberg              JP, Shapiro              B, Van Ranst              M. 2007.            Ancient papillomavirus-host co-speciation in Felidae.              <i>Genome Biol<\/i>          8: R57.","DOI":"10.1186\/gb-2007-8-4-r57"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Santos              EUD, Silva              MAR, Pontes              NE, Coutinho              LCA, Paiva              SSL, Castro              RS, Freitas              AC. 2016.            Detection of different bovine papillomavirus types and co-infection in            bloodstream of cattle. <i>Transbound Emerg            Dis<\/i>          63: e103\u2013e108.","DOI":"10.1111\/tbed.12237"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Scheffner              M, Werness              BA,                Huibregtse              JM, Levine              AJ, Howley              PM. 1990.            The E6 oncoprotein encoded by human papillomavirus types 16 and 18            promotes the degradation of p53. <i>Cell<\/i>          63: 1129\u20131136.","DOI":"10.1016\/0092-8674(90)90409-8"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Schindler              S, Magalh\u00e3es              RA, Costa              ELF, Brites              C. 2022.            Genital cytokines in HIV\/human papillomavirus co-Infection: a systematic            review. <i>AIDS Res Hum Retroviruses<\/i>          38: 683\u2013691.","DOI":"10.1089\/aid.2021.0139"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Slebos              RJ, Lee              MH, Plunkett              BS, Kessis              TD, Williams              BO, Jacks              T, Hedrick              L, Kastan              MB, Cho              KR. 1994.            p53-dependent G1 arrest involves pRB-related proteins and is disrupted by            the human papillomavirus 16 E7 oncoprotein. <i>Proc Natl              Acad Sci USA<\/i>          91: 5320\u20135324.","DOI":"10.1073\/pnas.91.12.5320"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Steurer              S, Riemann              C, B\u00fcscheck              F, Luebke              AM, Kluth              M, Hube-Magg              C, Hinsch              A, H\u00f6flmayer              D, Weidemann              S, Fraune              C, M\u00f6ller              K, Menz              A, Fisch              M, Rink              M,                Bernreuther              C, Lebok              P, Clauditz              TS, Sauter              G, Uhlig              R, Wilczak              W, Dum              D, Simon              R, Minner              S, Burandt              E, Krech              R, Krech              T, Marx              AH. 2021.            p63 expression in human tumors and normal tissues: a tissue microarray            study on 10,200 tumors. <i>Biomark Res<\/i>          9: 7.","DOI":"10.1186\/s40364-021-00260-5"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Sumi              A, Chambers              JK, Ito              S, Kojima              K, Omachi              T, Doi              M, Uchida              K. 2024.            Different expression patterns of p63 and p73 in Felis catus            papillomavirus type 2-associated feline Merkel cell carcinomas and other epidermal            carcinomas. <i>J Vet Med Sci<\/i>          86: 39\u201348.","DOI":"10.1292\/jvms.23-0293"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Uchimura              Y, Sim              JJ, Hirano              S, Hifumi              T, Miyoshi              N, Takahashi              M, Endo              Y. 2025.            Detection of Felis catus papillomavirus-derived genes in squamous cell            carcinoma tissues in cats in Japan. <i>J Vet Med              Sci<\/i>          87: 626\u2013633.","DOI":"10.1292\/jvms.24-0503"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Vascellari              M, Mazzei              M, Zanardello              C, Melchiotti              E, Albanese              F, Forzan              M, Croce              MF, Alberti              A, Abramo              F. 2019.            Felis catus papillomavirus types 1, 2, 3, 4, and 5 in feline bowenoid              <i>in situ<\/i> carcinoma: an <i>in situ<\/i> hybridization            study. <i>Vet Pathol<\/i>          56: 818\u2013825.","DOI":"10.1177\/0300985819859874"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Warren              CJ, Van                Doorslaer              K, Pandey              A, Espinosa              JM, Pyeon              D. 2015.            Role of the host restriction factor APOBEC3 on papillomavirus            evolution. <i>Virus Evol<\/i>          1: vev015.","DOI":"10.1093\/ve\/vev015"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Westra              WH. 2014.            Detection of human papillomavirus (HPV) in clinical samples: evolving            methods and strategies for the accurate determination of HPV status of head and neck            carcinomas. <i>Oral Oncol<\/i>          50: 771\u2013779.","DOI":"10.1016\/j.oraloncology.2014.05.004"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Zhu              B, Xiao              Y, Yeager              M, Clifford              G, Wentzensen              N, Cullen              M, Boland              JF, Bass              S, Steinberg              MK,                Raine-Bennett              T, Lee              D, Burk              RD, Pinheiro              M, Song              L, Dean              M, Nelson              CW, Burdett              L, Yu              K, Roberson              D, Lorey              T, Franceschi              S, Castle              PE, Walker              J, Zuna              R, Schiffman              M, Mirabello              L. 2020.            Mutations in the HPV16 genome induced by APOBEC3 are associated with            viral clearance. <i>Nat Commun<\/i>          11: 886.","DOI":"10.1038\/s41467-020-14730-1"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/88\/5\/88_25-0517\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:26:50Z","timestamp":1777692410000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/88\/5\/88_25-0517\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.25-0517","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"25-0517"}}