{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:58:54Z","timestamp":1785560334470,"version":"3.56.0"},"reference-count":43,"publisher":"Japanese Society of Veterinary Science","issue":"8","funder":[{"DOI":"10.13039\/501100020959","name":"JST-Mirai Program","doi-asserted-by":"publisher","award":["JPMJSP2119"],"award-info":[{"award-number":["JPMJSP2119"]}],"id":[{"id":"10.13039\/501100020959","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Science and Technology","award":["20K20633"],"award-info":[{"award-number":["20K20633"]}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H03545"],"award-info":[{"award-number":["23H03545"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K28235"],"award-info":[{"award-number":["23K28235"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H04919"],"award-info":[{"award-number":["21H04919"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22KK0163"],"award-info":[{"award-number":["22KK0163"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001695","name":"Japan Science and Technology Corporation","doi-asserted-by":"publisher","award":["JPMJSA1501"],"award-info":[{"award-number":["JPMJSA1501"]}],"id":[{"id":"10.13039\/501100001695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100025017","name":"aXis","doi-asserted-by":"crossref","award":["JPMJAS2001"],"award-info":[{"award-number":["JPMJAS2001"]}],"id":[{"id":"10.13039\/501100025017","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001695","name":"Japan Science and Technology Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001695","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Vet. Med. Sci.","The Journal of Veterinary Medical Science"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1292\/jvms.25-0549","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:09:35Z","timestamp":1780524575000},"page":"1208-1219","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Lead exposure\u2019s link to autism-like behavior and Shank 3 gene expression in C57BL\/6J mice"],"prefix":"10.1292","volume":"88","author":[{"given":"Sunao","family":"TAKABA","sequence":"first","affiliation":[{"name":"Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"BANDA","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rio","family":"DOYA","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nyein Chan","family":"SOE","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Parasitology, University of Veterinary Science, Nay Pyi Taw, Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"OGASAWARA","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anri","family":"HIRAI","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"IKENAKA","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan"},{"name":"Water Research Group, School of Environmental Sciences and Development, North-West University, Potchefstroom, South Africa"},{"name":"Translational Research Unit, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan"},{"name":"One Health Research Centre, Hokkaido University, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"ISHIZUKA","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouta MM","family":"NAKAYAMA","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan"},{"name":"Biomedical Sciences Department, School of Veterinary Medicine, The University of Zambia, Lusaka, Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"122","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Aguilar-Valles A, S\u00e1nchez E, de Gortari P, Balderas I, Ram\u00edrez-Amaya V, Berm\u00fadez-Rattoni F, Joseph-Bravo P.  2005. Analysis of the stress response in rats trained in the water-maze: differential expression of corticotropin-releasing hormone, CRH-R1, glucocorticoid receptors and brain-derived neurotrophic factor in limbic regions. <i>Neuroendocrinology<\/i> 82: 306\u2013319.","DOI":"10.1159\/000093129"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Bhowmik A, Khan R, Ghosh MK.  2015. Blood brain barrier: a challenge for effectual therapy of brain tumors. <i>BioMed Res Int<\/i> 2015: 320941.","DOI":"10.1155\/2015\/320941"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Brunner D, Kabitzke P, He D, Cox K, Thiede L, Hanania T, Sabath E, Alexandrov V, Saxe M, Peles E, Mills A, Spooren W, Ghosh A, Feliciano P, Benedetti M, Luo Clayton A, Biemans B.  2015. Comprehensive analysis of the 16p11.2 deletion and null cntnap2 mouse models of autism spectrum disorder. <i>PLoS One<\/i> 10: e0134572.","DOI":"10.1371\/journal.pone.0134572"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Byrnes EM, Bridges RS.  2006. Reproductive experience alters anxiety-like behavior in the female rat. <i>Horm Behav<\/i> 50: 70\u201376.","DOI":"10.1016\/j.yhbeh.2006.01.006"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Carmona A, Roudeau S, Ortega R.  2021. Molecular Mechanisms of Environmental Metal Neurotoxicity: a focus on the interactions of metals with synapse structure and function. <i>Toxics<\/i> 9: 198.","DOI":"10.3390\/toxics9090198"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Chari T, Griswold S, Andrews NA, Fagiolini M.  2020. The stage of the estrus cycle is critical for interpretation of female mouse social interaction behavior. <i>Front Behav Neurosci<\/i> 14: 113.","DOI":"10.3389\/fnbeh.2020.00113"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Courchesne E, Gazestani VH, Lewis NE.  2020. Prenatal origins of asd: the when, what and how of asd development. <i>Trends Neurosci<\/i> 43: 326\u2013342.","DOI":"10.1016\/j.tins.2020.03.005"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Din\u00e7kol \u00d6, Fuentes B, Tartaglione AM, Pino A, Calamandrei G, Ricceri L.  2022. Low-level lead exposure during development differentially affects neurobehavioral responses in male and female mouse offspring: a longitudinal study. <i>Neurotoxicology<\/i> 91: 188\u2013199.","DOI":"10.1016\/j.neuro.2022.05.007"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Gilbert J, Man HY.  2017. Fundamental elements in autism: from neurogenesis and neurite growth to synaptic plasticity. <i>Front Cell Neurosci<\/i> 11: 359.","DOI":"10.3389\/fncel.2017.00359"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Goel A, Aschner M.  2021. The effect of lead exposure on autism development. <i>Int J Mol Sci<\/i> 22: 1\u201312.","DOI":"10.3390\/ijms22041637"},{"key":"11","unstructured":"11. Golub M. and Lanoue L. 2023. Mouse Metabolic Phenotyping Centers MMPC-Live Protocols Morris Water Maze. MMPC-live protocols. 1\u20138."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Guo B, Chen J, Chen Q, Ren K, Feng D, Mao H, Yao H, Yang J, Liu H, Liu Y, Jia F, Qi C, Lynn-Jones T, Hu H, Fu Z, Feng G, Wang W, Wu S.  2019. Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice. <i>Nat Neurosci<\/i> 22: 1223\u20131234.","DOI":"10.1038\/s41593-019-0445-9"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Hagmeyer S, Mangus K, Boeckers TM, Grabrucker AM.  2015. Effects of trace metal profiles characteristic for autism on synapses in cultured neurons. <i>Neural Plast<\/i> 2015: 985083.","DOI":"10.1155\/2015\/985083"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Hern\u00e1ndez M, Zhang Y, Filippelli GM, Boehm SL 2nd 2023. Early-life low-level lead exposure alters anxiety-like behavior, voluntary alcohol consumption and AC5 protein content in adult male and female C57BL\/6 J mice. <i>Neurotoxicol Teratol<\/i> 95: 107149.","DOI":"10.1016\/j.ntt.2022.107149"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Hill DS, Cabrera R, Wallis Schultz D, Zhu H, Lu W, Finnell RH, Wlodarczyk BJ.  2015. Autism-like behavior and epigenetic changes associated with autism as consequences of in utero exposure to environmental pollutants in a mouse model. <i>Behav Neurol<\/i> 2015: 426263.","DOI":"10.1155\/2015\/426263"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Islam MS, Islam S, Sachi S,S,Hasan MR. 2021. An investigation of chronic exposure of lead to the pregnant laboratory animal and its effects on their offspring: Autism investigation to the laboratory animal model in Bangladesh. <i>World J Biology Pharm Health Sci<\/i> 5: 85\u201394.","DOI":"10.30574\/wjbphs.2021.5.3.0022"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Kaidanovich-Beilin O, Lipina T, Vukobradovic I, Roder J, Woodgett JR.  2011. Assessment of social interaction behaviors. <i>J Vis Exp<\/i> 48: 2473.","DOI":"10.3791\/2473-v"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Kuhn CM, Schanberg SM.  1998. Responses to maternal separation: mechanisms and mediators. <i>Int J Dev Neurosci<\/i> 16: 261\u2013270.","DOI":"10.1016\/S0736-5748(98)00034-3"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Laszlo K, Bacova Z, Zelena D, Bakos J.  2025. Developmental disturbances in animal models of autism spectrum disorder. <i>Dev Neurobiol<\/i> 85: e22977.","DOI":"10.1002\/dneu.22977"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Leblond CS, Nava C, Polge A, Gauthier J, Huguet G, Lumbroso S, Giuliano F, Stordeur C, Depienne C, Mouzat K, Pinto D, Howe J, Lemi\u00e8re N, Durand CM, Guibert J, Ey E, Toro R, Peyre H, Mathieu A, Amsellem F, Rastam M, Gillberg IC, Rappold GA, Holt R, Monaco AP, Maestrini E, Galan P, Heron D, Jacquette A, Afenjar A, Rastetter A, Brice A, Devillard F, Assouline B, Laffargue F, Lespinasse J, Chiesa J, Rivier F, Bonneau D, Regnault B, Zelenika D, Delepine M, Lathrop M, Sanlaville D, Schluth-Bolard C, Edery P, Perrin L, Tabet AC, Schmeisser MJ, Boeckers TM, Coleman M, Sato D, Szatmari P, Scherer SW, Rouleau GA, Betancur C, Leboyer M, Gillberg C, Delorme R, Bourgeron T.  2014. Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: a gradient of severity in cognitive impairments. <i>PLoS Genet<\/i> 10: e1004580.","DOI":"10.1371\/journal.pgen.1004580"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Liu L, Zhou X, Ma Z, Liu R, Zhang Y, Wang Y, Liu Y, Xia X, Wang J.  2025. Hippocampal proteomics reveals the novel molecular profiling of postnatal lead (Pb) exposure on autism-like behaviors. <i>Toxics<\/i> 13: 465.","DOI":"10.3390\/toxics13060465"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Lu Z, Yang T, Wang L, Qiu Q, Zhao Y, Wu A, Li T, Cheng W, Wang B, Li Y, Yang J, Zhao M.  2020. Comparison of different protocols of Morris water maze in cognitive impairment with heart failure. <i>Brain Behav<\/i> 10: e01519.","DOI":"10.1002\/brb3.1519"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Masini E, Loi E, Vega-Benedetti AF, Carta M, Doneddu G, Fadda R, Zavattari P.  2020. An overview of the main genetic, epigenetic and environmental factors involved in autism spectrum disorder focusing on synaptic activity. <i>Int J Mol Sci<\/i> 21: 1\u201322.","DOI":"10.3390\/ijms21218290"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Menon S, George E, Osterman M, Pecht M.  2015. High lead solder (over 85%) solder in the electronics industry: RoHS exemptions and alternatives. <i>J Mater Sci Mater Electron<\/i> 26: 4021\u20134030.","DOI":"10.1007\/s10854-015-2940-4"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Mohseni F, Ghorbani Behnam S, Rafaiee R.  2020. a review of the historical evolutionary process of dry and water maze tests in rodents. <i>Basic Clin Neurosci<\/i> 11: 389\u2013402.","DOI":"10.32598\/bcn.11.4.1425.1"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Monteiro P, Feng G.  2017. SHANK proteins: roles at the synapse and in autism spectrum disorder. <i>Nat Rev Neurosci<\/i> 18: 147\u2013157.","DOI":"10.1038\/nrn.2016.183"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Montrose L, Faulk C, Francis J, Dolinoy DC.  2017. Perinatal lead (Pb) exposure results in sex and tissue-dependent adult DNA methylation alterations in murine IAP transposons. <i>Environ Mol Mutagen<\/i> 58: 540\u2013550.","DOI":"10.1002\/em.22119"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Nakata H, Nakayama SMM, Yabe J, Liazambi A, Mizukawa H, Darwish WS, Ikenaka Y, Ishizuka M.  2016. Reliability of stable Pb isotopes to identify Pb sources and verifying biological fractionation of Pb isotopes in goats and chickens. <i>Environ Pollut<\/i> 208Pt B: 395\u2013403.","DOI":"10.1016\/j.envpol.2015.10.006"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. O\u2019Connor D, Hou D, Ye J, Zhang Y, Ok YS, Song Y, Coulon F, Peng T, Tian L.  2018. Lead-based paint remains a major public health concern: A critical review of global production, trade, use, exposure, health risk, and implications. <i>Environ Int<\/i> 121: 85\u2013101.","DOI":"10.1016\/j.envint.2018.08.052"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Omotosho IO, Akinade AO, Lagunju IA, Yakubu MA.  2021. Oxidative stress indices in ASD children in Sub-Sahara Africa. <i>J Neurodev Disord<\/i> 13: 50\u201357.","DOI":"10.1186\/s11689-021-09379-w"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Pearson BL, Defensor EB, Blanchard DC, Blanchard RJ.  2010. C57BL\/6J mice fail to exhibit preference for social novelty in the three-chamber apparatus. <i>Behav Brain Res<\/i> 213: 189\u2013194.","DOI":"10.1016\/j.bbr.2010.04.054"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Portmann T, Yang M, Mao R, Panagiotakos G, Ellegood J, Dolen G, Bader PL, Grueter BA, Goold C, Fisher E, Clifford K, Rengarajan P, Kalikhman D, Loureiro D, Saw NL, Zhengqui Z, Miller MA, Lerch JP, Henkelman M, Shamloo M, Malenka RC, Crawley JN, Dolmetsch RE.  2014. Behavioral abnormalities and circuit defects in the basal ganglia of a mouse model of 16p11.2 deletion syndrome. <i>Cell Rep<\/i> 7: 1077\u20131092.","DOI":"10.1016\/j.celrep.2014.03.036"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Qin L, Ma K, Wang ZJ, Hu Z, Matas E, Wei J, Yan Z.  2018. Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition. <i>Nat Neurosci<\/i> 21: 564\u2013575.","DOI":"10.1038\/s41593-018-0110-8"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Rein B, Ma K, Yan Z.  2020. A standardized social preference protocol for measuring social deficits in mouse models of autism. <i>Nat Protoc<\/i> 15: 3464\u20133477.","DOI":"10.1038\/s41596-020-0382-9"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Sanders T, Liu Y, Buchner V, Tchounwou PB.  2009. Neurotoxic effects and biomarkers of lead exposure: a review. <i>Rev Environ Health<\/i> 24: 15\u201345.","DOI":"10.1515\/REVEH.2009.24.1.15"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Shi JX, Cheng C, Ruan HN, Li J, Liu CM.  2023. Isochlorogenic acid B alleviates lead-induced anxiety, depression and neuroinflammation in mice by the BDNF pathway. <i>Neurotoxicology<\/i> 98: 1\u20138.","DOI":"10.1016\/j.neuro.2023.06.007"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Silverman JL, Yang M, Lord C, Crawley JN.  2010. Behavioural phenotyping assays for mouse models of autism. <i>Nat Rev Neurosci<\/i> 11: 490\u2013502.","DOI":"10.1038\/nrn2851"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Stoppel LJ, Kazdoba TM, Schaffler MD, Preza AR, Heynen A, Crawley JN, Bear MF.  2018. R-baclofen reverses cognitive deficits and improves social interactions in two lines of 16p11.2 deletion mice. <i>Neuropsychopharmacology<\/i> 43: 513\u2013524.","DOI":"10.1038\/npp.2017.236"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Togao M, Nakayama SMM, Ikenaka Y, Mizukawa H, Makino Y, Kubota A, Matsukawa T, Yokoyama K, Hirata T, Ishizuka M.  2020. Bioimaging of Pb and STIM1 in mice liver, kidney and brain using Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) and immunohistochemistry. <i>Chemosphere<\/i> 238: 124581.","DOI":"10.1016\/j.chemosphere.2019.124581"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Triantafyllidou S, Edwards M.  2012. Lead (Pb) in tap water and in blood: Implications for lead exposure in the United States. <i>Crit Rev Environ Sci Technol<\/i> 42: 1297\u20131352.","DOI":"10.1080\/10643389.2011.556556"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Vorhees CV, Williams MT.  2014. Assessing spatial learning and memory in rodents. <i>ILAR J<\/i> 55: 310\u2013332.","DOI":"10.1093\/ilar\/ilu013"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Vyas Y, Lee K, Jung Y, Montgomery JM.  2020. Influence of maternal zinc supplementation on the development of autism-associated behavioural and synaptic deficits in offspring Shank3-knockout mice. <i>Mol Brain<\/i> 13: 110\u2013119.","DOI":"10.1186\/s13041-020-00650-0"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Wade AM, Richter DD, Craft CB, Bao NY, Heine PR, Osteen MC, Tan KG.  2021. Urban-soil pedogenesis drives contrasting legacies of lead from paint and gasoline in city soil. <i>Environ Sci Technol<\/i> 55: 7981\u20137989.","DOI":"10.1021\/acs.est.1c00546"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/88\/8\/88_25-0549\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:29:33Z","timestamp":1785558573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/88\/8\/88_25-0549\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.25-0549","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"25-0549"}}