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Abdelrahman M, Liu G, Al-Saeed FA, Liu Y, Hou F, Yang H, Farooq U, Ahmed S, Jiang X.  2025. Deciphering the colostral-immunity transfer: from mammary gland to neonates small intestine. <i>Vet Res Commun<\/i> 49: 72.","DOI":"10.1007\/s11259-025-10646-7"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Anmol K, Akanksha H, Zhengguo X.  2022. Are CD45RO<sup>+<\/sup> and CD45RA<sup>\u2212<\/sup> genuine markers for bovine memory T cells?<i>Anim Dis<\/i> 2: 23.","DOI":"10.1186\/s44149-022-00057-5"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Barton MH, Hurley D, Norton N, Heusner G, Costa L, Jones S, Byars D, Watanabe K.  2006. Serum lactoferrin and immunoglobulin G concentrations in healthy or ill neonatal foals and healthy adult horses. <i>J Vet Intern Med<\/i> 20: 1457\u20131462.","DOI":"10.1111\/j.1939-1676.2006.tb00766.x"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Bigler NA, Bruckmaier RM, Gross JJ.  2022. Implications of placentation type on species-specific colostrum properties in mammals. <i>J Anim Sci<\/i> 100: skac287.","DOI":"10.1093\/jas\/skac287"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Burton AB, Wagner B, Erb HN, Ainsworth DM.  2009. Serum interleukin-6 (IL-6) and IL-10 concentrations in normal and septic neonatal foals. <i>Vet Immunol Immunopathol<\/i> 132: 122\u2013128.","DOI":"10.1016\/j.vetimm.2009.05.006"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Concha C, Holmberg O, Morein B.  1980. Characterization and response to mitogens of mammary lymphocytes from the bovine dry-period secretion. <i>J Dairy Res<\/i> 47: 305\u2013311.","DOI":"10.1017\/S0022029900021191"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Donovan DC, Reber AJ, Gabbard JD, Aceves-Avila M, Galland KL, Holbert KA, Ely LO, Hurley DJ.  2007. Effect of maternal cells transferred with colostrum on cellular responses to pathogen antigens in neonatal calves. <i>Am J Vet Res<\/i> 68: 778\u2013782.","DOI":"10.2460\/ajvr.68.7.778"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Fedorka CE, Loux SL, Scoggin KE, Adams AA, Troedsson MHT, Ball BA.  2020. Alterations in T cell-related transcripts at the feto-maternal interface throughout equine gestation. <i>Placenta<\/i> 89: 78\u201387.","DOI":"10.1016\/j.placenta.2019.10.011"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Flaminio MJBF, Rush BR, Davis EG, Hennessy K, Shuman W, Wilkerson MJ.  2000. Characterization of peripheral blood and pulmonary leukocyte function in healthy foals. <i>Vet Immunol Immunopathol<\/i> 73: 267\u2013285.","DOI":"10.1016\/S0165-2427(00)00149-5"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Gonzalez DD, Dus Santos MJ.  2017. Bovine colostral cells-the often forgotten component of colostrum. <i>J Am Vet Med Assoc<\/i> 250: 998\u20131005.","DOI":"10.2460\/javma.250.9.998"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Hamza E, Mirkovitch J, Steinbach F, Marti E.  2015. Regulatory T cells in early life: comparative study of CD4+CD25high T cells from foals and adult horses. <i>PLoS One<\/i> 10: e0120661.","DOI":"10.1371\/journal.pone.0120661"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Hodgkinson AJ, Carpenter EA, Smith CS, Molan PC, Prosser CG.  2007. Adhesion molecule expression in the bovine mammary gland. <i>Vet Immunol Immunopathol<\/i> 115: 205\u2013215.","DOI":"10.1016\/j.vetimm.2006.10.020"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Holling TM, van der Stoep N, Quinten E, van den Elsen PJ.  2002. Activated human T cells accomplish MHC class II expression through T cell-specific occupation of class II transactivator promoter III. <i>J Immunol<\/i> 168: 763\u2013770.","DOI":"10.4049\/jimmunol.168.2.763"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Hughes K.  2021. Development and pathology of the equine mammary gland. <i>J Mammary Gland Biol Neoplasia<\/i> 26: 121\u2013134.","DOI":"10.1007\/s10911-020-09471-2"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Jeffcott LB.  1974. Some practical aspects of the transfer of passive immunity to newborn foals. <i>Equine Vet J<\/i> 6: 109\u2013115.","DOI":"10.1111\/j.2042-3306.1974.tb03942.x"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Kandel A, Li L, Hada A, Xiao Z.  2022. Differential expression of CD45RO and CD45RA in bovine T cells. <i>Cells<\/i> 11: 1844.","DOI":"10.3390\/cells11111844"},{"key":"17","unstructured":"17. Knottenbelt DC, Holdstock N, Madigan JE, Cornford A.  2004. Equine Neonatology: Medicine and Surgery, Saunders, Philadelphia."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Lal G, Shaila MS, Nayak R.  2005. Activated mouse T-cells synthesize MHC class II, process, and present morbillivirus nucleocapsid protein to primed T-cells. <i>Cell Immunol<\/i> 234: 133\u2013145.","DOI":"10.1016\/j.cellimm.2005.06.002"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Lavoie JP, Spensley MS, Smith BP, Mihalyi J.  1989. Absorption of bovine colostral immunoglobulins G and M in newborn foals. <i>Am J Vet Res<\/i> 50: 1598\u20131603.","DOI":"10.2460\/ajvr.1989.50.09.1598"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Lecce JG, Morgan DO.  1962. Effect of dietary regimen on cessation of intestinal absorption of large molecules (closure) in the neonatal pig and lamb. <i>J Nutr<\/i> 78: 263\u2013268.","DOI":"10.1093\/jn\/78.3.263"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Liebler-Tenorio EM, Riedel-Caspari G, Pohlenz JF.  2002. Uptake of colostral leukocytes in the intestinal tract of newborn calves. <i>Vet Immunol Immunopathol<\/i> 85: 33\u201340.","DOI":"10.1016\/S0165-2427(01)00404-4"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Lunn DP, Holmes MA, Duffus WPH.  1993. Equine T-lymphocyte MHC II expression: variation with age and subset. <i>Vet Immunol Immunopathol<\/i> 35: 225\u2013238.","DOI":"10.1016\/0165-2427(93)90036-4"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Mahnke YD, Brodie TM, Sallusto F, Roederer M, Lugli E.  2013. The who\u2019s who of T-cell differentiation: human memory T-cell subsets. <i>Eur J Immunol<\/i> 43: 2797\u20132809.","DOI":"10.1002\/eji.201343751"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Mariella J, Castagnetti C, Prosperi A, Scagliarini A, Peli A.  2017. 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Gamma globulin absorption in the baby pig: the nonselective absorption of heterologous globulins and factors influencing absorption time. <i>J Nutr<\/i> 76: 151\u2013158.","DOI":"10.1093\/jn\/76.2.151"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Perkins GA, Wagner B.  2015. The development of equine immunity: Current knowledge on immunology in the young horse. <i>Equine Vet J<\/i> 47: 267\u2013274.","DOI":"10.1111\/evj.12387"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Perkins GA, Goodman LB, Wimer C, Freer H, Babasyan S, Wagner B.  2014. Maternal T-lymphocytes in equine colostrum express a primarily inflammatory phenotype. <i>Vet Immunol Immunopathol<\/i> 161: 141\u2013150.","DOI":"10.1016\/j.vetimm.2014.07.009"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Peroni DG, Chirumbolo S, Veneri D, Piacentini GL, Tenero L, Vella A, Ortolani R, Raffaelli R, Boner AL.  2013. 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