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Sci.","The Journal of Veterinary Medical Science"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1292\/jvms.26-0035","type":"journal-article","created":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T22:08:24Z","timestamp":1774822104000},"page":"746-755","source":"Crossref","is-referenced-by-count":0,"title":["Developmental disorders of the reproductive tract in            C57BL\/6N-XY&lt;sup&gt;POS&lt;\/sup&gt; mice"],"prefix":"10.1292","volume":"88","author":[{"given":"Honoka","family":"KAWAI","sequence":"first","affiliation":[{"name":"Department of Animal Science, Graduate School of Agricultural Science, Kobe              University, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshifumi","family":"YOKOYAMA","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Graduate School of Agricultural Science, Kobe              University, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"INUZUKA","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Graduate School of Agricultural Science, Kobe              University, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachika","family":"KURAMOTO","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Graduate School of Agricultural Science, Kobe              University, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaichi","family":"HOSHIKAWA","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Graduate School of Agricultural Science, Kobe              University, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youhei","family":"MANTANI","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Graduate School of Agricultural Science, Kobe              University, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"MIKI","sequence":"additional","affiliation":[{"name":"Departments of Anatomy and Neurobiology, Faculty of Medicine, Kagawa              University, Kagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiko","family":"HOSHI","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Graduate School of Agricultural Science, Kobe              University, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"122","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Albrecht              KH, Eicher              EM. 1997.            DNA sequence analysis of <i>Sry<\/i> alleles (subgenus Mus)            implicates misregulation as the cause of C57BL\/6J-Y<sup>POS<\/sup> sex reversal and            defines the SRY functional unit.            <i>Genetics<\/i>          147: 1267\u20131277.","DOI":"10.1093\/genetics\/147.3.1267"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Albrecht              KH, Capel              B, Washburn              LL, Eicher              EM. 2000.            Defective mesonephric cell migration is associated with abnormal testis            cord development in C57BL\/6J XY<i><sup>Mus domesticus<\/sup><\/i>            mice. <i>Dev Biol<\/i>          225: 26\u201336.","DOI":"10.1006\/dbio.2000.9819"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Albrecht              KH, Young              M, Washburn              LL, Eicher              EM. 2003.              <i>Sry<\/i> expression level and protein isoform differences            play a role in abnormal testis development in C57BL\/6J mice carrying certain              <i>Sry<\/i> alleles.            <i>Genetics<\/i>          164: 277\u2013288.","DOI":"10.1093\/genetics\/164.1.277"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Biason-Lauber              A. 2012.            WNT4, RSPO1, and FOXL2 in sex development.              <i>Semin Reprod Med<\/i>          30: 387\u2013395.","DOI":"10.1055\/s-0032-1324722"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Bullejos              M, Koopman              P. 2001.            Spatially dynamic expression of <i>Sry<\/i> in mouse genital            ridges. <i>Dev Dyn<\/i>          221: 201\u2013205.","DOI":"10.1002\/dvdy.1134"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Bullejos              M, Koopman              P. 2005.            Delayed <i>Sry<\/i> and <i>Sox9<\/i> expression in            developing mouse gonads underlies B6-Y<sup>DOM<\/sup> sex reversal.              <i>Dev Biol<\/i>          278: 473\u2013481.","DOI":"10.1016\/j.ydbio.2004.11.030"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Combes              AN, Lesieur              E, Harley              VR, Sinclair              AH, Little              MH, Wilhelm              D, Koopman              P. 2009.            Three-dimensional visualization of testis cord morphogenesis, a novel            tubulogenic mechanism in development. <i>Dev            Dyn<\/i>          238: 1033\u20131041.","DOI":"10.1002\/dvdy.21925"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Combes              AN, Wilhelm              D, Davidson              T, Dejana              E, Harley              V, Sinclair              A, Koopman              P. 2009.            Endothelial cell migration directs testis cord formation.              <i>Dev Biol<\/i>          326: 112\u2013120.","DOI":"10.1016\/j.ydbio.2008.10.040"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Cool              J, DeFalco              T, Capel              B. 2012.            Testis formation in the fetal mouse: dynamic and complex <i>de              novo<\/i> tubulogenesis. <i>Wiley Interdiscip Rev Dev              Biol<\/i>          1: 847\u2013859.","DOI":"10.1002\/wdev.62"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Coveney              D, Cool              J, Oliver              T, Capel              B. 2008.            Four-dimensional analysis of vascularization during primary development            of an organ, the gonad. <i>Proc Natl Acad Sci            USA<\/i>          105: 7212\u20137217.","DOI":"10.1073\/pnas.0707674105"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Eicher              EM, Shown              EP, Washburn              LL. 1995.            Sex reversal in C57BL\/6J-Y<sup>POS<\/sup> mice corrected by a              <i>Sry<\/i> transgene. <i>Philos Trans R Soc              Lond B Biol Sci<\/i>          350: 263\u2013268, discussion 268\u2013269.","DOI":"10.1098\/rstb.1995.0160"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Hermo              L, Dworkin              J. 1988.            Transitional cells at the junction of seminiferous tubules with the rete            testis of the rat: their fine structure, endocytic activity, and basement            membrane. <i>Am J Anat<\/i>          181: 111\u2013131.","DOI":"10.1002\/aja.1001810202"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Hiramatsu              R, Matoba              S,                Kanai-Azuma              M, Tsunekawa              N,                Katoh-Fukui              Y, Kurohmaru              M, Morohashi              K, Wilhelm              D, Koopman              P, Kanai              Y. 2009.            A critical time window of <i>Sry<\/i> action in gonadal sex            determination in mice. <i>Development<\/i>          136: 129\u2013138.","DOI":"10.1242\/dev.029587"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Kulibin              AY, Malolina              EA. 2020.            Formation of the rete testis during mouse embryonic            development. <i>Dev Dyn<\/i>          249: 1486\u20131499.","DOI":"10.1002\/dvdy.242"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Miyawaki              S, Kuroki              S, Maeda              R, Okashita              N, Koopman              P, Tachibana              M. 2020.            The mouse <i>Sry<\/i> locus harbors a cryptic exon that is            essential for male sex determination.            <i>Science<\/i>          370: 121\u2013124.","DOI":"10.1126\/science.abb6430"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Morales              C, Clermont              Y. 1986.            Receptor-mediated endocytosis of transferrin by Sertoli cells of the            rat. <i>Biol Reprod<\/i>          35: 393\u2013405.","DOI":"10.1095\/biolreprod35.2.393"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Munger              SC, Natarajan              A, Looger              LL, Ohler              U, Capel              B. 2013.            Fine time course expression analysis identifies cascades of activation            and repression and maps a putative regulator of mammalian sex            determination. <i>PLoS Genet<\/i>          9: e1003630.","DOI":"10.1371\/journal.pgen.1003630"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Nakajima              T, Iguchi              T, Sato              T. 2016.            Retinoic acid signaling determines the fate of uterine stroma in the            mouse M\u00fcllerian duct. <i>Proc Natl Acad Sci            USA<\/i>          113: 14354\u201314359.","DOI":"10.1073\/pnas.1608808113"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Narita              H, Yokoyama              T, Okunishi              N, Kato              S, Fujikawa              T, Kirizuki              Y, Mantani              Y, Miki              T, Hoshi              N. 2023.            Substrain differences in Sry expression at the stage of sex determination            in C57BL\/6 mouse strains. <i>J Vet Med            Sci<\/i>          85: 507\u2013514.","DOI":"10.1292\/jvms.23-0039"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Omotehara              T, Wu              X, Kuramasu              M, Itoh              M. 2020.            Connection between seminiferous tubules and epididymal duct is originally            induced before sex differentiation in a sex-independent manner.              <i>Dev Dyn<\/i>          249: 754\u2013764.","DOI":"10.1002\/dvdy.155"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Schmahl              J, Capel              B. 2003.            Cell proliferation is necessary for the determination of male fate in the            gonad. <i>Dev Biol<\/i>          258: 264\u2013276.","DOI":"10.1016\/S0012-1606(03)00122-2"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Schmahl              J, Eicher              EM, Washburn              LL, Capel              B. 2000.              <i>Sry<\/i> induces cell proliferation in the mouse            gonad. <i>Development<\/i>          127: 65\u201373.","DOI":"10.1242\/dev.127.1.65"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Sekido              R. 2010.            SRY: A transcriptional activator of mammalian testis            determination. <i>Int J Biochem Cell Biol<\/i>          42: 417\u2013420.","DOI":"10.1016\/j.biocel.2009.12.005"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Taketo              T, Lee              CH, Zhang              J, Li              Y, Lee              CYG, Lau              YFC. 2005.            Expression of SRY proteins in both normal and sex-reversed XY fetal mouse            gonads. <i>Dev Dyn<\/i>          233: 612\u2013622.","DOI":"10.1002\/dvdy.20352"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Uchida              A, Imaimatsu              K, Suzuki              H, Han              X, Ushioda              H, Uemura              M,                Imura-Kishi              K, Hiramatsu              R, Takase              HM, Hirate              Y, Ogura              A,                Kanai-Azuma              M, Kudo              A, Kanai              Y. 2022.            SOX17-positive rete testis epithelium is required for Sertoli valve            formation and normal spermiogenesis in the male mouse.              <i>Nat Commun<\/i>          13: 7860.","DOI":"10.1038\/s41467-022-35465-1"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Umemura              Y, Miyamoto              R, Hashimoto              R, Kinoshita              K, Omotehara              T, Nagahara              D, Hirano              T, Kubota              N, Minami              K, Yanai              S, Masuda              N, Yuasa              H, Mantani              Y, Matsuo              E, Yokoyama              T, Kitagawa              H, Hoshi              N. 2016.            Ontogenic and morphological study of gonadal formation in            genetically-modified sex reversal XY<sup>POS<\/sup> mice.              <i>J Vet Med Sci<\/i>          77: 1587\u20131598.","DOI":"10.1292\/jvms.15-0292"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Valeri              C, Lovaisa              MM, Racine              C, Edelsztein              NY, Riggio              M,                Giulianelli              S, Venara              M, Bedecarr\u00e1s              P, Ballerini              MG, di                Clemente              N, Lamb              CA,                Schteingart              HF, Rey              RA. 2020.            Molecular mechanisms underlying AMH elevation in hyperoestrogenic states            in males. <i>Sci Rep<\/i>          10: 15062.","DOI":"10.1038\/s41598-020-71675-7"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Wiersma              R, Ramdial              PK. 2009.            The gonads of 111 South African patients with ovotesticular disorder of            sex differentiation. <i>J Pediatr Surg<\/i>          44: 556\u2013560.","DOI":"10.1016\/j.jpedsurg.2008.08.013"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Wilhelm              D, Washburn              LL, Truong              V, Fellous              M, Eicher              EM, Koopman              P. 2009.            Antagonism of the testis- and ovary-determining pathways during ovotestis            development in mice. <i>Mech Dev<\/i>          126: 324\u2013336.","DOI":"10.1016\/j.mod.2009.02.006"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Wilhelm              D,                Perea-Gomez              A, Newton              A,                Chaboissier              MC. 2025.            Gonadal sex determination in vertebrates: rethinking established            mechanisms. <i>Development<\/i>          152: dev.204592.","DOI":"10.1242\/dev.204592"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Yamamoto              A, Omotehara              T, Miura              Y, Takada              T, Yoneda              N, Hirano              T, Mantani              Y, Kitagawa              H, Yokoyama              T, Hoshi              N. 2018.            The mechanisms underlying the effects of AMH on M\u00fcllerian duct regression            in male mice. <i>J Vet Med Sci<\/i>          80: 557\u2013567.","DOI":"10.1292\/jvms.18-0023"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Yokoyama              T, Miura              Y, Yamamoto              A, Hasegawa              C, Kawanishi              K, Takada              N, Omotehara              T, Hirano              T, Mantani              Y, Miki              T, Hoshi              N. 2019.            Genetic differences between C57BL\/6 substrains affect the process of            testis differentiation in Y<sup>POS<\/sup> mice. <i>J Vet              Med Sci<\/i>          81: 608\u2013611.","DOI":"10.1292\/jvms.18-0621"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Zhao              F, Yao              HH. 2019.            A tale of two tracts: history, current advances, and future directions of            research on sexual differentiation of reproductive tracts.              <i>Biol Reprod<\/i>          101: 602\u2013616.","DOI":"10.1093\/biolre\/ioz079"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/88\/5\/88_26-0035\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:25:57Z","timestamp":1777692357000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/88\/5\/88_26-0035\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.26-0035","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"26-0035"}}