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Aoki              T, Eki              K. 2024.            Comparative study of the effects of antitussive drugs in a canine acute            cough model. <i>Vet Med Sci<\/i>          10: e1549.","DOI":"10.1002\/vms3.1549"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Bolser              DC. 2010.            Pharmacologic management of cough.              <i>Otolaryngol Clin North Am<\/i>          43: 147\u2013155, xi.","DOI":"10.1016\/j.otc.2009.11.008"},{"key":"3","unstructured":"3. Canning              BJ, Chang              AB, Bolser              DC, Smith              JA, Mazzone              SB, McGarvey              L. CHEST Expert            Cough Panel.          2014. Anatomy and neurophysiology of cough: CHEST Guideline            and Expert Panel report. <i>Chest<\/i>          146: 1633\u20131648."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Canning              BJ, Mori              N, Mazzone              SB. 2006.            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Risk factors for coughing in dogs with naturally acquired myxomatous            mitral valve disease. <i>J Vet Intern Med<\/i>          27: 286\u2013292.","DOI":"10.1111\/jvim.12039"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Ford              AP, Undem              BJ. 2013.            The therapeutic promise of ATP antagonism at P2X3 receptors in            respiratory and urological disorders. <i>Front Cell              Neurosci<\/i>          7: 267.","DOI":"10.3389\/fncel.2013.00267"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Grobman              M, Reinero              C. 2016.            Investigation of neurokinin-1 receptor antagonism as a novel treatment            for chronic bronchitis in dogs. <i>J Vet Intern              Med<\/i>          30: 847\u2013852.","DOI":"10.1111\/jvim.13935"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Hsieh              BM, Beets              AK. 2020.            Coughing in small animal patients. <i>Front              Vet Sci<\/i>          6: 513.","DOI":"10.3389\/fvets.2019.00513"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Johnson              LR, Pollard              RE. 2010.            Tracheal collapse and bronchomalacia in dogs: 58 cases            (7\/2001-1\/2008). <i>J Vet Intern Med<\/i>          24: 298\u2013305.","DOI":"10.1111\/j.1939-1676.2009.0451.x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Kogan              DA, Johnson              LR, Sturges              BK, Jandrey              KE, Pollard              RE. 2008.            Etiology and clinical outcome in dogs with aspiration pneumonia: 88 cases            (2004\u20132006). <i>J Am Vet Med Assoc<\/i>          233: 1748\u20131755.","DOI":"10.2460\/javma.233.11.1748"},{"key":"12","unstructured":"12. Kyorin Pharmaceutical Co.            Ltd. 2025. Lyfnua<sup>\u00ae<\/sup> Tablets 45 mg Interview Form,          6th ed., revised June 2025. Kyorin Pharmaceutical, Tokyo."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Lebastard              M, Le Boedec              K, Howes              M, Joslyn              S, Matheson              JS, O\u2019Brien              RT. 2021.            Evaluation of bronchial narrowing in coughing dogs with heart murmurs            using computed tomography. <i>J Vet Intern            Med<\/i>          35: 1509\u20131518.","DOI":"10.1111\/jvim.16115"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. McGarvey              LP, Birring              SS, Morice              AH,                Dicpinigaitis              PV, Pavord              ID,                Schelfhout              J, Nguyen              AM, Li              Q, Tzontcheva              A, Iskold              B, Green              SA, Rosa              C, Muccino              DR, Smith              JA. COUGH-1 and            COUGH-2 Investigators.          2022. Efficacy and safety of gefapixant, a P2X<sub>3<\/sub>            receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1            and COUGH-2): results from two double-blind, randomised, parallel-group,            placebo-controlled, phase 3 trials.            <i>Lancet<\/i>          399: 909\u2013923.","DOI":"10.1016\/S0140-6736(21)02348-5"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Nafe              LA, Grobman              ME, Masseau              I, Reinero              CR. 2018.            Aspiration-related respiratory disorders in dogs.              <i>J Am Vet Med Assoc<\/i>          253: 292\u2013300.","DOI":"10.2460\/javma.253.3.292"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Nakagawa              T, Doi              A, Ohno              K, Yokoyama              N, Tsujimoto              H. 2019.            Clinical features and prognosis of canine megaesophagus in            Japan. <i>J Vet Med Sci<\/i>          81: 348\u2013352.","DOI":"10.1292\/jvms.18-0493"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Sluyter              R,                Sophocleous              RA, Stokes              L. 2023.            P2X receptors: Insights from the study of the domestic            dog. <i>Neuropharmacology<\/i>          224: 109358.","DOI":"10.1016\/j.neuropharm.2022.109358"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Xue              Q, Wang              R, Wang              L, Xiong              B, Li              L, Qian              J, Hao              L, Wang              Z, Liu              D, Deng              C, Rong              S, Yao              Y, Jiang              Y, Zhu              Q, Huang              J. 2021.            Downregulating the P2X3 receptor in the carotid body to reduce blood            pressure via acoustic gene delivery in canines. <i>Transl              Res<\/i>          227: 30\u201341.","DOI":"10.1016\/j.trsl.2020.06.005"}],"container-title":["Journal of Veterinary Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/88\/11\/88_26-0250\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T03:47:46Z","timestamp":1794023266000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/88\/11\/88_26-0250\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1292\/jvms.26-0250","relation":{},"ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"26-0250"}}