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Lesions of the islets of Langerhans in encephalomyocarditis virus-infected mice with diabetes mellitus-like disease. I . Acute lesions. Am. J. Pathol. 74: 287-300."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Cudworth, A. G. and Festenstein, H. 1978. HLA genetic heterogeneity in diabetes mellitus. Br. Med. Bull. 34: 285-289.","DOI":"10.1093\/oxfordjournals.bmb.a071513"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Doniach, I. and Morgan, A. G. 1973. Islets of Langerhans in juvenile diabetes mellitus. Clin. Endocrinol. 2: 233-248.","DOI":"10.1111\/j.1365-2265.1973.tb00425.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/BF00274217"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Freytag, G. and Kloppel, G. 1973. Insulitis-a morphological review. Curr. Top. 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Heterogeneity of islet pathology in two infants with recent onset diabetes mellitus. Virchows Arch. 425: 631-640.","DOI":"10.1007\/BF00199353"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Lohmann, T., Seissler, J., Verlohren, H. J., Schroder, S., Rotger, J., Dahn, K., Morgenthaler, N. and Scherbaum, W. A. 1997 . Distinct genetic and immunological features in patients with onset of IDDM before and after age 40. Diabetes Care 20: 524-529.","DOI":"10.2337\/diacare.20.4.524"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)90281-5"},{"key":"35","unstructured":"35) Meyenburg, H. von. 1940. Uber &ldquo;Insulitis&rdquo; bei Diabetes. Schweiz Med. Wochenschr. 21: 554-557."},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Menser, M. A., Forrest, J. M. and Bransby, R. D. 1978. Rubella infection and diabetes mellitus. 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