{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T05:03:24Z","timestamp":1649135004640},"reference-count":19,"publisher":"Japanese Society of Toxicologic Pathology","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Toxicol Pathol"],"published-print":{"date-parts":[[2013]]},"DOI":"10.1293\/tox.2013-0012","type":"journal-article","created":{"date-parts":[[2013,12,25]],"date-time":"2013-12-25T22:48:38Z","timestamp":1388011718000},"page":"375-384","source":"Crossref","is-referenced-by-count":3,"title":["Spleen-Specific Development of Germinal Centers in Rats Treated with Antithyroid Drugs"],"prefix":"10.1293","volume":"26","author":[{"given":"Motoko","family":"Fukui","sequence":"first","affiliation":[{"name":"Safety Research Department, ASKA Pharmaceutical Co., Ltd., 5-36-1 Shimosakunobe, Takatsu-ku, Kawasaki, Kanagawa213-8522, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Fukui","sequence":"additional","affiliation":[{"name":"Safety Research Department, ASKA Pharmaceutical Co., Ltd., 5-36-1 Shimosakunobe, Takatsu-ku, Kawasaki, Kanagawa213-8522, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuniyoshi","family":"Sakai","sequence":"additional","affiliation":[{"name":"Product Research Department, ASKA Pharmaceutical Co., Ltd., 3-4-3 Sakaecho, Hamura, Tokyo 205-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Product Research Department, ASKA Pharmaceutical Co., Ltd., 3-4-3 Sakaecho, Hamura, Tokyo 205-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Nagasaki","sequence":"additional","affiliation":[{"name":"Drug Discovery Department, ASKA Pharmaceutical Co., Ltd., 5-36-1 Shimosakunobe, Takatsu-ku, Kawasaki, Kanagawa213-8522, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Shibata","sequence":"additional","affiliation":[{"name":"Safety Research Department, ASKA Pharmaceutical Co., Ltd., 5-36-1 Shimosakunobe, Takatsu-ku, Kawasaki, Kanagawa213-8522, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sei-ichi","family":"Araki","sequence":"additional","affiliation":[{"name":"Safety Research Department, ASKA Pharmaceutical Co., Ltd., 5-36-1 Shimosakunobe, Takatsu-ku, Kawasaki, Kanagawa213-8522, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsui","family":"Isobe","sequence":"additional","affiliation":[{"name":"Safety Research Department, ASKA Pharmaceutical Co., Ltd., 5-36-1 Shimosakunobe, Takatsu-ku, Kawasaki, Kanagawa213-8522, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Hisada","sequence":"additional","affiliation":[{"name":"Developmental Research Center, ASKA Pharmaceutical Co., Ltd., 5-36-1 Shimosakunobe, Takatsu-ku, Kawasaki, Kanagawa213-8522, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"121","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Cooper DS. Antithyroid drugs. N Engl J Med. 352: 905\u2013917. 2005.","DOI":"10.1056\/NEJMra042972"},{"key":"2","unstructured":"2. Arimura Y. Drug-induced ANCA-associated vasculitis. Saishin Igaku. 68: 252\u2013258. 2013."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Uetrecht J. Immune-mediated adverse drug reactions. Chem Res Toxicol. 22: 24\u201334. 2009.","DOI":"10.1021\/tx800389u"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Putman E, Van Loveren H, Bode G, Dean J, Hastings K, Nakamura K, Verdier F, and Van Der Laan J-W. Assessment of the immunotoxic potential of human pharmaceuticals: A workshop report. Drug Inform J. 36: 417\u2013427. 2002.","DOI":"10.1177\/009286150203600221"},{"key":"5","unstructured":"5. ICH. Immunotoxicity Studies for Human Pharmaceuticals ICH S8 Guideline Step 5."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Allen CD, Okada T, and Cyster JG. Germinal center organization and cellular dynamics. Immunity. 27: 190\u2013202. 2007.","DOI":"10.1016\/j.immuni.2007.07.009"},{"key":"7","unstructured":"7. Kuper CF, de Heer E, Van Loveren H, and Vos JG. Immune system. In: Handbook of Toxicologic Pathology, 2nd ed. WM Hascheck, CG Rousseaux, and MA Walling (eds). Academic Press, San Diego. 585\u2013646. 2002."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Rehg JE, Bush D, and Ward JM. The utility of immunohistochemistry for the identification of hematopoietic and lymphoid cells in normal tissues and interpretation of proliferative and inflammatory lesions of mice and rats. Toxicol Pathol. 40: 345\u2013374. 2012.","DOI":"10.1177\/0192623311430695"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Elmore SA. Histopathology of the lymph nodes. Toxicol Pathol. 34: 425\u2013454. 2006.","DOI":"10.1080\/01926230600964722"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Cesta MF. Normal structure, function, and histology of the spleen. Toxicol Pathol. 34: 455\u2013465. 2006.","DOI":"10.1080\/01926230600867743"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Elmore SA. Enhanced histopathology of the spleen. Toxicol Pathol. 34: 648\u2013655. 2006.","DOI":"10.1080\/01926230600865523"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Mebius RE, and Kraal G. Structure and function of the spleen. Nat Rev Immunol. 5: 606\u2013616. 2005.","DOI":"10.1038\/nri1669"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Uetrecht JP. The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions. Drug Metab Rev. 24: 299\u2013366. 1992.","DOI":"10.3109\/03602539208996297"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Wolford A, McDonald TS, Eng H, Hansel S, Chen Y, Bauman J, Sharma R, and Kalgutkar AS. Immune-mediated agranulocytosis caused by the cocaine adulterant levamisole: a case for reactive metabolite(s) involvement. Drug Metab Dispos. 40: 1067\u20131075. 2012.","DOI":"10.1124\/dmd.112.045021"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. T\u00f6tterman TH, Karlsson FA, Bengtsson M, and Mendel-Hartvig I. Induction of circulating activated suppressor-like T cells by methimazole therapy for Graves\u2019 disease. N Engl J Med. 316: 15\u201322. 1987.","DOI":"10.1056\/NEJM198701013160104"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Whitacre CC. Sex differences in autoimmune disease. Nat Immunol. 2: 777\u2013780. 2001.","DOI":"10.1038\/ni0901-777"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Lee TP, and Chiang BL. Sex differences in spontaneous versus induced animal models of autoimmunity. Autoimmun Rev. 11: A422\u2013A429. 2012.","DOI":"10.1016\/j.autrev.2011.11.020"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Cano-Europa E, Blas-Valdivia V, Franco-Colin M, Gallardo-Casas CA, and Ortiz-Butr\u00f3n R. Methimazole-induced hypothyroidism causes cellular damage in the spleen, heart, liver, lung and kidney. Acta Histochem. 113: 1\u20135. 2011.","DOI":"10.1016\/j.acthis.2009.07.004"},{"key":"19","unstructured":"19. Kariya K, Dawson E, and Neal RA. Toxic effects of propylthiouracil in the rat. Res Commun Chem Pathol Pharmacol. 40: 333\u2013336. 1983."}],"container-title":["Journal of Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tox\/26\/4\/26_2013-0012\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T01:59:48Z","timestamp":1617155988000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tox\/26\/4\/26_2013-0012\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1293\/tox.2013-0012","relation":{},"ISSN":["0914-9198","1881-915X"],"issn-type":[{"value":"0914-9198","type":"print"},{"value":"1881-915X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}