{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:41:52Z","timestamp":1790487712741,"version":"4.1.0"},"reference-count":28,"publisher":"Japanese Society of Toxicologic Pathology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Toxicol Pathol"],"published-print":{"date-parts":[[2015]]},"DOI":"10.1293\/tox.2015-0025","type":"journal-article","created":{"date-parts":[[2015,5,31]],"date-time":"2015-05-31T18:10:48Z","timestamp":1433095848000},"page":"125-132","source":"Crossref","is-referenced-by-count":25,"title":["Practical approaches for evaluating adrenal toxicity in nonclinical safety assessment"],"prefix":"10.1293","volume":"28","author":[{"given":"Akira","family":"Inomata","sequence":"first","affiliation":[{"name":"Tsukuba Drug Safety, Global Drug Safety, Biopharmaceutical Assessments Core Function Unit, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Sasano","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"121","reference":[{"key":"1","doi-asserted-by":"publisher","unstructured":"1. Hammer GD, Parker KL, and Schimmer BP. Minireview: transcriptional regulation of adrenocortical development. Endocrinology. 146: 1018\u20131024. 2005.","DOI":"10.1210\/en.2004-1385"},{"key":"2","unstructured":"2. Vinson GP, Whitehouse BJ, and Hinson JP. The Adrenal Cortex. Prentice Hall, New Jersey. 1992."},{"key":"3","unstructured":"3. Kierszenbaum AL. Endocrine system. In: Histology and Cell Biology: An Introduction to Pathology, 2nd ed. Elsevier Ltd., Philadelphia. 537\u2013567. 2007."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Hornsby PJ. The regulation of adrenocortical function by control of growth and structure. In: Adrenal Cortex. DC Anderson and JSD Winter (eds). Butterworth, London. 1\u201331. 1985.","DOI":"10.1016\/B978-0-407-02275-1.50006-5"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Hornsby PJ. Physiological and pathological effects of steroids on the function of the adrenal cortex. J Steroid Biochem. 27: 1161\u20131171. 1987.","DOI":"10.1016\/0022-4731(87)90203-2"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Kim AC, and Hammer GD. Adrenocortical cells with stem\/progenitor cell properties: recent advances. Mol Cell Endocrinol. 265-266: 10\u201316. 2007.","DOI":"10.1016\/j.mce.2006.12.028"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Capen CC, DeLellis RA, and Yarrington JT. Endocrine system. In: Handbook of Toxicologic Pathology. WM Haschek and CG Rousseaux (eds). Academic Press, New York. 675\u2013760. 1991.","DOI":"10.1016\/B978-0-12-330220-5.50026-7"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Rosol TJ, Yarrington JT, Latendresse J, and Capen CC. Adrenal gland: structure, function, and mechanisms of toxicity. Toxicol Pathol. 29: 41\u201348. 2001.","DOI":"10.1080\/019262301301418847"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Reincke M, Beuschlein F, Menig G, Hofmockel G, Arlt W, Lehmann R, Karl M, and Allolio B. Localization and expression of adrenocorticotropic hormone receptor mRNA in normal and neoplastic human adrenal cortex. J Endocrinol. 156: 415\u2013423. 1998.","DOI":"10.1677\/joe.0.1560415"},{"key":"10","unstructured":"10. Sasano H, Sato F, Shizawa S, Nagura H, and Coughtrie MWH. Immunolocalization of dehydroepiandrosterone sulfotransferase in normal and pathologic human adrenal gland. Mod Pathol. 8: 891\u2013896. 1995."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Suzuki T, Sasano H, Takeyama J, Kaneko C, Freije WA, Carr BR, and Rainey WE. Developmental changes in steroidogenic enzymes in human postnatal adrenal cortex: immunohistochemical studies. Clin Endocrinol (Oxf). 53: 739\u2013747. 2000.","DOI":"10.1046\/j.1365-2265.2000.01144.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Hinson JP, and Raven PW. Effects of endocrine-disrupting chemicals on adrenal function. Best Pract Res Clin Endocrinol Metab. 20: 111\u2013120. 2006.","DOI":"10.1016\/j.beem.2005.09.006"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Hornsby PJ, and Crivello JF. The role of lipid peroxidation and biological antioxidants in the function of the adrenal cortex. Part 1: A background review. Mol Cell Endocrinol. 30: 1\u201320. 1983.","DOI":"10.1016\/0303-7207(83)90197-1"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Hornsby PJ, and Crivello JF. The role of lipid peroxidation and biological antioxidants in the function of the adrenal cortex. Part 2. Mol Cell Endocrinol. 30: 123\u2013147. 1983.","DOI":"10.1016\/0303-7207(83)90043-6"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Hornsby PJ. Steroid and xenobiotic effects on the adrenal cortex: mediation by oxidative and other mechanisms. Free Radic Biol Med. 6: 103\u2013115. 1989.","DOI":"10.1016\/0891-5849(89)90163-9"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. T\u00f3th IE. Lipoprotein receptors and steroidogenesis in adrenocortical cells. J Steroid Biochem Mol Biol. 43: 395\u2013402. 1992.","DOI":"10.1016\/0960-0760(92)90075-T"},{"key":"17","unstructured":"17. Carney JA. Adrenal gland. In: Histology for Pathologists. SS Sternberg (ed). Raven Press, New York. 1992."},{"key":"18","unstructured":"18. Cormack MJ. The endocrine system. In: Ham\u2019s Textbook of Histology, 9th ed. Harper and Row, New York. 611\u2013615. 1989."},{"key":"19","doi-asserted-by":"publisher","unstructured":"19. Wurtman RJ, and Axelrod J. Adrenaline synthesis: control by the pituitary gland and adrenal glucocorticoids. Science. 150: 1464\u20131465. 1965.","DOI":"10.1126\/science.150.3702.1464"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Ehrhart-Bornstein M, and Bornstein SR. Cross-talk between adrenal medulla and adrenal cortex in stress. Ann N Y Acad Sci. 1148: 112\u2013117. 2008.","DOI":"10.1196\/annals.1410.053"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Bielohuby M, Herbach N, Wanke R, Maser-Gluth C, Beuschlein F, Wolf E, and Hoeflich A. Growth analysis of the mouse adrenal gland from weaning to adulthood: time- and gender-dependent alterations of cell size and number in the cortical compartment. Am J Physiol Endocrinol Metab. 293: E139\u2013E146. 2007.","DOI":"10.1152\/ajpendo.00705.2006"},{"key":"22","unstructured":"22. Malendowicz LK. Cytophysiology of the mammarian adrenal cortex. PTPN, Poznan. 1994."},{"key":"23","unstructured":"23. Frith CH, and Ward JM. Color atlas of neoplastic and non-neoplastic lesions in aging mice. In: Endocrine System. CH Frith and JM Ward (eds). Elsevier, Amsterdam, Oxford, New York, Tokyo. 33\u201342. 1988."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Ribelin WE. The effects of drugs and chemicals upon the structure of the adrenal gland. Fundam Appl Toxicol. 4: 105\u2013119. 1984.","DOI":"10.1016\/0272-0590(84)90224-0"},{"key":"25","unstructured":"25. Colby HD, and Longhurst PA. Toxicology of the adrenal gland. In: Endocrine Toxicology. CK Atterwill and JD Flack (eds). Cambridge University Press, Cambridge. 1992."},{"key":"26","unstructured":"26. Hinson JP, and Raven PW. Adrenal morphology and hormone synthesis and regulation. In: The Adrenal in Toxicology. PW Harvey (ed). Taylor and Francis, London, Bristol. 1996."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Inomata A. [Drug-induced endocrine toxicity]. Nihon Yakurigaku Zasshi. 132: 297\u2013300. 2008.","DOI":"10.1254\/fpj.132.297"},{"key":"28","unstructured":"28. Ferguson DC, and Hoenig M. Endocrine system. In: Duncan & Prasse\u2019s Veterinary Laboratory Medicine: Clinical Pathology, 4th ed. KS Latimer, EA Mahaffey and KW Prasse (eds). Iowa State Press, Iowa. 270\u2013303. 2003."}],"container-title":["Journal of Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tox\/28\/3\/28_2015-0025\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T18:07:43Z","timestamp":1566756463000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tox\/28\/3\/28_2015-0025\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1293\/tox.2015-0025","relation":{},"ISSN":["0914-9198","1881-915X"],"issn-type":[{"value":"0914-9198","type":"print"},{"value":"1881-915X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}