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Chou SM, and Hartmann HA. Axonal lesions and waltzing syndrome after idpn administration in rats. with a concept\u2013\u201caxostasis\u201d. Acta Neuropathol. 3: 428\u2013450. 1964.","DOI":"10.1007\/BF00688453"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Llorens J, Dem\u00eames D, and Sans A. The behavioral syndrome caused by 3,3\u2032-iminodipropionitrile and related nitriles in the rat is associated with degeneration of the vestibular sensory hair cells. Toxicol Appl Pharmacol. 123: 199\u2013210. 1993.","DOI":"10.1006\/taap.1993.1238"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Okazaki S, Takashima H, Yamaguchi M, Hamamura M, Yamashita K, Okada M, Sunaga M, Tanaka R, Sato S, Umano T, Tsuji R, Yosioka T, and Fujii T. [Neurobehavioral toxicity of acrylamide and IDPN (3,3\u2032-iminodipropionitrile) in rats by 28-day oral administration--problems encountered in collaborative study and a commentary on conducting neurobehavioral testing]. J Toxicol Sci. 28(Suppl 1): 1\u201314. 2003; (in Japanese).","DOI":"10.2131\/jts.28.1"},{"key":"4","doi-asserted-by":"publisher","unstructured":"4. Griffin JW, Hoffman PN, Clark AW, Carroll PT, and Price DL. Slow axonal transport of neurofilament proteins: impairment of beta,beta\u2019-iminodipropionitrile administration. Science. 202: 633\u2013635. 1978.","DOI":"10.1126\/science.81524"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Schulze GE, and Boysen BG. A neurotoxicity screening battery for use in safety evaluation: effects of acrylamide and 3\u2032,3\u2032-iminodipropionitrile. Fundam Appl Toxicol. 16: 602\u2013615. 1991.","DOI":"10.1016\/0272-0590(91)90099-P"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Zhu Q, Lindenbaum M, Levavasseur F, Jacomy H, and Julien JP. Disruption of the NF-H gene increases axonal microtubule content and velocity of neurofilament transport: relief of axonopathy resulting from the toxin beta,beta\u2019-iminodipropionitrile. J Cell Biol. 143: 183\u2013193. 1998.","DOI":"10.1083\/jcb.143.1.183"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Yoshioka T, Hamamura M, Yoshimura S, Okazaki Y, Yamaguchi Y, Sunaga M, Hoshuyama S, Iwata H, Okada M, Takei Y, Yamaguchi M, Mitsumori K, Imai K, Narama I, and Okuno Y. Neuropathological evaluation of acrylamide and 3,3\u2032-iminodipropionitrile-induced neurotoxicity in a rat 28-day oral toxicity study-collaborative project for standardization of test procedures and evaluation of neurotoxicity. J Toxicol Pathol. 14: 279\u2013287. 2001.","DOI":"10.1293\/tox.14.279"},{"key":"8","doi-asserted-by":"publisher","unstructured":"8. Ambros V. The functions of animal microRNAs. Nature. 431: 350\u2013355. 2004.","DOI":"10.1038\/nature02871"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Miska EA. How microRNAs control cell division, differentiation and death. Curr Opin Genet Dev. 15: 563\u2013568. 2005.","DOI":"10.1016\/j.gde.2005.08.005"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Kloosterman WP, and Plasterk RH. The diverse functions of microRNAs in animal development and disease. Dev Cell. 11: 441\u2013450. 2006.","DOI":"10.1016\/j.devcel.2006.09.009"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Kaur P, Armugam A, and Jeyaseelan K. MicroRNAs in Neurotoxicity. J Toxicol. 2012: 870150. 2012.","DOI":"10.1155\/2012\/870150"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Wang X, Zhou S, Ding X, Zhu G, and Guo J. Effect of triazophos, fipronil and their mixture on miRNA expression in adult zebrafish. J Environ Sci Health B. 45: 648\u2013657. 2010.","DOI":"10.1080\/03601234.2010.502435"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13. Tal TL, and Tanguay RL. Non-coding RNAs--novel targets in neurotoxicity. Neurotoxicology. 33: 530\u2013544. 2012.","DOI":"10.1016\/j.neuro.2012.02.013"},{"key":"14","first-page":"S1","volume":"15","year":"2014","unstructured":"14. Deng Y, Ai J, Guan X, Wang Z, Yan B, Zhang D, Liu C, Wilbanks MS, Escalon BL, Meyers SA, Yang MQ, and Perkins EJ. MicroRNA and messenger RNA profiling reveals new biomarkers and mechanisms for RDX induced neurotoxicity. BMC Genomics. 15(Suppl 11): S1. 2014.","journal-title":"BMC Genomics","ISSN":"https:\/\/id.crossref.org\/issn\/1471-2164","issn-type":"print"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Qi Y, Zhang M, Li H, Frank JA, Dai L, Liu H, and Chen G. MicroRNA-29b regulates ethanol-induced neuronal apoptosis in the developing cerebellum through SP1\/RAX\/PKR cascade. J Biol Chem. 289: 10201\u201310210. 2014.","DOI":"10.1074\/jbc.M113.535195"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. An J, Cai T, Che H, Yu T, Cao Z, Liu X, Zhao F, Jing J, Shen X, Liu M, Du K, Chen J, and Luo W. The changes of miRNA expression in rat hippocampus following chronic lead exposure. Toxicol Lett. 229: 158\u2013166. 2014.","DOI":"10.1016\/j.toxlet.2014.06.002"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Ogata K, Sumida K, Miyata K, Kushida M, Kuwamura M, and Yamate J. Circulating miR-9* and miR-384-5p as potential indicators for trimethyltin-induced neurotoxicity. Toxicol Pathol. 43: 198\u2013208. 2015.","DOI":"10.1177\/0192623314530533"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Hu Z, Yu D, Gu QH, Yang Y, Tu K, Zhu J, and Li Z. miR-191 and miR-135 are required for long-lasting spine remodelling associated with synaptic long-term depression. Nat Commun. 5: 3263. 2014.","DOI":"10.1038\/ncomms4263"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Chen CL, Liu H, and Guan X. Changes in microRNA expression profile in hippocampus during the acquisition and extinction of cocaine-induced conditioned place preference in rats. J Biomed Sci. 20: 96. 2013.","DOI":"10.1186\/1423-0127-20-96"},{"key":"20","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1186\/1471-2164-14-473","volume":"14","year":"2013","unstructured":"20. Masliah-Planchon J, Pasmant E, Luscan A, Laurendeau I, Ortonne N, Hivelin M, Varin J, Valeyrie-Allanore L, Dumaine V, Lantieri L, Leroy K, Parfait B, Wolkenstein P, Vidaud M, Vidaud D, and Bi\u00e8che I. MicroRNAome profiling in benign and malignant neurofibromatosis type 1-associated nerve sheath tumors: evidences of PTEN pathway alterations in early NF1 tumorigenesis. BMC Genomics. 14: 473. 2013.","journal-title":"BMC Genomics","ISSN":"https:\/\/id.crossref.org\/issn\/1471-2164","issn-type":"print"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Wang LL, Zhang Z, Li Q, Yang R, Pei X, Xu Y, Wang J, Zhou SF, and Li Y. Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation. Hum Reprod. 24: 562\u2013579. 2009.","DOI":"10.1093\/humrep\/den439"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Zheng H, Law PY, and Loh HH. Non-Coding RNAs Regulating Morphine Function: With Emphasis on the In vivo and In vitro Functions of miR-190. Front Genet. 3: 113. 2012.","DOI":"10.3389\/fgene.2012.00113"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Meissner L, Gallozzi M, Balbi M, Schwarzmaier S, Tiedt S, Terpolilli NA, and Plesnila N. Temporal Profile of MicroRNA Expression in Contused Cortex after Traumatic Brain Injury in Mice. J Neurotrauma. 33: 713\u2013720. 2016.","DOI":"10.1089\/neu.2015.4077"},{"key":"24","doi-asserted-by":"publisher","unstructured":"24. Mandolesi G, Vanni V, Cesa R, Grasselli G, Puglisi F, Cesare P, and Strata P. Distribution of the SNAP25 and SNAP23 synaptosomal-associated protein isoforms in rat cerebellar cortex. Neuroscience. 164: 1084\u20131096. 2009.","DOI":"10.1016\/j.neuroscience.2009.08.067"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Malarkey EB, and Parpura V. Temporal characteristics of vesicular fusion in astrocytes: examination of synaptobrevin 2-laden vesicles at single vesicle resolution. J Physiol. 589: 4271\u20134300. 2011.","DOI":"10.1113\/jphysiol.2011.210435"},{"key":"26","doi-asserted-by":"publisher","unstructured":"26. Bragina L, Candiracci C, Barbaresi P, Gioved\u00ec S, Benfenati F, and Conti F. Heterogeneity of glutamatergic and GABAergic release machinery in cerebral cortex. Neuroscience. 146: 1829\u20131840. 2007.","DOI":"10.1016\/j.neuroscience.2007.02.060"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Stigliani S, Zappettini S, Raiteri L, Passalacqua M, Melloni E, Venturi C, Tacchetti C, Diaspro A, Usai C, and Bonanno G. Glia re-sealed particles freshly prepared from adult rat brain are competent for exocytotic release of glutamate. J Neurochem. 96: 656\u2013668. 2006.","DOI":"10.1111\/j.1471-4159.2005.03631.x"},{"key":"28","unstructured":"28. Yamamori S, and Itakura M. [Differential expression and function of SNAP-25 family proteins in the mouse brain]. Seikagaku. 85: 1016\u20131020. 2013; (in Japanese)."},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Wilhelm A, Volknandt W, Langer D, Nolte C, Kettenmann H, and Zimmermann H. Localization of SNARE proteins and secretory organelle proteins in astrocytes in vitro and in situ. Neurosci Res. 48: 249\u2013257. 2004.","DOI":"10.1016\/j.neures.2003.11.002"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Verderio C, Pozzi D, Pravettoni E, Inverardi F, Schenk U, Coco S, Proux-Gillardeaux V, Galli T, Rossetto O, Frassoni C, and Matteoli M. SNAP-25 modulation of calcium dynamics underlies differences in GABAergic and glutamatergic responsiveness to depolarization. Neuron. 41: 599\u2013610. 2004.","DOI":"10.1016\/S0896-6273(04)00077-7"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Weng N, Thomas DD, and Groblewski GE. Pancreatic acinar cells express vesicle-associated membrane protein 2- and 8-specific populations of zymogen granules with distinct and overlapping roles in secretion. J Biol Chem. 282: 9635\u20139645. 2007.","DOI":"10.1074\/jbc.M611108200"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Stoeckelhuber M, Scherer EQ, Janssen KP, Slotta-Huspenina J, Loeffelbein DJ, Rohleder NH, Nieberler M, Hasler R, and Kesting MR. The human submandibular gland: immunohistochemical analysis of SNAREs and cytoskeletal proteins. J Histochem Cytochem. 60: 110\u2013120. 2012.","DOI":"10.1369\/0022155411432785"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Imai A, Nashida T, Yoshie S, and Shimomura H. Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane. Arch Oral Biol. 48: 597\u2013604. 2003.","DOI":"10.1016\/S0003-9969(03)00116-X"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Low SH, Roche PA, Anderson HA, van Ijzendoorn SC, Zhang M, Mostov KE, and Weimbs T. Targeting of SNAP-23 and SNAP-25 in polarized epithelial cells. J Biol Chem. 273: 3422\u20133430. 1998.","DOI":"10.1074\/jbc.273.6.3422"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Fink DJ, Purkiss D, and Mata M. beta,beta\u2019-Iminodipropionitrile impairs retrograde axonal transport. J Neurochem. 47: 1032\u20131038. 1986.","DOI":"10.1111\/j.1471-4159.1986.tb00717.x"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Llorens J, Crofton KM, and O\u2019Callaghan JP. Administration of 3,3\u2032-iminodipropionitrile to the rat results in region-dependent damage to the central nervous system at levels above the brain stem. J Pharmacol Exp Ther. 265: 1492\u20131498. 1993.","DOI":"10.1016\/S0022-3565(25)38285-6"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Crofton KM, Janssen R, Prazma J, Pulver S, and Barone S Jr. The ototoxicity of 3,3\u2032-iminodipropionitrile: functional and morphological evidence of cochlear damage. Hear Res. 80: 129\u2013140. 1994.","DOI":"10.1016\/0378-5955(94)90104-X"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Llorens J, and Rodr\u00edguez-Farr\u00e9 E. Comparison of behavioral, vestibular, and axonal effects of subchronic IDPN in the rat. Neurotoxicol Teratol. 19: 117\u2013127. 1997.","DOI":"10.1016\/S0892-0362(96)00216-4"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Seoane A, Dem\u00eames D, and Llorens J. Pathology of the rat vestibular sensory epithelia during subchronic 3,3\u2032-iminodipropionitrile exposure: hair cells may not be the primary target of toxicity. Acta Neuropathol. 102: 339\u2013348. 2001.","DOI":"10.1007\/s004010100387"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Khan HA, Alhomida AS, and Arif IA. Neurovestibular toxicities of acrylonitrile and iminodipropionitrile in rats: a comparative evaluation of putative mechanisms and target sites. Toxicol Sci. 109: 124\u2013131. 2009.","DOI":"10.1093\/toxsci\/kfp043"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Seoane A, Espejo M, Pall\u00e0s M, Rodr\u00edguez-Farr\u00e9 E, Ambrosio S, and Llorens J. Degeneration and gliosis in rat retina and central nervous system following 3,3\u2032-iminodipropionitrile exposure. 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