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Kato              T,                Relator              R,                Ngouv              H,                Hirohashi              Y,                Takaki              O,                Kakimoto              T, and                Okada              K. Segmental            HOG: new descriptor for glomerulus detection in kidney microscopy image.            BMC Bioinformatics. 16: 316.            2015.","journal-title":"BMC Bioinformatics","ISSN":"https:\/\/id.crossref.org\/issn\/1471-2105","issn-type":"print"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6.  Horai              Y,                Kakimoto              T,                Takemoto              K, and                Tanaka              M. Quantitative            analysis of histopathological findings using image processing software.            J Toxicol Pathol. 30:            351\u2013358. 2017.","DOI":"10.1293\/tox.2017-0031"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7.  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Automated            histological classification of whole slide images of colorectal biopsy            specimens. Oncotarget. 8:            90719\u201390729. 2017.","DOI":"10.18632\/oncotarget.21819"},{"key":"9","doi-asserted-by":"crossref","unstructured":"10.  Horai              Y,                Utsumi              H,                Ono              Y,                Kishimoto              T,                Ono              Y, and                Fukunari              A. Pathological            characterization and morphometric analysis of hepatic lesions in SHRSP5\/Dmcr, an            experimental non-alcoholic steatohepatitis model, induced by high-fat and            high-cholesterol diet. Int J Exp Pathol.            97: 75\u201385. 2016.","DOI":"10.1111\/iep.12169"},{"key":"10","doi-asserted-by":"crossref","unstructured":"11.  Van                Cutsem              E,                Bang              YJ,                Mansoor              W,                Petty              RD,                Chao              Y,                Cunningham              D,                Ferry              DR,                Smith              NR,                Frewer              P,                Ratnayake              J,                Stockman              PK,                Kilgour              E, and                Landers              D. A            randomized, open-label study of the efficacy and safety of AZD4547 monotherapy versus            paclitaxel for the treatment of advanced gastric adenocarcinoma with FGFR2 polysomy or            gene amplification. Ann Oncol. 28:            1316\u20131324. 2017.","DOI":"10.1093\/annonc\/mdx107"},{"key":"11","doi-asserted-by":"crossref","unstructured":"12.  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