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The            expression and environmental regulation of P450 enzymes in human            placenta. Crit Rev Toxicol. 24:            211\u2013229. 1994.","DOI":"10.3109\/10408449409021606"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4.  Syme              MR,                Paxton              JW, and                Keelan              JA. Drug            transfer and metabolism by the human placenta. Clin            Pharmacokinet. 43: 487\u2013514.            2004.","DOI":"10.2165\/00003088-200443080-00001"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5.  Stejskalova              L, and                Pavek              P. The function            of cytochrome P450 1A1 enzyme (CYP1A1) and aryl hydrocarbon receptor (AhR) in the            placenta. Curr Pharm Biotechnol. 12:            715\u2013730. 2011.","DOI":"10.2174\/138920111795470994"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6.  Garry              VF, and                Truran              P. Teratogenicity. In:          Reproductive and Developmental Toxicology, 2nd ed. RC Gupta (ed). Academic press, London.          1167\u20131181. 2017.","DOI":"10.1016\/B978-0-12-804239-7.00062-7"},{"key":"7","unstructured":"7.  Shiverick              KT,                Ortiz              E,                Fuhrman-Lane              C, and                Crowley              P. Effects of            beta-naphthoflavone and 3-methylcholanthrene administered to pregnant rats on steroid            metabolism in the isolated basal zone of the placenta. J            Pharmacol Exp Ther. 230:          761\u2013767. 1984."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8.  McKillop              D, and                Case              DE.            Mutagenicity, carcinogenicity and toxicity of beta-naphthoflavone, a            potent inducer of P448. Biochem Pharmacol.            41: 1\u20137. 1991.","DOI":"10.1016\/0006-2952(91)90003-N"},{"key":"9","unstructured":"9.  Shiverick              KT,                Swanson              C,                Salhab              AS, and                James              MO.            Differential induction of ethoxyresorufin-O-deethylase in tissues of the            rat placenta. J Pharmacol Exp Ther.            238: 1108\u20131113. 1986."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10.  Czekaj              P,                Wiaderkiewicz              A,                Florek              E, and                Wiaderkiewicz              R. Tobacco            smoke-dependent changes in cytochrome P450 1A1, 1A2, and 2E1 protein expressions in            fetuses, newborns, pregnant rats, and human placenta. Arch            Toxicol. 79: 13\u201324.            2005.","DOI":"10.1007\/s00204-004-0607-7"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11.  Engelbregt              MJ,                van Weissenbruch              MM,                Popp-Snijders              C,                Lips              P, and                Delemarre-van de Waal              HA. Body mass            index, body composition, and leptin at onset of puberty in male and female rats after            intrauterine growth retardation and after early postnatal food            restriction. Pediatr Res. 50:            474\u2013478. 2001.","DOI":"10.1203\/00006450-200110000-00009"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12.  Huang              J,                Zhou              S,                Ping              J,                Pan              X,                Liang              G,                Xu              D,                Kou              H,                Bao              C, and                Wang              H. Role of            p53-dependent placental apoptosis in the reproductive and developmental toxicities of            caffeine in rodents. Clin Exp Pharmacol Physiol.            39: 357\u2013363. 2012.","DOI":"10.1111\/j.1440-1681.2012.05676.x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13.  Furukawa              S,                Nagaike              M, and                Ozaki              K. Databases            for technical aspects of immunohistochemistry. J Toxicol            Pathol. 30: 79\u2013107.            2017.","DOI":"10.1293\/tox.2016-0047"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14.  Nebert              DW,                Dalton              TP,                Okey              AB, and                Gonzalez              FJ. Role of            aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental            toxicity and cancer. J Biol Chem. 279:            23847\u201323850. 2004.","DOI":"10.1074\/jbc.R400004200"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15.  Collier              AC,                Tingle              MD,                Paxton              JW,                Mitchell              MD, and                Keelan              JA.            Metabolizing enzyme localization and activities in the first trimester            human placenta: the effect of maternal and gestational age, smoking and alcohol            consumption. Hum Reprod. 17:            2564\u20132572. 2002.","DOI":"10.1093\/humrep\/17.10.2564"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16.  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Wang              T,                Chen              M,                Yan              YE,                Xiao              FQ,                Pan              XL, and                Wang              H. Growth            retardation of fetal rats exposed to nicotine in utero: possible involvement of CYP1A1,            CYP2E1, and P-glycoprotein. Environ Toxicol.            24: 33\u201342. 2009.","DOI":"10.1002\/tox.20391"},{"key":"22","doi-asserted-by":"publisher","unstructured":"22.  Annas              A, and                Brittebo              EB.            Localization of cytochrome P4501A1 and covalent binding of a mutagenic            heterocyclic amine in blood vessel endothelia of rodents.            Toxicology. 129:          145\u2013156. 1998.","DOI":"10.1016\/S0300-483X(98)00087-0"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23.  Yan              YE,                Wang              H, and                Feng              YH. Alterations            of placental cytochrome P450 1A1 and P-glycoprotein in tobacco-induced intrauterine            growth retardation in rats. Acta Pharmacol Sin.            26: 1387\u20131394. 2005.","DOI":"10.1111\/j.1745-7254.2005.00209.x"},{"key":"24","unstructured":"24.  Fuhrman-Lane              C,                Ortiz              E, and                Shiverick              KT. Effects of            beta-naphthoflavone administration to pregnant rats on steroid hormone biosynthesis and            metabolism in ovarian microsomes. J Pharmacol Exp Ther.            227: 248\u2013253. 1983."},{"key":"25","doi-asserted-by":"crossref","unstructured":"25.  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Histomorphological comparison of rat placentas by different timing of            chlorpromazine-administration. Exp Toxicol Pathol.            67: 443\u2013452. 2015.","DOI":"10.1016\/j.etp.2015.06.001"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29.  Nishimura              T,                Takanohashi              T,                Tomi              M,                Horikoshi              M,                Higuchi              K,                Sai              Y, and                Nakashima              E. Evaluation            of rat in vivo fetal-to-maternal transfer clearances of various xenobiotics by umbilical            perfusion. J Pharm Sci. 102:            3356\u20133363. 2013.","DOI":"10.1002\/jps.23551"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30.  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