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Numano              T,                Sugiyama              T,                Kawabe              M,                Mera              Y,                Ogawa              R,                Nishioka              A,                Fukui              H,                Sato              K, and                Hagiwara              Y. Lung            toxicity of a vapor-grown carbon fiber in comparison with a multi-walled carbon nanotube            in F344 rats. J Toxicol Pathol. 34:            57\u201371. 2021.","DOI":"10.1293\/tox.2020-0064"},{"key":"10","unstructured":"10.  Runkle              BK, and                Hahn              FF. The            toxicity of H2SO4 aerosols to CD-1 mice and Fisher-344 rats. Ann            Rep Inhal Toxicol Res Inst. 435\u2013439.            1976."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11.  Davies              B, and                Morris              T.            Physiological parameters in laboratory animals and          humans. Pharm Res. 10:            1093\u20131095. 1993.","DOI":"10.1023\/A:1018943613122"},{"key":"12","unstructured":"12.   OECD. SIDS Initial Assessment Report for 11th          SIAM. 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