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Liu              X,                Wu              Y,                Yang              Y,                Li              W,                Huang              C,                Meng              X, and                Li              J. Role of            NLRC5 in progression and reversal of hepatic fibrosis. Toxicol            Appl Pharmacol. 294: 43\u201353.            2016.","DOI":"10.1016\/j.taap.2016.01.012"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2.  Zheng              H,                Wang              X,                Zhang              Y,                Chen              L,                Hua              L, and                Xu              W.            Pien-Tze-Huang ameliorates hepatic fibrosis via suppressing NF-\u03baB pathway            and promoting HSC apoptosis. J Ethnopharmacol.            244: 111856. 2019.","DOI":"10.1016\/j.jep.2019.111856"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3.  George              J,                Tsuchishima              M, and                Tsutsumi              M. Molecular            mechanisms in the pathogenesis of N-nitrosodimethylamine induced hepatic            fibrosis. Cell Death Dis. 10:            18. 2019.","DOI":"10.1038\/s41419-018-1272-8"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4.  Shay              JES, and                Hamilton              JP. Hepatic            fibrosis: avenues of investigation and clinical implications.            Clin Liver Dis (Hoboken). 11:            111\u2013114. 2018.","DOI":"10.1002\/cld.702"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5.  Zhou              WC,                Zhang              QB, and                Qiao              L. Pathogenesis            of liver cirrhosis. World J Gastroenterol.            20: 7312\u20137324. 2014.","DOI":"10.3748\/wjg.v20.i23.7312"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6.  George              J,                Tsuchishima              M, and                Tsutsumi              M. Metabolism            of N-nitrosodimethylamine, methylation of macromolecules, and development of hepatic            fibrosis in rodent models. J Mol Med (Berl).            98: 1203\u20131213. 2020.","DOI":"10.1007\/s00109-020-01950-7"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7.  Shan              L,                Liu              Z,                Ci              L,                Shuai              C,                Lv              X, and                Li              J. Research            progress on the anti-hepatic fibrosis action and mechanism of natural            products. Int Immunopharmacol. 75:            105765. 2019.","DOI":"10.1016\/j.intimp.2019.105765"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8.  Wu              H,                Chen              G,                Wang              J,                Deng              M,                Yuan              F, and                Gong              J. TIM-4            interference in Kupffer cells against CCL4-induced liver fibrosis by mediating            Akt1\/Mitophagy signalling pathway. Cell Prolif.            53: e12731. 2020.","DOI":"10.1111\/cpr.12731"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9.  Duffield              JS,                Forbes              SJ,                Constandinou              CM,                Clay              S,                Partolina              M,                Vuthoori              S,                Wu              S,                Lang              R, and                Iredale              JP. Selective            depletion of macrophages reveals distinct, opposing roles during liver injury and            repair. J Clin Invest. 115:            56\u201365. 2005.","DOI":"10.1172\/JCI200522675"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10.  Lodder              J,                Dena\u00ebs              T,                Chobert              MN,                Wan              J,                El-Benna              J,                Pawlotsky              JM,                Lotersztajn              S, and                Teixeira-Clerc              F. Macrophage            autophagy protects against liver fibrosis in mice.            Autophagy. 11:          1280\u20131292. 2015.","DOI":"10.1080\/15548627.2015.1058473"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11.  Klingberg              F,                Hinz              B, and                White              ES. The            myofibroblast matrix: implications for tissue repair and fibrosis.            J Pathol. 229: 298\u2013309.            2013.","DOI":"10.1002\/path.4104"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12.  Qu              C,                Zheng              D,                Li              S,                Liu              Y,                Lidofsky              A,                Holmes              JA,                Chen              J,                He              L,                Wei              L,                Liao              Y,                Yuan              H,                Jin              Q,                Lin              Z,                Hu              Q,                Jiang              Y,                Tu              M,                Chen              X,                Li              W,                Lin              W,                Fuchs              BC,                Chung              RT, and                Hong              J. Tyrosine            kinase SYK is a potential therapeutic target for liver fibrosis.            Hepatology. 68:            1125\u20131139. 2018.","DOI":"10.1002\/hep.29881"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13.  Tsuchida              T, and                Friedman              SL. Mechanisms            of hepatic stellate cell activation. Nat Rev Gastroenterol            Hepatol. 14: 397\u2013411.            2017.","DOI":"10.1038\/nrgastro.2017.38"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14.  George              J,                Tsutsumi              M, and                Tsuchishima              M. MMP-13            deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced            liver injury and fibrosis in mice. J Cell Mol Med.            21: 3821\u20133835. 2017.","DOI":"10.1111\/jcmm.13304"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15.  Ying              HZ,                Chen              Q,                Zhang              WY,                Zhang              HH,                Ma              Y,                Zhang              SZ,                Fang              J, and                Yu              CH. PDGF            signaling pathway in hepatic fibrosis pathogenesis and therapeutics            (Review). Mol Med Rep. 16:            7879\u20137889. 2017.","DOI":"10.3892\/mmr.2017.7641"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16.  Huang              Y,                Deng              X, and                Liang              J. Modulation            of hepatic stellate cells and reversibility of hepatic fibrosis.            Exp Cell Res. 352:            420\u2013426. 2017.","DOI":"10.1016\/j.yexcr.2017.02.038"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17.  Zhang              CY,                Yuan              WG,                He              P,                Lei              JH, and                Wang              CX. Liver            fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic            targets. World J Gastroenterol. 22:            10512\u201310522. 2016.","DOI":"10.3748\/wjg.v22.i48.10512"},{"key":"18","doi-asserted-by":"publisher","unstructured":"18.  Tomita              K,                Tamiya              G,                Ando              S,                Ohsumi              K,                Chiyo              T,                Mizutani              A,                Kitamura              N,                Toda              K,                Kaneko              T,                Horie              Y,                Han              JY,                Kato              S,                Shimoda              M,                Oike              Y,                Tomizawa              M,                Makino              S,                Ohkura              T,                Saito              H,                Kumagai              N,                Nagata              H,                Ishii              H, and                Hibi              T. Tumour            necrosis factor alpha signalling through activation of Kupffer cells plays an essential            role in liver fibrosis of non-alcoholic steatohepatitis in mice.            Gut. 55: 415\u2013424.            2006.","DOI":"10.1136\/gut.2005.071118"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19.  Osawa              Y,                Hoshi              M,                Yasuda              I,                Saibara              T,                Moriwaki              H, and                Kozawa              O. Tumor            necrosis factor-\u03b1 promotes cholestasis-induced liver fibrosis in the mouse through            tissue inhibitor of metalloproteinase-1 production in hepatic stellate            cells. PLoS One. 8:            e65251. 2013.","DOI":"10.1371\/journal.pone.0065251"},{"key":"20","doi-asserted-by":"publisher","unstructured":"20.  Yoshiji              H,                Kuriyama              S,                Miyamoto              Y,                Thorgeirsson              UP,                Gomez              DE,                Kawata              M,                Yoshii              J,                Ikenaka              Y,                Noguchi              R,                Tsujinoue              H,                Nakatani              T,                Thorgeirsson              SS, and                Fukui              H. Tissue            inhibitor of metalloproteinases-1 promotes liver fibrosis development in a transgenic            mouse model. Hepatology. 32:            1248\u20131254. 2000.","DOI":"10.1053\/jhep.2000.20521"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21.  Ma              C,                Liu              A,                Wang              Y,                Geng              X,                Hao              L,                Song              Q,                Sun              B,                Wang              H, and                Zhao              G. The            hepatocyte phase of Gd-EOB-DTPA-enhanced MRI in the evaluation of hepatic fibrosis and            early liver cirrhosis in a rat model: an experimental study.            Life Sci. 108: 104\u2013108.            2014.","DOI":"10.1016\/j.lfs.2014.05.016"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22.  Shen              X,                Guo              H,                Xu              J, and                Wang              J. Inhibition            of lncRNA HULC improves hepatic fibrosis and hepatocyte apoptosis by inhibiting the MAPK            signaling pathway in rats with nonalcoholic fatty liver disease.            J Cell Physiol. 234:            18169\u201318179. 2019.","DOI":"10.1002\/jcp.28450"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23.  Iqbal              U,                Dennis              BB,                Li              AA,                Cholankeril              G,                Kim              D,                Khan              MA, and                Ahmed              A. Use of            anti-platelet agents in the prevention of hepatic fibrosis in patients at risk for            chronic liver disease: a systematic review and meta-analysis.            Hepatol Int. 13: 84\u201390.            2019.","DOI":"10.1007\/s12072-018-9918-2"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24.  Tan              Z,                Liu              Q,                Jiang              R,                Lv              L,                Shoto              SS,                Maillet              I,                Quesniaux              V,                Tang              J,                Zhang              W,                Sun              B, and                Ryffel              B.            Interleukin-33 drives hepatic fibrosis through activation of hepatic            stellate cells. Cell Mol Immunol. 15:            388\u2013398. 2018.","DOI":"10.1038\/cmi.2016.63"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25.  Su              GL.            Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell            activation. Am J Physiol Gastrointest Liver Physiol.            283: G256\u2013G265. 2002.","DOI":"10.1152\/ajpgi.00550.2001"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26.  Szabo              G, and                Bala              S. Alcoholic            liver disease and the gut-liver axis. World J            Gastroenterol. 16: 1321\u20131329.            2010.","DOI":"10.3748\/wjg.v16.i11.1321"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27.  Mandrekar              P, and                Szabo              G. Signalling            pathways in alcohol-induced liver inflammation. J            Hepatol. 50: 1258\u20131266.            2009.","DOI":"10.1016\/j.jhep.2009.03.007"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28.  Hu              N,                Wang              C,                Dai              X,                Zhou              M,                Gong              L,                Yu              L,                Peng              C, and                Li              Y. Phillygenin            inhibits LPS-induced activation and inflammation of LX2 cells by TLR4\/MyD88\/NF-\u03baB            signaling pathway. J Ethnopharmacol.            248: 112361. 2020.","DOI":"10.1016\/j.jep.2019.112361"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29.  Miller              AM,                Horiguchi              N,                Jeong              WI,                Radaeva              S, and                Gao              B. Molecular            mechanisms of alcoholic liver disease: innate immunity and cytokines.            Alcohol Clin Exp Res. 35:            787\u2013793. 2011.","DOI":"10.1111\/j.1530-0277.2010.01399.x"},{"key":"30","unstructured":"30.  Lu              X,                Wang              B,                Xie              Y,                Liu              C, and                Fu              B. [Dynamic            change and expression of matrix metalloproteinase-2, -9 in alcoholic liver disease in            rats]. Zhonghua Gan Zang Bing Za Zhi.            9: 268\u2013270. 2001 (in          Chinese)."},{"key":"31","doi-asserted-by":"crossref","unstructured":"31.  Li              PZ,                Li              JZ,                Li              M,                Gong              JP, and                He              K. An efficient            method to isolate and culture mouse Kupffer cells. Immunol            Lett. 158: 52\u201356.            2014.","DOI":"10.1016\/j.imlet.2013.12.002"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32.  Zhang              Q,                Qu              Y,                Li              Z,                Zhang              Q,                Xu              M,                Cai              X,                Li              F, and                Lu              L. Isolation            and culture of single cell types from rat liver. Cells Tissues            Organs. 201: 253\u2013267.            2016.","DOI":"10.1159\/000444672"},{"key":"33","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","year":"2001","unstructured":"33.  Livak              KJ, and                Schmittgen              TD. Analysis of            relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta            C(T)) Method. Methods. 25:            402\u2013408. 2001.","journal-title":"Methods A Companion to Methods in Enzymology","ISSN":"https:\/\/id.crossref.org\/issn\/1046-2023","issn-type":"print"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34.  Hemmann              S,                Graf              J,                Roderfeld              M, and                Roeb              E. Expression            of MMPs and TIMPs in liver fibrosis\u2014a systematic review with special emphasis on            anti-fibrotic strategies. J Hepatol.            46: 955\u2013975. 2007.","DOI":"10.1016\/j.jhep.2007.02.003"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35.  Yao              L,                Kan              EM,                Lu              J,                Hao              A,                Dheen              ST,                Kaur              C, and                Ling              EA. Toll-like            receptor 4 mediates microglial activation and production of inflammatory mediators in            neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia.            J Neuroinflammation. 10: 23.            2013.","DOI":"10.1186\/1742-2094-10-23"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36.  Peng              Y,                Gong              JP,                Liu              CA,                Li              XH,                Gan              L, and                Li              SB. Expression            of toll-like receptor 4 and MD-2 gene and protein in Kupffer cells after            ischemia-reperfusion in rat liver graft. World J            Gastroenterol. 10: 2890\u20132893.            2004.","DOI":"10.3748\/wjg.v10.i19.2890"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37.  Miyake              K. Endotoxin            recognition molecules, Toll-like receptor 4-MD-2. Semin            Immunol. 16: 11\u201316.            2004.","DOI":"10.1016\/j.smim.2003.10.007"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38.  Re              F, and                Strominger              JL. Separate            functional domains of human MD-2 mediate Toll-like receptor 4-binding and            lipopolysaccharide responsiveness. J Immunol.            171: 5272\u20135276. 2003.","DOI":"10.4049\/jimmunol.171.10.5272"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39.  Akashi-Takamura              S,                Furuta              T,                Takahashi              K,                Tanimura              N,                Kusumoto              Y,                Kobayashi              T,                Saitoh              S,                Adachi              Y,                Doi              T, and                Miyake              K. Agonistic            antibody to TLR4\/MD-2 protects mice from acute lethal hepatitis induced by            TNF-alpha. J Immunol. 176:            4244\u20134251. 2006.","DOI":"10.4049\/jimmunol.176.7.4244"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40.  Csak              T,                Velayudham              A,                Hritz              I,                Petrasek              J,                Levin              I,                Lippai              D,                Catalano              D,                Mandrekar              P,                Dolganiuc              A,                Kurt-Jones              E, and                Szabo              G. Deficiency            in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates            nonalcoholic steatohepatitis and fibrosis in mice. Am J Physiol            Gastrointest Liver Physiol. 300:            G433\u2013G441. 2011.","DOI":"10.1152\/ajpgi.00163.2009"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41.  Yin              X,                Gong              X,                Jiang              R,                Kuang              G,                Wang              B,                Zhang              L,                Xu              G, and                Wan              J. Emodin            ameliorated lipopolysaccharide-induced fulminant hepatic failure by blockade of TLR4\/MD2            complex expression in D-galactosamine-sensitized mice. Int            Immunopharmacol. 23: 66\u201372.            2014.","DOI":"10.1016\/j.intimp.2014.08.018"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42.  Gustot              T,                Lemmers              A,                Moreno              C,                Nagy              N,                Quertinmont              E,                Nicaise              C,                Franchimont              D,                Louis              H,                Devi\u00e8re              J, and                Le Moine              O. Differential            liver sensitization to toll-like receptor pathways in mice with alcoholic fatty            liver. Hepatology. 43:            989\u20131000. 2006.","DOI":"10.1002\/hep.21138"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43.  Soares              JB,                Pimentel-Nunes              P,                Roncon-Albuquerque              R, and                Leite-Moreira              A. The role of            lipopolysaccharide\/toll-like receptor 4 signaling in chronic liver            diseases. Hepatol Int. 4:            659\u2013672. 2010.","DOI":"10.1007\/s12072-010-9219-x"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Ma B, Hottiger M O. Crosstalk between Wnt\/b-Catenin and\nNF-kB signaling pathway during inflammation. Frontiers\nin Immunology. 7: 378. 2016.","DOI":"10.3389\/fimmu.2016.00378"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45.  Ke              B,                Shen              XD,                Kamo              N,                Ji              H,                Yue              S,                Gao              F,                Busuttil              RW, and                Kupiec-Weglinski              JW. \u03b2-catenin            regulates innate and adaptive immunity in mouse liver ischemia-reperfusion            injury. Hepatology. 57:            1203\u20131214. 2013.","DOI":"10.1002\/hep.26100"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46.  Singh              S,                Arcaroli              J,                Thompson              DC,                Messersmith              W, and                Vasiliou              V. Acetaldehyde            and retinaldehyde-metabolizing enzymes in colon and pancreatic cancers.            Adv Exp Med Biol. 815:            281\u2013294. 2015.","DOI":"10.1007\/978-3-319-09614-8_16"},{"key":"47","doi-asserted-by":"publisher","unstructured":"47.  Tessoulin              B,                Descamps              G,                Moreau              P,                Ma\u00efga              S,                Lod\u00e9              L,                Godon              C,                Marionneau-Lambot              S,                Oullier              T,                Le Gouill              S,                Amiot              M, and                Pellat-Deceunynck              C. 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